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2. Abnormal physiological findings after FFR-based revascularisation deferral are associated with worse prognosis in women

Author

Hoshino, Masahiro, van de Hoef, Tim P., Lee, Joo Myung, Hamaya, Rikuta, Kanaji, Yoshihisa, Boerhout, Coen K. M., de Waard, Guus A., Jung, Ji-Hyun, Lee, Seung Hun, Mejia-Renteria, Hernan, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A., Marques, Koen, Doh, Joon-Hyung, Christiansen, Evald H., Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Murai, Tadashi, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Sasano, Tetsuo, Appelman, Yolande, Beijk, Marcel, Knaapen, Paul, van Royen, Niels, Escaned, Javier, Koo, Bon Kwon, Piek, Jan J., and Kakuta, Tsunekazu

Published
2023
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3. Prognostic Implications of Individual and Combinations of Resting and Hyperemic Coronary Pressure and Flow Parameters

Author

Yang, Seokhun, Hwang, Doyeon, Lee, Joo Myung, Lee, Seung Hun, Boerhout, Coen K.M., Woudstra, Janneke, Vink, Caitlin E.M., de Waard, Guus A., Jung, Ji Hyun, Renteria, Hernan Mejia, Hoshino, Masahiro, Pinto, Mauro Echavarria, Meuwissen, Martijn, Matsuo, Hitoshi, Cambero, Maribel Madera, Eftekhari, Ashkan, Effat, Mohamed A., Murai, Tadashi, Marques, Koen, Appelman, Yolande, Doh, Joon Hyung, Christiansen, Evald H., Banerjee, Rupak, Kim, Hyun Kuk, Nam, Chang Wook, Niccoli, Giampaolo, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun Seok, Beijk, Marcel A.M., Chamuleau, Steven A.J., van Royen, Niels, Knaapen, Paul, Kakuta, Tsunekazu, Escaned, Javier, Piek, Jan J., van de Hoef, Tim P., and Koo, Bon-Kwon

Published
2023
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4. Predicting the response to acetylcholine in ischemia or infarction with non-obstructive coronary arteries: The ABCD score

Author

Rinaldi, Riccardo, Colucci, Michele, Torre, Ilaria, Ausiello, Davide, Bonanni, Alice, Basile, Mattia, Salzillo, Carmine, Sanna, Tommaso, Liuzzo, Giovanna, Leone, Antonio Maria, Burzotta, Francesco, Trani, Carlo, Lanza, Gaetano Antonio, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Leone, Antonio M (ORCID:0000-0002-1276-9883), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Lanza, Gaetano A (ORCID:0000-0003-2187-6653), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco A, Rinaldi, Riccardo, Colucci, Michele, Torre, Ilaria, Ausiello, Davide, Bonanni, Alice, Basile, Mattia, Salzillo, Carmine, Sanna, Tommaso, Liuzzo, Giovanna, Leone, Antonio Maria, Burzotta, Francesco, Trani, Carlo, Lanza, Gaetano Antonio, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Leone, Antonio M (ORCID:0000-0002-1276-9883), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Lanza, Gaetano A (ORCID:0000-0003-2187-6653), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), and Montone, Rocco A

Abstract

Background and aims: Acetylcholine (ACh) provocation testing can detect vasomotor disorders in patients with ischemia and non-obstructed coronary arteries (INOCA) or myocardial infarction and non-obstructed coronary arteries (MINOCA). We aimed to derive and validate a simple risk score to predict a positive ACh test response. Methods: We prospectively enrolled consecutive INOCA and MINOCA patients undergoing ACh provocation testing. Patients were split in two cohorts (derivation and validation) according to time of enrolment. The score was derived in 386 patients (derivation cohort) and then validated in 165 patients (validation cohort). Results: 551 patients were enrolled, 371 (67.3%) INOCA and 180 (32.7%) MINOCA. ACh test was positive in 288 (52.3%) patients. MINOCA, myocardial bridge (MB), C-reactive protein (CRP) and dyslipidaemia were independent predictors of a positive ACh test in the derivation cohort. The ABCD (Acute presentation, Bridge, CRP, Dyslipidaemia) score was derived: 2 points were assigned to MINOCA, 3 to MB, 1 to elevated CRP and 1 to dyslipidaemia. The ABCD score accurately identified patients with a positive ACh test response with an AUC of 0.703 (CI 95% 0.652-0.754,p < 0.001) in the derivation cohort, and 0.705 (CI 95% 0.626-0.784, p < 0.001) in the validation cohort. In the whole population, an ABCD score ≥4 portended 94.3% risk of a positive ACh test and all patients with an ABCD score ≥6 presented a positive test. Conclusions: The ABCD score could avoid the need of ACh provocation testing in patients with a high score, reducing procedural risks, time, and costs, and allowing the implementation of a tailored treatment strategy. These results are hypothesis generating and further research involving larger cohorts and multicentre trials is needed to validate and refine the ABCD score.

Published
2024

6. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment

Author

Sen, Sayan, Ahmad, Yousif, Dehbi, Hakim-Moulay, Howard, James P, Iglesias, Juan F, Al-Lamee, Rasha, Petraco, Ricardo, Nijjer, Sukhjinder, Bhindi, Ravinay, Lehman, Sam, Walters, Darren, Sapontis, James, Janssens, Luc, Vrints, Christiaan J, Khashaba, Ahmed, Laine, Mika, Van Belle, Eric, Krackhardt, Florian, Bojara, Waldemar, Going, Olaf, Härle, Tobias, Indolfi, Ciro, Niccoli, Giampaolo, Ribichini, Flavio, Tanaka, Nobuhiro, Yokoi, Hiroyoshi, Takashima, Hiroaki, Kikuta, Yuetsu, Erglis, Andrejs, Vinhas, Hugo, Silva, Pedro Canas, Baptista, Sérgio B, Alghamdi, Ali, Hellig, Farrel, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Eun-Seok, Doh, Joon-Hyung, Brugaletta, Salvatore, Alegria-Barrero, Eduardo, Meuwissen, Martijin, Piek, Jan J, van Royen, Niels, Sezer, Murat, Di Mario, Carlo, Gerber, Robert T, Malik, Iqbal S, Sharp, Andrew SP, Talwar, Suneel, Tang, Kare, Samady, Habib, Altman, John, Seto, Arnold H, Singh, Jasvindar, Jeremias, Allen, Matsuo, Hitoshi, Kharbanda, Rajesh K, Patel, Manesh R, Serruys, Patrick, Escaned, Javier, and Davies, Justin E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease - Coronary Heart Disease, Heart Disease, Clinical Research, Cardiovascular, Good Health and Well Being, Aged, Coronary Angiography, Coronary Stenosis, Coronary Vessels, Female, Fractional Flow Reserve, Myocardial, Humans, Male, Middle Aged, Myocardial Revascularization, coronary stenosis, fractional flow reserve, instantaneous wave-free ratio, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundPhysicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR).ObjectivesThe purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial.MethodsMACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex.ResultsA total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22 to 0.95; p = 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI (unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p = 0.03; MI: 0.44% iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p = 0.06).ConclusionsiFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom iFR-guided deferral was performed had statistically significantly lower event rates than those with FFR-guided deferral.

Published
2019

7. Microvascular complications identify a specific coronary atherosclerotic phenotype in patients with type 2 diabetes mellitus

Author

Montone, Rocco A., Pitocco, Dario, Gurgoglione, Filippo Luca, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Rizzi, Alessandro, Tartaglione, Linda, Rizzo, Gaetano Emanuele, Di Leo, Mauro, Flex, Andrea, Russo, Michele, Liuzzo, Giovanna, Magnani, Giulia, Bonadonna, Riccardo C., Ardissino, Diego, Crea, Filippo, and Niccoli, Giampaolo

Published
2022
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9. Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

Author

Tuttolomondo, Domenico, primary, Niccoli, Giampaolo, additional, Martini, Chiara, additional, D’Ascenzo, Fabrizio, additional, De Filippo, Ovidio, additional, Nicolini, Francesco, additional, Formica, Francesco, additional, Carino, Davide, additional, Gurgoglione, Filippo Luca, additional, Denegri, Andrea, additional, Magnani, Giulia, additional, Vignali, Luigi, additional, De Filippo, Massimo, additional, Sverzellati, Nicola, additional, Ticinesi, Andrea, additional, Bergamaschi, Luca, additional, Pizzi, Carmine, additional, Gherbesi, Elisa, additional, Suma, Sergio, additional, and Gaibazzi, Nicola, additional

Published
2024
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16. Resultados tras 5 años de cirugía o abordaje percutáneo en coronariopatía grave. Metanálisis de ensayos aleatorizados con reconstrucción del tiempo hasta el evento

Author

Formica, Francesco, primary, Hernandez-Vaquero, Daniel, additional, Tuttolomondo, Domenico, additional, Gallingani, Alan, additional, Singh, Gurmeet, additional, Pattuzzi, Claudia, additional, Niccoli, Giampaolo, additional, Lorusso, Roberto, additional, and Nicolini, Francesco, additional

Published
2023
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18. Microvascular complications are associated with coronary collateralization in type 2 diabetes and chronic occlusion

Author

Gurgoglione, Filippo Luca, Pitocco, Dario, Montone, Rocco Antonio, Rinaldi, Riccardo, Bonadonna, Riccardo C, Magnani, Giulia, Calvieri, Camilla, Solinas, Emilia, Rizzi, Alessandro, Tartaglione, Linda, Flex, Andrea, Viti, Luca, Trani, Carlo, Ardissino, Diego, Crea, Filippo, Niccoli, Giampaolo, Pitocco, Dario (ORCID:0000-0002-6220-686X), Montone, Rocco A, Flex, Andrea (ORCID:0000-0003-2664-4165), Trani, Carlo (ORCID:0000-0001-9777-013X), Crea, Filippo (ORCID:0000-0001-9404-8846), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Gurgoglione, Filippo Luca, Pitocco, Dario, Montone, Rocco Antonio, Rinaldi, Riccardo, Bonadonna, Riccardo C, Magnani, Giulia, Calvieri, Camilla, Solinas, Emilia, Rizzi, Alessandro, Tartaglione, Linda, Flex, Andrea, Viti, Luca, Trani, Carlo, Ardissino, Diego, Crea, Filippo, Niccoli, Giampaolo, Pitocco, Dario (ORCID:0000-0002-6220-686X), Montone, Rocco A, Flex, Andrea (ORCID:0000-0003-2664-4165), Trani, Carlo (ORCID:0000-0001-9777-013X), Crea, Filippo (ORCID:0000-0001-9404-8846), and Niccoli, Giampaolo (ORCID:0000-0002-3187-6262)

Abstract

Context: Coronary collateral (CC) vessel development appears to be protective with regard to adverse cardiovascular events and survival in patients with coronary chronic total occlusion (CTO). The influence of type 2 diabetes mellitus (T2DM) on CC growth has been controversial. In particular, the role of diabetic microvascular complications (DMC) in determining coronary collateralization has not been elucidated. Objective: To investigate whether patients with DMC presented differences in CC vessels presence and grading as compared to those without DMC. Methods: We conducted a single-center observational study, including consecutive T2DM patients without previous cardiovascular history, undergoing a clinically indicated coronary angiography for chronic coronary syndrome (CCS) and angiographic evidence of at least one CTO. Patients were subdivided into two study groups according to the presence/absence of at least one of DMC (either neuropathy, nephropathy of retinopathy). The presence and the grading of angiographically visible CC development from the patent vessels to the occluded artery were assessed using the classification developed by Rentrop et al. Results: We enrolled in total 157 patients (mean age 68.6±9.8 years; 120 [76.4%] men). Patients with DMC (75 [47.8%]) had a higher prevalence of CC (69 [92.0%] vs. 62 [75.6%], p = 0.006) and high-grade CC (55 (73.3%) vs. 39 (47.6%), p = 0.001] compared to those without and a positive association between the number of DMC in each patient and the prevalence of high-grade CC was found. Conclusions: Among T2DM patients with coronary CTO, the presence of DMC was associated with a high CC development.

Published
2023

19. Air pollution and plaque healing in acute coronary syndromes

Author

Russo, Michele, Rinaldi, Riccardo, Camilli, Massimiliano, Bonanni, Alice, Caffè, Andrea, Basile, Mattia, Salzillo, Carmine, Colucci, Michele, Torre, Ilaria, Sanna, Tommaso, Liuzzo, Giovanna, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco A, Russo, Michele, Rinaldi, Riccardo, Camilli, Massimiliano, Bonanni, Alice, Caffè, Andrea, Basile, Mattia, Salzillo, Carmine, Colucci, Michele, Torre, Ilaria, Sanna, Tommaso, Liuzzo, Giovanna, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), and Montone, Rocco A

Abstract

N/A

Published
2023

20. Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction

Author

Galli, Mattia, Niccoli, Giampaolo, De Maria, Gianluigi, Brugaletta, Salvatore, Montone, Rocco Antonio, Vergallo, Rocco, Benenati, Stefano, Magnani, Giulia, D'Amario, Domenico, Porto, Italo, Burzotta, Francesco, Abbate, Antonio, Angiolillo, Dominick J, Crea, Filippo, Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Montone, Rocco A, Porto, Italo (ORCID:0000-0002-9854-5046), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Crea, Filippo (ORCID:0000-0001-9404-8846), Galli, Mattia, Niccoli, Giampaolo, De Maria, Gianluigi, Brugaletta, Salvatore, Montone, Rocco Antonio, Vergallo, Rocco, Benenati, Stefano, Magnani, Giulia, D'Amario, Domenico, Porto, Italo, Burzotta, Francesco, Abbate, Antonio, Angiolillo, Dominick J, Crea, Filippo, Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Montone, Rocco A, Porto, Italo (ORCID:0000-0002-9854-5046), Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

Despite prompt epicardial recanalization in patients presenting with ST-segment elevation myocardial infarction (STEMI), coronary microvascular obstruction and dysfunction (CMVO) is still fairly common and is associated with poor prognosis. Various pharmacological and mechanical strategies to treat CMVO have been proposed, but the positive results reported in preclinical and small proof-of-concept studies have not translated into benefits in large clinical trials conducted in the modern treatment setting of patients with STEMI. Therefore, the optimal management of these patients remains a topic of debate. In this Review, we appraise the pathophysiological mechanisms of CMVO, explore the evidence and provide future perspectives on strategies to be implemented to reduce the incidence of CMVO and improve prognosis in patients with STEMI.Coronary microvascular obstruction and dysfunction (CMVO) is common in patients with ST-segment elevation myocardial infarction (STEMI) despite prompt reperfusion. In this Review, the authors discuss the mechanisms of CMVO as well as strategies to reduce its incidence and improve prognosis.Coronary microvascular obstruction and dysfunction (CMVO) is fairly common in patients with ST-segment elevation myocardial infarction (STEMI) and is associated with poor prognosis.Prompt epicardial recanalization by timely primary percutaneous coronary intervention (PPCI) is the most effective strategy for the treatment and prevention of CMVO but is also a relevant confounding factor in the assessment of additional strategies to reduce CMVO in the modern management of patients with STEMI.The optimal strategies to reduce CMVO in clinical practice remain debated, given that promising results from preclinical and small proof-of-concept studies have often not translated into similarly positive results in large-scale clinical trials.The increasing understanding of the underlying mechanisms and the availability of more advanced tools for the prompt and pre

Published
2023

21. Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction

Author

Galli, Mattia, Niccoli, Giampaolo, De Maria, Gianluigi, Brugaletta, Salvatore, Montone, Rocco Antonio, Vergallo, Rocco, Benenati, Stefano, Magnani, Giulia, D'Amario, Domenico, Porto, Italo, Burzotta, Francesco, Abbate, Antonio, Angiolillo, Dominick J, Crea, Filippo, Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Montone, Rocco A, Porto, Italo (ORCID:0000-0002-9854-5046), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Crea, Filippo (ORCID:0000-0001-9404-8846), Galli, Mattia, Niccoli, Giampaolo, De Maria, Gianluigi, Brugaletta, Salvatore, Montone, Rocco Antonio, Vergallo, Rocco, Benenati, Stefano, Magnani, Giulia, D'Amario, Domenico, Porto, Italo, Burzotta, Francesco, Abbate, Antonio, Angiolillo, Dominick J, Crea, Filippo, Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Montone, Rocco A, Porto, Italo (ORCID:0000-0002-9854-5046), Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2023

