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1. High versus low positive end-expiratory pressure setting in patients receiving veno-venous extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome: study protocol for the multicentre, randomised ExPress SAVER Trial

Author

Nishikimi, Mitsuaki, primary, Ohshimo, Shinichiro, additional, Hamaguchi, Jun, additional, Fujizuka, Kenji, additional, Hagiwara, Yoshihiro, additional, Anzai, Tatsuhiko, additional, Ishii, Junki, additional, Ogata, Yoshitaka, additional, Aokage, Toshiyuki, additional, Ikeda, Tokuji, additional, Yagi, Tsukasa, additional, Suzuki, Ginga, additional, Ishikura, Ken, additional, Katsuta, Ken, additional, Konno, Daisuke, additional, Hattori, Noriyuki, additional, Nakamura, Tomoyuki, additional, Matsumura, Yosuke, additional, Kasugai, Daisuke, additional, Kikuchi, Hitoshi, additional, Iino, Tatsuhiko, additional, Kai, Shinichi, additional, Hashimoto, Haruka, additional, Yoshida, Takeshi, additional, Igarashi, Yumi, additional, Ogura, Takayuki, additional, Matsumura, Kazuki, additional, Shimizu, Keiki, additional, Nakamura, Mitsunobu, additional, Ichiba, Shingo, additional, Takahashi, Kunihiko, additional, and Shime, Nobuaki, additional

Published
2023
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3. Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry.

Author

Nishikimi, Mitsuaki, Ohshimo, Shinichiro, Fukumoto, Wataru, Hamaguchi, Jun, Matsumura, Kazuki, Fujizuka, Kenji, Hagiwara, Yoshihiro, Nakayama, Ryuichi, Bunya, Naofumi, Maruyama, Junichi, Abe, Toshikazu, Anzai, Tatsuhiko, Ogata, Yoshitaka, Naito, Hiromichi, Amemiya, Yu, Ikeda, Tokuji, Yagi, Masayuki, Furukawa, Yutaro, Taniguchi, Hayato, and Yagi, Tsukasa

Subjects
ADULT respiratory distress syndrome, COMPUTED tomography, EXTRACORPOREAL membrane oxygenation, SUBCUTANEOUS emphysema, BRONCHIECTASIS, HOSPITAL mortality, INTENSIVE care units
Abstract

Background: Chest computed tomography findings are helpful for understanding the pathophysiology of severe acute respiratory distress syndrome (ARDS). However, there is no large, multicenter, chest computed tomography registry for patients requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO). The aim of this study was to describe chest computed tomography findings at V-V ECMO initiation and to evaluate the association between the findings and outcomes in severe ARDS. Methods: This multicenter, retrospective cohort study enrolled patients with severe ARDS on V-V ECMO, who were admitted to the intensive care units of 24 hospitals in Japan between January 1, 2012, and December 31, 2022. Results: The primary outcome was 90-day in-hospital mortality. The secondary outcomes were the successful liberation from V-V ECMO and the values of static lung compliance. Among the 697 registry patients, of the 582 patients who underwent chest computed tomography at V-V ECMO initiation, 394 survived and 188 died. Multivariate Cox regression showed that traction bronchiectasis and subcutaneous emphysema increased the risk of 90-day in-hospital mortality (hazard ratio [95% confidence interval] 1.77 [1.19–2.63], p = 0.005 and 1.97 [1.02–3.79], p = 0.044, respectively). The presence of traction bronchiectasis was also associated with decreased successful liberation from V-V ECMO (odds ratio: 0.27 [0.14–0.52], p < 0.001). Lower static lung compliance was associated with some chest computed tomography findings related to changes outside of pulmonary opacity, but not with the findings related to pulmonary opacity. Conclusions: Traction bronchiectasis and subcutaneous emphysema increased the risk of 90-day in-hospital mortality in patients with severe ARDS who required V-V ECMO. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Combined use of veno‐venous extracorporeal membrane oxygenation and asynchronous independent lung ventilation after thoracic surgery for lung abscess.

