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Your search keyword '"Chen, Ruihuan"' showing total 33 results
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33 results on '"Chen, Ruihuan"'

1. Enhancing Older Adults' Gesture Typing Experience Using the T9 Keyboard on Small Touchscreen Devices

Author

Kuang, Emily, Chen, Ruihuan, and Fan, Mingming

Subjects
Computer Science - Human-Computer Interaction
Abstract

Older adults increasingly adopt small-screen devices, but limited motor dexterity hinders their ability to type effectively. While a 9-key (T9) keyboard allocates larger space to each key, it is shared by multiple consecutive letters. Consequently, users must interrupt their gestures when typing consecutive letters, leading to inefficiencies and poor user experience. Thus, we proposed a novel keyboard that leverages the currently unused key 1 to duplicate letters from the previous key, allowing the entry of consecutive letters without interruptions. A user study with 12 older adults showed that it significantly outperformed the T9 with wiggle gesture in typing speed, KSPC, insertion errors, and deletes per word while achieving comparable performance as the conventional T9. Repeating the typing tasks with 12 young adults found that the advantages of the novel T9 were consistent or enhanced. We also provide error analysis and design considerations for improving gesture typing on T9 for older adults., Comment: Proceedings of the 2023 CHI Conference on Human Factors in Computing Systems (CHI '23), April 23--28, 2023, Hamburg, Germany

Published
2023
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11. ALD-R491 regulates vimentin filament stability and solubility, cell contractile force, cell migration speed and directionality

Author

Kim, Hyejeong Rosemary, primary, Warrington, Samantha J., additional, López-Guajardo, Ana, additional, Al Hennawi, Khairat, additional, Cook, Sarah L., additional, Griffith, Zak D. J., additional, Symmes, Deebie, additional, Zhang, Tao, additional, Qu, Zhipeng, additional, Xu, Ying, additional, Chen, Ruihuan, additional, and Gad, Annica K. B., additional

Published
2022
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14. Efficient degradation of Bisphenol A by Fe3+/Fe2+ cycle activating persulfate with the assistance of biochar-supported MoO2

Author

Ouyang, Da, Wu, Ronghao, Xu, Zhaojun, Zhu, Xiaomin, Cai, Yimin, Chen, Ruihuan, Zhu, Changyin, Barceló, Damià, Zhang, Haibo, Ouyang, Da, Wu, Ronghao, Xu, Zhaojun, Zhu, Xiaomin, Cai, Yimin, Chen, Ruihuan, Zhu, Changyin, Barceló, Damià, and Zhang, Haibo

Abstract

Advanced oxidation processes (AOPs) based on persulfate (PDS) activation by iron materials have attracted significant attention due to their high organic pollution removal efficiency and relatively low remediation costs. However, one of the iron-based materials’ shortcomings is the weak activation ability of Fe3+ on PDS and the low sustainability of Fe2+ in the oxidation environment. In this study, biochar-supported molybdenum dioxide (MoO2@BC) was employed as a co-catalyst to enhance the Fe3+ based PDS activation for Bisphenol A (BPA) degradation. Results showed that >96 % of BPA was removed during 60 min, and the BPA degradation efficiencies only slightly decreased after four reuses of MoO2@BC. Electron paramagnetic resonance (EPR) analysis and quenching experiments indicated that reactive oxidation species (ROSs) contributing to the degradation of BPA were SO4[rad]−, [rad]OH and 1O2. Besides, it was found that biochar supporting favours the adsorption of Fe3+ on the MoO2 surface and promotes the electron transfer from Mo(IV) to Fe3+ based on the combination of X-ray photoelectron spectroscopy (XPS) analysis, electrochemical tests and density functional theory calculation (DFT). This work provides a new insight for enhancing the performance of organic contaminants degradation through AOPs based on persulfate activation by iron material.

Published
2022

17. A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

Author

Chen, Ruihuan, Nishimura, Merry C., Bumbaca, Stephanie M., Kharbanda, Samir, Forrest, William F., Kasman, Ian M., Greve, Joan M., Soriano, Robert H., Gilmour, Laurie L., Rivers, Celina Sanchez, Modrusan, Zora, Nacu, Serban, Guerrero, Steve, Edgar, Kyle A., Wallin, Jeffrey J., Lamszus, Katrin, Westphal, Manfred, Heim, Susanne, James, C. David, VandenBerg, Scott R., Costello, Joseph F., Moorefield, Scott, Cowdrey, Cynthia J., Prados, Michael, and Phillips, Heidi S.

Published
2010
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18. A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases

Author

Li, Zhizhen, primary, Wu, Jianping, additional, Zhou, Ji, additional, Yuan, Baoshi, additional, Chen, Jiqiao, additional, Wu, Wanchen, additional, Mo, Lian, additional, Qu, Zhipeng, additional, Zhou, Fei, additional, Dong, Yingying, additional, Huang, Kai, additional, Liu, Zhiwei, additional, Wang, Tao, additional, Symmes, Deebie, additional, Gu, Jingliang, additional, Sho, Eiketsu, additional, Zhang, Jingping, additional, Chen, Ruihuan, additional, and Xu, Ying, additional

Published
2021
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20. Abstract P35: Targeting vimentin impacts multiple cellular processes, blocks the spike protein-ACE2-mediated pseudoviral infection in vitro and reduces the symptom and lung injury in aged mice with mouse-adapted SARS-CoV-2 infection in vivo

Author

Li, Zhizhen, primary, Wu, Jianping, additional, Yuan, Baoshi, additional, Dinnon, Kenneth, additional, Mo, Lian, additional, Zhou, Fei, additional, Dong, Yingying, additional, Gully, Kendra, additional, Baric, Ralph, additional, Graham, Rachel, additional, Xu, Ying, additional, and Chen, Ruihuan, additional

Published
2021
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23. Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation

Author

Li, Sichen, primary, Chou, Arthur P., additional, Chen, Weidong, additional, Chen, Ruihuan, additional, Deng, Yuzhong, additional, Phillips, Heidi S., additional, Selfridge, Julia, additional, Zurayk, Mira, additional, Lou, Jerry J., additional, Everson, Richard G., additional, Wu, Kuan-Chung, additional, Faull, Kym F., additional, Cloughesy, Timothy, additional, Liau, Linda M., additional, and Lai, Albert, additional

Published
2012
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31. Self-assembling a 1,4-dioxane-degrading consortium and identifying the key role of Shinella sp. through dilution-to-extinction and reculturing.

Author

Tian K, Zhang Y, Chen R, Tan D, Zhong M, Yao D, Dong Y, and Liu Y

Subjects
Biodegradation, Environmental, Microbial Consortia, Dioxanes metabolism, Microbiota
Abstract

Importance: Assembling a functional microbial consortium and identifying key degraders involved in the degradation of 1,4-dioxane are crucial for the design of synergistic consortia used in enhancing the bioremediation of 1,4-dioxane-contaminated sites. However, due to the vast diversity of microbes, assembling a functional consortium and identifying novel degraders through a simple method remain a challenge. In this study, we reassembled 1,4-dioxane-degrading microbial consortia using a simple and easy-to-operate method by combining dilution-to-extinction and reculture techniques. We combined differential analysis of community structure and metabolic function and confirmed that Shinella species have a stronger 1,4-dioxane degradation ability than Xanthobacter species in the enriched consortium. In addition, a new dioxane-degrading bacterium was isolated, Shinella yambaruensis , which verified our findings. These results demonstrate that DTE and reculture techniques can be used beyond diversity reduction to assemble functional microbial communities, particularly to identify key degraders in contaminant-degrading consortia., Competing Interests: The authors declare no conflict of interest.

Published
2023
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32. Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.

Author

Chen R, Nishimura MC, Kharbanda S, Peale F, Deng Y, Daemen A, Forrest WF, Kwong M, Hedehus M, Hatzivassiliou G, Friedman LS, and Phillips HS

Subjects
Amino Acid Substitution, Animals, Brain Neoplasms pathology, Cell Line, Tumor, Female, Gene Knockdown Techniques, Genes, p53, Glioma pathology, Glutamate Dehydrogenase antagonists & inhibitors, Glutamic Acid metabolism, Humans, Mice, Mice, Inbred NOD, Mice, Nude, Mice, SCID, Neoplastic Stem Cells enzymology, Neoplastic Stem Cells pathology, Receptors, Glutamate genetics, Receptors, Glutamate metabolism, Brain Neoplasms enzymology, Brain Neoplasms genetics, Glioma enzymology, Glioma genetics, Glutamate Dehydrogenase genetics, Glutamate Dehydrogenase metabolism, Isocitrate Dehydrogenase genetics, Isocitrate Dehydrogenase metabolism, Mutant Proteins genetics, Mutant Proteins metabolism
Abstract

Somatic mutation of isocitrate dehydrogenase 1 (IDH1) is now recognized as the most common initiating event for secondary glioblastoma, a brain tumor type arising with high frequency in the frontal lobe. A puzzling feature of IDH1 mutation is the selective manifestation of glioma as the only neoplasm frequently associated with early postzygotic occurrence of this genomic alteration. We report here that IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. Using murine glioma progenitor cells, we demonstrate that IDH1(R132H) exerts a growth-inhibitory effect that is paralleled by deficiency in metabolic flux from glucose and glutamine to lipids. Examining human gliomas, we find that glutamate dehydrogenase 1 (GLUD1) and GLUD2 are overexpressed in IDH1-mutant tumors and that orthotopic growth of an IDH1-mutant glioma line is inhibited by knockdown of GLUD1/2. Strikingly, introduction of GLUD2 into murine glioma progenitor cells reverses deleterious effects of IDH1 mutation on metabolic flux and tumor growth. Further, we report that glutamate, a substrate of GLUD2 and a neurotransmitter abundant in mammalian neocortex, can support growth of glioma progenitor cells irrespective of IDH1 mutation status. These findings suggest that specialization of human neocortex for high glutamate neurotransmitter flux creates a metabolic niche conducive to growth of IDH1 mutant tumors.

Published
2014
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33. Aqua-[1,3-bis-(benzimidazol-2-yl)-2-oxapropane]-diethano-lmanganese(II) dipicrate ethanol disolvate.

Author

Sun T, Li K, Lai Y, Chen R, and Wu H

Abstract

In the title complex, [Mn(C(16)H(14)N(4)O)(C(2)H(5)OH)(2)(H(2)O)](C(6)H(2)N(3)O(7))(2)·2C(2)H(5)OH, the Mn(II) ion is in a distorted octa-hedral coordination environment, defined by an MnN(2)O(4) donor set. The 1,3-bis-(benz-imid-azol-2-yl)-2-oxapropane ligand is tridentate. In the crystal structure, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds link the components into a three-dimensional network. The O atoms of one of the nitro groups are disordered over two sets of sites with refined occupancies of 0.577 (11) and 0.423 (11).

Published
2010
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