1. Ductus venosus agenesis and fetal malformations: what can we expect? – a systematic review of the literature.
- Author
-
Pacheco, Diana, Brandão, Otília, Montenegro, Nuno, and Matias, Alexandra
- Subjects
- *
CHROMOSOME abnormalities , *COUNSELING , *FETAL diseases , *HEART diseases , *EVALUATION of medical care , *MEDLINE , *PREGNANCY , *PRENATAL diagnosis , *SYSTEMATIC reviews , *DOWN syndrome , *UMBILICAL veins , *TRISOMY 18 syndrome - Abstract
Background: The ductus venosus agenesis (DVA) is a rare condition with a variable prognosis that relies partly on the presence of associated conditions. The purpose of our study was to analyze the literature regarding the post-natal outcome of fetuses with DVA associated with fetal malformations, in order to discuss the best management options for couples. Methods: We performed a systematic review of the literature of MEDLINE and SCOPUS electronic databases in a 25-year period from 1992 to September 2017. Methods: We found 340 cases of DVA associated with fetal abnormalities. The most common chromosomal abnormalities were: monosomy X (12/48, 25%), trisomy 21 (11/48, 22.9%) and trisomy 18 (6/48, 12.5%). From the 340 cases with DVA, in 31 cases the umbilical venous shunt type was not reported. Of the fetuses, 60.8% (188/309) had an extrahepatic umbilical venous drainage while 39.2% (121/309) presented an intrahepatic connection. The DVA was associated in 71 cases (23.0%) with cardiac abnormalities, in 82 cases (26.5%) with extracardiac abnormalities and in 85 cases (27.5%) with both cardiac and extracardiac abnormalities. Conclusion: DVA associated with both cardiac and extracardiac malformations may confer a poorer fetal outcome, a clinically relevant fact that should clarify what can be expected from this entity and help prenatal counseling. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF