Search

Your search keyword '"Tanaka, Toshihiro"' showing total 1,048 results
Start Over Author "Tanaka, Toshihiro" Search Limiters Full Text Search Limiters Peer Reviewed Publication Year Range Last 50 years
1,048 results on '"Tanaka, Toshihiro"'

3. A novel method for predicting hepatocellular carcinoma response to chemoembolization using an intraprocedural CT hepatic arteriography-based enhancement mapping: a proof-of-concept analysis

Author

Taiji, Ryosuke, Lin, Yuan-Mao, Chintalapani, Gouthami, Lin, Ethan Y., Huang, Steven Y., Mahvash, Armeen, Avritscher, Rony, Liu, Chien-An, Lee, Rheun-Chuan, Resende, Vivian, Nishiofuku, Hideyuki, Tanaka, Toshihiro, Kichikawa, Kimihiko, Klotz, Ernst, Gupta, Sanjay, and Odisio, Bruno C.

Published
2023
Full Text
View/download PDF

4. Factors associated with viral RNA shedding and evaluation of potential viral infectivity at returning to school in influenza outpatients after treatment with baloxavir marboxil and neuraminidase inhibitors during 2013/2014–2019/2020 seasons in Japan: an observational study

Author

Li, Jiaming, Wagatsuma, Keita, Sun, Yuyang, Sato, Isamu, Kawashima, Takashi, Saito, Tadashi, Shimada, Yasushi, Ono, Yasuhiko, Kakuya, Fujio, Nagata, Nobuo, Minato, Michiyoshi, Kodo, Naoki, Suzuki, Eitaro, Kitano, Akito, Tanaka, Toshihiro, Aoki, Satoshi, Chon, Irina, Phyu, Wint Wint, Watanabe, Hisami, and Saito, Reiko

Published
2023
Full Text
View/download PDF

6. Immunohistochemistry of p53 surrogates TP53 mutation as an accurate predictor for early-relapse of surgically resected stage I-III lung adenocarcinoma

Author

Kurihara, Yasuyuki, Honda, Takayuki, Takemoto, Akira, Seto, Katsutoshi, Endo, Satoshi, Tanimoto, Kousuke, Kirimura, Susumu, Kobayashi, Masashi, Baba, Shunichi, Nakashima, Yasuhiro, Wakejima, Ryo, Sakakibara, Rie, Ishibashi, Hironori, Inazawa, Johji, Tanaka, Toshihiro, Miyazaki, Yasunari, and Okubo, Kenichi

Published
2024
Full Text
View/download PDF

10. HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease

Author

Shimizu, Chisato, Kim, Jihoon, Eleftherohorinou, Hariklia, Wright, Victoria J, Hoang, Long T, Tremoulet, Adriana H, Franco, Alessandra, Hibberd, Martin L, Takahashi, Atsushi, Kubo, Michiaki, Ito, Kaoru, Tanaka, Toshihiro, Onouchi, Yoshihiro, Coin, Lachlan JM, Levin, Michael, Burns, Jane C, Shike, Hiroko, and Consortium, on behalf of International Kawasaki Disease Genetic

Subjects
Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, Pediatric, Genetics, Prevention, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Alleles, Amino Acid Sequence, Amino Acid Substitution, Antigen Presentation, Binding Sites, Cohort Studies, Gene Frequency, Genetic Predisposition to Disease, Genotype, HLA-C Antigens, Histocompatibility Testing, Humans, Japan, Mucocutaneous Lymph Node Syndrome, Peptides, Polymorphism, Single Nucleotide, Protein Binding, Protein Domains, T-Lymphocytes, Cytotoxic, Kawasaki disease, HLA-C, Antigen presentation, Amino acid substitution, Cytotoxic T cells, International Kawasaki Disease Genetic Consortium
Abstract

Kawasaki disease (KD) is a pediatric vasculitis caused by an unknown trigger in genetically susceptible children. The incidence varies widely across genetically diverse populations. Several associations with HLA Class I alleles have been reported in single cohort studies. Using a genetic approach, from the nine single nucleotide variants (SNVs) associated with KD susceptibility in children of European descent, we identified SNVs near the HLA-C (rs6906846) and HLA-B genes (rs2254556) whose association was replicated in a Japanese descent cohort (rs6906846 p = 0.01, rs2254556 p = 0.005). The risk allele (A at rs6906846) was also associated with HLA-C*07:02 and HLA-C*04:01 in both US multi-ethnic and Japanese cohorts and HLA-C*12:02 only in the Japanese cohort. The risk A-allele was associated with eight non-conservative amino acid substitutions (amino acid positions); Asp or Ser (9), Arg (14), Ala (49), Ala (73), Ala (90), Arg (97), Phe or Ser (99), and Phe or Ser (116) in the HLA-C peptide binding groove that binds peptides for presentation to cytotoxic T cells (CTL). This raises the possibility of increased affinity to a "KD peptide" that contributes to the vasculitis of KD in genetically susceptible children.

Published
2019

12. Effects of Short-Term Lenvatinib Administration Prior to Transarterial Chemoembolization for Hepatocellular Carcinoma

Author

Tachiiri, Tetsuya, primary, Minamiguchi, Kiyoyuki, additional, Taiji, Ryosuke, additional, Sato, Takeshi, additional, Toyoda, Shohei, additional, Matsumoto, Takeshi, additional, Chanoki, Yuto, additional, Kunichika, Hideki, additional, Yamauchi, Satoshi, additional, Shimizu, Sho, additional, Nishiofuku, Hideyuki, additional, Marugami, Nagaaki, additional, Tsuji, Yuki, additional, Namisaki, Tadashi, additional, Yoshiji, Hitoshi, additional, and Tanaka, Toshihiro, additional

Published
2024
Full Text
View/download PDF

18. Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics

Author

Tanaka, Toshihiro, Zhang, Weici, Sun, Ying, Shuai, Zongwen, Chida, Asiya Seema, Kenny, Thomas P, Yang, Guo‐Xiang, Sanz, Ignacio, Ansari, Aftab, Bowlus, Christopher L, Ippolito, Gregory C, Coppel, Ross L, Okazaki, Kazuichi, He, Xiao‐Song, Leung, Patrick SC, and Gershwin, M Eric

Subjects
Biomedical and Clinical Sciences, Immunology, Biotechnology, Liver Disease, Digestive Diseases, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Antibodies, Monoclonal, Autoantigens, Autoimmunity, Cholangitis, Female, Gene Amplification, Humans, Immunoblotting, Male, Molecular Mimicry, Real-Time Polymerase Chain Reaction, Sensitivity and Specificity, Thioctic Acid, Xenobiotics, Medical Biochemistry and Metabolomics, Clinical Sciences, Gastroenterology & Hepatology, Clinical sciences
Abstract

A major problem in autoimmunity has been identification of the earliest events that lead to breach of tolerance. Although there have been major advances in dissecting effector pathways and the multilineage immune responses to mitochondrial self-antigens in primary biliary cholangitis, the critical links between environmental factors and tolerance remain elusive. We hypothesized that environmental xenobiotic modification of the E2 subunit of the pyruvate dehydrogenase (PDC-E2) inner lipoyl domain can lead to loss of tolerance to genetically susceptible hosts. Previously we demonstrated that serum anti-PDC-E2 autoantibodies cross-react with the chemical xenobiotics 2-octynoic acid and 6,8-bis (acetylthio) octanoic acid and further that there is a high frequency of PDC-E2-specific peripheral plasmablasts. Herein we generated 104 recombinant monoclonal antibodies (mAbs) based on paired heavy-chain and light-chain variable regions of individual plasmablasts derived from primary biliary cholangitis patients. We identified 32 mAbs reactive with native PDC-E2, including 20 specific for PDC-E2 and 12 cross-reactive with both PDC-E2 and 2-octynoic acid and 6,8-bis (acetylthio) octanoic acid. A lower frequency of replacement somatic hypermutations, indicating a lower level of affinity maturation, was observed in the complementarity-determining regions of the cross-reactive mAbs in comparison to mAbs exclusively recognizing PDC-E2 or those for irrelevant antigens. In particular, when the highly mutated heavy-chain gene of a cross-reactive mAb was reverted to the germline sequence, the PDC-E2 reactivity was reduced dramatically, whereas the xenobiotic reactivity was retained. Importantly, cross-reactive mAbs also recognized lipoic acid, a mitochondrial fatty acid that is covalently bound to PDC-E2.ConclusionOur data reflect that chemically modified lipoic acid or lipoic acid itself, through molecular mimicry, is the initial target that leads to the development of primary biliary cholangitis. (Hepatology 2017;66:885-895).

