1. Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells.
- Author
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Geng, Shanshan, Wang, Shijia, Zhu, Weiwei, Xie, Chunfeng, Li, Xiaoting, Wu, Jieshu, Zhu, Jianyun, Jiang, Ye, Yang, Xue, Li, Yuan, Chen, Yue, Wang, Xiaoqian, Meng, Yu, and Zhong, Caiyun
- Subjects
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CURCUMIN , *C-Jun N-terminal kinases , *BISPHENOL A , *INSULIN resistance , *LIQUID oxygen , *INFLAMMATION - Abstract
Objective To examine whether curcumin has protective effect on insulin resistance induced by bisphenol A (BPA) in LO2 cells and whether this effect was mediated by inhibiting the inflammatory mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathways. Methods LO2 cells were stimulated with BPA in the presence or absence of curcumin for 5 days. Glucose consumption, activation of insulin signaling, MAPKs and NF-κB pathways, levels of inflammatory cytokines and MDA production were analyzed. Results Curcumin prevented BPA-induced reduction of glucose consumption and suppression of insulin signaling pathway, indicating curcumin alleviated BPA-triggered insulin resistance in LO2 cells. mRNA and proteins levels of TNF-α and IL-6, as well as MDA level in LO2 cells treated with BPA were decreased by curcumin. Furthermore, curcumin downregulated the activation of p38, JNK, and NF-κB pathways upon stimulation with BPA. Inhibition of JNK pathway, but not p38 nor NF-κB pathway, improved glucose consumption and insulin signaling in BPA-treated LO2 cells. Conclusion Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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