11 results on '"Bunya VY"'
Search Results
2. Dry Eye Assessment and Management (DREAM©) Study: Study design and baseline characteristics.
- Author
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Asbell PA, Maguire MG, Peskin E, Bunya VY, and Kuklinski EJ
- Subjects
- Administration, Oral, Aged, Dietary Fats, Unsaturated administration & dosage, Dietary Supplements, Female, Humans, Male, Middle Aged, Olive Oil administration & dosage, Symptom Assessment methods, Treatment Outcome, Diagnostic Techniques, Ophthalmological, Docosahexaenoic Acids administration & dosage, Dry Eye Syndromes diagnosis, Dry Eye Syndromes physiopathology, Dry Eye Syndromes therapy, Eicosapentaenoic Acid administration & dosage
- Abstract
Purpose: Describe trial design and baseline characteristics of participants in the DRy Eye Assessment and Management (DREAM©) Study., Design: Prospective, multi-center, randomized, double-masked "real-world" clinical trial assessing efficacy and safety of oral omega-3 (ω3) supplementation for the treatment of dry eye disease (DED)., Methods: RESULTS: Mean age of participants was 58.0 ± 13.2 years. Mean OSDI score at baseline was 44.4 ± 14.2. Mean conjunctival staining score (scale 0-6) was 3.0 ± 1.4, corneal staining score (scale 0-15) was 3.9 ± 2.7, tear break-up time was 3.1 ± 1.5 s, and Schirmer test was 9.6 ± 6.5 mm/5 min., Conclusions: DREAM© participants mirror real world patients who seek intervention for their DED-related symptoms despite their current treatments. Results regarding the efficacy of omega-3 supplementation will be helpful to clinicians and patients with moderate to severe DED who are considering omega-3 as a treatment. This trial design may be a model for future RCT's on nutritional supplements and DED treatments seeking to provide useful information for clinical practice., Trial Registration: ClinicalTrials.gov number NCT02128763., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
3. Isolation of cell surface-specific human monoclonal antibodies using phage display and magnetically-activated cell sorting: applications in immunohematology.
- Author
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Siegel DL, Chang TY, Russell SL, and Bunya VY
- Subjects
- Antibody Specificity, Antigens, Surface metabolism, Biotin metabolism, Cloning, Molecular, Erythrocytes immunology, Gene Library, Humans, Immunoglobulin Fab Fragments analysis, Indicators and Reagents, Lymphocytes immunology, Lymphocytes metabolism, Rh-Hr Blood-Group System immunology, Antibodies, Monoclonal chemistry, Antigens, Surface immunology, Bacteriophage lambda immunology, Blood Grouping and Crossmatching methods, Immunomagnetic Separation methods
- Abstract
A method is described for the isolation of filamentous phage-displayed human monoclonal antibodies directed at unpurifiable cell surface-expressed molecules. To optimize the capture of antigen-specific phage and minimize the binding of irrelevant phage antibodies, a simultaneous positive and negative selection strategy is employed. Cells bearing the antigen of interest are pre-coated with magnetic beads and diluted into an excess of unmodified antigen-negative cells. Following incubation of the cell admixture with a Fab/phage library, the antigen-positive cell population is retrieved using magnetically-activated cell sorting and antigen-specific Fab/phage are eluted and propagated in bacterial culture. Utilizing this protocol with magnetically-labeled Rh(D)-positive and excess unlabeled Rh(D)-negative human red blood cells and a Fab/phage library constructed from human peripheral blood lymphocytes, dozens of unique clinically-useful gamma 1 kappa and gamma 1 lambda anti-Rh(D) antibodies were isolated from a single alloimmunized individual. This cell-surface selection method is readily adaptable for use in other systems, such as for the identification of putative tumor-specific antigens and provides a rapid (< 1 month), high-yield approach for isolating self-replicative antibody reagents directed at novel or conformationally-dependent cell-surface epitopes.
- Published
- 1997
- Full Text
- View/download PDF
4. Adler's Physiology of the Eye E-Book
- Author
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Leonard A Levin, Paul L. Kaufman, Mary Elizabeth Hartnett, Leonard A Levin, Paul L. Kaufman, and Mary Elizabeth Hartnett
- Subjects
- Eye--Physiology
- Abstract
Written and designed to enhance your understanding of ocular function, structure, and anatomy, Adler's Physiology of the Eye is a classic, best-selling text that makes critical information easier to learn and retain. The fully revised 12th Edition continues the successful Adler's approach that connects basic science and clinical aspects in a user-friendly, highly visual format—ideal for study, review, and exam preparation. It captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. - Covers the full structure and function of the eye and its related anatomy and makes the connection between physiology and clinical practice. - Includes major updates throughout, including new information on OCT/OCTA imaging, new drug delivery methods, ocular biomechanics, and evolving gene therapies. - Organizes content by function, rather than anatomy, to help you make a stronger connection between physiological principles and clinical practice. - Explains the physiological principles that underlie visual acuity, intraocular pressure, ocular circulation, the extraocular muscles, and much more. - Features approximately 1,000 illustrations throughout, including medical artwork; schematics, charts, and graphs; clinical photographs; and more. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.