Published
2017

21. Percutaneous Trans-jejunum Pancreatojejunostomy Reconstruction for Intractable Pancreatic Fistula after Pancreatoduodenectomy

Author

Toyoda, Shohei, primary, Nishiofuku, Hideyuki, additional, Matsumoto, Takeshi, additional, Sato, Takeshi, additional, Maeda, Shinsaku, additional, Chanoki, Yuto, additional, Oshima, Keisuke, additional, Irizato, Mariko, additional, Masada, Tetsuya, additional, Sueyoshi, Satoru, additional, and Tanaka, Toshihiro, additional

Published
2023
Full Text
View/download PDF

22. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Author

Spracklen, Cassandra N, Chen, Peng, Kim, Young Jin, Wang, Xu, Cai, Hui, Li, Shengxu, Long, Jirong, Wu, Ying, Wang, Ya Xing, Takeuchi, Fumihiko, Wu, Jer-Yuarn, Jung, Keum-Ji, Hu, Cheng, Akiyama, Koichi, Zhang, Yonghong, Moon, Sanghoon, Johnson, Todd A, Li, Huaixing, Dorajoo, Rajkumar, He, Meian, Cannon, Maren E, Roman, Tamara S, Salfati, Elias, Lin, Keng-Hung, Guo, Xiuqing, Sheu, Wayne HH, Absher, Devin, Adair, Linda S, Assimes, Themistocles L, Aung, Tin, Cai, Qiuyin, Chang, Li-Ching, Chen, Chien-Hsiun, Chien, Li-Hsin, Chuang, Lee-Ming, Chuang, Shu-Chun, Du, Shufa, Fan, Qiao, Fann, Cathy SJ, Feranil, Alan B, Friedlander, Yechiel, Gordon-Larsen, Penny, Gu, Dongfeng, Gui, Lixuan, Guo, Zhirong, Heng, Chew-Kiat, Hixson, James, Hou, Xuhong, Hsiung, Chao Agnes, Hu, Yao, Hwang, Mi Yeong, Hwu, Chii-Min, Isono, Masato, Juang, Jyh-Ming Jimmy, Khor, Chiea-Chuen, Kim, Yun Kyoung, Koh, Woon-Puay, Kubo, Michiaki, Lee, I-Te, Lee, Sun-Ju, Lee, Wen-Jane, Liang, Kae-Woei, Lim, Blanche, Lim, Sing-Hui, Liu, Jianjun, Nabika, Toru, Pan, Wen-Harn, Peng, Hao, Quertermous, Thomas, Sabanayagam, Charumathi, Sandow, Kevin, Shi, Jinxiu, Sun, Liang, Tan, Pok Chien, Tan, Shu-Pei, Taylor, Kent D, Teo, Yik-Ying, Toh, Sue-Anne, Tsunoda, Tatsuhiko, van Dam, Rob M, Wang, Aili, Wang, Feijie, Wang, Jie, Bin Wei, Wen, Xiang, Yong-Bing, Yao, Jie, Yuan, Jian-Min, Zhang, Rong, Zhao, Wanting, Chen, Yii-Der Ida, Rich, Stephen S, Rotter, Jerome I, Wang, Tzung-Dau, Wu, Tangchun, Lin, Xu, Han, Bok-Ghee, Tanaka, Toshihiro, Cho, Yoon Shin, Katsuya, Tomohiro, and Jia, Weiping

Subjects
Genetics, Human Genome, Atherosclerosis, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adult, Alleles, Asian People, Cholesterol, Ethnicity, Female, Gene Frequency, Genetic Association Studies, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Lipids, Lipoproteins, HDL, Lipoproteins, LDL, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Triglycerides, White People, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P

Published
2017

23. Sex differences in alopecia areata treated with steroid pulse therapy: A retrospective study and review of literature

Author

Kokubu, Hiraku, Kato, Takeshi, Fujimoto, Sino, Tanaka, Toshihiro, and Fujimoto, Noriki

Subjects
Methylprednisolone -- Analysis, Corticosteroids -- Analysis, Baldness -- Care and treatment, Alopecia -- Care and treatment, Health
Abstract

Byline: Hiraku. Kokubu, Takeshi. Kato, Sino. Fujimoto, Toshihiro. Tanaka, Noriki. Fujimoto Context: Few reports focused on the sex differences in alopecia areata (AA) treated with steroid pulse therapy. Aims: This [...]

