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Your search keyword '"Young, B. L."' showing total 3 results
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3 results on '"Young, B. L."'

1. Sensitivity and performance of three novel quantitative assays of SARS-CoV-2 nucleoprotein in blood.

Author

Hillig, Thore, Kristensen, Josephine R., Brasen, Claus L., Brandslund, Ivan, Olsen, Dorte A., Davidsen, Camilla, Madsen, Jonna S., Jensen, Claus A., Hansen, Young B. L., and Friis-Hansen, Lennart

Subjects
SARS-CoV-2, COVID-19, C-kit protein, SENSITIVITY & specificity (Statistics), ELECTROCHEMILUMINESCENCE
Abstract

To assess if SARS-CoV-2 (COVID-19) systemic disease can be determined by available nucleoprotein assays, we compared the performance of three commercial SARS-CoV-2 nucleoprotein (N) assays in plasma. A total of 272 plasma samples collected in the period November–December 2021 were analyzed by the methods Simoa SARS CoV‐2 N Protein Advantage Kit [Quanterix Simoa], Solsten SARS-CoV-2 Antigen enzyme immunosorbent assay (ELISA) [Solsten ELISA], and Elecsys SARS‐CoV‐2 Antigen electrochemiluminescence immunoassay [Elecsys ECLIA]. Additionally, a dilution series of inactivated virus culture was analyzed by the three assays. The SARS CoV-2 PCR-status was not known for the patients. Linear correlation in the pairwise correlation between assays as well as linearity of dilution series of inactivated virus culture was estimated by Spearman score. Sensitivity and specificity were estimated by pairwise comparison. The three assays showed poor agreement on patient samples with regards to concentration. Performance on virus culture was excellent but with different level of detection (LOD). Positive vs negative results show comparable sensitivity and specificity of Quanterix Simoa and Solsten ELISA, with a higher LOD in Elecsys ECLIA and thus lower sensitivity and high specificity. N by all tested assays can be used as a marker for systemic COVID-19 disease. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Interplay Of Magnetism And Superconductivity In Cecoin5.

Author

Movshovich, R., Tokiwa, Y., Ronning, F., Bianchi, A., Capan, C., Young, B. L., Urbano, R. R., Curro, N. J., Park, T., Thompson, J. D., Bauer, E., and Sarrao, J. L.

Abstract

CeCoIn5 is a heavy fermion superconductor which appears to be straddling the boundary between the superconducting and magnetic ground states. At the superconducting critical field Hc2 this material displays NFL behavior in transport and thermodynamic properties, pointing at a Quantum Critical Point (QCP) at Hc2, and hinting at the presence of magnetic fluctuations, probably due to an AFM order superseded by the superconductivity. In the High-Field-Low-Temperature (HFLT) corner of the superconducting phase of CeCoIn5, within 20% off Hc2, an additional phase appears within the superconducting phase, and the normal-to-superconducting transition itself becomes first order. This behavior is consistent with a strong Pauli limited superconductivity, and the low temperature high field phase being an inhomogeneous superconducting FFLO phase. Recent NMR experiments, however, point to a long range magnetic order within HFLT state. Experiments on CeRhIn5 under pressure show magnetic field induced AFM order within the superconducting phase, with some similarities to the phase diagram of CeCoIn5. Could the HFLT phase transition be due to magnetic order? Importantly, the HFLT phase does not extend into the normal state above Hc2. We need a picture of a magnetism ˵attracted″ to superconductivity to explain the data on the HFLT phase in CeCoIn5. [ABSTRACT FROM AUTHOR]

Published
2009
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