64 results on '"Roth, Andreas"'
Search Results
2. Preoperative dental screening can reduce periprosthetic infections of hip and knee endoprostheses in the first month after surgery: results of a cohort study.
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Fenske, Fabian, Kujat, Benjamin, Krause, Leah, Meyer, Stephan, Sander, Anna-Katharina, Repmann, Jaqueline, Neuhaus, Michael, Haak, Rainer, Roth, Andreas, Lethaus, Bernd, Ziebolz, Dirk, and Schmalz, Gerhard
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PREVENTION of surgical complications ,PROSTHESIS-related infections ,TOTAL hip replacement ,INTERPROFESSIONAL relations ,MULTIPLE regression analysis ,PREOPERATIVE care ,DESCRIPTIVE statistics ,ODDS ratio ,TOTAL knee replacement ,STATISTICS ,MEDICAL screening ,COMPARATIVE studies ,CONFIDENCE intervals ,ORAL health ,MEDICAL referrals - Abstract
Purpose: The oral cavity and, in particular, potential oral foci might pose a risk of periprosthetic joint infection (PJI). The aim of this cohort study was to determine whether practical preoperative dental screening would reduce the prevalence of early PJI in the first month after surgery. Methods: Patients attending a specialized endoprosthesis implantation clinic between 2018 and 2022 were recruited. Two groups were examined. The test group consisted of patients attending the clinic between 2020 and 2022 and who were referred to their family dentist using a standardized form. The comparison group consisted of patients who were treated in the clinic between 2018 and 2020. They were not referred to their family dentist. The two groups were compared for the prevalence of PJI. Univariate analysis followed by multiple logistic regression was performed to confirm risk factors for PJI in this cohort. Results: 2560 individuals (test group: 1227, comparison group: 1333) were included. The prevalence of PJI was significantly lower in the test group (0.8% vs. 1.8%, p = 0.04). Multiple logistic regression with PJI as the dependent variable showed that a dental referral was a strong predictor of a lower prevalence of PJI (OR: 0.43, CI
95 0.205–0.917, p = 0.03). Male gender was also strongly associated with a higher frequency of PJI (OR: 2.68, CI95 1.32–5.42, p = 0.01). Age (OR: 1.06, CI95 1.01–1.10, p = 0.01) and BMI (OR: 1.11, CI95 1.05–1.17, p < 0.01) had little effect on the risk of PJI. Conclusion: Dental referral using a standardized form can reduce the prevalence of early PJI. Accordingly, orthopedists and dentists should collaborate in this practical way. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Osteoporotische Wirbelkörperfrakturen.
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Heyde, Christoph-E., Roth, Andreas, and Putzier, Michael
- Abstract
Copyright of Die Orthopädie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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4. BMP-2 (and partially GDF-5) coating significantly accelerates and augments bone formation close to hydroxyapatite/tricalcium-phosphate/brushite implant cylinders for tibial bone defects in senile, osteopenic sheep.
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Sachse, André, Hasenbein, Ines, Hortschansky, Peter, Schmuck, Klaus D., Maenz, Stefan, Illerhaus, Bernhard, Kuehmstedt, Peter, Ramm, Roland, Huber, René, Kunisch, Elke, Horbert, Victoria, Gunnella, Francesca, Roth, Andreas, Schubert, Harald, and Kinne, Raimund W.
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BONE growth ,FRACTURE healing ,GROWTH differentiation factors ,SHEEP ,TIBIAL fractures ,X-ray computed microtomography ,BONE density - Abstract
Bilateral defects (diameter 8 mm) in the medial tibial head of senile, osteopenic female sheep (n = 48; 9.63 ± 0.10 years; mean ± SEM) were treated with hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP)/dicalcium phosphate dihydrate (DCPD; brushite) cylinders coated with BMP-2 (25 or 250 micrograms) or growth differentiation factor (GDF)-5 (125 or 1250 micrograms; left side); cylinders without BMP served as controls (right side). Three, 6, and 9 months post-operation (n = 6 each group), bone structure and formation were analyzed in vivo by X-ray and ex vivo by osteodensitometry, histomorphometry, and micro-computed tomography (micro-CT) at 3 and 9 months. Semi-quantitative X-ray evaluation showed significantly increasing bone densities around all implant cylinders over time. High-dose BMP-2-coated cylinders (3 and 9 months) and low-dose GDF-5-coated cylinders (3 and 6 months) demonstrated significantly higher densities than controls (dose-dependent for BMP-2 at 3 months). This was confirmed by osteodensitometry at 9 months for high-dose BMP-2-coated cylinders (and selected GDF-5 groups), and was again dose-dependent for BMP-2. Osteoinduction by BMP-2 was most pronounced in the adjacent bone marrow (dynamic histomorphometry/micro-CT). BMP-2 (and partially GDF-5) significantly increased the bone formation in the vicinity of HA/TCP/DCPD cylinders used to fill tibial bone defects in senile osteopenic sheep and may be suitable for surgical therapy of critical size, non-load-bearing bone defects in cases of failed tibial head fracture or defect healing. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Zukunft der Orthopädie und Unfallchirurgie in Deutschland.
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Roth, Andreas, Böcker, Wolfgang, and Madry, Henning
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- 2024
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6. Atraumatic femoral head necrosis: a biomechanical, histological and radiological examination compared to primary hip osteoarthritis.