Published
2022

25. Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients

Author

Hangai, Mayumi, primary, Kawaguchi, Takahisa, additional, Takagi, Masatoshi, additional, Matsuo, Keitaro, additional, Jeon, Soyoung, additional, Chiang, Charleston W.K., additional, Dewan, Andrew T., additional, De Smith, Adam J., additional, Imamura, Toshihiko, additional, Okamoto, Yasuhiro, additional, Saito, Akiko M., additional, Deguchi, Takao, additional, Kubo, Michiaki, additional, Tanaka, Yoichi, additional, Ayukawa, Yoko, additional, Hori, Toshinari, additional, Ohki, Kentaro, additional, Kiyokawa, Nobutaka, additional, Inukai, Takeshi, additional, Arakawa, Yuki, additional, Mori, Makiko, additional, Hasegawa, Daisuke, additional, Tomizawa, Daisuke, additional, Fukushima, Hiroko, additional, Yuza, Yuki, additional, Noguchi, Yasushi, additional, Taneyama, Yuichi, additional, Ota, Setsuo, additional, Goto, Hiroaki, additional, Yanagimachi, Masakatsu, additional, Keino, Dai, additional, Koike, Kazutoshi, additional, Toyama, Daisuke, additional, Nakazawa, Yozo, additional, Nakamura, Kozue, additional, Moriwaki, Koichi, additional, Sekinaka, Yujin, additional, Morita, Daisuke, additional, Hirabayashi, Shinsuke, additional, Hosoya, Yosuke, additional, Yoshimoto, Yuri, additional, Yoshihara, Hiroki, additional, Ozawa, Miwa, additional, Kobayashi, Shinobu, additional, Morisaki, Naho, additional, Gyeltshen, Tshewang, additional, Takahashi, Osamu, additional, Okada, Yukinori, additional, Matsuda, Makiko, additional, Tanaka, Toshihiro, additional, Inazawa, Johji, additional, Takita, Junko, additional, Ishida, Yasushi, additional, Ohara, Akira, additional, Metayer, Catherine, additional, Wiemels, Joseph L., additional, Ma, Xiaomei, additional, Mizutani, Shuki, additional, Koh, Katsuyoshi, additional, Momozawa, Yukihide, additional, Horibe, Keizo, additional, Matsuda, Fumihiko, additional, Kato, Motohiro, additional, Manabe, Atsushi, additional, and Urayama, Kevin Y., additional

Published
2023
Full Text
View/download PDF

27. The possibility of mutations of RAS signaling genes and/or TP53 in combination as a negative prognostic impact on pathological stage I non‐small cell lung cancer

Author

Honda, Takayuki, primary, Seto, Katsutoshi, additional, Endo, Satoshi, additional, Takemoto, Akira, additional, Tanimoto, Kousuke, additional, Kobayashi, Masashi, additional, Kitano, Masatake, additional, Sakakibara, Rie, additional, Mitsumura, Takahiro, additional, Ishibashi, Hironori, additional, Inazawa, Johji, additional, Tanaka, Toshihiro, additional, Miyazaki, Yasunari, additional, and Okubo, Kenichi, additional

