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• We used the Simplified MEV to model extreme rainfall quantiles in tropical regions. • Weibull distribution well approximates the tail of daily rainfall distribution. • Statistical parameters and rainfall quantiles significantly depend on latitude. • Homogeneous patterns in regional temporal trends are related to altitude. • Extreme daily rainfall amounts in the Volta basin increased during 1978–2018. Sub-Saharan Africa's economy and livelihood are primarily dependent on agriculture, which makes it highly vulnerable to the impacts of extreme weather events and climate change. Modelling and quantifying extreme rainfall and its temporal changes in such environments could thus provide crucial information for design, insurance, management, ecology and climate adaptation. Rain gauge networks in the area are relatively sparse, and often characterized by missing data, which hamper the use of extreme-value methods for estimating extreme precipitation quantiles. In this study, we adopted the Simplified Metastatistical Extreme Value approach for the estimation of extreme return levels based on ordinary events (i.e., all the independent realizations of the variable of interest), which was shown to be more accurate than traditional extreme-value methods in the presence of short data records. We examined data from 66 rain gauges covering diverse hydro-climatic regions across Ghana with the aim of (i) validating the robustness of the statistical approach, (ii) characterising the climatic and altitudinal controls on the occurrence, frequency and intensity of rainfall extremes, and (iii) quantifying recent changes in the characteristics of extremes. We found that a two-parameter Weibull distribution well approximates the tail of the daily rainfall distribution throughout the area. Our statistical approach can quantify extremes with largely reduced uncertainties (7–17% uncertainty in the 100-year return levels computed using 10 years of data versus 11–62% of extreme-value based methods). Extreme precipitation statistics (daily intensity distribution, number of wet days, extreme rainfall quantiles) are found to significantly depend on latitude, so that the four latitudinally layered hydro-climatic regions typically adopted in the area well represent spatial variations. Elevation significantly affects the tail heaviness of the daily intensity distribution and thus extreme rainfall quantiles. Temporal changes during the period 1978–2018 are found to be non-homogeneous in the area as well as within the four hydro-climatic regions, but are homogeneous in three altitude-based regions. We report contrasting trends in extreme return levels in low-elevation (<200 m a.s.l.) and hilly regions, related to contrasting changes in the daily intensity distribution. Statistically significant positive trends in extreme daily rainfall amounts are observed in the inland low-elevation region of the Volta river basin, which call for further investigation of changes in future precipitation extremes in this extremely important hydrological region in Sub-Saharan Africa. [ABSTRACT FROM AUTHOR]