- Published
- 2024
5. Cecil Essentials of Medicine E-Book : Cecil Essentials of Medicine E-Book
- Author
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Edward J. Wing, Fred J. Schiffman, Edward J. Wing, and Fred J. Schiffman
- Subjects
- Internal medicine--Textbooks, Internal medicine
- Abstract
Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science. - New focus on high-yield, core knowledge necessary for clerkships or residencies in medicine, with concise, complete coverage of the core principles of medicine and how they apply to patient care. - Each section describes key physiology and biochemistry, followed by comprehensive accounts of the diseases of the organ system or field covered in the chapters. - Full-color design enhances readability and retention of concepts, while numerous imaging videos cover cardiovascular disease, endoscopy, sphincterotomy, and more. - Superb images and photographs vividly illustrate the appearance and clinical features of disease. - New chapters cover Women's Cancer and Transitions in Care from Children to Adults with Pulmonary Disease.
- Published
- 2022
6. Keratoconus : Keratoconus,E-Book
- Author
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Luis Izquierdo, Maria A. Henriquez, Mark J Mannis, Luis Izquierdo, Maria A. Henriquez, and Mark J Mannis
- Subjects
- Keratoconus, Keratoconus--Diagnosis, Keratoconus--Treatment
- Abstract
Offering practical clinical guidance for early diagnosis and effective management, Keratoconus: Diagnosis and Management is a concise, easy-to-read guide to help mitigate loss of vision in patients in a way that does not interfere with quality of life. From early diagnosis and intervention through the most up-to-date treatment and surgical approaches, this consolidated reference covers the essential information needed by cornea fellows and specialists, general ophthalmologists, residents, and optometrists. Provides expert, step-by-step guidance and real-world perspectives from global contributors in the field. Covers the latest advances in cornea transplantation, corneal collagen cross-linking (CXL) in adult and pediatric patients, intrastromal corneal rings, intraocular lenses, corneal regeneration, and laser surgery. Includes quick-reference boxes throughout highlighting essential clinical facts, pitfalls, potential complications, and clinical guidelines. Presents real-world case studies of actual patient scenarios from early to advanced disease states. Features high-quality imaging for keratoconus at various stages, including OCT, Brillouin scanning microscopy, Scheimpflug and combined Placido and Scheimpflug, combined Placido and AS-OCT, clinical and surgical photos, and more.
- Published
- 2022
7. Textbook of Pediatric Rheumatology E-Book
- Author
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Ross E. Petty, Ronald M. Laxer, Carol B Lindsley, Lucy Wedderburn, Robert C Fuhlbrigge, Elizabeth D. Mellins, Ross E. Petty, Ronald M. Laxer, Carol B Lindsley, Lucy Wedderburn, Robert C Fuhlbrigge, and Elizabeth D. Mellins
- Subjects
- Arthritis, Children, Rheumatism, Pediatric rheumatology, Rheumatism in children, Connective tissues--Diseases, Vasculitis
- Abstract
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. - Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. - Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. - Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. - Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Published
- 2021
8. Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book : Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book
- Author
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Frederick T. Fraunfelder, Frederick W. Fraunfelder, Frederick T. Fraunfelder, and Frederick W. Fraunfelder
- Subjects
- Drugs--Side effects, Drug interactions, Drugs--Side effects--Handbooks, manuals, etc, Ocular toxicology--Handbooks, manuals, etc, Ocular pharmacology--Handbooks, manuals, etc, Iatrogenic diseases
- Abstract
Written by global experts in the field of chemical- and drug-related ocular problems, Drug-Induced Ocular Side Effects, 8th Edition, provides need-to-know information on all aspects of ocular toxicology in one concise reference. This best-selling, user-friendly resource features a templated format, numerous full-color illustrations, and sweeping content updates throughout – all designed to eliminate uncertainty and ensure accurate diagnosis and treatment guidance. - Provides comprehensive coverage of drugs'generic and trade names, primary uses, ocular and systemic side effects, and clinical significance. - Features a unique side effect index, a new concise paperback format for portability, and clinical photos of ocular symptoms of adverse drug reactions. - Covers dozens of new drugs used in the U.S. and internationally, as well as extensive updates to drug registry information to ensure access to the latest data. - Includes expanded sections on how to follow patients with visual adverse drug reactions to chloroquine, hydroxychloroquine, isotretinoin, ethambutol, and more. Guidelines can be copied to use as patient handouts. - Offers extensive discussions of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics. - Provides the WHO classification system to help you determine whether a particular side effect is certain, probable, or likely to occur. - Ideal for ophthalmologists, optometrists, and busy clinicians in primary care, emergency medicine, and more – anyone who needs quick, on-the-spot consultation on ocular toxicology. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Published