22. Sex Differences in Instantaneous Wave-Free Ratio or Fractional Flow Reserve–Guided Revascularization Strategy

Author

Kim, Chee Hae, Koo, Bon-Kwon, Dehbi, Hakim-Moulay, Lee, Joo Myung, Doh, Joon-Hyung, Nam, Chang-Wook, Shin, Eun-Seok, Cook, Christopher M., Al-Lamee, Rasha, Petraco, Ricardo, Sen, Sayan, Malik, Iqbal S., Nijjer, Sukhjinder S., Mejía-Rentería, Hernán, Alegria-Barrero, Eduardo, Alghamdi, Ali, Altman, John, Baptista, Sérgio B., Bhindi, Ravinay, Bojara, Waldemar, Brugaletta, Salvatore, Silva, Pedro Canas, Di Mario, Carlo, Erglis, Andrejs, Gerber, Robert T., Going, Olaf, Härle, Tobias, Hellig, Farrel, Indolfi, Ciro, Janssens, Luc, Jeremias, Allen, Kharbanda, Rajesh K., Khashaba, Ahmed, Kikuta, Yuetsu, Krackhardt, Florian, Laine, Mika, Lehman, Sam J., Matsuo, Hitoshi, Meuwissen, Martijin, Niccoli, Giampaolo, Piek, Jan J., Ribichini, Flavo, Samady, Habib, Sapontis, James, Seto, Arnold H., Sezer, Murat, Sharp, Andrew S.P., Singh, Jasvindar, Takashima, Hiroaki, Talwar, Suneel, Tanaka, Nobuhiro, Tang, Kare, Van Belle, Eric, van Royen, Niels, Vinhas, Hugo, Vrints, Christiaan J., Walters, Darren, Yokoi, Hiroyoshi, Samuels, Bruce, Buller, Christopher, Patel, Manesh R., Serruys, Patrick W., Escaned, Javier, and Davies, Justin E.

Published
2019
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23. Calcified Plaques in Patients With Acute Coronary Syndromes

Author

Sugiyama, Tomoyo, Yamamoto, Erika, Fracassi, Francesco, Lee, Hang, Yonetsu, Taishi, Kakuta, Tsunekazu, Soeda, Tsunenari, Saito, Yoshihiko, Yan, Bryan P., Kurihara, Osamu, Takano, Masamichi, Niccoli, Giampaolo, Crea, Filippo, Higuma, Takumi, Kimura, Shigeki, Minami, Yoshiyasu, Ako, Junya, Adriaenssens, Tom, Boeder, Niklas F., Nef, Holger M., Fujimoto, James G., Fuster, Valentin, Finn, Aloke V., Falk, Erling, and Jang, Ik-Kyung

Published
2019
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24. Excimer Laser LEsion Modification to Expand Non-dilatable sTents: The ELLEMENT Registry

Author

Latib, Azeem, Takagi, Kensuke, Chizzola, Giuliano, Tobis, Jonathan, Ambrosini, Vittorio, Niccoli, Giampaolo, Sardella, Gennaro, DiSalvo, Maria Elena, Armigliato, Pietro, Valgimigli, Marco, Tarsia, Giandomenico, Gabrielli, Gabriele, Lazar, Lawrence, Maffeo, Diego, and Colombo, Antonio

Subjects
Bioengineering, Cardiovascular, Heart Disease, Heart Disease - Coronary Heart Disease, Atherosclerosis, Assistive Technology, Aged, Aged, 80 and over, Angioplasty, Balloon, Laser-Assisted, Contrast Media, Coronary Angiography, Coronary Restenosis, Coronary Stenosis, Coronary Thrombosis, Feasibility Studies, Female, Humans, Italy, Lasers, Excimer, Male, Middle Aged, Myocardial Infarction, Pilot Projects, Prospective Studies, Prosthesis Design, Registries, Stents, Time Factors, Treatment Outcome, Ultrasonography, Interventional, Vascular Calcification, In-stent restenosis, Excimer Laser Coronary Angioplasty, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

Background/objectivesStent underexpansion is a risk factor for in-stent restenosis and stent thrombosis. Existing techniques to optimize stent expansion are sometimes ineffective. The aim of this study was to evaluate the effectiveness and feasibility of Excimer Laser Coronary Angioplasty (ELCA) in improving stent expansion when high-pressure non-compliant balloon inflation was ineffective.Methods and resultsECLA ablation was performed at high energy during contrast injection and only within the underexpanded stent. The primary endpoint of successful laser dilatation was defined as an increase of at least 1mm(2) in minimal stent cross-sectional area (MSA) on IVUS or an increase of at least 20% in minimal stent diameter (MSD) by QCA, following redilatation with the same non-compliant balloon that had been unsuccessful prior to ELCA. Secondary endpoints were cardiac death, myocardial infarction (MI) and target lesion revascularization. Between June 2009 and November 2011, 28 patients with an underexpanded stent despite high-pressure balloon inflation were included. The mean laser catheter size was 1.2±0.4 (range 0.9-2.0mm) and a mean of 62±12mJ/mm(2) at 62±21hertz were required for optimal expansion. Laser-assisted stent dilatation was successful in 27 cases (96.4%), with an improvement in MSD by QCA (1.6±0.6mm at baseline to 2.6±0.6mm post-procedure) and MSA by IVUS (3.5±1.1mm(2) to 7.1±1.9mm(2)). Periprocedural MI occurred in 7.1%, transient slow-flow in 3.6% and ST elevation in 3.6%. During follow-up, there were no MIs, there was 1 cardiac-death, and TLR occurred in 6.7%.ConclusionsThe ELLEMENT study confirms the feasibility of ELCA with contrast injection to improve stent underexpansion in undilatable stented lesions.

Published
2014

25. Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders.

Author

Gurgoglione, Filippo Luca, Vignali, Luigi, Montone, Rocco Antonio, Rinaldi, Riccardo, Benatti, Giorgio, Solinas, Emilia, Leone, Antonio Maria, Galante, Domenico, Campo, Gianluca, Biscaglia, Simone, Porto, Italo, Benenati, Stefano, and Niccoli, Giampaolo

Subjects
CORONARY vasospasm, VASCULAR smooth muscle, ACETYLCHOLINE, PROGNOSIS, SPASMS, MUSCLE cells, CORONARY arteries, CORONARY circulation
Abstract

Coronary vasomotor disorders (CVD) are characterized by transient hypercontraction of coronary vascular smooth muscle cells, leading to hypercontraction of epicardial and/or microvascular coronary circulation. CVDs play a relevant role in the pathogenesis of ischemia, angina and myocardial infarction with non-obstructive coronary arteries. Invasive provocative testing with intracoronary Acetylcholine (ACh) administration is the gold standard tool for addressing CVD, providing relevant therapeutic and prognostic implications. However, safety concerns preclude the widespread incorporation of the ACh test into clinical practice. The purpose of this review is to shed light on the pathophysiology underlying CVD and on the clinical role of the ACh test, focusing on safety profile and prognostic implications. We will also discuss contemporary evidence on the management of CVD and the role of the ACh test in driving a personalized approach of patients with CVD. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Antithrombotic Therapy in Patients Undergoing Transcatheter Interventions for Structural Heart Disease

Author

Calabrò, Paolo, Gragnano, Felice, Niccoli, Giampaolo, Marcucci, Rossella, Zimarino, Marco, Spaccarotella, Carmen, Renda, Giulia, Patti, Giuseppe, Andò, Giuseppe, Moscarella, Elisabetta, Mancone, Massimo, Cesaro, Arturo, Giustino, Gennaro, De Caterina, Raffaele, Mehran, Roxana, Capodanno, Davide, Valgimigli, Marco, Windecker, Stephan, Dangas, George D., Indolfi, Ciro, and Angiolillo, Dominick J.

Published
2021
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28. Dual Antiplatelet Therapy or Antiplatelet Plus Anticoagulant Therapy in Patients with Peripheral and Chronic Coronary Artery Disease: An Updated Review

Author

Magnani, Giulia, primary, Denegri, Andrea, additional, Gurgoglione, Filippo Luca, additional, Barocelli, Federico, additional, Indrigo, Elia, additional, Catellani, Davide, additional, Signoretta, Gianluca, additional, Bettella, Alberto, additional, Tuttolomondo, Domenico, additional, Solinas, Emilia, additional, Nicolini, Francesco, additional, Niccoli, Giampaolo, additional, and Ardissino, Diego, additional

Published
2023
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30. Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes

Author

Escaned, Javier, Ryan, Nicola, Mejía-Rentería, Hernán, Cook, Christopher M., Dehbi, Hakim-Moulay, Alegria-Barrero, Eduardo, Alghamdi, Ali, Al-Lamee, Rasha, Altman, John, Ambrosia, Alphonse, Baptista, Sérgio B., Bertilsson, Maria, Bhindi, Ravinay, Birgander, Mats, Bojara, Waldemar, Brugaletta, Salvatore, Buller, Christopher, Calais, Fredrik, Silva, Pedro Canas, Carlsson, Jörg, Christiansen, Evald H., Danielewicz, Mikael, Di Mario, Carlo, Doh, Joon-Hyung, Erglis, Andrejs, Erlinge, David, Gerber, Robert T., Going, Olaf, Gudmundsdottir, Ingibjörg, Härle, Tobias, Hauer, Dario, Hellig, Farrel, Indolfi, Ciro, Jakobsen, Lars, Janssens, Luc, Jensen, Jens, Jeremias, Allen, Kåregren, Amra, Karlsson, Ann-Charlotte, Kharbanda, Rajesh K., Khashaba, Ahmed, Kikuta, Yuetsu, Krackhardt, Florian, Koo, Bon-Kwon, Koul, Sasha, Laine, Mika, Lehman, Sam J., Lindroos, Pontus, Malik, Iqbal S., Maeng, Michael, Matsuo, Hitoshi, Meuwissen, Martijn, Nam, Chang-Wook, Niccoli, Giampaolo, Nijjer, Sukhjinder S., Olsson, Hans, Olsson, Sven-Erik, Omerovic, Elmir, Panayi, Georgios, Petraco, Ricardo, Piek, Jan J., Ribichini, Flavo, Samady, Habib, Samuels, Bruce, Sandhall, Lennart, Sapontis, James, Sen, Sayan, Seto, Arnold H., Sezer, Murat, Sharp, Andrew S.P., Shin, Eun-Seok, Singh, Jasvindar, Takashima, Hiroaki, Talwar, Suneel, Tanaka, Nobuhiro, Tang, Kare, Van Belle, Eric, van Royen, Niels, Varenhorst, Christoph, Vinhas, Hugo, Vrints, Christiaan J., Walters, Darren, Yokoi, Hiroyoshi, Fröbert, Ole, Patel, Manesh R., Serruys, Patrick, Davies, Justin E., and Götberg, Matthias

Published
2018
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31. Excimer Laser LEsion Modification to Expand Non-dilatable sTents (The ELLEMENT Registry

Author

Lotih, Azeem, Takagi, Kensuke, Chizzola, Giuliano, Niccoli, Giampaolo, Ambrosini, Vittorio, Sardella, Gennaro, DiSalvo, Maria Elena, Armigliato, Pietro, Valgimigli, Marco, Tobis, Jonathan, Montorfano, Matteo, and Colombo, Antonio

Subjects
Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Published
2011

32. Microvascular Complications Are Associated With Coronary Collateralization in Type 2 Diabetes and Chronic Occlusion

Author

Gurgoglione, Filippo Luca, primary, Pitocco, Dario, additional, Montone, Rocco A, additional, Rinaldi, Riccardo, additional, Bonadonna, Riccardo C, additional, Magnani, Giulia, additional, Calvieri, Camilla, additional, Solinas, Emilia, additional, Rizzi, Alessandro, additional, Tartaglione, Linda, additional, Flex, Andrea, additional, Viti, Luca, additional, Trani, Carlo, additional, Ardissino, Diego, additional, Crea, Filippo, additional, and Niccoli, Giampaolo, additional