Published
2023
Full Text
View/download PDF

29. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Author

He, Meian, Xu, Min, Zhang, Ben, Liang, Jun, Chen, Peng, Lee, Jong-Young, Johnson, Todd A, Li, Huaixing, Yang, Xiaobo, Dai, Juncheng, Liang, Liming, Gui, Lixuan, Qi, Qibin, Huang, Jinyan, Li, Yanping, Adair, Linda S, Aung, Tin, Cai, Qiuyin, Cheng, Ching-Yu, Cho, Myeong-Chan, Cho, Yoon Shin, Chu, Minjie, Cui, Bin, Gao, Yu-Tang, Go, Min Jin, Gu, Dongfeng, Gu, Weiqiong, Guo, Huan, Hao, Yongchen, Hong, Jie, Hu, Zhibin, Hu, Yanling, Huang, Jianfeng, Hwang, Joo-Yeon, Ikram, Mohammad Kamran, Jin, Guangfu, Kang, Dae-Hee, Khor, Chiea Chuen, Kim, Bong-Jo, Kim, Hung Tae, Kubo, Michiaki, Lee, Jeannette, Lee, Juyoung, Lee, Nanette R, Li, Ruoying, Li, Jun, Liu, JianJun, Longe, Jirong, Lu, Wei, Lu, Xiangfeng, Miao, Xiaoping, Okada, Yukinori, Ong, Rick Twee-Hee, Qiu, Gaokun, Seielstad, Mark, Sim, Xueling, Song, Huaidong, Takeuchi, Fumihiko, Tanaka, Toshihiro, Taylor, Phil R, Wang, Laiyuan, Wang, Weiqing, Wang, Yiqin, Wu, Chen, Wu, Ying, Xiang, Yong-Bing, Yamamoto, Ken, Yang, Handong, Liao, Ming, Yokota, Mitsuhiro, Young, Terri, Zhang, Xiaomin, Kato, Norihiro, Wang, Qing K, Zheng, Wei, Hu, Frank B, Lin, Dongxin, Shen, Hongbing, Teo, Yik Ying, Mo, Zengnan, Wong, Tien Yin, Lin, Xu, Mohlke, Karen L, Ning, Guang, Tsunoda, Tatsuhiko, Han, Bok-Ghee, Shu, Xiao-Ou, Tai, E Shyong, Wu, Tangchun, and Qi, Lu

Subjects
Prevention, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Aged, Aged, 80 and over, Asian People, Body Height, Asia, Eastern, Female, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Humans, Male, Metabolic Networks and Pathways, Middle Aged, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatases, White People, Young Adult, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

Published
2015

32. Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.

Author

Chen, Peng, Takeuchi, Fumihiko, Lee, Jong-Young, Li, Huaixing, Wu, Jer-Yuarn, Liang, Jun, Long, Jirong, Tabara, Yasuharu, Goodarzi, Mark, Pereira, Mark, Kim, Young, Go, Min, Stram, Daniel, Vithana, Eranga, Khor, Chiea-Chuen, Liu, Jianjun, Liao, Jiemin, Ye, Xingwang, Wang, Yiqin, Lu, Ling, Young, Terri, Lee, Jeannette, Thai, Ah, Cheng, Ching-Yu, van Dam, Rob, Friedlander, Yechiel, Heng, Chew-Kiat, Koh, Woon-Puay, Chen, Chien-Hsiun, Chang, Li-Ching, Pan, Wen-Harn, Qi, Qibin, Isono, Masato, Zheng, Wei, Cai, Qiuyin, Gao, Yutang, Yamamoto, Ken, Ohnaka, Keizo, Takayanagi, Ryoichi, Kita, Yoshikuni, Ueshima, Hirotsugu, Hsiung, Chao, Cui, Jinrui, Sheu, Wayne, Chen, Yii-Der, Hsu, Chris, Okada, Yukinori, Kubo, Michiaki, Takahashi, Atsushi, Tanaka, Toshihiro, van Rooij, Frank, Ganesh, Santhi, Huang, Jinyan, Huang, Tao, Yuan, Jianmin, Hwang, Joo-Yeon, Gross, Myron, Assimes, Themistocles, Miki, Tetsuro, Shu, Xiao-Ou, Qi, Lu, Chen, Yuan-Tson, Lin, Xu, Aung, Tin, Wong, Tien-Yin, Teo, Yik-Ying, Kim, Bong-Jo, Kato, Norihiro, Tai, E-Shyong, and Rotter, Jerome

Subjects
Adult, Aged, Asian People, Blood Glucose, Cohort Studies, Asia, Eastern, Female, Genetic Heterogeneity, Genetic Loci, Genome-Wide Association Study, Glycated Hemoglobin, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (

Published
2014

33. Novel Genetic Markers Associate With Atrial Fibrillation Risk in Europeans and Japanese

Author

Lubitz, Steven A, Lunetta, Kathryn L, Lin, Honghuang, Arking, Dan E, Trompet, Stella, Li, Guo, Krijthe, Bouwe P, Chasman, Daniel I, Barnard, John, Kleber, Marcus E, Dörr, Marcus, Ozaki, Kouichi, Smith, Albert V, Müller-Nurasyid, Martina, Walter, Stefan, Agarwal, Sunil K, Bis, Joshua C, Brody, Jennifer A, Chen, Lin Y, Everett, Brendan M, Ford, Ian, Franco, Oscar H, Harris, Tamara B, Hofman, Albert, Kääb, Stefan, Mahida, Saagar, Kathiresan, Sekar, Kubo, Michiaki, Launer, Lenore J, Macfarlane, Peter W, Magnani, Jared W, McKnight, Barbara, McManus, David D, Peters, Annette, Psaty, Bruce M, Rose, Lynda M, Rotter, Jerome I, Silbernagel, Guenther, Smith, Jonathan D, Sotoodehnia, Nona, Stott, David J, Taylor, Kent D, Tomaschitz, Andreas, Tsunoda, Tatsuhiko, Uitterlinden, Andre G, Van Wagoner, David R, Völker, Uwe, Völzke, Henry, Murabito, Joanne M, Sinner, Moritz F, Gudnason, Vilmundur, Felix, Stephan B, März, Winfried, Chung, Mina, Albert, Christine M, Stricker, Bruno H, Tanaka, Toshihiro, Heckbert, Susan R, Jukema, J Wouter, Alonso, Alvaro, Benjamin, Emelia J, and Ellinor, Patrick T

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Genetics, Heart Disease, Cardiovascular, Clinical Research, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Adult, Aged, Aged, 80 and over, Asian People, Atrial Fibrillation, Chromosome Mapping, Chromosomes, Human, Pair 4, Europe, Female, Genetic Markers, Genetic Predisposition to Disease, Homeodomain Proteins, Humans, Japan, Male, Middle Aged, Polymorphism, Single Nucleotide, Transcription Factors, White People, atrial fibrillation, atrial flutter, genetic, prognosis, risk, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

ObjectivesThis study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk.BackgroundAF-associated loci span broad genomic regions that may contain multiple susceptibility signals. Whether multiple signals exist at AF loci has not been systematically explored.MethodsWe performed association testing conditioned on the most significant, independently associated genetic markers at 9 established AF loci using 2 complementary techniques in 64,683 individuals of European ancestry (3,869 incident and 3,302 prevalent AF cases). Genetic risk scores were created and tested for association with AF in Europeans and an independent sample of 11,309 individuals of Japanese ancestry (7,916 prevalent AF cases).ResultsWe observed at least 4 distinct AF susceptibility signals on chromosome 4q25 upstream of PITX2, but not at the remaining 8 AF loci. A multilocus score comprised 12 genetic markers demonstrated an estimated 5-fold gradient in AF risk. We observed a similar spectrum of risk associated with these markers in Japanese. Regions containing AF signals on chromosome 4q25 displayed a greater degree of evolutionary conservation than the remainder of the locus, suggesting that they may tag regulatory elements.ConclusionsThe chromosome 4q25 AF locus is architecturally complex and harbors at least 4 AF susceptibility signals in individuals of European ancestry. Similar polygenic AF susceptibility exists between Europeans and Japanese. Future work is necessary to identify causal variants, determine mechanisms by which associated loci predispose to AF, and explore whether AF susceptibility signals classify individuals at risk for AF and related morbidity.