Author

Yoneda, Ryuhei, Matsuyoshi, Takeo, Yogi, Tatsuro, Sato, Yuichi, Hamaguchi, Jun, and Shimizu, Keiki

Subjects
EXTRACORPOREAL membrane oxygenation, LUNG surgery, THORACIC surgery, LUNGS, ABSCESSES
Abstract

Key Clinical Message: We used independent lung ventilation (ILV) during veno‐venous extracorporeal membrane oxygenation (V‐V ECMO) after lung abscess surgery in a patient with severe hypoxia and air leak. ILV can be effective in V‐V ECMO as unilateral lung air leak. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Heat stroke management during the COVID‐19 pandemic: Recommendations from the experts in Japan (2nd edition)

Author

Kanda, Jun, primary, Wakasugi, Masahiro, additional, Kondo, Yutaka, additional, Ueno, Satoru, additional, Kaneko, Hitoshi, additional, Okada, Yohei, additional, Okano, Yuichi, additional, Kishihara, Yuki, additional, Hamaguchi, Jun, additional, Ishihara, Tadashi, additional, Igarashi, Yutaka, additional, Nakae, Ryuta, additional, Miyamoto, Sohma, additional, Yamada, Eri, additional, Ikechi, Daisuke, additional, Yamazaki, Maiko, additional, Tanaka, Daiki, additional, Sawada, Yusuke, additional, Suda, Chiaki, additional, Yoshimura, Satoshi, additional, Onodera, Ryuta, additional, Kano, Kenichi, additional, Hongo, Takashi, additional, Endo, Kaori, additional, Iwasaki, Yohei, additional, Kodaira, Hiroshi, additional, Yasuo, Shunsuke, additional, Seki, Nozomu, additional, Okuda, Hiroshi, additional, Nakajima, Satoshi, additional, Nagato, Tadashi, additional, Terazumi, Keiko, additional, Nakamura, Satoshi, additional, and Yokobori, Shoji, additional

Published
2023
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8. An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Author

