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This study provides a long-term (1891–2014) global assessment of precipitation trends using data from two station-based gridded datasets and climate model outputs evolved through the fifth and sixth phases of the Coupled Model Intercomparison Project (CMIP5 and CMIP6, respectively). Our analysis employs a variety of modeling groups that incorporate low- and high-top level members, with the aim of assessing the possible effects of including a well-resolved stratosphere on the model's ability to reproduce long-term observed annual precipitation trends. Results demonstrate that only a few regions show statistically significant differences in precipitation trends between observations and models. Nevertheless, this pattern is mostly caused by the strong interannual variability of precipitation in most of the world regions. Thus, statistically significant model-observation differences on trends (1891–2014) are found at the zonal mean scale. The different model groups clearly fail to reproduce the spatial patterns of annual precipitation trends and the regions where stronger increases or decreases are recorded. This study also stresses that there are no significant differences between low- and high-top models in capturing observed precipitation trends, indicating that having a well-resolved stratosphere has a low impact on the accuracy of precipitation projections. [ABSTRACT FROM AUTHOR]

The European precipitation response to El Niño (EN) has been found to present interdecadal changes, with alternated periods of important or negligible EN impact in late winter. These periods are associated with opposite phases of multi-decadal sea surface temperature (SST) variability, which modifies the tropospheric background and EN teleconnections. In addition, other studies have shown how SST anomalies in the equatorial Pacific, and in particular, the location of the largest anomalous SST, modulate the stratospheric response to EN. Nevertheless, the role of the stratosphere on the stationarity of EN response has not been investigated in detail so far. Using reanalysis data, we present a comprehensive study of EN teleconnections to Europe including the role of the ocean background and the stratosphere in the stationarity of the signal. The results reveal multidecadal variability in the location of EN-related SST anomalies that determines different teleconnections. In periods with relevant precipitation signal over Europe, the EN SST pattern resembles Eastern Pacific EN and the stratospheric pathway plays a key role in transmitting the signal to Europe in February, together with two tropospheric wavetrains that transmit the signal in February and April. Conversely, the stratospheric pathway is not detected in periods with a weak EN impact on European precipitation, corresponding to EN-related SST anomalies primarily located over the central Pacific. SST mean state and its associated atmospheric background control the location of EN-related SST anomalies in different periods and modulate the establishment of the aforementioned stratospheric pathway of EN teleconnection to Europe too. [ABSTRACT FROM AUTHOR]

Purpose: Physicians and nurses often underestimate the incidence of chemotherapy-induced nausea and vomiting (CINV) after both highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). This study assesses physicians' and nurses' perceptions of CINV in their own practices after the introduction of aprepitant.Methods: A prospective observational study of patients receiving the first cycle of HEC regimens with CDDP and without CDDP or MEC was performed. Eligible patients completed a 6-day diary recording emetic episodes, nausea assessment, and antiemetic medication use. Physicians and nurses estimated the incidence of acute and delayed CINV after the first administration of HEC and MEC. The observed incidence rates of CINV were compared with the rates predicted by healthcare providers. Aprepitant was given to patients receiving HEC regimes with CDDP.Results: Twenty-nine physicians and nurses and 95 patients (87% receiving HEC and 14% MEC) were recruited. The global control of CINV was 66.67% for all patients and 73.33%, 47.06%, and 55.56% for patients receiving HEC regimens with CDDP, HEC regimens without CDDP and MEC, respectively. Physicians and nurses underestimated the control of acute CINV in patients receiving HEC regimens with CDDP, but they accurately predicted the control of delayed CINV. All physicians and nurses predicted the control of acute CINV after HEC regiments without CDDP and after MEC quite accurately, whereas they overestimated the control of delayed CINV after both regimens.Conclusions: Aprepitant allows for better control of CINV in HEC regimens with CDDP, and this control is accurately perceived by physicians and nurses. However, physicians and nurses overestimate the control of delayed CINV after HEC regimens without CDDP and after MEC. CINV is still an important target for improved therapeutic intervention and the healthcare providers must be aware of its actual incidence. [ABSTRACT FROM AUTHOR]