Published
2014

34. Transarterial Chemoembolization with Irinotecan-loaded Beads Followed by Arterial Infusion of 5-Fluorouracil for Metastatic Liver Tumors Refractory to Standard Systemic Chemotherapy

Author

Irizato, Mariko, primary, Nishiofuku, Hideyuki, additional, Sato, Takeshi, additional, Maeda, Shinsaku, additional, Toyoda, Shouhei, additional, Matsumoto, Takeshi, additional, Chanoki, Yuto, additional, Oshima, Keisuke, additional, Furuichi, Kinya, additional, Sueyoshi, Satoru, additional, and Tanaka, Toshihiro, additional

Published
2023
Full Text
View/download PDF

35. A Case of Refractory Esophageal Varices Caused by an Inferior Mesenteric Arteriovenous Malformation with All Portal System Occlusion Successfully Treated via Transarterial Embolization

Author

Saito, Natsuhiko, primary, Inoue, Masayoshi, additional, Ishida, Kentaro, additional, Taguchi, Hidehiko, additional, Haga, Masayo, additional, Shimoda, Emiko, additional, Morimoto, Kengo, additional, Takahama, Junko, additional, and Tanaka, Toshihiro, additional

Published
2023
Full Text
View/download PDF

37. Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma

Author

Tachiiri, Tetsuya, primary, Nishiofuku, Hideyuki, additional, Maeda, Shinsaku, additional, Sato, Takeshi, additional, Toyoda, Shohei, additional, Matsumoto, Takeshi, additional, Chanoki, Yuto, additional, Minamiguchi, Kiyoyuki, additional, Taiji, Ryosuke, additional, Kunichika, Hideki, additional, Yamauchi, Satoshi, additional, Ito, Takahiro, additional, Marugami, Nagaaki, additional, and Tanaka, Toshihiro, additional

Published
2023
Full Text
View/download PDF

38. Predictive Factors of Complete Response to Transarterial Chemoembolization in Intermediate Stage Hepatocellular Carcinoma beyond Up-To-7 Criteria

Author

Saito, Natsuhiko, primary, Nishiofuku, Hideyuki, additional, Sato, Takeshi, additional, Maeda, Shinsaku, additional, Minamiguchi, Kiyoyuki, additional, Taiji, Ryosuke, additional, Matsumoto, Takeshi, additional, Chanoki, Yuto, additional, Tachiiri, Tetsuya, additional, Kunichika, Hideki, additional, Marugami, Nagaaki, additional, and Tanaka, Toshihiro, additional

Published
2023
Full Text
View/download PDF

42. Genome-wide association analysis of common genetic variants of resistant hypertension

Author

El Rouby, Nihal, McDonough, Caitrin W., Gong, Yan, McClure, Leslie A., Mitchell, Braxton D., Horenstein, Richard B., Talbert, Robert L., Crawford, Dana C., on behalf of eMERGE network, Gitzendanner, Matthew A., Takahashi, Atsushi, Tanaka, Toshihiro, Kubo, Michiaki, Pepine, Carl J., Cooper-DeHoff, Rhonda M., Benavente, Oscar R., Shuldiner, Alan R., and Johnson, Julie A.

Published
2019
Full Text
View/download PDF

44. Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

Author

Okada, Yukinori, Sim, Xueling, Go, Min Jin, Wu, Jer-Yuarn, Gu, Dongfeng, Takeuchi, Fumihiko, Takahashi, Atsushi, Maeda, Shiro, Tsunoda, Tatsuhiko, Chen, Peng, Lim, Su-Chi, Wong, Tien-Yin, Liu, Jianjun, Young, Terri L, Aung, Tin, Seielstad, Mark, Teo, Yik-Ying, Kim, Young Jin, Lee, Jong-Young, Han, Bok-Ghee, Kang, Daehee, Chen, Chien-Hsiun, Tsai, Fuu-Jen, Chang, Li-Ching, Fann, S-J Cathy, Mei, Hao, Rao, Dabeeru C, Hixson, James E, Chen, Shufeng, Katsuya, Tomohiro, Isono, Masato, Ogihara, Toshio, Chambers, John C, Zhang, Weihua, Kooner, Jaspal S, Albrecht, Eva, Yamamoto, Kazuhiko, Kubo, Michiaki, Nakamura, Yusuke, Kamatani, Naoyuki, Kato, Norihiro, He, Jiang, Chen, Yuan-Tsong, Cho, Yoon Shin, Tai, E-Shyong, and Tanaka, Toshihiro