Li Bassi, Gianluigi, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Shrapnel, Sally, Fanning, Jonathon P., Liquet, Benoit, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E., Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung, Fraser, John F., Al-Dabbous, Tala, Alfoudri, Huda, Shamsah, Mohammed, Elapavaluru, Subbarao, Berg, Ashley, Horn, Christina, Schroll, Stephan, Velazco, Jorge, Fikes, Wanda, Ploskanych, Ludmyla, Meyer, Dan, Shalabi-McGuire, Maysoon, Witt, Trent, Ehlers, Ashley, Grazioli, Lorenzo, Grandin, E. Wilson, Nunez, Jose, Reyes, Tiago, Joseph, Mark, Mitchell, Brook, Tenzer, Martha, Abe, Ryuzo, Hayashi, Yosuke, Cho, Hwa Jin, Jeong, In Seok, Brozzi, Nicolas, Hernandez-Montfort, Jaime, Mehkri, Omar, Houltham, Stuart, Graf, Jerónimo, Perez, Rodrigo, Diaz, Roderigo, Delgado, Camila, González, Joyce, Sanchez, Maria Soledad, Rincón, Diego Fernando Bautista, Duque, Melissa Bustamante, Yanten, Angela Maria Marulanda, Brodie, Dan, Rusmawatiningtyas, Desy, Ragazzo, Gabrielle, Taufik, Azhari, Gunawan, Margaretha, Irawany, Vera, Rayhan, Muhammad, Wardoyo, Elizabeth Yasmin, Coppola, Silvia, Colombo, Sebastiano, Grasselli, Giacomo, Leone, Michela, Zanella, Alberto, Antonelli, Massimo, Carelli, Simone, Grieco, Domenico L., Asaki, Motohiro, Hoshino, Kota, Salazar, Leonardo, Duarte, Laura, McCaffrey, Joseph, Bone, Allison, Thomson, David, Arnold-Day, Christel, Cupido, Jerome, Fanie, Zainap, Miller, Malcom, Seymore, Lisa, van Straaten, Dawid, Hassan, Ibrahim, Hssain, Ali Ait, Aliudin, Jeffrey, Alqahtani, Al-Reem, Mohamed, Khoulod, Mohamed, Ahmed, Tan, Darwin, Villanueva, Joy, Zaqout, Ahmed, Kurtzman, Ethan, Ademi, Arben, Dobrita, Ana, Aoudi, Khadija El, Segura, Juliet, Giwangkancana, Gezy, Ohshimo, Shinichiro, Hoshino, Koji, Hitoshi, Saito, Uchinami, Yuka, Osatnik, Javier, Joosten, Anne, Motos, Ana, Yang, Minlan, Arancibia, Francisco, Williams, Virginie, Noel, Alexandre, Luque, Nestor, Trung, Trieu Huynh, Yacoub, Sophie, Fantini, Marina, García, Ruth Noemi Jorge, Alvarez, Enrique Chicote, Greti, Anna, Lomeli, Oscar, Ceccato, Adrian, Sanchez, Angel, Vazquez, Ana Loza, Roche-Campo, Ferran, Tuazon, Divina, Duculan, Toni, Shimizu, Hiroaki, Amato, Marcelo, Cassimiro, Luciana, Pola, Flavio, Ribeiro, Francis, Fonseca, Guilherme, Dalton, Heidi, Desai, Mehul, Osborn, Erik, Deeb, Hala, Arcadipane, Antonio, Bianco, Claudia, Cuffaro, Raffaele, Martucci, Gennaro, Occhipinti, Giovanna, Rossetti, Matteo, Vitiello, Chiara, Cho, Sung-Min, Calligy, Kate, Whitman, Glenn, Moriyama, Naoki, Kim, Jae-Burm, Kitamura, Nobuya, Shimazui, Takashi, Al-Hudaib, Abdullah, Gebauer, Johannes, Yokoyama, Toshiki, Al-Fares, Abdulrahman, Alamad, Esam, Alawadhi, Fatma, Alawadi, Kalthoum, Buabbas, Sarah, Tanaka, Hiro, Hashimoto, Satoru, Yamazaki, Masaki, Oh, Tak-Hyuck, Epler, Mark, Forney, Cathleen, Feister, Jared, Grobengieser, Katherine, Kruse, Louise, Williamson, Joelle, Gnall, Eric, Caroline, Mara, Golden, Sasha, Karaj, Colleen, McDermott, Sherry, Sher, Lynn, Shapiro, Timothy, Thome, Lisa, Vanderland, Mark, Welch, Mary, Brazzi, Luca, Ogston, Tawnya, Nagpal, Dave, Fischer, Karlee, Lorusso, Roberto, de Piero, Maria, Esperatti, Mariano, O’Briain, Diarmuid, Carton, Edmund G., Sen, Ayan, Palacios, Amanda, Rainey, Deborah, Seefeldt, Cassandra, Durham, Lucia, Falcucci, Octavio, Emmrich, Amanda, Guy, Jennifer, Johns, Carling, Neumann, Emily, Buchtele, Nina, Schwameis, Michael, Stecher, Stephanie-Susanne, Singh, Delila, Barnikel, Michaela, Arenz, Lukas, Zaaqoq, Akram, Galloway, Lan Anh, Merley, Caitlin, Csete, Marc, Quesada, Luisa, Saba, Isabela, Kasugai, Daisuke, Hiraiwa, Hiroaki, Tanaka, Taku, Marwali, Eva, Purnama, Yoel, Dewayanti, Santi Rahayu, Ardiyan, Siagian, Debby, Chen, Yih-Sharng, McNicholas, Bairbre, Cosgrave, David, VanDyk, Marlice, MacDonald, Sarah, Seppelt, Ian, Ratsep, Indrek, Enneveer, Lauri, Erikson, Kristo, Oigus, Getter, Post, Andra-Maris, Sillaots, Piret, Manetta, Frank, Komats, Mamoru, Satyapriya, S. Veena, Bhatt, Amar, Echeverria, Marco, Fiorda, Juan, Gonzalez, Alicia, Mokadam, Nahush A., McKeown, Johnny, Pasek, Joshua, Shi, Haixia, Uribe, Alberto, Moreno, Rita, Zakhary, Bishoy, Johnson, Hannah, Pow, Nolan, Cavana, Marco, Cucino, Alberto, Foti, Giuseppe, Giani, Marco, Russotto, Vincenzo, Castagna, Valentina, Dell’Amore, Andrea, Shum, Hoi-Ping, Vuysteke, Alain, Usman, Asad, Acker, Andrew, Mergler, Blake, Rizer, Nicolas, Sertic, Federico, Smood, Benjamin, Sperry, Alexandra, Subramanian, Madhu, Lolong, Navy, Akmal, Ernita, Burhan, Erlina, Rasmin, Menaldi, Naivedh, Bhat, Sitompu, Faya, Barrett, Peter, Daugherty, Julia, Dean, David, Loforte, Antonio, Khan, Irfan, DeSantis, Olivia, Quraishi, Mohammed Abraar, Salt, Gavin, So, Dominic, Kandamby, Darshana, Mandei, Jose M., Natanael, Hans, YudhaLantang, Eka, Lantang, Anastasia, Jung, Anna, Hammond, Terese, Ng, George, Ng, Wing Yiu, Yeung, Pauline, Adachi, Shingo, Blanco, Pablo, Prieto, Ana, Sánchez, Jesús, Nicholson, Meghan, Farquharson, Michael, Butt, Warwick, Serratore, Alyssa, Delzoppo, Carmel, Janin, Pierre, Yarad, Elizabeth, Totaro, Richard, Coles, Jennifer, Balk, Robert, Fox, Samuel, Hays, James, Kapania, Esha, Mishin, Pavel, Vissing, Andy, Yantosh, Garrett, Yuliarto, Saptadi, Santoso, Kohar Hari, Djajalaksana, Susanthy, Fatoni, Arie Zainul, Fukuda, Masahiro, Liu, Keibun, Pelosi, Paolo, Battaglini, Denise, Jiménez, Juan Fernando Masa, Gaião, Sérgio, Roncon-Albuquerque, Roberto, Buchner, Jessica, Cho, Young-Jae, Lee, Sang Min, Lee, Su Hwan, Kawasaki, Tatsuya, Sakiyalak, Pranya, Nitayavardhana, Prompak, Seitz, Tamara, Arora, Rakesh, Kent, David, Parwar, Swapnil, Cheng, Andrew, Miller, Jennene, Marino, Daniel, Deacon, Jillian E., Fujitani, Shigeki, Shimizu, Naoki, Madhok, Jai, Owyang, Clark, Buscher, Hergen, Reynolds, Claire, Maasikas, Olavi, Beljantsev, Aleksandr, Mihnovits, Vladislav, Akimoto, Takako, Aizawa, Mariko, Horibe, Kanako, Onodera, Ryota, Young, Meredith, Smith, Timothy, Bartone, Cheryl, George, Timothy, Shekar, Kiran, McGuinness, Niki, Irvine, Lacey, Flynn, Brigid, Houchin, Abigail, Shimizu, Keiki, Hamaguchi, Jun, Lussier, Leslie, Kersker, Grace, Reich, John Adam, Lotz, Gösta, Malfertheiner, Maximilian, Dreier, Esther, Maier, Lars, Kusumastuti, Neurinda Permata, McCloskey, Colin, Dabaliz, Al-Awwab, Elshazly, Tarek B., Smith, Josiah, Szuldrzynski, Konstanty S., Bielański, Piotr, Hakeem, Yusuff, Wille, Keith, Holt, Rebecca, Parhar, Ken Kuljit S., Fiest, Kirsten M., Codan, Cassidy, Shahid, Anmol, Fayed, Mohamed, Evans, Timothy, Garcia, Rebekah, Gutierrez, Ashley, Song, Tae, Rose, Rebecca, Bennett, Suzanne, Richardson, Denise, Peek, Giles, Lopez-Colon, Dalia, Arora, Lovkesh, Rappapport, Kristina, Rudolph, Kristina, Sibenaller, Zita, Stout, Lori, Walter, Alicia, Herr, Daniel, Vedadi, Nazli, Sindt, Lace, Ewald, Cale, Hoffman, Julie, Rajnic, Sean, Thompson, Shaun, Kennedy, Ryan, Griffee, Matthew, Ciullo, Anna, Kida, Yuri, Roca, Ricard Ferrer, Alegre, Cynthia, Contreras, Sofia, Riera, JordI, Kay, Christy, Fischer, Irene, Renner, Elizabeth, Taniguci, Hayato, Abbate, Gabriella, Hassan, Halah, Heinsar, Silver, Karnik, Varun A., Ki, Katrina, O’Neill, Hollier F., Obonyo, Nchafatso, Pimenta, Leticia Pretti, Reid, Janice D., Sato, Kei, Wildi, Karin S., Wood, Emily S., Yerkovich, Stephanie, RS: Carim - V04 Surgical intervention, CTC, MUMC+: MA Med Staf Spec CTC (9), and Consortium, COVID-19 Critical Care

