1. In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in a solid human carcinoma xenograft model.
- Author
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Chun-Lin Ye, Jian-Wen Liu, Dong-Zhi Wei, Yan-Hua Lu, and Feng Qian
- Subjects
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ANTINEOPLASTIC agents , *DRUGS , *CANCER , *ANTINEOPLASTIC antibiotics , *THERAPEUTICS , *XENOGRAFTS , *TRANSPLANTATION of organs, tissues, etc. , *CANCER cells - Abstract
Previously, we showed that 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC), isolated from the buds ofCleistocalyx operculatus, significantly inhibited the growth of human liver cancer SMMC-7721 cells and could induce SMMC-7721 cells apoptosis in vitro. Here, we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft model with a human liver cancer SMMC-7721 cell line. Our results revealed that the average tumor weight in a control group and a 150-mg/kg DMC injection group was 1.42±0.11 g and 0.59±0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated the existence of an aneuploid peak (representing 33.60±0.80% of the total in the 150-mg/kg DMC injection group). To our knowledge, this is the first time that chalcone compounds were applied to a human tumor xenograft model. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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