Subjects
Biological Sciences, Genetics, Kidney Disease, Human Genome, Renal and urogenital, Asian People, Blood Urea Nitrogen, Cohort Studies, Creatinine, Genetic Predisposition to Disease, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Polymorphism, Single Nucleotide, Renal Insufficiency, Chronic, Uric Acid, KidneyGen Consortium, CKDGen Consortium, GUGC consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Published
2012

47. Quantitative Analysis of Signal Heterogeneity in the Hepatobiliary Phase of Pretreatment Gadoxetic Acid-Enhanced MRI as a Prognostic Imaging Biomarker in Transarterial Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma

Author

Minamiguchi, Kiyoyuki, primary, Nishiofuku, Hideyuki, additional, Saito, Natsuhiko, additional, Sato, Takeshi, additional, Taiji, Ryosuke, additional, Matsumoto, Takeshi, additional, Maeda, Shinsaku, additional, Chanoki, Yuto, additional, Tachiiri, Tetsuya, additional, Kunichika, Hideki, additional, Inoue, Takashi, additional, Marugami, Nagaaki, additional, and Tanaka, Toshihiro, additional

Published
2023
Full Text
View/download PDF

48. Overview of BioBank Japan follow-up data in 32 diseases

Author

Shiono, Masaki, Misumi, Kazuo, Kaieda, Reiji, Harada, Hiromasa, Minami, Shiro, Watanabe, Atsushi, Emoto, Naoya, Takahashi, Kazuhisa, Takeda, Satoru, Funaki, Toshinari, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Sugimoto, Yoshihisa, Koretsune, Yukihiro, Kusuoka, Hideo, Yoshimori, Kozo, Hirata, Makoto, Nagai, Akiko, Kamatani, Yoichiro, Ninomiya, Toshiharu, Tamakoshi, Akiko, Yamagata, Zentaro, Kubo, Michiaki, Muto, Kaori, Kiyohara, Yutaka, Mushiroda, Taisei, Murakami, Yoshinori, Yuji, Koichiro, Furukawa, Yoichi, Zembutsu, Hitoshi, Tanaka, Toshihiro, Ohnishi, Yozo, Nakamura, Yusuke, and Matsuda, Koichi

Published
2017
Full Text
View/download PDF

49. Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases

Author

Shiono, Masaki, Misumi, Kazuo, Kaieda, Reiji, Harada, Hiromasa, Minami, Shiro, Emi, Mitsuru, Emoto, Naoya, Arai, Hajime, Yamaji, Ken, Hiratsuka, Yoshimune, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Sugimoto, Yoshihisa, Koretsune, Yukihiro, Kusuoka, Hideo, Yoshiyama, Takashi, Hirata, Makoto, Kamatani, Yoichiro, Nagai, Akiko, Kiyohara, Yutaka, Ninomiya, Toshiharu, Tamakoshi, Akiko, Yamagata, Zentaro, Kubo, Michiaki, Muto, Kaori, Mushiroda, Taisei, Murakami, Yoshinori, Yuji, Koichiro, Furukawa, Yoichi, Zembutsu, Hitoshi, Tanaka, Toshihiro, Ohnishi, Yozo, Nakamura, Yusuke, and Matsuda, Koichi

Published
2017
Full Text
View/download PDF

50. Overview of the BioBank Japan Project: Study design and profile

Author

Shiono, Masaki, Misumi, Kazuo, Kaieda, Reiji, Harada, Hiromasa, Minami, Shiro, Emi, Mitsuru, Emoto, Naoya, Daida, Hiroyuki, Miyauchi, Katsumi, Murakami, Akira, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Sugimoto, Yoshihisa, Koretsune, Yukihiro, Kusuoka, Hideo, Yanai, Hideki, Nagai, Akiko, Hirata, Makoto, Kamatani, Yoichiro, Muto, Kaori, Matsuda, Koichi, Kiyohara, Yutaka, Ninomiya, Toshiharu, Tamakoshi, Akiko, Yamagata, Zentaro, Mushiroda, Taisei, Murakami, Yoshinori, Yuji, Koichiro, Furukawa, Yoichi, Zembutsu, Hitoshi, Tanaka, Toshihiro, Ohnishi, Yozo, Nakamura, Yusuke, and Kubo, Michiaki

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results