Subjects
Male, medicine.medical_treatment, ARDS, COVID-19, Compliance, Mechanical ventilation, SARS-CoV-2, Adult, Cohort Studies, Critical Care, Europe, Female, Humans, Intensive Care Units, Lung Compliance, Middle Aged, Respiration, Artificial, Respiratory Distress Syndrome, Retrospective Studies, Severity of Illness Index, Complications (Medicine), Overweight, Pulmonary compliance, Respiració artificial, Critical Care and Intensive Care Medicine, Hypoxemia, Respiratory Distress Syndrome/etiology, Clinical trials, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Respiratory system, Unitats de cures intensives, Artificial/methods, Tidal volume, Intensive care units, Respiration, Critical Care/methods, Medical emergencies. Critical care. Intensive care. First aid, respiratory system, DISTRESS-SYNDROME, Artificial respiration, Artificial, COVID-19/complications, Lung Compliance/physiology, medicine.symptom, Cohort study, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Respiration, Artificial/methods, INTENSIVE-CARE, 03 medical and health sciences, Intensive care, Internal medicine, Severity of illness, otorhinolaryngologic diseases, Intensive care medicine, RC86-88.9, business.industry, Research, MORTALITY, 030208 emergency & critical care medicine, Retrospective cohort study, Coronavirus, Compliance (physiology), Complicacions (Medicina), business, Body mass index, Assaigs clínics
Abstract