Published
2023
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33. Microvascular resistance reserve: diagnostic and prognostic performance in the ILIAS registry

Author

Boerhout, Coen K M, primary, Lee, Joo Myung, additional, de Waard, Guus A, additional, Mejia-Renteria, Hernan, additional, Lee, Seung Hun, additional, Jung, Ji-Hyun, additional, Hoshino, Masahiro, additional, Echavarria-Pinto, Mauro, additional, Meuwissen, Martijn, additional, Matsuo, Hitoshi, additional, Madera-Cambero, Maribel, additional, Eftekhari, Ashkan, additional, Effat, Mohamed A, additional, Murai, Tadashi, additional, Marques, Koen, additional, Doh, Joon-Hyung, additional, Christiansen, Evald H, additional, Banerjee, Rupak, additional, Nam, Chang-Wook, additional, Niccoli, Giampaolo, additional, Nakayama, Masafumi, additional, Tanaka, Nobuhiro, additional, Shin, Eun-Seok, additional, Appelman, Yolande, additional, Beijk, Marcel A M, additional, van Royen, Niels, additional, Knaapen, Paul, additional, Escaned, Javier, additional, Kakuta, Tsunekazu, additional, Koo, Bon Kwon, additional, Piek, Jan J, additional, and van de Hoef, Tim P, additional

Published
2023
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35. Personalized Management of Sudden Death Risk in Primary Cardiomyopathies: From Clinical Evaluation and Multimodality Imaging to Ablation and Cardioverter-Defibrillator Implant

Author

Lazzeroni, Davide, primary, Crocamo, Antonio, additional, Ziveri, Valentina, additional, Notarangelo, Maria Francesca, additional, Rizzello, Davide, additional, Spoladori, Matteo, additional, Donelli, Davide, additional, Cacciola, Giovanna, additional, Ardissino, Diego, additional, Niccoli, Giampaolo, additional, and Peretto, Giovanni, additional

Published
2023
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36. Pathophysiology and Treatment of the No-Reflow Phenomenon in ST-Segment Elevation Myocardial Infarction: Focus on Low-Dose Fibrinolysis during Primary Percutaneous Intervention.

Author

Pelliccia, Francesco, Niccoli, Giampaolo, Zimarino, Marco, Andò, Giuseppe, Porto, Italo, Calabrò, Paolo, De Rosa, Salvatore, Gragnano, Felice, Piccolo, Raffaele, Moscarella, Elisabetta, Fabris, Enrico, Montone, Rocco Antonio, Spaccarotella, Carmen, Indolfi, Ciro, Sinagra, Gianfranco, and Perrone Filardi, Pasquale

Abstract

Primary percutaneous coronary intervention (PCI) is the current class I therapeutic approach to treat acute ST-elevation myocardial infarction (STEMI). While primary PCI can restore adequate flow in the infarcted artery in the majority of cases, some patients experience the 'no-reflow' phenomenon, i.e., an abnormal myocardial reperfusion occurring even after the occluded coronary artery has been opened. No-reflow occurs when microvascular obstruction arises from embolization of thrombus or components of the atheromatous plaques. These embolic materials travel downstream within the infarct-related artery at time of primary PCI, leading to compromised blood flow. Currently, no expert consensus documents exist to outline an optimal strategy to prevent or treat no-reflow. Interventional cardiologists frequently employ intracoronary adenosine, calcium channel blockers, nicorandil, nitroprusside or glycoprotein IIb/IIIa inhibitors. However, evidence suggests that these interventions consistently enhance myocardial blood flow in only a specific subset of patients experiencing no-reflow. A recent and innovative therapeutic approach gaining attention is low-dose fibrinolysis during primary PCI, which offers the potential to augment coronary flow post-myocardial revascularization. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Correction: Clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries

Author

Montone, Rocco Antonio, Niccoli, Giampaolo, Russo, Michele, Giaccari, Marta, Del Buono, Marco Giuseppe, Meucci, Maria Chiara, Gurgoglione, Filippo, Vergallo, Rocco, D'Amario, Domenico, Buffon, Antonino Maria Tommaso, Leone, Antonio Maria, Burzotta, Francesco, Aurigemma, Cristina, Trani, Carlo, Liuzzo, Giovanna, Lanza, Gaetano Antonio, Crea, Filippo, Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Buffon, Antonino (ORCID:0000-0002-6910-8357), Leone, Antonio M (ORCID:0000-0002-1276-9883), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Lanza, Gaetano A (ORCID:0000-0003-2187-6653), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco Antonio, Niccoli, Giampaolo, Russo, Michele, Giaccari, Marta, Del Buono, Marco Giuseppe, Meucci, Maria Chiara, Gurgoglione, Filippo, Vergallo, Rocco, D'Amario, Domenico, Buffon, Antonino Maria Tommaso, Leone, Antonio Maria, Burzotta, Francesco, Aurigemma, Cristina, Trani, Carlo, Liuzzo, Giovanna, Lanza, Gaetano Antonio, Crea, Filippo, Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Buffon, Antonino (ORCID:0000-0002-6910-8357), Leone, Antonio M (ORCID:0000-0002-1276-9883), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Lanza, Gaetano A (ORCID:0000-0003-2187-6653), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2022

38. Microvascular complications identify a specific coronary atherosclerotic phenotype in patients with type 2 diabetes mellitus

