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Sex/gender-specific medicine (SGM) is defined as the practice of medicine based on the understanding that biology and social roles are important in men and women for prevention, screening, diagnosis, and treatment. Current research demonstrates differences in disease incidence, symptomatology, morbidity, and mortality depending on sex and gender. Sex/gender-specific medicine is a fundamental aspect of tailored therapy and precision medicine. Therefore, the variables must be considered in medical education and practice as well as in research models ranging from human participants, animals and cells. This concept could be applied in the whole clinical areas from Neuroscience, Psychiatry, Gastroenterology, Cardiology, and Rehabilitation, etc. Nowadays estrogen is known to play a key role in the prevention of colon cancer and in the resistant progression of liver cirrhosis and hepatocellular carcinoma, especially in women. This book covers the sex/gender-specific medicine in the whole clinical areas in the adults as well as in the pediatrics. In addition, research results of basic science are also introduced in the colon cancer and Alzheimer's disease.

This is the third, fully revised edition of a well received book that provides clear practical guidance on all aspects of the penetrating trauma surgical treatment. It aims at fostering the type of strategic thinking that can save patients'lives. The coverage encompasses prehospital care and operative management in penetrating injuries to various body regions and specific organs. Tips, tricks and technical pearls are highlighted by experienced doctors and each chapter includes a list of the most important points to observe. This third edition of Penetrating Trauma has been extensively revised and updated – with inclusion of some entirely new chapters – to take into account the most recent trends in resuscitation, diagnostics, and treatment. It will be an ideal resource for all physicians managing penetrating trauma.

Der Klassiker der Intensivmedizin in 13. Auflage!In diesem großen Standardwerk für die Intensivmedizin finden Sie alle Themen der modernen, interdisziplinären Intensivmedizin zusammengetragen. Es bietet höchsten Standard für die ärztliche Weiterbildung und ist gleichzeitig ein wertvolles Nachschlagewerk im klinischen Alltag für Ärztinnen und Ärzte auf Intensivstationen aller Fachrichtungen, u.a. aus Anästhesiologie, Innere Medizin, Chirurgie und Neurologie. Dargestellt werden u.a. moderne Diagnostik, Monitoring - und Therapieverfahren, intensivmedizinisch relevante Krankheitsbilder und Notfälle, Intensivtherapie nach neurochirurgischen, herzchirurgischen, thoraxchirurgischen und abdominalchirurgischen Eingriffen sowie ethische, psychosoziale und pflegerische Aspekte. Weitere Themen sind: Teleintensivmedizin, Weiterbildung und Kompetenzvermittlung in der Intensivmedizin, Langzeitfolgen nach Intensivtherapie, Akut- und Frührehabilitation, Palliativmedizin in der Intensivmedizin, Risikomanagement und Fehlerkultur. Die 13. Auflage erscheint komplett überarbeitet und aktualisiert.

This textbook presents real-world cases and discussions that introduce the various psychiatric syndromes found in the aging population before delving into the core concepts covered by geriatric psychiatry curricula. The text follows each case study with the vital information necessary for physicians in training, including key features of each disorder and its presentation, practical guidelines for diagnosis and treatment, clinical pearls, and other devices that are essential to trainees in geriatric psychiatry. With the latest DSM-5-TR guidelines and with rich learning tools that include key points, review questions, tables, and illustrations, this text is the only resource that is specifically designed to train both US and Canadian candidates for specialty and subspecialty certification or recertification in geriatric psychiatry. It will also appeal to audiences worldwide as a state-of-the-art resource for practice guidance. The text meets the needs of the future head on with its straightforward coverage of the most frequently encountered challenges, including neuropsychiatric syndromes, psychopharmacology, elder care and the law, substance use disorders, psychiatric comorbidities in systemic medical illness, consultation-liaison psychiatry, palliative care, climate change and health, and equity/diversity/inclusion matters in the care of older adults. Written by experts in the field, Geriatric Psychiatry: A Case-Based Textbook, 2nd edition will be the ultimate resource for graduate and undergraduate medical students and certificate candidates providing mental health care for aging adults, including psychiatrists, psychologists, geriatricians, primary care and family practice doctors, neurologists, social workers, nurses, and others.