Background Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level. Methods We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe CRS—calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)]—and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. Results We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of CRS within the first seven days of MV. Median (IQR) age was 62 (52–71), patients were predominantly males (68%) and from Europe/North and South America (88%). CRS, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p = 0.417) nor with PaO2/FiO2 (p = 0.100). Females presented lower CRS than males (95% CI of CRS difference between females-males: − 11.8 to − 7.4 mL/cmH2O p CRS was marginal (p = 0.139). Ventilatory management varied across CRS range, resulting in a significant association between CRS and driving pressure (estimated decrease − 0.31 cmH2O/L per mL/cmH20 of CRS, 95% CI − 0.48 to − 0.14, p CRS (+ 10 mL/cm H2O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02–1.28, p = 0.018). Conclusions This multicentre report provides a comprehensive account of CRS in COVID-19 patients on MV. CRS measured within 48 h from commencement of MV has marginal predictive value for 28-day mortality, but was associated with being discharged from ICU within the same period. Trial documentation: Available at https://www.covid-critical.com/study. Trial registration: ACTRN12620000421932.

Published
2021

9. Heatstroke management during the COVID‐19 epidemic: recommendations from the experts in Japan

Author

Yokobori, Shoji, Kanda, Jun, Okada, Yohei, Okano, Yuichi, Kaneko, Hitoshi, Kobayashi, Tatsuho, Kondo, Yutaka, Shimazaki, Junya, Takauji, Shuhei, Hayashida, Kei, Hifumi, Toru, Fujita, Motoki, Moriya, Takashi, Yagi, Masaharu, Yamaguchi, Junko, Oda, Yasutaka, Shiraishi, Shinichiro, Wakasugi, Masahiro, Shimizu, Keiki, Miyake, Yasufumi, Yokota, Hiroyuki, Yaguchi, Arino, Shimazu, Takeshi, Asami, Masahiro, Hamaguchi, Jun, Ishihara, Tadashi, Kawagishi, Toshiomi, Igarashi, Yutaka, Hirano, Yohei, Nakae, Ryuta, Miyamoto, Yuki Arakawa Soma, Yamada, Eri, Ikechi, Daisuke, Sasaki, Junichi, Nakahara, Shinji, Ono, Masashi, Kawahara, Takashi, Tonouchi, Michihiko, Ikaga, Toshiharu, Sakamoto, Yuzo, Ueno, Satoshi, Mizobata, Yasumitsu, Morimura, Naoto, Tomioka, Joji, Fujimi, Satoshi, Matsuda, Kiyoshi, Moriya, Shun, Tanabe, Haruyama, Nagashima, Kimiyuki, Morizumi, Toshimitsu, Sato, Noriaki, Unei, Hiroko, Nishiike, Shigeaki, Okudera, Hiroshi, Kato, Masaya, Tanaka, Shuji, Sakamoto, Tetsuya, Ohge, Hiroki, Tateda, Kazuhiro, Matsumoto, Tomoshige, Mukae, Hiroshi, and Yokoyama, Akihito

