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Ecological protection and high-quality development in the Yellow River Basin has become a major national strategy, and the coupling coordination of economic growth, industrial development and ecology in this area is becoming a research hot spot. This paper analyzed the coupling coordination mechanism of economic growth, industrial development and ecology in the Yellow River Basin and constructed an evaluation index system of coupling coordination degree. Using the coupling coordination model, the spatial autocorrelation model and grey relational model, this paper analyzed the space differences and time differences of the coupling coordination degree of 62 cities in the Yellow River Basin and their driving factors from 2012 to 2018, And the GM (1, 1) gray prediction method was used to predict the coupling coordination degree in the short term. The results showed that：① The overall level of economic growth, industrial development and ecology in the Yellow River Basin had shown a steady trend, and there were no significant differences in the speed of development. However, the coupling coordination of them was seriously out of coordination, and the coupling coordination of ecological protection and high-quality development in the Yellow River Basin had not yet reached a coordinated level,② The coupling coordination degree demonstrated significant global and local spatial autocorrelation features. The global spatial auto-correlation was positive and the convergence features were obvious. (3) The forecast results showed that the coupling coordination degree remained generally stable and coordination had not been reached during the forecast period in this area. The rate of improvement was relatively slow. Finally, a support system incorporating organizational guarantee, spatial governance, policy guarantee and institutional mechanism was established for economic growth and ecological protection in the Yellow River Basin. It is expected that this paper can provide a theoretical basis and lay a certain scientific decision-making foundation for the ecological protection and high-quality development in the Yellow River Basin, [ABSTRACT FROM AUTHOR]