This book provides extensive information on the management of advanced heart failure, cardiogenic shock and mechanical circulatory support. In this regard, this book is unique in emphasizing the physiologic interaction between physician and technology, bridging the gap between theoretical physiology and its clinical application, with a focus on the practical aspects of cardiovascular physiology in advanced heart failure/cardiogenic shock, and focusing on each part of the patient's clinical ‘journey'. Hemodynamic Physiology in Advanced Heart Failure and Cardiogenic Shock integrates complex topics in advanced heart failure and cardiogenic shock, such as the man-machine interactive physiology and the theoretical physiology-clinical application. It therefore provides an accessible resource for cardiologists, surgeons, intensivists, specialist nurses and critical care practitioners, and is also suitable for trainees and more senior clinicians with an interest in a physiology-guided approach to advanced heart failure/cardiogenic shock and mechanical circulatory support.

The second edition comprehensively reviews the wide field of rare pulmonary diseases. Issues such as less common diseases affecting the airways, systematic disorders with lung involvement, interstitial lung diseases, and many other orphan conditions of the lungs are explored in this book. The progress and advances made in the field and the limited number of patients presenting each condition makes it very difficult for clinicians to be up-to-date in this field. Readers will discover how to diagnose and manage these rare orphan diseases. Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease is a practical, informative book written by a team of international authors with much experience in rare pulmonary diseases Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease, second edition provides synthesized and easily accessible information about the main orphan lung diseases, to aid clinicians in charge of patients with rare disease,or who consider the diagnosis of a rare disease in their patient. It is a practical, informative guide written by a team of international experienced authors in rare pulmonary diseases.

Asthma is a common chronic respiratory disease that causes substantial morbidity and has been challenging to treat due to its heterogeneous onset, environmental triggers, severity, and treatment response. To update the field on the rapid advances in this field, Precision Approaches to Heterogeneity in Asthma follows its highly successful predecessor, Heterogeneity in Asthma. In this new volume, noted authorities Allan R Brasier and Nizar N Jarjour and a cadre of leaders in the field incorporate new work advancing our understanding of phenotypes (endotypes) of disease, regional variations in ventilation, systems approach to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials. This work will facilitate our current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions.

This practical question and answer book covers topics within the field of neurocritical care, including aspects of neurology, neurosurgery, general critical care, and emergency medicine. The updated second edition, with hundreds of new and revised test items, contains two full length practice exams that mimic the tone and scope of the recently introduced American Board of Psychiatry and Neurology (ABPN) certifying exam in Neurocritical Care, based on approval from the American Board of Medical Specialties (ABMS). At the conclusion of each exam, answer choices, rationale, and references are provided. The book is geared towards critical care fellows, but may also be useful for residents in the fields of neurology, neurosurgery, emergency medicine, and internal medicine.

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers.Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented.This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

The current medical practice has become more of a team effort rather than an isolated practice. The current evaluation of patients in the daily practice is essentially performed by medical assessment of the patient in question followed by diagnostic imaging, and when needed and possible the evaluation of tissue for diagnosis with its subsequent assessment of biomarkers and other ancillary tools that play an important role in the evaluation and prognosis. The book herein proposed will exactly provide such assessment focused in the thoracic assessment of patients afflicted with any particular disease of the thorax. Expert clinician in pulmonary medicine will provide the state of the art in the evaluation of such patients, which will provide the most important background in the clinical impression and further assessment of these patients. This assessment in most cases is followed by the evaluation of imaging, which provides a highly important information of not only the exact location of the process but also of the nature of whether is localized, infiltrative, diffuse, bilateral, etc., as well as the possible compromise of other adjacent structures. Such information is crucial as imaging and clinical information will provide a working diagnosis, which ultimately will be defined by the pathological assessment. Therefore, in real practice neither one of these subspecialties works alone or in isolation. On the contrary, each one depends on the other for the final diagnosis and proper management of patients with thoracic diseases. Based on such experience is that the current text will provide in the same text of the needed information that a clinician, radiologist or pathologist will need in order to arrive to the best possible conclusion.The scope of this book is unique in its nature as currently, even though there are several text on either one of those specialties, those publication are strictly on the either radiology, medicine or pathology. Our proposed text will bring all those together in a single text and written by experts in their respective field. This book should be of interest to all of those in the practice of thoracic medicine (radiologist, pulmonologist, pathologists) and any one who in the general practice is confronted with the evaluation of these patients.