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Medical treatment, business.industry, Prevention, General Engineering, Heatstroke, Acute medicine, 030229 sport sciences, medicine.disease, Medical care, Guideline Article, Treatment, Clinical Practice, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Infectious disease (medical specialty), Diagnosis, medicine, 030212 general & internal medicine, Medical emergency, business, Guideline Articles
Abstract

Fever and hyperthermia are the main symptoms of COVID‐19 and heatstroke, it is difficult to distinguish them. We came to think that there is a need to discuss safe prevention and medical treatment for heatstroke. In view of the above issues, the Japanese Association for Acute Medicine “Committee on Heatstroke and Hypothermia” established a "Working group on heatstroke medical care given the COVID‐19 epidemic" jointly with the Japanese Society for Emergency Medicine that focuses on emergency medical personnel including paramedics and nurses, the Japanese Association for Infectious Diseases, an academic society of infectious disease, and the Japanese Respiratory Society, an academic organization on respiratory diseases. The precautions for prevention of heatstroke this summer during the coronavirus epidemic was summarized in "Proposals on heatstroke prevention based on the COVID‐19 epidemic" as follows and was issued on June 1, 2020. Based on the above, we have determined that guidance in clinical practice is necessary not only from the viewpoint of heatstroke prevention, but also from the viewpoint of medical treatment. As such, we have created this guidance in the form of supplementary recommendation.

Published
2020
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12. Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines

Author

Sato Yuji, Oshima Takahiro, Sun Bailong, Kamiyama Naoya, Kudo Takeaki, Takahashi Masato, Nakagawa Hiroaki, Hamaguchi Jun, Deguchi Kisaburo, Todo Satoru, and Nishimura Shin-Ichiro

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Drug resistance is a major problem in cancer chemotherapy. Acquisition of chemo-resistance not only reduces the effectiveness of drugs, but also promotes side effects and markedly reduces the patient's quality of life. However, a number of resistance mechanisms have been reported and are thought to be the reason for the difficulties in solving drug-resistance problems. Result To investigate the mechanisms of drug resistance, a set of cell lines with different levels of sensitivity and possessing different mechanisms of resistance to 5-fluorouracil (5-FU) was established from a colorectal cancer cell line. The expression of thymidylate synthase, orotic acid phosphoribosyltransferase and dihydropyrimidine dehydrogenase, which are well known to be related to drug resistance, differed among these cell lines, indicating that these cell lines acquired different resistance mechanisms. However, swainsonine, an inhibitor of N-glycan biosynthesis, reduced 5-FU-tolerance in all resistant cells, whereas the sensitivity of the parental cells was unchanged. Further analysis of the N-glycan profiles of all cell lines showed partial inhibition of biosynthesis and no cytotoxicity at the swainsonine dosage tested. Conclusion These observations suggest that N-linked oligosaccharides affect 5-FU resistance more widely than do drug-resistance related enzymes in colorectal cancer cells, and that the N-glycan could be a universal target for chemotherapy. Further, swainsonine may enhance the performance of chemotherapy by reducing tolerance.

Published
2007
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13. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma

Author

Nakagawa Takahito, Nakanishi Kazuaki, Yokoo Hideki, Kamiyama Naoya, Hamaguchi Jun, Takahashi Masato, Nakagawa Hiroaki, Kudo Takeaki, Kamiyama Toshiya, Deguchi Kisaburo, Nishimura Shin-Ichiro, and Todo Satoru

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Correlations of disease phenotypes with glycosylation changes have been analysed intensively in the tumor biology field. Glycoforms potentially associated with carcinogenesis, tumor progression and cancer metastasis have been identified. In cancer therapy, drug resistance is a severe problem, reducing therapeutic effect of drugs and adding to patient suffering. Although multiple mechanisms likely underlie resistance of cancer cells to anticancer drugs, including overexpression of transporters, the relationship of glycans to drug resistance is not well understood. Results We established epirubicin (EPI) – and mitoxantrone (MIT) – resistant cell lines (HLE-EPI and HLE-MIT) from the human hepatocellular carcinoma cell line (HLE). HLE-EPI and HLE-MIT overexpressed transporters MDR1/ABCB1 and BCRP/ABCG2, respectively. Here we compared the glycomics of HLE-EPI and HLE-MIT cells with the parental HLE line. Core fucosylated triantennary oligosaccharides were increased in the two resistant lines. We investigated mRNA levels of glycosyltransferases synthesizing this oligosaccharide, namely, N-acetylglucosaminyltransferase (GnT)-IVa, GnT-IVb and α1,6-fucosyltransferase (α1,6-FucT), and found that α1,6-FucT was particularly overexpressed in HLE-MIT cells. In HLE-EPI cells, GnT-IVa expression was decreased, while GnT-IVb was increased. Both GnT-IVs were downregulated in HLE-MIT cells. HLE-MIT cells also showed decreases in fucosylated tetraantennary oligosaccharide, the product of GnT-V. GnT-V expression was decreased in both lines, but particularly so in HLE-MIT cells. Thus both N-glycan and glycosyltransferase expression was altered as cells acquired tolerance, suggesting novel mechanisms of drug resistance. Conclusion N-glycan and glycosyltransferase expression in HLE-EPI and HLE-MIT were analysed and presented that glycans altered according with acquired tolerance. These results suggested novel mechanisms of drug resistance.

Published
2007
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14. Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid

Author

MATSUZAWA, FUMIHIKO, primary, EINAMA, TAKAHIRO, additional, ABE, HIRONORI, additional, SUZUKI, TAKASHI, additional, HAMAGUCHI, JUN, additional, KAGA, TERUMI, additional, SATO, MAMI, additional, OOMURA, MASAKO, additional, TAKATA, YUMIKO, additional, FUJIBE, AYAKO, additional, TAKEDA, CHIE, additional, TAMURA, ETSUYA, additional, TAKETOMI, AKINOBU, additional, and KYUNO, KENICHI, additional

Published
2014
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16. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma

Author

Kudo, Takeaki, primary, Nakagawa, Hiroaki, additional, Takahashi, Masato, additional, Hamaguchi, Jun, additional, Kamiyama, Naoya, additional, Yokoo, Hideki, additional, Nakanishi, Kazuaki, additional, Nakagawa, Takahito, additional, Kamiyama, Toshiya, additional, Deguchi, Kisaburo, additional, Nishimura, Shin-Ichiro, additional, and Todo, Satoru, additional

Published
2007
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17. Swainsonine reduces 5-fluorouracil tolerance in the multistageresistance of colorectal cancer cell lines.

Author

Hamaguchi, Jun, Nakagawa, Hiroaki, Takahashi, Masato, Kudo, Takeaki, Kamiyama, Naoya, Sun, Bailong, and Oshima, Takahiro

Subjects
*SWAINSONINE, *COLON cancer, *DRUG resistance, *DRUG therapy, *CANCER cells, *CANCER patients
Abstract

Background: Drug resistance is a major problem in cancer chemotherapy. Acquisition of chemo-resistance not only reduces the effectiveness of drugs, but also promotes side effects and markedly reduces the patient's quality of life. However, a number of resistance mechanisms have been reported and are thought to be the reason for the difficulties in solving drug-resistance problems. Result: To investigate the mechanisms of drug resistance, a set of cell lines with different levels of sensitivity and possessing different mechanisms of resistance to 5-fluorouracil (5-FU) was established from a colorectal cancer cell line. The expression of thymidylate synthase, orotic acid phosphoribosyltransferase and dihydropyrimidine dehydrogenase, which are well known to be related to drug resistance, differed among these cell lines, indicating that these cell lines acquired different resistance mechanisms. However, swainsonine, an inhibitor of N-glycan biosynthesis, reduced 5-FU-tolerance in all resistant cells, whereas the sensitivity of the parental cells was unchanged. Further analysis of the N-glycan profiles of all cell lines showed partial inhibition of biosynthesis and no cytotoxicity at the swainsonine dosage tested. Conclusion: These observations suggest that N-linked oligosaccharides affect 5-FU resistance more widely than do drug-resistance related enzymes in colorectal cancer cells, and that the Nglycan could be a universal target for chemotherapy. Further, swainsonine may enhance the performance of chemotherapy by reducing tolerance. [ABSTRACT FROM AUTHOR]

