1. A randomized trial testing digital medicine support models for mild-to-moderate alcohol use disorder.
- Author
-
Quanbeck, Andrew, Chih, Ming-Yuan, Park, Linda, Li, Xiang, Xie, Qiang, Pulvermacher, Alice, Voelker, Samantha, Lundwall, Rachel, Eby, Katherine, Barrett, Bruce, and Brown, Randall
- Subjects
ALCOHOLISM treatment ,SUPPORT groups ,SELF-evaluation ,RESEARCH funding ,MENTAL health ,MEDICAL care ,DIGITAL health ,STATISTICAL sampling ,INTERNET ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,ODDS ratio ,QUALITY of life ,COMPARATIVE studies ,CONFIDENCE intervals - Abstract
This paper reports the results of a hybrid effectiveness-implementation randomized trial that systematically varied levels of human oversight required to support the implementation of a digital medicine intervention for persons with mild-to-moderate alcohol use disorder (AUD). Participants were randomly assigned to three groups representing possible digital health support models within a health system: self-monitored use (SM; n = 185), peer-supported use (PS; n = 186), or a clinically integrated model CI; (n = 187). Across all three groups, the percentage of self-reported heavy drinking days dropped from 38.4% at baseline (95% CI [35.8%, 41%]) to 22.5% (19.5%, 25.5%) at 12 months. The clinically integrated group showed significant improvements in mental health and quality of life compared to the self-monitoring group (p = 0.011). However, higher attrition rates in the clinically integrated group warrant consideration in interpreting this result. Results suggest that making a self-guided digital intervention available to patients may be a viable option for health systems looking to promote alcohol risk reduction. This study was prospectively registered at clinicaltrials.gov on 7/03/2019 (NCT04011644). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF