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Objective: To investigate the effect of three pull method of spine combined with celecoxib on the activity of thoracolumbar vertebrae and the signal pathway of bone morphogenetic protein (BMP) / Cell signal transducer (Smad) in patients with ankylosing spondylitis (AS). Methods: From July 2016 to December 2018, 150 patients with AS in our hospital were selcted, they were randomly divided into three groups: group A (n=50, treated with spine triple pull method), group B (n=50, treated with celecoxib) and group C (n=50, treated with spine triple pull method combined with celecoxib). The efficacy, thoracolumbar activity, BMP/Smad signal pathway related indicators and adverse reactions of the three groups were compared. Results: The total clinical effective rate of group C was 94.00% (47/50), which was higher than that of group A 66.00% (33/50) and group B 72.00% (36/50) (P<0.05). 6 months after treatment, the activity of lumbar vertebrae and thorax in group C were higher than those in group A and group B (P<0.05), and the distance between fingers and ground were shorter than that in group A and group B (P<0.05). 6 months after treatment, BMP-Ⅰrecipient, BMP-Ⅱrecipient, Smad1 and Smad4 in group C were lower than those in group A and group B (P<0.05). There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05). Conclusion: The three pull method of spine combined with celecoxib in the treatment of patients with AS, the effect is significant, it can effectively improve the thoracolumbar activity, and does not increase the incidence of adverse reactions, the specific mechanism may be through the regulation of BMP/Smad signal pathway. [ABSTRACT FROM AUTHOR]

Objective: To study the correlation of NGF protein and prostate F2琢receptor in the adenomyosis dysmenorrhea. Methods: 36 cases of uterine adenomyosis dysmenorrhea patients who received therapy from July 2016 to July 2016 in our hospital were treated, according to the visual analogue scale (VAS) score, those patients were divided into 11 cases in the mild groups, 14 cases in the moderate groups and 11 cases in the severe groups. In the same period, 36 patients were selected as the control group. The serum levels of NGF protein and plasma PTGFR were compared between different groups, and the correlation between them and dysmenorrhea score as well as the sensitivity, specificity and area under the ROC curve for the diagnosis of dysmenorrhea in adenomyosis when detected alone or in combination were analyzed. Results: The levels of serum NGF protein and plasma PTFFR in the dysmenorrhea group were significantly higher than those in the control group (P<0.05). The levels of serum NGF protein and plasma PTFFR in the mild dysmenorrhea group were significantly lower than those in the moderate group, and lower than the severe group (P<0.05). Serum levels of NGF protein and plasma PTFFR were significantly positively correlated with uterine adenomyosis dysmenorrhea scores, r were 0.812, 0.884(P<0.05). The ROC curve analysis showed that the area under the ROC curve of serum NGF protein combined with plasma PTFFR protein in the diagnosis of adenomyosis was significantly greater than that of serum NFG protein and plasma PTFFR (P<0.05). Conclusion: NGF protein and PTFFR may be involved in the occurrence and development of dysmenorrhea in adenomyosis. Combined detection of NGF protein and PTFFR may help to diagnose THE dysmenorrhea of adenomyosis. Serum levels of NGF protein and plasma PTGFR protein were positively correlated with the uterine adenomyosis. [ABSTRACT FROM AUTHOR]