1. Does Dosage Matter? A Pilot Study of Hand-Arm Bimanual Intensive Training (HABIT) Dose and Dosing Schedule in Children with Unilateral Cerebral Palsy.
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Brandão, Marina B., Mancini, Marisa C., Ferre, Claudio L., Figueiredo, Priscilla R.P., Oliveira, Rachel H. S., Gonçalves, Shirley C., Dias, Miriam C.S., and Gordon, Andrew M.
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ANALYSIS of variance , *CHI-squared test , *CONFIDENCE intervals , *DOSE-response relationship in biochemistry , *INTERVIEWING , *RESEARCH methodology , *PHYSICAL therapy , *PROBABILITY theory , *RESEARCH funding , *STATISTICAL sampling , *STATISTICS , *T-test (Statistics) , *ARM exercises , *PILOT projects , *DATA analysis , *TREATMENT effectiveness , *PRE-tests & post-tests , *DATA analysis software , *DESCRIPTIVE statistics ,REHABILITATION of children with cerebral palsy - Abstract
Aim : We compared the efficacy of hand-arm bimanual intensive training (HABIT) in two doses (90 vs. 45 hours) and two schedules of the same dose (90 vs. 2 × 45 hours) on hand and daily functioning.Method : Eighteen children with unilateral cerebral palsy were randomized to receive 6 hours of daily training over 3 weeks, totaling 90 hours (Group 90,n = 9) or receive 6 hours of daily training over 1.5 weeks, totaling 45 hours (Group 2 × 45,n = 9). After 6 months, Group 2 × 45 received an additional 45 hours. Hand (Jebsen-Taylor Test of Hand Function, Assisting Hand Assessment) and daily functioning tests (Canadian Occupational Performance Measure, Pediatric Evaluation of Disability Inventory) were administered before, immediately after, and 6 months after interventions.Results : Both groups demonstrated significant improvements in hand and daily functioning after 90 hours (Group 90) or the first 45 hours (Group 2 × 45), without differences between groups. However, more children from Group 90 obtained smallest detectable differences in the Assisting Hand Assessment. The addition of the second bout of 45 hours (Group 2 × 45) did not lead to further improvements.Conclusions : As this study was powered to test for large differences between groups, future investigations on larger samples will be needed to compare differences at the two dosage levels. [ABSTRACT FROM AUTHOR]- Published
- 2018
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