Published
2007
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18. Safety of Supraclavicular Approach for Dual-Lumen Catheter Placement in Veno-Venous Extracorporeal Membrane Oxygenation: A Case Report.

Author

Horikoshi Y, Hamaguchi J, Asano K, Matsuyoshi T, and Shimizu K

Abstract

In veno-venous extracorporeal membrane oxygenation (V-V ECMO), the dual-lumen catheter (DLC) facilitates mobility, reduces recirculation, and mitigates the risk of infection. The right internal jugular vein (IJV) is the most common site for DLC insertion. Still, it is often unavailable for various reasons, including local infection, hematoma, or thrombus. A 64-year-old male patient with mantle lymphoma, which was in remission after autogenous blood transplantation, suffered lung damage and refractory pneumothorax from coronavirus disease 2019 (COVID-19) and required V-V ECMO treatment initiated on day 39. The patient was unable to be weaned off V-V ECMO due to uncontrolled high serum carbon dioxide (CO 2 ) concentration and required long-term V-V ECMO treatment for more than 80 days. DLC placement was necessary to implement aggressive rehabilitation, reduce puncture site-induced infections, and reduce recirculation. On day 119, a supraclavicular approach was used for DLC placement under fluoroscopic guidance using ultrasound guidance because a thrombus in the right IJV prevented the DLC insertion at a usual puncture site. Rehabilitation was safely performed at a higher intensity than preoperatively of DLC insertion. Overall, the DLC catheter was maintained for more than 30 days until the patient died due to septic shock by an unknown focus on day 150, with no complications such as bleeding or infection. This case report highlights the significance of using the supraclavicular approach for DLC placement in V-V ECMO in cases where IJV is not possible due to thrombus presence. In conclusion, the supraclavicular approach is safe and feasible for V-V ECMO insertion as an alternative to the IJV., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Horikoshi et al.)

Published
2024
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19. Combined use of veno-venous extracorporeal membrane oxygenation and asynchronous independent lung ventilation after thoracic surgery for lung abscess.

Author

Yoneda R, Matsuyoshi T, Yogi T, Sato Y, Hamaguchi J, and Shimizu K

Abstract

We used independent lung ventilation (ILV) during veno-venous extracorporeal membrane oxygenation (V-V ECMO) after lung abscess surgery in a patient with severe hypoxia and air leak. ILV can be effective in V-V ECMO as unilateral lung air leak., Competing Interests: None declared., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)

Published
2023
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20. Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid.

Author

Matsuzawa F, Einama T, Abe H, Suzuki T, Hamaguchi J, Kaga T, Sato M, Oomura M, Takata Y, Fujibe A, Takeda C, Tamura E, Taketomi A, and Kyuno K

Abstract

Axillary lymph node enlargement following sentinel lymph node biopsy (SLNB) is often difficult to accurately diagnose. In keeping with the characteristically tortuous and aberrant pattern of tumor neovasculature, metastatic lymph nodes exhibit peripheral and mixed vascularity, resulting in a microvasculature that is often difficult to visualize. Contrast-enhanced ultrasonography (CEUS) with Sonazoid, a new generation contrast agent for ultrasonography, allows for the visualization of lymph node microvessels and may enable a more accurate evaluation of lymph node metastasis. This is a case report of axillary lymph node enlargement following SLNB, in which CEUS with Sonazoid resulted in an accurate diagnosis. On the basis of our experience with this case, we have initiated a clinical trial to evaluate the detection of lymph node metastasis through the use of CEUS in breast cancer patients.

Published
2015
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