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Hofmann, Alexander, Fischer, Benjamin, Schleifenbaum, Stefan, Kurz, Sascha, Edel, Melanie, Borte, Gudrun, Lehmann, Gabriele, and Roth, Andreas
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Introduction: Atraumatic necrosis of the femoral head (AFHN) is a common disease with an incidence of 5000–7000 middle-aged adults in Germany. There is no uniform consensus in the literature regarding the configuration of the bone in AFHN. The clinical picture of our patients varies from very hard bone, especially in idiopathic findings, and rather soft bone in cortisone-induced necrosis. A better understanding of the underlying process could be decisive for establishing a morphology-dependent approach. The aim of this study is the closer examination of the condition of the bone in the AFHN compared to the primary hip osteo arthritis (PHOA). Materials and methods: The preparations were obtained as part of elective endoprosthetic treatment of the hip joint. Immediately after sample collection, thin-slice CT of the preserved femoral heads was performed to determine the exact density of the bone in the necrosis zone. Reconstruction was done in 0.8–1 mm layers in two directions, coronary and axial, starting from the femoral neck axis. Density of the femoral heads was determined by grey value analysis. The value in Hounsfield units per sample head was averaged from three individual measurements to minimize fluctuations. For biomechanical and histomorphological evaluation, the samples were extracted in the load bearing zone perpendicular to the surface of the femoral head. Group-dependent statistical evaluation was performed using single factor variance analysis (ANOVA). Results: A total of 41 patients with a mean age of 64.44 years were included. The mean bone density of the AFHN samples, at 1.432 g/cm
3 , was about 7% higher than in the PHOA group with a mean value of 1.350 g/cm3 (p = 0.040). The biomechanical testing in the AFHN group showed a 22% higher—but not significant—mean compressive strength (20.397 MPa) than in the PHOA group (16.733 MPa). On the basis of histological analysis, no differentiation between AFHN and PHOA samples was possible. Conclusions: The present study (NCT, evidence level II) shows that AFHN has a very well detectable higher bone density compared to PHOA. However, neither biomechanical stress tests nor histomorphological evaluation did show any significant difference between the groups. The results allow the conclusion that there is no "soft" necrosis at all in the AFHN group. [ABSTRACT FROM AUTHOR]- Published
- 2022
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7. Factors associated with dislocation after bipolar hemiarthroplasty through an (antero-)lateral approach in elderly patients with a femoral neck fracture: a retrospective cohort study with a nested case–control subanalysis of radiographic parameters.
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Fakler, Johannes Karl Maria, Rositzka, Markus, Schopow, Nicolas, Roth, Andreas, Zajonz, Dirk, Ghanem, Mohamed, Kleber, Christian, and Osterhoff, Georg
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TOTAL hip replacement ,HEMIARTHROPLASTY ,JOINT dislocations ,RETROSPECTIVE studies ,CASE-control method ,RISK assessment ,PELVIC bones ,DESCRIPTIVE statistics ,RESEARCH funding ,BODY mass index ,FEMORAL neck fractures ,COMORBIDITY ,DISEASE risk factors ,OLD age - Abstract
Introduction: Dislocations of hip hemiarthroplasty (HHA) are serious complications. The aim of the study was to identify clinical aspects and radiographic parameters of the hip that put patients at risk for dislocation after HHA for femoral neck fractures. Methods: This retrospective analysis included elderly patients with a femoral neck fracture treated with a HHA. A lateral (90.7%) and an anterolateral (9.3%) approach was applied. On pelvic radiographs, a nested-controlled analysis was performed. Two control patients were matched to one patient suffering a dislocation with respect to age, sex, and body-mass-index (BMI). Results: In 527 HHA, 10 dislocations (1.9%) were identified. In the dislocation group (DG), all patients were female (100% vs. 73.5%, p = 0.071). No significant differences between the DG and the control group (CG) were found with respect to age, body-mass-index (BMI), ASA Score, routine laboratory parameters, and comorbidity. Radiographic analysis revealed a smaller center edge angle (CEA, 39.0, IQR 33.0–42.5 vs. 43.0, IQR 41.0–46.0, p = 0.013), a more varus neck-shaft angle (NSA, 130.0, IQR 125.8–133.5 vs. 135.0, IQR 134.0–137.0, p = 0.011) of the contralateral side and a higher femoral head extrusion index (FHEI) in the DG (FHEI, 11.5, IQR 9.8–16.3 vs. 2.0 IQR 0.0–9.0, p = 0.003). In addition, a greater trochanteric fracture was associated with an increased likelihood for HHA dislocations (30.0% vs 6.0%, p = 0.022). Conclusion: A smaller radiographic center edge angle, a more varus neck-shaft angle of the contralateral side, a higher femoral head extrusion index and intraoperative fractures of the greater trochanter are associated with an increased risk of HHA dislocation. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Simultaneous 18F-FDG-PET/MRI for the detection of periprosthetic joint infections after knee or hip arthroplasty: a prospective feasibility study.
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Henkelmann, Jeanette, Henkelmann, Ralf, Denecke, Timm, Zajonz, Dirk, Roth, Andreas, Sabri, Osama, and Purz, Sandra
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Purpose: This study investigated the diagnostic value of simultaneous
18 F-fluordeoxyglucose positron emission tomography/magnetic resonance imaging (PET/MRI) in suspected periprosthetic joint infection (PJI) of the hip and knee. Methods: Sixteen prostheses from 13 patients with suspected PJI were prospectively examined using PET/MRI. Image datasets were evaluated in consensus by a radiologist and a nuclear physician for the overall diagnosis of 'PJI' (yes/no) and its anatomical involvement, such as the periprosthetic bone margin, bone marrow, and soft tissue. The imaging results were compared with the reference standard obtained from surgical or biopsy specimens and subjected to statistical analysis. Results: Using the reference standard, ten out of the 13 prostheses (ten hips, threes knees) were diagnosed with PJI. Using PET/MRI, every patient with PJI was correctly diagnosed (sensitivity, 100%; specificity, 100%). Considering the anatomical regions, the sensitivity and specificity were 57% and 50% in the periprosthetic bone margin, 75% and 33% in the bone marrow, and 100% and 100% in the soft tissue. Conclusion: PET/MRI can be reliably used for the diagnosis of PJI. However, assessment of the periprosthetic bone remains difficult due to the presence of artefacts. Thus, currently, this modality is unlikely to be recommended in clinical practice. [ABSTRACT FROM AUTHOR]- Published
- 2022
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9. Risk factors for intraoperative greater trochanteric fractures in hemiarthroplasty for intracapsular femoral neck fractures.
