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Two new ent-clerodane diterpenoids, named isoscoparins R and S (1 and 2), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HRESIMS data, and the relative configuration of compound 1 was determined by single-crystal X-ray diffraction. Compound 2 showed weak activity as an autophagic inhibitor. [ABSTRACT FROM AUTHOR]

The EtOH extract of the roots of Platycodon grandiflorum afforded two new triterpene saponins platycoside P (1) and platycoside Q (2). Their structures were elucidated based on spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against LPS-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed inhibitory activity with the inhibition ratios (%) of 38.6 and 44.1 at 50 μM, respectively. [ABSTRACT FROM AUTHOR]

The EtOH extract of the roots and rhizomes of Clematis chinensis afforded two new macrocyclic glucosides clemochinenosides C (1) and D (2). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against lipopolysaccharides-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed moderate inhibitory activity with IC50 values of 12.9 ± 2.3 and 18.4 ± 2.7 μM, respectively. In addition, a proliferation study was used to evaluate the anti-angiogenic effects of these compounds in vitro (VEGF-induced human umbilical vein endothelial cell proliferation). Compounds 1 and 2 displayed weak inhibitory effects with inhibition rates of 26.3 ± 1.8 and 19.2 ± 2.6% at 50 μM, respectively. [ABSTRACT FROM AUTHOR]

The EtOH extract of the roots and rhizomes ofClematis mandshuricaafforded two new lignans clemomanshurinane C (1)and clemomanshurinane D (2), and three known compounds (3–5). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. All compounds displayed moderate inhibitory activity against enzyme lipoxygenase. [ABSTRACT FROM AUTHOR]

Two new C-glucosyl flavonoids 6′′-O-feruloylspinosin and 6′′-O-feruloyl-6′′′-p-hydroxybenzoylspinosin, together with five known compounds, were isolated from the seeds ofZiziphus jujube(Rhamnaceae family). Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds1–7showed moderate inhibitory effects against COX-1 and COX-2 enzymes. [ABSTRACT FROM PUBLISHER]

The EtOH extract of the roots ofPaeonia veitchiiafforded two new monoterpene glycosides paeonidanin I (1)and paeonidanin J (2), and a new dimeric monoterpene glycoside paeonidanin K (3). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. [ABSTRACT FROM PUBLISHER]

Three new triterpene saponins, clematochinenosides H–J (1–3), were isolated from the roots and rhizomes ofClematis chinensis. Their structures were elucidated on the basis of spectroscopic means including 1D and 2D NMR experiments and hydrolysis products. [ABSTRACT FROM PUBLISHER]