1. Assessment of Apoptotic Activity Dysregulation and Oxidative Stress in the Development of Epithelial Ovarian Cancer: A Case-Controlled Descriptive Analysis.
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Incebiyik, adnan, Camuzcuoglu, Hakan, Vural, Mehmet, Hilali, Nese Gul, Camuzcuoglu, aysun, Seker, ahmet, Taskin, abdullah, and aksoy, Nurten
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OVARIAN epithelial cancer , *OXIDATIVE stress , *APOPTOSIS , *BLOOD testing , *BLOOD serum analysis , *OVARIAN tumors , *PROTEINS , *CASE-control method ,EPITHELIAL cell tumors - Abstract
Aim: In the present study, we aimed to assess whether oxidative stress and apoptotic activity play a role in the development of epithelial ovarian cancer (EOC).Methods: The study group included patients with EOC (n = 26) and benign ovarian tumour (BOT) (n = 25), while 30 healthy women were employed as a control group. Venous blood samples were drawn to evaluate oxidative stress parameters and serum M30/M65 antigen levels before surgery. In addition, blood samples were taken for the second time on postoperative day 8 to analyse whether the postoperative tumour load was decreased.Results: When the groups were assessed regarding oxidative stress, the highest values were detected in patients with EOC. Serum M30/M65 levels were found to be higher in patients with EOC when compared to the other groups (p < 0.001). A significant decrease was determined in the M30/M65 levels of serum samples taken on postoperative day 8 from the patients in the EOC and BOT groups (p < 0.001).Conclusion: Our results suggest that dysregulation of apoptotic activity could be effective in the development of ovarian tumoural tissue, whereas oxidative stress could be effective in malignant transformation. [ABSTRACT FROM AUTHOR]- Published
- 2016
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