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Fakler, Johannes Karl Maria, Brand, Alexander, Lycke, Christian, Pempe, Christina, Ghanem, Mohamed, Roth, Andreas, Osterhoff, Georg, Spiegl, Ulrich Josef Albert, Höch, Andreas, and Zajonz, Dirk
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FEMUR radiography ,PROSTHETICS ,PROTHROMBIN time ,INTRAOPERATIVE care ,HIP fractures ,HEMIARTHROPLASTY ,RETROSPECTIVE studies ,ARTIFICIAL implants ,RISK assessment ,SURGICAL site infections ,REOPERATION ,DESCRIPTIVE statistics ,FEMORAL neck fractures ,DISEASE risk factors - Abstract
Purpose: Hemiarthroplasty is widely accepted as the treatment of choice in elderly patients with a displaced intracapsular femoral neck fracture. Intraoperative greater trochanteric fractures thwart this successful procedure, resulting in prolonged recovery, inferior outcome, and increased risk of revision surgery. Hence, this study analyzed factors potentially associated with an increased risk for intraoperative greater trochanteric fracture. Methods: This retrospective study included 512 hemiarthroplasties in 496 patients with a geriatric intracapsular femoral neck fracture from July 2010 to March 2020. All patients received the same implant type of which 90.4% were cemented and 9.6% non-cemented. Intra- and postoperative radiographs and reports were reviewed and particularly screened for greater trochanteric fractures. Results: Female patients accounted for 74% and mean age of the patients was 82.3 (± 8.7) years. 34 (6.6%) intraoperative greater trochanteric fractures were identified. In relation to patient-specific factors, only a shorter prothrombin time was found to be significantly associated with increased risk of intraoperative greater trochanteric fracture (median 96%, IQR 82–106% vs. median 86.5%, IQR 68.8–101.5%; p = 0.046). Other factors associated with greater trochanteric fracture were a shorter preoperative waiting time and changes in perioperative settings. Outcome of patients with greater trochanteric fracture was worse with significantly more surgical site infection requiring revision surgery (17.6% vs. 4.2%, p = 0.005). Conclusion: Prolonged prothrombin time, a shorter preoperative waiting time, and implementing new procedural standards and surgeons may be associated with an increased risk of a greater trochanteric fracture. Addressing these risk factors may reduce early periprosthetic infection which is strongly related to greater trochanteric fractures. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Zungenschmerz und Erblindung – eine ungewöhnliche Kombination.
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Stenzl, Anna, Ikenberg, Benno, Mogler, Carolin, Moog, Philipp, Röper, Kristin, Stimmer, Herbert, Wollenberg, Barbara, Hofauer, Benedikt, and Roth, Andreas
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- 2022
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11. Intraoperative hyperspectral imaging (HSI) as a new diagnostic tool for the detection of cartilage degeneration.
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Kistler, Max, Köhler, Hannes, Theopold, Jan, Gockel, Ines, Roth, Andreas, Hepp, Pierre, and Osterhoff, Georg
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CARTILAGE ,RECEIVER operating characteristic curves - Abstract
To investigate, whether hyperspectral imaging (HSI) is able to reliably differentiate between healthy and damaged cartilage tissue. A prospective diagnostic study was performed including 21 patients undergoing open knee surgery. HSI data were acquired during surgery, and the joint surface's cartilage was assessed according to the ICRS cartilage injury score. The HSI system records light spectra from 500 to 1000 nm and generates several parameters including tissue water index (TWI) and the absorbance at 960 nm and 540 nm. Receiver operating characteristic curves were calculated to assess test parameters for threshold values of HSI. Areas with a cartilage defect ICRS grade ≥ 3 showed a significantly lower TWI (p = 0.026) and higher values for 540 nm (p < 0.001). No difference was seen for 960 nm (p = 0.244). For a threshold of 540 nm > 0.74, a cartilage defect ICRS grade ≥ 3 could be detected with a sensitivity of 0.81 and a specificity of 0.81. TWI was not suitable for cartilage defect detection. HSI can provide reliable parameters to differentiate healthy and damaged cartilage. Our data clearly suggest that the difference in absorbance at 540 nm would be the best parameter to achieve accurate identification of damaged cartilage. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Osteoporose.
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Roth, Andreas and Maus, Uwe
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- 2023
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13. Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β.
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Nickel, Sandra, Vlaic, Sebastian, Christ, Madlen, Schubert, Kristin, Henschler, Reinhard, Tautenhahn, Franziska, Burger, Caroline, Kühne, Hagen, Erler, Silvio, Roth, Andreas, Wild, Christiane, Brach, Janine, Hammad, Seddik, Gittel, Claudia, Baunack, Manja, Lange, Undine, Broschewitz, Johannes, Stock, Peggy, Metelmann, Isabella, and Bartels, Michael
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LIVER cells ,STROMAL cells ,LIVER surgery ,GENE expression profiling ,THROMBOSPONDIN-1 ,EPITHELIAL-mesenchymal transition - Abstract
Post-surgery liver failure is a serious complication for patients after extended partial hepatectomies (ePHx). Previously, we demonstrated in the pig model that transplantation of mesenchymal stromal cells (MSC) improved circulatory maintenance and supported multi-organ functions after 70% liver resection. Mechanisms behind the beneficial MSC effects remained unknown. Here we performed 70% liver resection in pigs with and without MSC treatment, and animals were monitored for 24 h post surgery. Gene expression profiles were determined in the lung and liver. Bioinformatics analysis predicted organ-independent MSC targets, importantly a role for thrombospondin-1 linked to transforming growth factor-β (TGF-β) and downstream signaling towards providing epithelial plasticity and epithelial-mesenchymal transition (EMT). This prediction was supported histologically and mechanistically, the latter with primary hepatocyte cell cultures. MSC attenuated the surgery-induced increase of tissue damage, of thrombospondin-1 and TGF-β, as well as of epithelial plasticity in both the liver and lung. This suggests that MSC ameliorated surgery-induced hepatocellular stress and EMT, thus supporting epithelial integrity and facilitating regeneration. MSC-derived soluble factor(s) did not directly interfere with intracellular TGF-β signaling, but inhibited thrombospondin-1 secretion from thrombocytes and non-parenchymal liver cells, therewith obviously reducing the availability of active TGF-β. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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14. Predictors for blood loss and transfusion frequency to guide blood saving programs in primary knee- and hip-arthroplasty.
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Pempe, Christina, Werdehausen, Robert, Pieroh, Philip, Federbusch, Martin, Petros, Sirak, Henschler, Reinhard, Roth, Andreas, and Pfrepper, Christian
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BLOOD loss estimation ,RED blood cell transfusion ,TOTAL knee replacement ,HEMOGLOBINS ,TRANEXAMIC acid - Abstract
Endoprosthetic surgery can lead to relevant blood loss resulting in red blood cell (RBC) transfusions. This study aimed to identify risk factors for blood loss and RBC transfusion that enable the prediction of an individualized transfusion probability to guide preoperative RBC provision and blood saving programs. A retrospective analysis of patients who underwent primary hip or knee arthroplasty was performed. Risk factors for blood loss and transfusions were identified and transfusion probabilities computed. The number needed to treat (NNT) of a potential correction of preoperative anemia with iron substitution for the prevention of RBC transfusion was calculated. A total of 308 patients were included, of whom 12 (3.9%) received RBC transfusions. Factors influencing the maximum hemoglobin drop were the use of drain, tranexamic acid, duration of surgery, anticoagulation, BMI, ASA status and mechanical heart valves. In multivariate analysis, the use of a drain, low preoperative Hb and mechanical heart valves were predictors for RBC transfusions. The transfusion probability of patients with a hemoglobin of 9.0–10.0 g/dL, 10.0–11.0 g/dL, 11.0–12.0 g/dL and 12.0–13.0 g/dL was 100%, 33.3%, 10% and 5.6%, and the NNT 1.5, 4.3, 22.7 and 17.3, while it was 100%, 50%, 25% and 14.3% with a NNT of 2.0, 4.0, 9.3 and 7.0 in patients with a drain, respectively. Preoperative anemia and the insertion of drains are more predictive for RBC transfusions than the use of tranexamic acid. Based on this, a personalized transfusion probability can be computed, that may help to identify patients who could benefit from blood saving programs. [ABSTRACT FROM AUTHOR]
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- 2021
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15. The impact of polyethylene abrasion on the occurrence of periprosthetic proximal femoral fractures in patients with total hip arthroplasty.
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Zajonz, Dirk, Lang, Nora, Pönick, Cathleen, Edel, Melanie, Möbius, Robert, Busse, Harald, Josten, Christoph, Roth, Andreas, and Fakler, Johannes K. M.
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TOTAL hip replacement ,BONE resorption ,POLYETHYLENE ,BRUISES ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,PERIPROSTHETIC fractures ,PROXIMAL femoral fractures ,COMPLICATIONS of prosthesis - Abstract
Introduction: In addition to abrasion-induced osteolysis and ensuing instabilities, the polyethylene (PE) abrasion of total hip arthroplasty (THA) inlays can also cause gait instability due to the decentralization of the hip joint. The current literature yields, as yet, insufficient findings whether these two factors are linked directly or indirectly to a higher risk for periprosthetic proximal femoral fractures (PPFF). The aim of our retrospective evaluation is to analyse the impact of PE abrasion on the pathology of PPFF in patients with THA. Material and methods: The retrospective evaluation comprises all PPFF in patients with THA in the period from 01/2010 up to 12/2016. The study group (SG) included 66 cases (n = 66). The control group (CG) was comprised of patients with asymptomatic THA (n = 66), who were treated by our outpatient department including routine check-ups and X-ray examinations. We used the matched-pair methodology to scale the period of postsurgical care of the CG to the lifetime of the implant up to PPFF in the SG. We included epidemiologic data, radiological femoral head decentralization, osteolysis (Gruen classification), instabilities, acetabular cup position, and implant properties in our analysis. For the SG, we also included intra-operative signs of abrasion. Findings: The SG showed significantly higher numbers of decentralized THA as signs of inlay erosion with 73% compared to only 41% in the CG (p > 0.001). The SG showed 1 ± 0.68 mm hip joint decentralization as to 0.5 ± 0.59 mm in the CG (p = 0.004). We found significantly more cases of osteolysis in the SG (n = 25) than in the CG (n = 13) (p = 0.003). We found no notable differences in acetabular cup inclination or anteversion as well as cup size. However, differences were significant in femoral head size (SG 32 ± 2.3 mm, CG 36 ± 2.4 mm; p = 0.042) and head material. We found more widespread use of metal femoral heads in the SG than in the CG (SG 1:1, CG 1:21; p = 0.001). Conclusion: PPFF patients showed significantly higher rates of inlay erosion, resulting in femoral head decentralization and osteolysis. The higher rate of fracture is likely caused by the increasing instability of the implant fixation due to abrasion-induced osteolysis and the associated degradation of bone quality. It is conceivable that the abrasion and decentralization of the THA can also lead to gait instability, and thus, a higher proneness to falls. Gait instability can also be aggravated by increased granulation tissue and effusion due to the inlay abrasion. Although this cannot be substantiated by the investigation. In patients with decentralization of the THA and osteolysis, a radiological follow-up should be performed, and in case of gait instability (femoral head and) inlay replacements should be considered. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Long-term follow-up of bone remodelling after cementless hip arthroplasty using different stems.
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Brodt, Steffen, Matziolis, Georg, Buckwitz, Bettina, Zippelius, Timo, Strube, Patrick, and Roth, Andreas
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TOTAL hip replacement ,BONE remodeling ,DUAL-energy X-ray absorptiometry ,PHYSIOLOGICAL stress ,BONE density - Abstract
The present paper is concerned with the investigation of the phenomenon of long-term bone remodelling on cementless hip replacements. Changes in bone density in the periprosthetic region around the stem, measured by dual X–ray absorptiometry (DXA), were used as a measure of the osseous adaptation reaction. A postoperative follow-up of the use of four different types of prostheses of varying design after on average 13.3 (11.4–14.5) years. Specifically, the prostheses assessed in this study were the CLS/Spotorno stem with the Allofit cup by Zimmer, the Vision 2000 stem with the Duraloc cup by DePuy Synthes, the AlphaFit stem with the AlphaLock cup by Corin and the Mayo stem with the Trilogy cup by Zimmer. For the DXA measurement, the femur was divided into the zones suggested by Gruen et al. On the femur, there was a significant reduction in bone mineral density (BMD) in the proximal Region Of Interest (ROI) 1 (p = 0.003) and 7 (p < 0.001), whilst there was a significant increase in ROI 4 (p = 0.03). A greater degree of bone atrophy was seen in patients aged 60 years and older and in female patients. A remarkable finding when comparing the stems was a significantly greater reduction in BMD in ROI 6 (p = 0.003) in the case of the Vision 2000 stem and a markedly, but not statistically significantly smaller reduction in BMD in ROI 7 (p = 0.18) in the case of the short-stem Mayo-type prosthesis. The best clinical results were found with the use of the latter. The investigations provide a starting point for establishing a differential indication in the choice of prosthesis types, depending on age and sex, the use of short-stem prostheses, as well as the administration of bone-effective drugs for the prevention of stress shielding. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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17. Nontraumatic avascular necrosis of the femoral head: Arthroscopic and navigation-supported core decompression.
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Theopold, Jan, Armonies, Sarah, Pieroh, Philipp, Hepp, Pierre, and Roth, Andreas
- Abstract
Copyright of Operative Orthopädie und Traumatologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
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18. Risk factors for early infection following hemiarthroplasty in elderly patients with a femoral neck fracture.
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Brand, Alexander, Lycke, Christian, Özkurtul, Orkun, Theopold, Jan, Spiegl, Ulrich J. A., Roth, Andreas, Josten, Christoph, Fakler, Johannes K. M., and Zajonz, Dirk
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THERAPEUTIC use of glucocorticoids ,INFECTION risk factors ,SURGICAL complication risk factors ,FEMUR neck ,RISK of prosthesis complications ,SURGICAL site infections ,C-reactive protein ,CONFIDENCE intervals ,BONE fractures ,HIP joint injuries ,LENGTH of stay in hospitals ,REGRESSION analysis ,RISK assessment ,TOTAL hip replacement ,BODY mass index ,RETROSPECTIVE studies ,TREATMENT duration ,DESCRIPTIVE statistics ,HOSPITAL mortality ,HEMIARTHROPLASTY ,ODDS ratio ,OLD age ,SURGERY ,DISEASE risk factors - Abstract
Purpose: Periprosthetic joint infections (PJI) after hemiarthroplasty for geriatric femoral neck fractures are a devastating complication that results in serious morbidity and increased mortality. Identifying risk factors associated with early infection after HA for hip fractures may offer an opportunity to address and prevent this complication in many patients. The aim of this study was to evaluate preoperative risk factors for early PJI after HA in hip fracture patients. Methods: From January 2010 to December 2015, 312 femoral neck fractures (AO/OTA 31-B) in 305 patients were included in this single-center, retrospective study. PJI was defined according to the Centers for Disease Control (CDC) definition of deep incisional surgical site infection. Early infection referred to a postoperative period of 4 weeks. Binary univariable and multivariable regression analysis with backward elimination was applied to identify predictors of PJI. Results: Median age of all patients was 83.0 (IQR 76–89) years. We identified 16 (5.1%) early PJI which all required surgical revision. Median length of in-hospital stay (LOS) was 20.0 (IQR 10–36) days after PJI compared to 10.0 (8–15) days without deep wound infection. In-hospital mortality was 30.8 vs. 6.6%, respectively. Preoperative CRP levels (OR 1.009; 95% CI 1.002–1.018; p = 0.044), higher BMI (OR 1.092; 95% CI 1.002–1.189; p = 0.044) and prolonged surgery time (OR 1.013; 95% CI 1.000–1.025; p = 0.041) were independent risk factors for PJI. Excluding infection following major revision due to mechanical complications identified preoperative CRP levels (OR 1.012; 95% CI 1.003–1.021; p = 0.007) and chronic glucocorticoid therapy (OR 6.314; 95% CI 1.223–32.587; p = 0.028) as risk factors, a clear trend was seen for higher BMI (OR 1.114; 95% CI 1.000–1.242; p = 0.051). A cut-off value at CRP levels ≥ 14 mg/l demonstrated a sensitivity of 69% and a specificity of 70% with a fair accuracy (AUC 0.707). Conclusion: Preoperative serum CRP levels, higher BMI and prolonged surgery time are independent predictors of early PJI. Excluding PJI secondary to major revision surgery revealed chronic glucocorticoid use as a risk factor apart from preoperative CRP levels. [ABSTRACT FROM AUTHOR]
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- 2019
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19. FrontMatter.
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Roth, Andreas
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- 2017
20. Spine.
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Roth, Andreas
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- 2017
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21. Upper Extremity.
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Roth, Andreas
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- 2017
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22. Lower Extremity.
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Roth, Andreas
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- 2017
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23. Der unmögliche Freistoß.
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Bock, Wolfgang and Roth, Andreas
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- 2017
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24. Fischlifte und Fischschleusensysteme.
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Fischer, Johann, Metzka, Rudolf, Kruczek, Helmut, Schmalz, Maria, Thürmer, Konrad, Meyer, Matthias, Schweizer, Steffen, Andrey, Elena, Fankhauser, Andres, Schläppi, Sandro, Müller, Willy, Flück, Martin, Schletterer, Martin, Reindl, Robert, Thonhauser, Stefan, Roth, Andreas, Baumann, Georg, Kühlmann, Markus, Weyand, Michael, and Knotte, Hermann
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- 2017
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25. Hochintensives Intervalltraining im Sportunterricht.
