1. Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy: A Multicenter Retrospective Study.
- Author
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Koulaouzidis, Anastasios, Sipponen, Taina, Nemeth, Artur, Makins, Richard, Kopylov, Uri, Nadler, Moshe, Giannakou, Andry, Yung, Diana, Johansson, Gabriele, Bartzis, Leonidas, Thorlacius, Henrik, Seidman, Ernest, Eliakim, Rami, Plevris, John, Toth, Ervin, Yung, Diana E, Johansson, Gabriele Wurm, Seidman, Ernest G, and Plevris, John N
- Subjects
LECTINS ,CAPSULE endoscopy ,INFLAMMATION ,INFLAMMATORY bowel disease diagnosis ,BIOMARKERS ,C-reactive protein ,COMPARATIVE studies ,FECES ,SMALL intestine ,RESEARCH methodology ,MEDICAL cooperation ,MONOCYTES ,RESEARCH ,EVALUATION research ,RETROSPECTIVE studies - Abstract
Background: Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images.Goals: Multicenter retrospective study aiming to investigate correlation between LS and FC in a large group of patients undergoing CE for suspected or known small-bowel IBD, and to develop a model for prediction of CE results (LS) based on FC levels.Study: Five academic centers and a district general hospital offering CE in UK, Finland, Sweden, Canada, and Israel. In total, 333 patients were recruited. They had small-bowel CE and FC done within 3 months.Results: Overall, correlation between FC and LS was weak (r s: 0.232, P < 0.001). When two clinically significant FC thresholds (100 and 250 μg/g) were examined, the r s between FC and LS was 0.247 (weak) and 0.337 (moderate), respectively (P = 0.307). For clinically significant (LS ≥ 135) or negative (LS < 135) for SB inflammation, ROC curves gave an optimum cutoff point of FC 76 μg/g with sensitivity 0.59 and specificity 0.41.Limitations: Retrospective design.Conclusions: LS appears to show low correlation with FC as well as other serology markers of inflammation. FC does not appear to be a reliable biomarker for significant small-bowel inflammation. Nevertheless, FC level ≥ 76 μg/g may be associated with appreciable visual inflammation on small-bowel CE in patients with negative prior diagnostic workup. [ABSTRACT FROM AUTHOR]- Published
- 2016
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