This fully revised and expanded second edition provides a comprehensive and up-to-date overview of nasal physiology and pathophysiology. With the help of numerous tables, schematic drawings, and color photographs, it helps readers gain a better understanding of the impact of structural changes and the process of disease development, and to make treatment decisions. Each chapter has been written by a leading expert in the field and addresses one important aspect in an accessible way. Covering all four functions of the nose: respiration, defense, olfaction and cosmesis, the book discusses the various techniques for the clinical evaluation of nasal function as well as current trends and future directions in nasal physiologic research. This second edition also includes additional chapters on rhinomanometry, local nasal inflammation, T cells and B cells, and artificial intelligence for the nose. Given its scope, the book is a valuable resource for both experienced otorhinolaryngologists and novices in the field.

The book covers vigorously debated controversial topics in the field of critical care medicine over the years. It provides the reader with a balanced approach and guidance based on historical and currently available evidence in dealing with contentious clinical scenarios. The book reviews the most relevant, contemporaneous evidence on each topic and provides practical guidelines for clinical practice. The book includes chapters that follow a structured approach to controversies related to specific organ systems. The topics covered provide a summary of the most relevant, practice-changing studies in the field of critical care medicine. Each topic describes the basic applied physiology, points of controversy, the evidence base, and summarizes the key points at the end. It includes brief description of landmark studies on each controversial topic. The book serves as an important clinical guide to practitioners of critical care medicine when confronted with challenging clinical scenarios. Besides, it is a useful source of information to postgraduate trainees in various medical specialties. The topics addressed are among the most widely discussed during postgraduate examinations. It is also relevant for practitioners in general medicine and specialized areas of practice, including pulmonology (respiratory medicine), cardiology, neurology, nephrology, gastroenterology, and surgical specialties.

In different sections of this book the relationships between the patterns of psychological response in acute and chronic respiratory failure, as well as the epidemiology of neuropsychiatric disorders in ventilator management, are collected and analyzed. Main concepts such as “vulnerability to stress”, critical illness-psychological stress and susceptibility that may develop during NIV support, as well as the diagnosis of neuropsychiatric disorders in respiratory failure are also summarized. A section is devoted to the most frequent indications of NIV, also including a special use of NIV in pandemic and high-risk infections, as well as in several other conditions such as acute and chronic respiratory failures and neurological disorders. A summary of practical approaches for treatment and prevention in neurologic and psychiatric disorders during noninvasive mechanical ventilation, as well as the perspective in terms of outcomes, quality-of-life, palliative care is also given.The book is intended for all those healthcare professionals treating patients suffering from neurological or psychiatric disorders and who develop acute or chronic respiratory failure. Neurologists, psychiatrists, pulmonary critical care professionals, geriatricians, internists and psychologists will find in the book a valuable guide for their everyday clinical practice.

This heavily revised second edition provides a comprehensive multi-disciplinary resource on blast injuries. It features detailed information on the basic science, engineering, and medicine associated with blast injuries. Clear, easy to understand descriptions of the basic science are accompanied by case studies of a variety of clinical problems including heterotopic ossification, hearing damage, and traumatic brain injury, enabling the reader to develop a deep understanding of how to appropriately apply the relevant science into their clinical practice. The use of prosthetics, orthotics and osseointegration in rehabilitation is also covered. Blast Injury Science and Engineering: A Guide for Clinicians and Researchers is a valuable interdisciplinary text primarily focused towards clinical medical professionals and trainees seeking to develop a thorough understanding of injury mechanisms, and the latest treatment techniques. In addition, this resource is of use to individuals in other fields whose work centres around blast injury science such as injury mitigation researchers, military scientists and engineers.

This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles.Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.

Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease. Although acute respiratory distress syndrome (ARDS) is defined by the acute onset of noncardiogenic pulmonary edema, hypoxemia and the need for mechanical ventilation, it is a heterogeneous disease entity, which makes it difficult to develop specific therapies. Treatment tends to focus on lung-protective ventilation, and no specific pharmacotherapies have been identified. All chapters were written by respected experts in the field, and summarize the latest trends, share recent research findings, and outline future prospects. Specific chapters are devoted to novel, promising diagnostic approaches, such as microRNA, which may improve our ability to identify early ARDS or at-risk patients. In addition, a dedicated chapter explores cell-based therapies and regenerative medicine, which offer potential therapeutic options.Acute Respiratory Distress Syndrome - Advances in Diagnostic Tools and Disease Management offers a valuable reference guide not only for young physicians and trainees, but also for experienced or teaching physicians, medical educators, and basic researchers. Readers will find the latest information on ARDS and come to understand the current challenges, encouraging them to further advance the diagnosis, treatment and clinical research on this disease.