Author

Montone, Rocco Antonio, Pitocco, Dario, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Rizzi, Alessandro, Tartaglione, Linda, Rizzo, Gaetano Emanuele, Di Leo, Mauro, Flex, Andrea, Russo, Michele, Liuzzo, Giovanna, Bonadonna, Riccardo C, Ardissino, Diego, Crea, Filippo, Niccoli, Giampaolo, Montone, Rocco A, Pitocco, Dario (ORCID:0000-0002-6220-686X), Flex, Andrea (ORCID:0000-0003-2664-4165), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Crea, Filippo (ORCID:0000-0001-9404-8846), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Montone, Rocco Antonio, Pitocco, Dario, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Rizzi, Alessandro, Tartaglione, Linda, Rizzo, Gaetano Emanuele, Di Leo, Mauro, Flex, Andrea, Russo, Michele, Liuzzo, Giovanna, Bonadonna, Riccardo C, Ardissino, Diego, Crea, Filippo, Niccoli, Giampaolo, Montone, Rocco A, Pitocco, Dario (ORCID:0000-0002-6220-686X), Flex, Andrea (ORCID:0000-0003-2664-4165), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Crea, Filippo (ORCID:0000-0001-9404-8846), and Niccoli, Giampaolo (ORCID:0000-0002-3187-6262)

Abstract

Background Patients with type 2 diabetes mellitus (T2DM) are considered as a homogeneous cohort of patients. However, the specific role of diabetic microvascular complications (DMC), in determining the features of coronary plaques is poorly known. We investigated whether the presence of DMC may identify a different phenotype of patients associated to specific clinical, angiographic, optical coherence tomography (OCT) features and different prognosis. Methods We prospectively enrolled consecutive T2DM patients with obstructive coronary artery disease (CAD) at their first coronary event. Patients were stratified according to the presence or absence of DMC, including diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. OCT assessment of the culprit vessel was performed in a subgroup of patients. The incidence of major adverse cardiac events (MACEs) was assessed at follow-up. Results We enrolled 320 T2DM patients (mean age 70.3 +/- 8.8 years; 234 [73.1%] men, 40% acute coronary syndrome, 60% chronic coronary syndrome). Patients with DMC (172 [53.75%]) presented a different clinical and biochemical profile and, of importance, a higher prevalence of multivessel CAD (109 [63.4%] vs. 68 [45.9%], p = 0.002). At OCT analysis, DMC was associated to a higher prevalence of large calcifications and healed plaques and to a lower prevalence of lipid plaques. Finally, MACEs rate was significantly higher (25 [14.5%] vs. 12 [8.1%], p = 0.007) in DMC patients, mainly driven by a higher rate of planned revascularizations, and DMC predicted the occurrence of MACEs (mean follow-up 33.4 +/- 15.6 months). Conclusions The presence of DMC identifies a distinct diabetic population with more severe CAD but with a more stable pattern of coronary atherosclerosis.

Published
2022

39. Precision medicine versus standard of care for patients with myocardial infarction with non-obstructive coronary arteries (MINOCA): rationale and design of the multicentre, randomised PROMISE trial

Author

Montone, Rocco Antonio, Cosentino, Nicola, Graziani, Francesca, Gorla, Riccardo, Del Buono, Marco Giuseppe, La Vecchia, Giulia, Rinaldi, Riccardo, Marenzi, Giancarlo, Bartorelli, Antonio L, De Marco, Federico, Testa, Luca, Bedogni, Francesco, Trani, Carlo, Liuzzo, Giovanna, Niccoli, Giampaolo, Crea, Filippo, Graziani, Francesca (ORCID:0000-0002-4520-5689), Trani, Carlo (ORCID:0000-0001-9777-013X), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco Antonio, Cosentino, Nicola, Graziani, Francesca, Gorla, Riccardo, Del Buono, Marco Giuseppe, La Vecchia, Giulia, Rinaldi, Riccardo, Marenzi, Giancarlo, Bartorelli, Antonio L, De Marco, Federico, Testa, Luca, Bedogni, Francesco, Trani, Carlo, Liuzzo, Giovanna, Niccoli, Giampaolo, Crea, Filippo, Graziani, Francesca (ORCID:0000-0002-4520-5689), Trani, Carlo (ORCID:0000-0001-9777-013X), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2022

40. Safety and prognostic relevance of acetylcholine testing in patients with stable myocardial ischaemia or myocardial infarction and non-obstructive coronary arteries

Author

Montone, Rocco Antonio, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Gurgoglione, Filippo, La Vecchia, Giulia, Russo, Michele, Caffè, Andrea, Burzotta, Francesco, Leone, Antonio Maria, Romagnoli, Enrico, Sanna, Tommaso, Pelargonio, Gemma, Trani, Carlo, Lanza, Gaetano Antonio, Niccoli, Giampaolo, Crea, Filippo, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Trani, Carlo (ORCID:0000-0001-9777-013X), Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco Antonio, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Gurgoglione, Filippo, La Vecchia, Giulia, Russo, Michele, Caffè, Andrea, Burzotta, Francesco, Leone, Antonio Maria, Romagnoli, Enrico, Sanna, Tommaso, Pelargonio, Gemma, Trani, Carlo, Lanza, Gaetano Antonio, Niccoli, Giampaolo, Crea, Filippo, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Trani, Carlo (ORCID:0000-0001-9777-013X), Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2022

41. Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy: A Contemporary Perspective

Author

Gragnano, Felice, primary, Pelliccia, Francesco, additional, Guarnaccia, Natale, additional, Niccoli, Giampaolo, additional, De Rosa, Salvatore, additional, Piccolo, Raffaele, additional, Moscarella, Elisabetta, additional, Fabris, Enrico, additional, Montone, Rocco Antonio, additional, Cesaro, Arturo, additional, Porto, Italo, additional, Indolfi, Ciro, additional, Sinagra, Gianfranco, additional, Perrone Filardi, Pasquale, additional, Andò, Giuseppe, additional, and Calabrò, Paolo, additional

