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The amount of knowledge accumulated in published scientific papers has increased due to the continuing progress being made in scientific research. Since numerous papers have only reported fragments of scientific facts, there are possibilities for discovering new knowledge by connecting these facts. We therefore developed a system called BioTermNet to draft a conceptual network with hybrid methods of information extraction and information retrieval. Two concepts are regarded as related in this system if (a) their relationship is clearly described in MEDLINE abstracts or (b) they have distinctively co-occurred in abstracts. PRIME data, including protein interactions and functions extracted by NLP techniques, are used in the former, and the Singhal-measure for information retrieval is used in the latter. Relationships that are not clearly or directly described in an abstract can be extracted by connecting multiple concepts. To evaluate how well this system performs, Swanson's association between Raynaud's disease and fish oil and that between migraine and magnesium were tested with abstracts that had been published before the discovery of these associations. The result was that when start and end concepts were given, plausible and understandable intermediate concepts connecting them could be detected. When only the start concept was given, not only the focused concept (magnesium and fish oil) but also other probable concepts could be detected as related concept candidates. Finally, this system was applied to find diseases related to the BRCA1 gene. Some other new potentially related diseases were detected along with diseases whose relations to BRCA1 were already known. The BioTermNet is available at http://btn.ontology.ims.u-tokyo.ac.jp. [ABSTRACT FROM AUTHOR]

A new document representation model is presented in this paper. This model is based on the idea of representing a document by two or more pictures of the document taken from different perspectives. It is shown that by applying the stereo representation model, enhanced textual retrieval performance is achieved because the new model improves the capability of capturing individual features of the document. Experiments have been conducted on two standard corpora, TIME and ADI, using the standard term vector method and the latent semantic indexing (LSI) method based upon both the stereo representation model and the traditional representation model. Statistical t-tests on the experimental results have convincingly illustrated that these methods achieve significant improvements in retrieval performances with the stereo representation model over those with the traditional representation model. [ABSTRACT FROM AUTHOR]