This book offers a comprehensive overview on lifestyle habits related to development of risk factors of chronic diseases. It provides a summary of the impacts of various modifiable factors that influence long-term health status. The accumulation of unhealthy lifestyle habits shows that over the life course, increasing the number, duration, and severity of unhealthy behaviors would increase the risk of disease development. This contributed volume highlights the fact that establishing a healthy lifestyle is easier and more effective than focusing on lifestyle change

This textbook addresses the classical use of Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex Sonography (TCCS), focusing on the usefulness of neurological monitoring beyond classical acute brain injuries present in the daily intensive care medical practice. It encompasses a wide range of critical pathologies where neurological impact is part of clinical evolution, offering practical approaches for managing, application and interpretation of neurosonology to assist the physician to making real-time individualized decisions at bedside.It is an academic guide developed and edited by international experts being a very useful resource in daily practice for intensivists, neurologists, neurosurgeons and other specialists involving in critical care.

In dealing with the unprecedented COVID-19 pandemic, there are an increased number of patients requiring personalized management as the disease pathology varies. With variable lung compliance and airway resistance as well as the severity of the disease, one size will not fit all patients. This book is problem-oriented with evidence-based discussions of the daily encountered scenarios in the ICU for mechanically ventilated patients, dealing with the pathology, monitoring and troubleshooting facing intensivists daily. These scenarios are managed utilizing a goal-directed approach and algorithms to achieve these goals. All chapters contain an explanation of a different solution illustrating the respiratory mechanics, physiology and pathology involved in such a scenario. Each chapter also closes with a take-home message to summarize the content. In addition to describing the ventilation of different patient categories, this text also features ventilation cases specific to COVID-19 including airway management in the enhanced air born isolated patient, pulmonary embolism, different states of shock and differential lung ventilation. There is also a specific chapter on monitoring mechanical ventilation with point of care ultrasound, which is an available modality in most ICUs. Another unique chapter describes how to connect more than one patient to one ventilator in case of a shortage of machines. Written by experts in the field, Personalized Mechanical Ventilation is a timely and valuable resource for critical care physicians, nurses and respiratory therapists on the front lines of both COVID-19 and day-to-day care of mechanically ventilated patients in the ICU.

This book presents a broad range of perspectives on the topic of CPAP adherence. This includes theoretical underpinnings of adherence; multi-disciplinary practical approaches as well as special considerations in diverse clinical populations, age groups and cultures by authors from five continents. CPAP Adherence is a novel and highly relevant publication for sleep physicians, psychologists, dentists, respiratory therapists, sleep technicians, family physicians as well as PAP and oral appliance providers. This book will help improve patient care and quality of life.

Plant extracts or their pure natural constituents have been used traditionally for thousands of years for treating diseases with considerable success in India and other Asian countries. In addition, they have also been used as complements or supplements with conventional medicine. This book discusses the latest research in the application of combination therapy, namely herbs and drugs, in the treatment of a range of communicable and non-communicable diseases to achieve a synergistic effect. This synergy may help in reducing the amount of drug, its toxicity, side effects, and development of resistance as well as improve its efficacy. The book also discusses the pharmacodynamic and pharmacokinetic parameters, experimental tools to determine the impact of combination, computational approaches to identify synergy, statistical analysis of data, and clinical and regulatory issues. The book is useful for researchers in the fields of pharmacology, pharmacy and medicinal chemistry andthose working in pharmaceutical and nutraceutical industries. This book could open up new strategies to focus on multiple targets to combat complex diseases unlike the single targeted drugs that are being currently marketed by the pharmaceuticals industries.

