1. Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure.
- Author
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Bennett, Claire E., Conway, Gerard S., Macpherson, James N., Jacobs, Patricia A., and Murray, Anna
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PREMATURE ovarian failure , *OVARY abnormalities , *INTELLECTUAL disabilities , *CHROMOSOME abnormalities , *DISEASES in women , *GENETIC mutation , *GENETICS , *ALLELES , *COMPARATIVE studies , *DNA , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *NERVE tissue proteins , *OVARIAN diseases , *RESEARCH , *EVALUATION research , *CASE-control method - Abstract
Background: It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but the role of smaller repeats at the boundary of premutation and normal is less clear.Methods: We have therefore investigated the incidence of these intermediate sized FMR1 CGG repeats (35-58 repeats) in a series of 366 women ascertained because of menopause before the age of 40.Results: We found no significant difference in the incidence of intermediates in cases compared with controls. Thus, we were unable to replicate previous studies showing a positive association, despite a significantly larger sample size.Conclusions: We therefore conclude that intermediate sized FMR1 CGG repeat alleles should not be considered a high-risk factor for POF based on current evidence. [ABSTRACT FROM AUTHOR]- Published
- 2010
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