1. Thymosinα1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells
- Author
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Li, Min, Feurino, Louis W., Li, Fei, Wang, Hao, Zhai, Qihui, Fisher, William E., Chen, Changyi, and Yao, Qizhi
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THYMOSIN , *CANCER cell proliferation , *CYTOKINES , *MESSENGER RNA , *RNA metabolism , *BIOCHEMISTRY , *CELL lines , *CELL physiology , *COMPARATIVE studies , *DOSE-effect relationship in pharmacology , *GENES , *IMMUNOHISTOCHEMISTRY , *INTERLEUKINS , *PHENOMENOLOGY , *RESEARCH methodology , *MEDICAL cooperation , *PANCREATIC tumors , *PEPTIDE hormones , *POLYMERASE chain reaction , *RESEARCH , *RNA , *T cells , *TRANSFERASES , *EVALUATION research , *REVERSE transcriptase polymerase chain reaction - Abstract
Abstract: In this study, we investigated the expression and function of thymosinα1 (Thyα1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyα1 as compared to the normal human pancreatic ductal epithelium (HPDE) cells.. Thyα1 mRNA and protein levels were also over-expressed in clinical pancreatic adenocarcinoma specimens. In addition, synthetic Thyα1 significantly promoted Panc-1 cell proliferation and increased phosphorylation of ERK1/2 and JNK. Furthermore, Thyα1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyα1 may have a new role in pancreatic cancer pathogenesis. [Copyright &y& Elsevier]
- Published
- 2007
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