1. It's a DoG-eat-DoG world—altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.
- Author
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Morgan, Marc, Shiekhattar, Ramin, Shilatifard, Ali, and Lauberth, Shannon M.
- Subjects
- *
NON-coding RNA , *DOGS , *CELL physiology , *RNA , *GENETIC transcription regulation - Abstract
The past decade has revolutionized our understanding of regulatory noncoding RNAs (ncRNAs). Among the most recently identified ncRNAs are downstream-of-gene (DoG)-containing transcripts that are produced by widespread transcriptional readthrough. The discovery of DoGs has set the stage for future studies to address many unanswered questions regarding the mechanisms that promote readthrough transcription, RNA processing, and the cellular functions of the unique transcripts. In this review, we summarize current findings regarding the biogenesis, function, and mechanisms regulating this exciting new class of RNA molecules. Downstream-of-gene-containing transcripts (DoGs) are noncoding RNAs (ncRNAs) that are becoming increasingly identified as hallmarks of cellular stress and disease. Their discovery has laid the foundation for the next decade to be an exciting time for unraveling the enigmas that control DoG biogenesis and function. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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