This book discusses the evidence behind the relationship between COVID-19 and heart disease based on emerging state-of-the-art data. The rapid and unexpected global spread of the COVID-19 has revealed proportional levels of cardiovascular and metabolic complications. A myriad of pathogenetic mechanisms has come to the surface. There is still much research required to define whether cardiovascular disease causes COVID-19 complications or that cardiovascular disease appears as a result of the infection and which mechanisms are responsible. With cardiovascular and metabolic diseases already at pandemic levels and expected to increase further, this book provides readers with an urgent and thorough analysis of this association.Cardiovascular Complications of COVID-19: Risk, Pathogenesis and Outcomes provides answers to the increasing numbers of questions related to heart disease in COVID-19, highlighting the association between these pandemics and including risk factors, mechanisms and how these may impact diverse patients populations. It describes how COVID-19 impacts older patients and those with metabolic illnesses such as obesity and diabetes mellitus, while providing an overview of the observed gender dichotomy among patients. It therefore represents an essential resource not only for all cardiovascular physicians but also for any healthcare professionals managing patients with these diseases or those exploring COVID-19.

This book provides an overview of the typical nature-based solutions (NBS) used for flood mitigation at different scales and in different areas (e.g. from catchment to hillslope scale; from urban to coastal areas). NBS can provide several ecosystem services, such as water regulation and water quality enhancement, and as such offer relevant technical solutions to complement typical grey infrastructures to mitigate flood hazard and water quality problems. In recent years, political awareness and interest from the scientific community have led to increasing implementation of NBS worldwide. In light of this trend, this book provides valuable insights into the environmental aspects of NBS, particularly their effectiveness for flood and pollution mitigation, and discusses socio-economic aspects related to the implementation of NBS, including regulatory aspects, cost, and citizens'perceptions of NBS. Compiling the latest research, the book furthers our understanding of the role of NBS for flood mitigation and its relation to environmental aspects, to guide scientists and stakeholders in future NBS projects. It is intended for the scientific community and stakeholders, such as spatial planners and landscape managers.Chapter'Nature-based solutions for flood mitigation and resilience in urban areas'is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book provides a practical guide to decision making within the realm of trauma surgery. Each chapter covers the ideal approach, rather than customary care, for the treatment of the chosen difficult decision or controversy. A broad range of topics are covered with particular attention given to resuscitation, wound management, thoracic and abdominal trauma, antimicrobial management, transplant considerations, vascular trauma, traumatic brain injury, pediatric trauma and ethics.Difficult Decisions in Trauma Surgery aims to help improve the treatment of trauma patients and is relevant to surgical trainees and practicing surgeons, and as well as medical professionals working within trauma medicine.

This book aims to give a comprehensive overview of the current challenges and solution posed to the health care professionals who need to use mechanical ventilation to treat their patients.Mechanical ventilation is a cornerstone of the treatment of critically ill patients, as also dramatically underlined by the recent COVID-19 pandemic. The topic is not simple to approach, since it requires integration of multiple data which, in turn, result from complex interplays between patient's condition and ventilatory settings. While technological development empowered advanced monitoring and decision support, these also increase the burden of data on the practitioners. Furthermore, considering that sometimes mechanical ventilation is seen under two, apparently opposite, approaches, “physiology vs. protocols”, the book aims to reconcile these two aspects. And this has been done by each author following the above trajectory in their chapters. The exposure of the topic begins from the “pathophysiology” (i.e. the “physiology of the disease”) so that the reader can better understand the concept and rationale of any given approach. At the same time, any rationale or hypothesis (for as much as supported by physiology) must hold at the proof of clinical research and evidence, which is summarized in each chapter.In summary, the purposes is that the readers understand not only which is the best clinical practice to adopt but also why and which mechanisms this is based upon and how to approach a novel issue they might encounter. The book – addressed to physicians, nurses and respiratory therapist – features chapters on “novel” or “hot” topics like, obviously, COVID-19, ECMO, but also MV in low resource setting.

