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A plasma jet enhanced oil-based drug, named plasma-activated oil (PAO) is produced in sunflower oil by a single-step, room temperature, energy-efficient, and environment-friendly dry plasma jet enabled process. Plasma jets with two different working gas combinations, argon + air and argon + O2, were generated, namely PAO (air) and PAO (O2), respectively. Several hours of plasma jet treatment substantially increased the hydrogen peroxide and carboxylic acid concentrations in the PAO. Although the electrophilic fatty acid nitroalkenes produced by nitric oxide and nitrite of the argon + air plasma jet increased the acid value of PAO (air), similar sterilization and wound healing effect suggest that PAO (air) and PAO (O2) have similar concentrations of hydrogen peroxide and carboxylic acid. PAO killed the common Gram-positive bacteria [methicillin-resistant staphylococcus aureus (MRSA) and Micrococcus luteus] and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) efficiently. PAO accelerated the healing of infected wounds by 33%. [ABSTRACT FROM AUTHOR]

The aim of this experiment is to enhance selected species in atmospheric pressure plasma jet (APPJ) that might be helpful for the wound healing purpose and to test the performance using basic diagnosis in plasma-treated liquid. A homemade APPJ device is driven by sinusoidal voltage with a excitation frequency of 25 kHz. Argon with admixture of small percentage of nitrogen, oxygen, and water vapor was selected to be carrier gas as the main sources of reactive species. Discharge power consumption is calculated by two approaches. Reactive oxygen species and reactive nitrogen species in the excited states are characterized by optical emission spectroscopy (OES). Excitation temperature $T_{\mathrm {exc}}$ in argon plasmas is calculated to estimate the electron energy distribution. The results show that argon plasmas with small addition of nitrogen and oxygen in this jet configuration are more efficient to generate desired reactive species in terms of OES diagnosis and liquid acidification. Moreover, the distinct efficiency of liquid acidification between direct and indirect plasma treatment of liquid has also been observed. [ABSTRACT FROM AUTHOR]