- 2021
9. Sjogren's Syndrome : A Clinical Handbook
- Author
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Frederick B. Vivino and Frederick B. Vivino
- Subjects
- Sjogren's syndrome--Treatment, Sjogren's syndrome, Sjogren's syndrome--Diagnosis
- Abstract
Written by leaders in the field and edited by Dr. Frederick Vivino, this concise, practical resource provides best practices for the diagnosis and treatment of Sjogren's Syndrome. It offers a concise overview of this complex autoimmune disease, including information on specific clinical settings, childhood Sjogren's, extra-oral and extra-ocular manifestations, vaccine safety, complementary and alternative medicine, and much more. - Provides concise, clinically focused content with an emphasis on diagnosis and treatment. - Includes Sjogren's Syndrome Foundation Practice Guidelines and the most recent ACR-EULAR classification criteria. - Consolidates today's available information and experience in this important area into one convenient resource.
- Published
- 2020
10. Side Effects of Drugs Annual : A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
- Author
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Jeffrey K Aronson and Jeffrey K Aronson
- Subjects
- Drugs--Side effects
- Abstract
The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading. - Provides a critical yearly survey of new data and trends - Special reviews in this Annual include, among other topics, epidemiology of the use of ecstasy, paracetamol and the risk of asthma, combination vaccines/multiple immunizations, interactions of herbal medicines with warfarin, and tyrosine kinase inhibitors
- Published
- 2012
11. Enfermedades infecciosas : principios y práctica
- Author
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Mandell, Gerald L., Bennett, John E., Dolin, Raphael, Mandell, Gerald L., Bennett, John E., and Dolin, Raphael
- Subjects
- Antibiotics--Handbooks, manuals, etc, Communicable diseases
- Abstract
Después de treinta años, este libro sigue siendo la referencia de elección para la orientación integral y global del diagnóstico y el tratamiento de las enfermedades infecciosas más complejas. Esta nueva edición se ha revisado ampliamente y actualizado de forma minuciosa para asegurar la inclusión de los últimos conocimientos clínicos y científicos en el campo de las enfermedades infecciosas.Incluye el acceso en línea a todas las figuras del libro a través de la página web www.elsevier.es/mandell, incluidas 1.100 fotografías a todo color y de alta calidad, que ilustran signos clínicos de pacientes reales.Ahora en dos volúmenes, cubre con mayor profundidad la epidemiología, etiología, patología, microbiología, inmunología, y el tratamiento de los agentes infecciosos que en cualquier otro libro disponible, lo que permite obtener la respuesta a cualquier pregunta.Incluye nuevos capítulos sobre temas de candente actualidad como probióticos, investigación de epidemias, infección de dispositivos cardiovasculares no valvulares y neumonía por Chlamydophila; e incorpora nuevos autores internacionales en 44 capítulos, que aportan una visión completamente nueva al capítulo.Cuenta con una organización uniforme de los capítulos, para que su lectura sea más fácil. Después de treinta años, este libro sigue siendo la referencia de elección para la orientación integral y global del diagnóstico y el tratamiento de las enfermedades infecciosas más complejas. Esta nueva edición se ha revisado ampliamente y actualizado de forma minuciosa para asegurar la inclusión de los últimos conocimientos clínicos y científicos en el campo de las enfermedades infecciosas. Incluye el acceso en línea a todas las figuras del libro a través de la página web www.elsevier.es/mandell, incluidas 1.100 fotografías a todo color y de alta calidad, que ilustran signos clínicos de pacientes reales. Ahora en dos volúmenes, cubre con mayor profundidad la epidemiología, etiología, patología, microbiología, inmunología, y el tratamiento de los agentes infecciosos que en cualquier otro libro disponible, lo que permite obtener la respuesta a cualquier pregunta. Incluye nuevos capítulos sobre temas de candente actualidad como probióticos, investigación de epidemias, infección de dispositivos cardiovasculares no valvulares y neumonía por Chlamydophila; e incorpora nuevos autores internacionales en 44 capítulos, que aportan una visión completamente nueva al capítulo. Cuenta con una organización uniforme de los capítulos, para que su lectura sea más fácil.
- Published
- 2012
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