This book comprehensively presents all the necessary information health professionals need to become Certified Asthma Educators. Competent asthma educators must possess a number of skills: they must have appropriate and sound medical and pharmaceutical knowledge; be proficient and effective educators who can influence their patients'behaviors for the better; and, finally, they need the administrative and organizational skills needed to set up and run efficient clinics at their places of work. The book is divided into three sections to meet those needs: Asthma: The Fundamentals; The Role of Education; and, The Effective Asthma Educator. The first section covers clinical knowledge of asthma, with chapters including lung structure and function, clinical presentation of asthma, and environmental issues in asthma management. The second section delves into the role of educating patients and teaches readers how to best do that with an integrated approach between physician, educator, and patient. The third section looks further into educating techniques with a view of the learning process, considerations for instruction locations, and the role the educator plays overall. The final chapter in the book presents example cases for readers to assess the knowledge they have learned throughout. This second edition serves as both textbook and study guide for certification as well as a long-term reference publication. It has been fully updated from the previous edition with the latest treatment guidelines, medications, and disease monitoring methods. This is an ideal guide for asthma educators, those seeking NAECB certification, and any health professional involved with individuals who have asthma.

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities.Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.

The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

This unique book discusses the management of neurocritical care patients, including basic concepts, pathophysiologic principles, monitoring, treatment indications, and factors that affect outcomes in patients requiring neurocritical care assistance. It addresses the need to improve continuing education in this area, highlighting patient care in the perioperative period. This is the first book to provide a simplified overview for neurosurgeons and neurologists to understand the neurocritical patient journey. It is divided into three parts: the first covers the basics concepts, from monitoring to the interpretation of exams; the second explores general management of specific situations encountered in intensive care and the last part includes prognostic and rehabilitation models, as well as new perspectives. Thanks to the accessible, neurosurgical specific language, the book is well suited for all professionals involvedin neurocritical care, including students, but is also a valuable resource for residents and researches, as well as experienced neurosurgeons or neurologists looking for updated information and guidelines.

The book introduces the definition, classification, source and structure of hydrocolloids and provides a comprehensive description of their functionalities and food-related applications. The emphasis is put on the basic concepts and mechanisms underlying functionalities, and the new developments in fundamental knowledge and practice. The book would be useful for students or professionals working in the fields of food science & technology, and biopolymers etc. It would help to organize hydrocolloids knowledge in a more systematic framework and enlighten further profound investigations.

This book offers a comprehensive overview of the basic physiology of the cardiac and pulmonary systems, tools for cardiopulmonary monitoring, and related issues in the management of specific conditions. The volume is divided into three main parts. The first part examines the functional basis of normal and abnormal physiology, organized into cardiac and pulmonary units and followed by a “combined” interactive component. The next section discusses cardiopulmonary monitoring tools and variables and is also divided into cardiac (e.g, echocardiography, heart rate, cardiac output), pulmonary (e.g, lung volume, pleural pressure, electrical impedance tomography), and combined tools such as radiology/MRI and tissue perfusion tests. The third section concerns the management and application of specific clinical problems such as pulmonary hypertension, cardiac shunts, cardiogenic shock, and ECMO with an emphasis on the physiological basics. Cardiopulmonary Monitoring: Basic Physiology, Tools, and Bedside Management for the Critically Ill is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, critical care, emergency medicine, anesthesiology, and radiology.

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.

This book highlights quantitative risk assessment and modeling methods for assessing health risks caused by air pollution, as well as characterizing and communicating remaining uncertainties. It shows how to apply modern data science, artificial intelligence and machine learning, causal analytics, mathematical modeling, and risk analysis to better quantify human health risks caused by environmental and occupational exposures to air pollutants. The adverse health effects that are caused by air pollution, and preventable by reducing it, instead of merely being statistically associated with exposure to air pollution (and with other many conditions, from cold weather to low income) have proved to be difficult to quantify with high precision and confidence, largely because correlation is not causation. This book shows how to use recent advances in causal analytics and risk analysis to determine more accurately how reducing exposures affects human health risks. Quantitative Risk Analysis of Air Pollution Health Effects is divided into three parts. Part I focuses mainly on quantitative simulation modelling of biological responses to exposures and resulting health risks. It considers occupational risks from asbestos and crystalline silica as examples, showing how dynamic simulation models can provide insights into more effective policies for protecting worker health. Part II examines limitations of regression models and the potential to instead apply machine learning, causal analysis, and Bayesian network learning methods for more accurate quantitative risk assessment, with applications to occupational risks from inhalation exposures. Finally, Part III examines applications to public health risks from air pollution, especially fine particulate matter (PM2.5) air pollution. The book applies freely available browser analytics software and data sets that allow readers to download data and carry out many of the analyses described, in addition to applying the techniques discussed to their own data.http://cox-associates.com:8899/