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Four new sesquiterpenoids (1 – 4) and two known ones (5 – 6) were isolated and identified from the stems of Datura metel L. The structures of the isolated compounds were established by 1D and 2D NMR spectra, as well as HR-ESI-MS. Additionally, the compounds 1 – 3 possessed the similar novel skelecton and compounds 5 – 6 were isolated from the Datura genus for the first time. The hypothetical biogenetic pathway was teased and provided. Meanwhile, the antiproliferative activities were evaluated on the two human cancer cells of HepG2 and Hela, respectively. Unlabelled Image [ABSTRACT FROM AUTHOR]

Five new sesquiterpenoids named acasenterpene A-E (1–5) were isolated from the fruits of Acanthopanax senticosus. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HR-ESI-MS) combined with physico-chemical analysis methods (enzyme hydrolysis, optical rotation, and CD). The cytotoxicity of all compounds in vitro against four human cancer cell lines (MGC-803, Ishikawa, LN-229 and SMMC-7721) were evaluated by CCK-8 assay. Unlabelled Image [ABSTRACT FROM AUTHOR]