8 results on '"Nordestgaard, Børge G"'
Search Results
2. Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in Life.
- Author
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Robinson, Jennifer G., Williams, Kevin Jon, Gidding, Samuel, Borén, Jan, Tabas, Ira, Fisher, Edward A., Packard, Chris, Pencina, Michael, Fayad, Zahi A., Mani, Venkatesh, Rye, Kerry Anne, Nordestgaard, Børge G., Tybjærg-Hansen, Anne, Douglas, Pamela S., Nicholls, Stephen J., Pagidipati, Neha, and Sniderman, Allan
- Published
- 2018
- Full Text
- View/download PDF
3. Risk Prediction of Atrial Fibrillation Based on Electrocardiographic Interatrial Block.
- Author
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Skov, Morten W., Ghouse, Jonas, Kühl, Jørgen T., Platonov, Pyotr G., Graff, Claus, Fuchs, Andreas, Rasmussen, Peter V., Pietersen, Adrian, Nordestgaard, Børge G., Torp‐Pedersen, Christian, Hansen, Steen M., Olesen, Morten S., Haunsø, Stig, Køber, Lars, Gerds, Thomas A., Kofoed, Klaus F., Svendsen, Jesper H., Holst, Anders G., Nielsen, Jonas B., and Torp-Pedersen, Christian
- Published
- 2018
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- View/download PDF
4. <italic>ABCA7</italic> and risk of dementia and vascular disease in the Danish population.
- Author
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Kjeldsen, Emilie W., Tybjærg‐Hansen, Anne, Nordestgaard, Børge G., and Frikke‐Schmidt, Ruth
- Subjects
DEMENTIA ,VASCULAR diseases ,ADENOSINE triphosphate ,CEREBROVASCULAR disease ,GENOTYPES - Abstract
Abstract: Objective: ATP‐binding‐cassette transporter A7(
ABCA7 ) is suggested to be involved in lipid transport as well as in phagocytosis of amyloid‐β in the brain. We tested the hypothesis that a common genetic variant inABCA7 is associated with dementia, ischemic heart disease, ischemic cerebrovascular disease, and with lipid levels in the general population, independent of the common apolipoprotein E(APOE ) genotype. Methods: For this purpose, we genotyped a common genetic variant inABCA7, identified in genome‐wide‐association‐studies of Alzheimer's disease, in 104,258 individuals from the Danish general population, and also meta‐analyzed our results with publicly available consortia data. Results: Multifactorially adjusted hazard ratios for Alzheimer's disease were 1.07 (95% confidence interval:0.93–1.23) and 1.72 (1.24–2.40) for GA and AA versus GG genotype. Results were similar afterAPOE genotype adjustment and when onlyAPOE ɛ 33 carriers were studied. Including 178,304 individuals, the meta‐analyzed odds ratio for Alzheimer's disease per one alleleABCA7 rs4147929 increase was 1.15 (1.12–1.18).ABCA7 genotype was not convincingly associated with vascular dementia, ischemic heart disease, ischemic cerebrovascular disease, or with lipid levels. Including 288,563 individuals, meta‐analyzed odds ratios for ischemic heart disease per one alleleABCA7 rs4147929 increase was 1.01 (0.99–1.03). Interpretation: A common genetic variant inABCA7 was associated with high risk of Alzheimer's disease independent ofAPOE genotype. The lack of association with vascular dementia, ischemic heart disease, ischemic cerebrovascular disease, and with lipid levels suggests thatABCA7 is not important for atherosclerosis. Thus, our findings support the suggested role ofABCA7 in Alzheimer's disease pathology and phagocytic clearance of amyloid‐β in the brain. [ABSTRACT FROM AUTHOR]- Published
- 2018
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- View/download PDF
5. AT1 mutations and risk of atrial fibrillation based on genotypes from 71 000 individuals from the general population.
- Author
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Marott, Sarah C. W., Nordestgaard, Børge G., Jensen, Gorm B., Tybjærg‐Hansen, Anne, and Benn, Marianne
- Subjects
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ANGIOTENSIN II , *ATRIAL fibrillation , *GENOTYPE-environment interaction , *CARDIOMYOPATHIES , *HYPERTENSION , *CARDIOVASCULAR diseases risk factors - Abstract
Aims Activation of the angiotensin II type 1 (AT1) receptor has been shown to mediate the structural and electrical remodelling of the atrial myocardium associated with atrial fibrillation. We hypothesized that AT1 genotypic variation is associated with atrial fibrillation or diseases predisposing to atrial fibrillation, such as hypertension, heart failure, ischaemic heart disease and myocardial infarction, in the general population. Methods We resequenced the AT1 gene in 760 individuals with atrial fibrillation and identified two nonsynonymous variants ( I103 T and A244 S), which were subsequently genotyped in the prospective Copenhagen City Heart Study ( n = 10 603) and the prospective Copenhagen General Population Study ( n = 60 647). Results Risk of atrial fibrillation for heterozygotes for AT1 genetic variants A244 S and I103 T/ A244 S vs. noncarriers was increased by 2.7-fold (95% confidence interval 1.5- to 5.1-fold) and 2.6-fold (95% confidence interval 1.6- to 4.2-fold), respectively, for men. Conclusions Heterozygosity for the nonsynonymous AT1 genetic variants A244 S and I103 T/ A244 S was associated with increased risk of atrial fibrillation in men. The AT1 recptor might be a target for the pharmaceutical industry. This finding needs to be validated in independent studies. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
6. Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults.