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Engel, Florian Azad, Wagner, Matthias, Roth, Andreas, Scharenberg, Swantje, Bossmann, Thomas, Woll, Alexander, and Sperlich, Billy
- Abstract
Copyright of German Journal of Exercise & Sport Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
26. BackMatter.
- Author
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Roth, Andreas
- Published
- 2015
27. Obere Extremität.
- Author
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Roth, Andreas
- Published
- 2015
- Full Text
- View/download PDF
28. Untere Extremität.
- Author
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Roth, Andreas
- Published
- 2015
- Full Text
- View/download PDF
29. Wirbelsäule.
- Author
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Roth, Andreas
- Published
- 2015
- Full Text
- View/download PDF
30. FrontMatter.
- Author
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Roth, Andreas
- Published
- 2015
31. Correction to: Atraumatic femoral head necrosis: a biomechanical, histological and radiological examination compared to primary hip osteoarthritis.
- Author
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Hofmann, Alexander, Fischer, Benjamin, Schleifenbaum, Stefan, Kurz, Sascha, Edel, Melanie, Borte, Gudrun, Lehmann, Gabriele, and Roth, Andreas
- Abstract
Correction to: Archives of Orthopaedic and Trauma Surgery https://doi.org/10.1007/s00402-021-... The original version of this article unfortunately contained a mistake. The correct given name and family name should be: Alexander Hofmann - Benjamin Fischer - Stefan Schleifenbaum - Sascha Kurz - Melanie Edel - Gudrun Borte - Gabriele Lehmann - Andreas Roth The original article has been corrected. [Extracted from the article]
- Published
- 2022
- Full Text
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32. BackMatter.
- Author
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Roth, Andreas
- Published
- 2017
33. Business Information Sector.
- Author
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Wieczorek, Sebastian, Kozyura, Vitaly, Wei, Wei, Roth, Andreas, and Stefanescu, Alin
- Published
- 2013
- Full Text
- View/download PDF
34. Patienteneigene Medikation.
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Roth, Andreas
- Published
- 2012
- Full Text
- View/download PDF
35. Töten und den Tod erleiden.
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Jütte, Robert, Wuermeling, Hans-Bernhard, Krones, Tanja, Frewer, Andreas, Joerden, Jan C., Erlemeier, Norbert, Lindner-Braun, Christa, Fenner, Dagmar, Roth, Andreas, Wittwer, Héctor, Groß, Dominik, Knust, Christine, Glahn, Julia, Schmuhl, Hans-Walter, Frenschkowski, Marco, Prinz, Armin, Karenberg, Axel, and Meggle, Georg
- Published
- 2010
- Full Text
- View/download PDF
36. Applying Model Checking to Generate Model-Based Integration Tests from Choreography Models.
- Author
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Wieczorek, Sebastian, Kozyura, Vitaly, Roth, Andreas, Leuschel, Michael, Bendisposto, Jens, Plagge, Daniel, and Schieferdecker, Ina
- Abstract
Choreography models describe the communication protocols between services. Testing of service choreographies is an important task for the quality assurance of service-based systems as used e.g. in the context of service-oriented architectures (SOA). The formal modeling of service choreographies enables a model-based integration testing (MBIT) approach. We present MBIT methods for our service choreography modeling approach called Message Choreography Models (MCM). For the model-based testing of service choreographies, MCMs are translated into Event-B models and used as input for our test generator which uses the model checker ProB. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
37. Formal Specification.
- Author
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Carbonell, Jaime G., Siekmann, Jörg, Beckert, Bernhard, Hähnle, Reiner, Roth, Andreas, and Schmitt, Peter H.
- Abstract
This chapter serves as an introduction to formal specifications. In Sect. 5.1 we reconsider in greater detail, but still on a fairly general level, the basic building blocks of formal specification—pre- and postconditions, invariants, and modifies clauses—that have already been informally introduced in Sect. 1.3. The next two sections then show how these notions can be formulated in two popular specification languages, OCL and JML. A short comparison between the two languages in Section 5.4 concludes this chapter. Methodological questions like: How should operation contracts be inherited by subclasses? At which system states are invariants required to hold? How can modular specification and verification be effected? will be postponed till Chapter 8. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
38. Proof Obligations.
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Carbonell, Jaime G., Siekmann, Jörg, Beckert, Bernhard, Hähnle, Reiner, Schmitt, Peter H., and Roth, Andreas
- Abstract
This chapter deals with the question how we can prove properties of specifications and of the relations between specifications and programs. The most important instance of such a property is the correctness of a program with respect to its specification. In Chapter 5 we discussed specifications expressed with the languages UML/OCL and JML and their translations into the first-order fragment of Java Card DL. We now present our answers to the questions we left open there. What is the role we want class invariants to play? In which states should they hold and how do we prove this? What is the relation between postconditions and invariants? We formulate a series of proof obligations templates. These contain parameters that can be instantiated with a specification or parts of a specification to yield proof obligations. These are finite sets of Java Card DL formulae that can be submitted to the KeY prover. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
39. Automatic Validation of Transformation Rules for Java Verification Against a Rewriting Semantics.
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Sutcliffe, Geoff, Voronkov, Andrei, Ahrendt, Wolfgang, Roth, Andreas, and Sasse, Ralf
- Abstract
This paper presents a methodology for automatically validating program transformation rules that are part of a calculus for Java source code verification. We target the Java Dynamic Logic calculus which is implemented in the interactive prover of the system. As a basis for validation, we take an existing SOS style rewriting logic semantics for Java, formalized in the input language of the Maude system. That semantics is ‘lifted' to cope with schematic programs like the ones appearing in program transformation rules. The rewriting theory is further extended to generate valid initial states for involved program fragments, and to check the final states for equivalence. The result is used in frequent validation runs over the relevant fragment of the calculus in the system. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