Published
2023
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44. Changes in microvascular resistance following percutaneous coronary intervention - From the ILIAS global registry

Author

Team Medisch, Eftekhari, Ashkan, van de Hoef, Tim P, Hoshino, Masahiro, Lee, Joo Myung, Boerhout, Coen K M, de Waard, Guus A, Jung, Ji-Hyun, Lee, Seung Hun, Mejia-Renteria, Hernan, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Effat, Mohamed A, Marques, Koen, Doh, Joon-Hyung, Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Murai, Tadashi, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Knaapen, Paul, van Royen, Niels, Escaned, Javier, Koo, Bon Kwon, Chamuleau, Steven A J, Kakuta, Tsunekazu, Piek, Jan J, Christiansen, Evald Høj, Team Medisch, Eftekhari, Ashkan, van de Hoef, Tim P, Hoshino, Masahiro, Lee, Joo Myung, Boerhout, Coen K M, de Waard, Guus A, Jung, Ji-Hyun, Lee, Seung Hun, Mejia-Renteria, Hernan, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Effat, Mohamed A, Marques, Koen, Doh, Joon-Hyung, Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Murai, Tadashi, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Knaapen, Paul, van Royen, Niels, Escaned, Javier, Koo, Bon Kwon, Chamuleau, Steven A J, Kakuta, Tsunekazu, Piek, Jan J, and Christiansen, Evald Høj

Published
2023

45. Microvascular resistance reserve: diagnostic and prognostic performance in the ILIAS registry

Author

Team Medisch, Boerhout, Coen K M, Lee, Joo Myung, de Waard, Guus A, Mejia-Renteria, Hernan, Lee, Seung Hun, Jung, Ji-Hyun, Hoshino, Masahiro, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A, Murai, Tadashi, Marques, Koen, Doh, Joon-Hyung, Christiansen, Evald H, Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Appelman, Yolande, Beijk, Marcel A M, van Royen, Niels, Knaapen, Paul, Escaned, Javier, Kakuta, Tsunekazu, Koo, Bon Kwon, Piek, Jan J, van de Hoef, Tim P, Team Medisch, Boerhout, Coen K M, Lee, Joo Myung, de Waard, Guus A, Mejia-Renteria, Hernan, Lee, Seung Hun, Jung, Ji-Hyun, Hoshino, Masahiro, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A, Murai, Tadashi, Marques, Koen, Doh, Joon-Hyung, Christiansen, Evald H, Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Appelman, Yolande, Beijk, Marcel A M, van Royen, Niels, Knaapen, Paul, Escaned, Javier, Kakuta, Tsunekazu, Koo, Bon Kwon, Piek, Jan J, and van de Hoef, Tim P

Published
2023

46. Impact of core laboratory assessment on treatment decisions and clinical outcomes using combined fractional flow reserve and coronary flow reserve measurements - DEFINE-FLOW core laboratory sub-study

Author

Team Medisch, van de Hoef, Tim P, Stegehuis, Valérie E, Madera-Cambero, Maribel I, van Royen, Niels, van der Hoeven, Nina W, de Waard, Guus A, Meuwissen, Martijn, Christiansen, Evald H, Eftekhari, Ashkan, Niccoli, Giampaolo, Lockie, Tim, Matsuo, Hitoshi, Nakayama, Masafumi, Kakuta, Tsunekazu, Tanaka, Nobuhiro, Casadonte, Lorena, Spaan, Jos A E, Siebes, Maria, Tijssen, Jan G P, Escaned, Javier, Piek, Jan J, Team Medisch, van de Hoef, Tim P, Stegehuis, Valérie E, Madera-Cambero, Maribel I, van Royen, Niels, van der Hoeven, Nina W, de Waard, Guus A, Meuwissen, Martijn, Christiansen, Evald H, Eftekhari, Ashkan, Niccoli, Giampaolo, Lockie, Tim, Matsuo, Hitoshi, Nakayama, Masafumi, Kakuta, Tsunekazu, Tanaka, Nobuhiro, Casadonte, Lorena, Spaan, Jos A E, Siebes, Maria, Tijssen, Jan G P, Escaned, Javier, and Piek, Jan J

Published
2023

47. Sex differences in prevalence and outcomes of the different endotypes of chronic coronary syndrome in symptomatic patients undergoing invasive coronary angiography: Insights from the global ILIAS invasive coronary physiology registry

Author

Team Medisch, Vink, Caitlin E M, Woudstra, Janneke, Lee, Joo Myung, Boerhout, Coen K M, Cook, Christopher M, Hoshino, Masahiro, Mejia-Renteria, Hernan, Lee, Seung Hun, Jung, Ji-Hyun, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A, Murai, Tadashi, Marques, Koen, Beijk, Marcel A M, Doh, Joon-Hyung, Piek, Jan J, van de Hoef, Tim P, Christiansen, Evald Høj, Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, van Royen, Niels, Chamuleau, Steven A J, Knaapen, Paul, Escaned, Javier, Kakuta, Tsunekazu, Koo, Bon-Kwon, Appelman, Yolande, de Waard, Guus A, Team Medisch, Vink, Caitlin E M, Woudstra, Janneke, Lee, Joo Myung, Boerhout, Coen K M, Cook, Christopher M, Hoshino, Masahiro, Mejia-Renteria, Hernan, Lee, Seung Hun, Jung, Ji-Hyun, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A, Murai, Tadashi, Marques, Koen, Beijk, Marcel A M, Doh, Joon-Hyung, Piek, Jan J, van de Hoef, Tim P, Christiansen, Evald Høj, Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, van Royen, Niels, Chamuleau, Steven A J, Knaapen, Paul, Escaned, Javier, Kakuta, Tsunekazu, Koo, Bon-Kwon, Appelman, Yolande, and de Waard, Guus A

Published
2023

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