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Lawlor DA, Harbord RM, Tybjaerg-Hansen A, Palmer TM, Zacho J, Benn M, Timpson NJ, Davey Smith G, Nordestgaard BG, Lawlor, Debbie A, Harbord, Roger M, Tybjaerg-Hansen, Anne, Palmer, Tom M, Zacho, Jeppe, Benn, Marianne, Timpson, Nicholas J, Smith, George Davey, and Nordestgaard, Børge G
- Abstract
Objective: We used genetic variants that are robustly associated with adiposity to examine the causal association of adiposity with psychological distress.Methods: We examined the association of adiposity with psychological distress in a large (N = 53,221) general population cohort of 20- to 99-year-old adults from Copenhagen, Denmark. Psychological distress was assessed using four questions that asked about: feeling stressed; not accomplishing very much; wanting to give up; and regular use of antidepressants/sedatives. We used the genetic loci FTO rs9939609 and MC4R rs17782313 as instrumental variables for adiposity quantified by body mass index (BMI) and waist to hip ratio (WHR).Results: In conventional multivariable analyses, BMI and WHR were positively associated with distress. For example, the odds ratio of reporting not accomplishing for each additional standard deviation increase for BMI was 1.11 (95% CI: 1.09, 1.13) and for WHR was 1.10 (95% CI: 1.08, 1.13) in the fully adjusted analyses. In contrast, instrumental variable analyses showed an inverse association of adiposity on distress; corresponding odds ratio in instrumental variable analyses was 0.64 (95% CI: 0.46, 0.89) for BMI and 0.49 (95% CI: 0.25, 0.94) for WHR (P-values for difference between the two approaches both = 0.001).Conclusion: The inverse associations of adiposity and psychological distress when genetic variants are used as instrumental variables could be explained by biological pathways linking adiposity and distress. The positive associations of adiposity with distress in multivariable analyses might be explained by residual confounding or reverse causality. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
7. Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults.
- Author
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Lawlor, Debbie A., Harbord, Roger M., Tybjaerg-Hansen, Anne, Palmer, Tom M., Zacho, Jeppe, Benn, Marianne, Timpson, Nicholas J., Davey Smith, George, and Nordestgaard, Børge G.
- Subjects
OBESITY & psychology ,PSYCHOLOGICAL distress ,BODY mass index ,BODY weight ,OVERWEIGHT persons ,WAIST-hip ratio ,PSYCHOLOGY - Abstract
Lawlor DA, Harbord RM, Tybjaerg-Hansen A, Palmer TM, Zacho J, Benn M, Timpson NJ, Smith GD, Nordestgaard BG (MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK; The Department of Social Medicine, University of Bristol, UK; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark; Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark) Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults. J Intern Med 2011; : 525-537. We used genetic variants that are robustly associated with adiposity to examine the causal association of adiposity with psychological distress. We examined the association of adiposity with psychological distress in a large ( N = 53 221) general population cohort of 20- to 99-year-old adults from Copenhagen, Denmark. Psychological distress was assessed using four questions that asked about: feeling stressed; not accomplishing very much; wanting to give up; and regular use of antidepressants/sedatives. We used the genetic loci FTO rs9939609 and MC4R rs17782313 as instrumental variables for adiposity quantified by body mass index (BMI) and waist to hip ratio (WHR). In conventional multivariable analyses, BMI and WHR were positively associated with distress. For example, the odds ratio of reporting not accomplishing for each additional standard deviation increase for BMI was 1.11 (95% CI: 1.09, 1.13) and for WHR was 1.10 (95% CI: 1.08, 1.13) in the fully adjusted analyses. In contrast, instrumental variable analyses showed an inverse association of adiposity on distress; corresponding odds ratio in instrumental variable analyses was 0.64 (95% CI: 0.46, 0.89) for BMI and 0.49 (95% CI: 0.25, 0.94) for WHR ( P-values for difference between the two approaches both = 0.001). The inverse associations of adiposity and psychological distress when genetic variants are used as instrumental variables could be explained by biological pathways linking adiposity and distress. The positive associations of adiposity with distress in multivariable analyses might be explained by residual confounding or reverse causality. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
8. AT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general population.
- Author
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Marott SC, Nordestgaard BG, Jensen GB, Tybjaerg-Hansen A, and Benn M
- Subjects
- Aged, Denmark, Female, Genetic Variation, Genotype, Heterozygote, Humans, Male, Middle Aged, Mutation, Prospective Studies, Risk, Sex Factors, Atrial Fibrillation genetics, Genetic Predisposition to Disease, Receptor, Angiotensin, Type 1 genetics
- Abstract
Aims: Activation of the angiotensin II type 1 (AT1 ) receptor has been shown to mediate the structural and electrical remodelling of the atrial myocardium associated with atrial fibrillation. We hypothesized that AT1 genotypic variation is associated with atrial fibrillation or diseases predisposing to atrial fibrillation, such as hypertension, heart failure, ischaemic heart disease and myocardial infarction, in the general population., Methods: We resequenced the AT1 gene in 760 individuals with atrial fibrillation and identified two nonsynonymous variants (I103T and A244S), which were subsequently genotyped in the prospective Copenhagen City Heart Study (n = 10 603) and the prospective Copenhagen General Population Study (n = 60 647)., Results: Risk of atrial fibrillation for heterozygotes for AT1 genetic variants A244S and I103T/A244S vs. noncarriers was increased by 2.7-fold (95% confidence interval 1.5- to 5.1-fold) and 2.6-fold (95% confidence interval 1.6- to 4.2-fold), respectively, for men., Conclusions: Heterozygosity for the nonsynonymous AT1 genetic variants A244S and I103T/A244S was associated with increased risk of atrial fibrillation in men. The AT1 recptor might be a target for the pharmaceutical industry. This finding needs to be validated in independent studies., (© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.)
- Published
- 2013
- Full Text
- View/download PDF
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