40. Specification and Verification of Encapsulation in Java Programs.
- Author
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Steffen, Martin, Zavattaro, Gianluigi, and Roth, Andreas
- Abstract
Encapsulation is a major concept in object-oriented designs as design pattern catalogues, approaches for alias control, and the need for modular correctness of components demonstrate. The way encapsulation can be formally specified in existing approaches has several shortcomings. We show how encapsulation in sequential Java programs is specified by means of a new concept, called encapsulation predicates, in a clearly defined and comprehensible way, well fitting into the concept of design by contract. Encapsulation predicates extend existing functional specification languages. There are two kinds: basic predicates, which provide the actual extension, and convenience predicates, which are abbreviations for often used specification patterns. With encapsulation predicates, encapsulation properties in design patterns can be modelled and approaches to control aliasing can be simulated. Specifications containing encapsulation predicates are deductively checkable, but can also be tackled by static analysis methods which are similar to alias control approaches. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
41. Infrared spectroscopy in hemodialysis: reagent-free monitoring of patient detoxification by infrared spectroscopy.
- Author
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Roth, Andreas, Dornuf, Fabian, Klein, Oliver, Schneditz, Daniel, Hafner-Gießauf, Hildegard, and Mäntele, Werner
- Subjects
- *
HEMODIALYSIS , *INFRARED spectroscopy , *MOLECULES , *GLUCOSE , *UREA - Abstract
A method for monitoring hemodialysis based on quantitative infrared spectroscopic determination of the molecules dialyzed from patient blood is reported. The measurements are reagent-free and aim at real-time and in-line monitoring of the hemodialysis patient. A flow cell using attenuated total reflection infrared spectroscopy is coupled downstream of the dialysis filter unit. A calibration model has been developed from real hemodialysis samples analyzed by chemical reference analysis and from artificially mixed dialysis samples. The infrared monitoring of hemodialysis includes quantitative determination of urea as the lead substance, as well as glucose, lactate, and creatinine, all at a precision only limited by the chemical reference analysis. The flow cell can be fitted to all standard hemodialysis systems. Preliminary tests with hemodialysis patients have demonstrated that detoxification can be clearly monitored. Furthermore, these experiments demonstrate that a wide, real-time control of the patient's physiological parameters is possible with this method, which could lead to increased patient safety. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
42. Spin polarization of the quantum spin Hall edge states.
- Author
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Brüne, Christoph, Roth, Andreas, Buhmann, Hartmut, Hankiewicz, Ewelina M., Molenkamp, Laurens W., Maciejko, Joseph, Qi, Xiao-Liang, and Zhang, Shou-Cheng
- Subjects
- *
HALL effect , *NANOSTRUCTURES , *QUANTUM wells , *POLARIZATION (Electricity) , *ELECTRIC currents , *DETECTORS - Abstract
The prediction and experimental verification of the quantum spin Hall state marked the discovery of a new state of matter now known as topological insulators. Two-dimensional topological insulators exhibit the quantum spin-Hall effect, characterized by gapless spin-polarized counter-propagating edge channels. Whereas the helical character of these edge channels is now well established, experimental confirmation that the transport in the edge channels is spin polarized is still outstanding. We report experiments on nanostructures fabricated from HgTe quantum wells with an inverted band structure, in which a split gate technique allows us to combine both quantum spin Hall and metallic spin Hall transport in a single device. In these devices, the quantum spin Hall effect can be used as a spin current injector and detector for the metallic spin Hall effect, and vice versa, allowing for an all-electrical detection of spin polarization. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
43. Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger.
- Author
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Driouch, Habib, Roth, Andreas, Dersch, Petra, and Wittmann, Christoph
- Subjects
- *
RECOMBINANT DNA , *BIOTECHNOLOGICAL process control , *ASPERGILLUS niger , *BIOCHEMICAL engineering , *GEL electrophoresis , *PHASE partition , *POLYACRYLAMIDE , *ELECTROPHORESIS , *INVERTASE - Abstract
A comprehensive approach of bioprocess design at various levels was used to optimize microbial production of extracellular fructofuranosidase, important as biocatalyst to derive fructooligosaccharides with broad application in food or pharmaceutical industry. For production, the recombinant strain Aspergillus niger SKAn1015 was used, which expresses the fructofuranosidase encoding gene suc1 under control of a strong constitutive promoter. In a first screening towards an optimized medium, glucose, nitrate, Fe2+, and Mn2+ were identified as beneficial for production. A minimal medium with optimized concentration of these key nutrients, obtained by central composite design experiments and quadratic modelling, provided a threefold increased fructofuranosidase activity in the culture supernatant (400 U/mL) as compared to the originally described medium. Utilizing the optimized medium, the process was then transferred from shake flask into a fed-batch-operated bioreactor. Hereby, the intended addition of talc microparticles allowed engineering the morphology of A. niger into a highly active mycelial form, which strongly boosted production. Fructofuranosidase production was highly specific as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis. The secreted enzyme activity of 2,800 U/mL, corresponding to about 3 g/L of fructofuranosidase, achieved by the microparticle-enhanced fed-batch process, is tenfold higher than that of any other process reported so far, so that the presented bioprocess strategy appears as a milestone towards future industrial fructofuranosidase production. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
44. A novel expression system for intracellular production and purification of recombinant affinity-tagged proteins in Aspergillus niger.
