1. Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases
- Author
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Zhu Xuejing, Xu Xiangqing, Yuan Shuguang, Liu Fuyou, Li Jun, and Tan Jiazhen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Article Subject ,Adolescent ,Health, Toxicology and Mutagenesis ,Urinary system ,Biopsy ,lcsh:Biotechnology ,Lupus nephritis ,lcsh:Medicine ,Kidney ,Gastroenterology ,Internal medicine ,lcsh:TP248.13-248.65 ,Genetics ,Medicine ,Humans ,Molecular Biology ,Pathological ,Chemokine CCL2 ,Chi-Square Distribution ,medicine.diagnostic_test ,business.industry ,Histocytochemistry ,Monocyte ,lcsh:R ,Cytokine TWEAK ,General Medicine ,Middle Aged ,medicine.disease ,Lupus Nephritis ,medicine.anatomical_structure ,Apoptosis ,Tumor Necrosis Factors ,Molecular Medicine ,Biomarker (medicine) ,Tumor necrosis factor alpha ,Female ,Renal biopsy ,business ,Biomarkers ,Biotechnology ,Research Article - Abstract
Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity.Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA.Results.Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index (r=0.825,P<0.01), glomerular activity index (r= 0.754,P<0.01), and tubulointerstitial qualitative activity index (r=0.751,P<0.01), while not significant correlated with chronicity Index (P>0.05). The association between urinary TWEAK levels and urinary MCP-1 levels were significant in active LN group (r=0.809,P<0.01) but not significant in non-active LN group (P>0.05).Conclusions. uWEAK levels were correlated with all active indexes of LN, suggesting its potential role as novel biomarker of active lupus nephritis.
- Published
- 2012