1. Epidemiological and Immunological Features of Influenza Viruses in Hospitalized Children with Influenza Illness in Hangzhou.
- Author
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Li, Wei, Liu, Li-Fang, Xu, Jia-Lu, and Shang, Shi-Qiang
- Subjects
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INFLUENZA viruses , *HOSPITAL care of children , *INFLUENZA B virus , *H7N9 Influenza , *VIRUS diseases , *INFLUENZA - Abstract
Objectives: We evaluated the epidemiological features and various inflammatory markers in hospitalized children with influenza virus infection in China. Methods: The real-time RT-PCR assay was performed for detection and genotyping of influenza A and B virus. Th1/Th2 cytokines, WBC, and CRP were determined in influenza virus positive children. Results: H1N1 and Yamagata were the prevalent genotypes of influenza A and B virus in Hangzhou, respectively. IL-2, IL-10, and CRP were significantly increased and IFN-γ was decreased in children with severe Influenza A virus infection, and TNF-α and IFN-γ levels were found to be significantly lower in children with severe Influenza B virus infection. Conclusion: Increased IL-2, IL-10, and CRP with decreased IFN-γ may indicate a severe influenza A virus infection, and decreased TNF-α and IFN-γ may indicate a severe influenza B virus infection in children. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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