- Author
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Roth, Andreas H. F. J. and Dersch, Petra
- Subjects
- *
GENETIC vectors , *RECOMBINANT proteins , *ASPERGILLUS niger , *GENES , *SUCROSE , *INVERTASE , *CARBON , *GREEN fluorescent protein , *CHROMATOGRAPHIC analysis - Abstract
A set of different integrative expression vectors for the intracellular production of recombinant proteins with or without affinity tag in Aspergillus niger was developed. Target genes can be expressed under the control of the highly efficient, constitutive pkiA promoter or the novel sucrose-inducible promoter of the β-fructofuranosidase ( sucA) gene of A. niger in the presence or absence of alternative carbon sources. All expression plasmids contain an identical multiple cloning sequence that allows parallel construction of N- or C-terminally His6- and StrepII-tagged versions of the target proteins. Production of two heterologous model proteins, the green fluorescence protein and the Thermobifida fusca hydrolase, proved the functionality of the vector system. Efficient production and easy detection of the target proteins as well as their fast purification by a one-step affinity chromatography, using the His6- or StrepII-tag sequence, was demonstrated. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
45. Der minimalinvasive, anterolaterale Zugang zum Hüftgelenk zur Implantation von Endoprothesen in Rückenlage.
- Author
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Roth, Andreas and Venbrocks, Rudolf
- Abstract
Copyright of Operative Orthopädie und Traumatologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2007
- Full Text
- View/download PDF
46. Atraumatische Femurkopfnekrose des Erwachsenen.
- Author
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Roth, Andreas and Tingart, Markus
- Published
- 2020
- Full Text
- View/download PDF
47. Rückfußkorrekturarthrodese am sog. Charcot-Fuß.
- Author
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Wagner, Andreas, Fuhrmann, Renée, and Roth, Andreas
- Abstract
Copyright of Operative Orthopädie und Traumatologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2005
- Full Text
- View/download PDF
48. The KeY tool.
- Author
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Ahrendt, Wolfgang, Baar, Thomas, Beckert, Bernhard, Bubel, Richard, Giese, Martin, Hähnle, Reiner, Menzel, Wolfram, Mostowski, Wojciech, Roth, Andreas, Schlager, Steffen, and Schmitt, Peter H.
- Subjects
COMPUTER software development ,EMBEDDED computer systems ,JAVA programming language ,UNIFIED modeling language ,SYSTEMS design ,INDUCTION (Logic) ,OCLC Cataloging Subsystem - Abstract
KeY is a tool that provides facilities for formal specification and verification of programs within a commercial platform for UML based software development. Using the KeY tool, formal methods and object-oriented development techniques are applied in an integrated manner. Formal specification is performed using the Object Constraint Language (OCL), which is part of the UML standard. KeY provides support for the authoring and formal analysis of OCL constraints. The target language of KeY based development isJava Card DL, a proper subset ofJavafor smart card applications and embedded systems. KeY uses a dynamic logic forJava Card DLto express proof obligations, and provides a state-of-the-art theorem prover for interactive and automated verification. Apart from its integration into UML based software development, a characteristic feature of KeY is that formal specification and verification can be introduced incrementally. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
49. Overwhelming septic infection with a multi-resistant Staphylococcus aureus (MRSA) after total knee replacement.
- Author
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Roth, Andreas, Fuhrmann, Reneè, Lange, Martina, Mollenhauer, J., Straube, Eberhard, and Venbrocks, R.
- Subjects
- *
TOTAL knee replacement , *ARTHROPLASTY , *KNEE surgery , *STAPHYLOCOCCUS aureus infections , *STAPHYLOCOCCAL diseases , *JOINTS (Anatomy) - Abstract
Introduction. The incidence of early deep infection after arthroplasty of the knee is very low but could represent a serious future problem. Material and methods. The authors report on a 71-year-old woman with gonarthritis who was supplied with a total knee endoprosthesis and developed a local infection followed by septic shock. Results. The infection was evidently caused by a multiresistant Staphylococcus aureus (Staph. aureus). The primary clinical signs closely resembled a necrotizing fasciitis. Systemic and local application of vancomycin led to an improvement of the symptoms at secondary sites, but only the amputation of the primarily infected leg was lifesaving. Conclusion. In order to prevent such events, the authors recommend a number of additional presurgical measures. Firstly, a swab from the nose and throat should be taken prior to an elective surgery in patients with elevated risk of immunodeficiency, for example in patients with diabetes. The diabetes should be adequately treated before an elective operation is undertaken. Secondly, an early punction of the knee joint should be carried out if there is any doubt regarding inflammation. Isolated infectious agents should be grounds for early revision, which should always be completed with a rinsing procedure and with adequate antibiotics. Immunotherapy should be taken into consideration. Antiepidemic measures are recommended in cases with known Staph. aureus. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
50. Salvage of the upper extremity in cases of tumorous destruction of the proximal humerus.
- Author
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Fuhrmann, Renée A., Roth, Andreas, and Venbrocks, Rolf A.
- Abstract
Malignant bone tumours or metastasis of the upper humerus may cause significant loss of function especially in those patients with resectional arthroplasty of the shoulder. One method for achieving functional reconstruction of the humerus concerned is replacement with a modular endoprosthesis. Little is known about clinical and radiologicial results in these rare circumstances. Between 1993 and 1997 we treated 21 patients (22 shoulders) with enlarged osteolytic destructions of the proximal humerus caused by metastatic spread or primary malignant tumours. Patients with additional involvement of the glenoid were excluded from this study. The average follow-up was 3.9 years. Every 3 months all patients were followed-up clinically and radiographically. Prior to surgery, diagnosis was established by incisional biopsy and the outcome determined the therapeutic algorithm (radiotherapy, chemotherapy, surgery). In most cases of metastatic lesions, surgery was the first treatment. According to the regional spread of the tumour, various amount of bone and soft tissues had to be removed. The distal stem of the prosthesis was inserted in a cementless way and secured to bone with two interlocking screws. The length of the diaphyseal part depended on the site of osteotomy. Soft-tissue coverage of the large implant was achieved in all patients. Early complications were lymphogenic oedema and superficial wound dehiscence. One patient developed a deep infection, which had to be managed surgically. According to the functional rating system of the Musculoskeletal Tumour Society for the upper extremity the overall results were inversely proportional to the extent of resection. None of our patients achieved unrestricted motion of the shoulder concerned. The most important finding was a proximal migration of the prosthesis causing a painful subacromial impingement, mainly a consequence of the resection of the deltoid muscle and the rotator cuff. In summary, a modular endoprosthesis cannot be recommended generally as the method of choice. If the muscular balance of the shoulder is too weak to act as a joint centralizer the endoprosthesis has no advantage over a simple diaphyseal spacer. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
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