Antidepressant medications are effective only in a subpopulation of patients with depression, and some patients respond to certain drugs, but not others. The biological bases for these clinical observations remain unexplained. To investigate individual differences in response to antidepressants, we have examined the effects of the norepinephrine reuptake inhibitor desipramine (DMI) and the selective serotonin reutake inhibitor fluoxetine (FLU) in the forced swim test (FST) in rats that differ in their emotional behavior. As response to novelty correlates with numerous other measures of emotionality and substance abuse, we contrasted animals that are high responders (HR) in a novel environment with animals that are low responders (LR) and asked whether the two groups exhibit differential responses to DMI (10mg/kg) and FLU (20mg/kg). At the behavioral level, DMI caused a significant decrease in immobility in LR animals only, while FLU caused a significant reduction in immobility in both groups. Moreover, at the neural level, DMI treatment led to a decrease in FST-induced c-fos messenger RNA levels in medial prefrontal cortex (PFC) and paraventricular nucleus of the hypothalamus (PVN) in LR but not HR animals. Taken together, our results suggest that the HR-LR model is a useful tool to investigate individual differences in responses to norepinephrine reuptake inhibitors (NRIs) and that a differential activation of PFC and/or PVN could underlie some of the inter-individual differences in the efficacy of NRIs. [ABSTRACT FROM AUTHOR]

Equivalent temperature based in the NCEP/NCAR reanalysis database has been used as a simultaneous measure of temperature and humidity. Its variations during the 1958-1998 added to the effect of the inclusion of satellite data during the late seventies have been analyzed. An increase of the globally averaged equivalent temperature has been detected, the trend has been considerably greater during the first half of the study period and significant differences can be found between continental and oceanic areas. The relation of the trend with four of the main modes of climate variability has been assessed. The North Atlantic Oscillation and the Artic Oscillations are closely related to the equivalent temperature over the North Atlantic basin, extending toward Northern Asia in the second case. El Niño/Southern Oscillation and the Antarctic Oscillation seem to have a more global effect. [ABSTRACT FROM AUTHOR]

Two different groups of indices have been defined to analyze the evolution of global temperature between 1958 and 1998. All the indices were evaluated at three different levels (850, 500 and 200 hPa), and averaged indices were calculated using the whole globe, continental areas and oceanic areas. The first group of indices analyzes the area of the world covered with higher and lower than normal temperatures, detecting a slight cooling in the 200 hPa level. The second group of indices studies the annual frequency of extreme events, and again, it is at 200 hPa where the most intense variation is detected. Finally, an analysis is performed to determine the regions most sensible to variations in the occurrence of extreme events. Tropical areas are mostly responsible of the variations detected in the second group of indices. [ABSTRACT FROM AUTHOR]

A numerical method for solving the thermal subproblem appearing in the modelization of polythermal ice sheets is described. This thermal problem mainly involves three nonlinearities: a reaction term due to the viscous dissipation, a Signorini boundary condition associated to the geothermic flux and an enthalpy term issued from the two phase Stefan formulation of the polythermal regime. The stationary temperature is obtained as the limit of an evolutive problem which is discretized in time with an upwind characteristics scheme and in space with finite elements. The nonlinearities are solved either by Newton-Raphson method or by duality techniques applied to maximal monotone operators. The application of the algorithms provides the dimensionless temperature distribution approximation and allows to identify the cold and temperate ice regions. [ABSTRACT FROM AUTHOR]

A novel geometry for generating a viscometric flow presents advantages of both cone and plate and parallel plate geometries, regarding uniform shear field and adjustable range of measurement. Kinematics and dynamics of the generated flow have been described mathematically utilizing an orthogonal curvilinear coordinate system based on the shapes of the shearing surfaces which are similar to the surface that generates the flow. Simple equations that allow the calculation of quantities of experimental interest in the rheological characterization of liquid materials, namely, shear rate, shear stress and two normal stress differences, have also been derived. The geometry, called pseudosphere, was tested with two types of fluids (Newtonian and pseudoplastic). Results show that the geometry can be used with low viscosity liquids (Newtonian liquids) by only adjusting the gap H. The behavior of pseudoplastic fluids for both low and moderately high viscosity could also be studied with this geometry. Very reproducible results were obtained when compared with those obtained with cone and plate geometry. Regions of lower shear rate could be studied using only the pseudosphere geometry. [ABSTRACT FROM AUTHOR]

The article discusses the spinal leptomeningeal metastases detected in the cerebral glioblastoma multiforme of a 59-year-old man using fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). It mentions that multiple meningeal foci were detected by magnetic resonance (MR) imaging around the cisternal area. Moreover, PET/computed tomography (CT) showed FDG uptake at the dorsal and cervical spinal cord on a mesial view which was detectable through increasing the contrast of the PET scan.