1. Prophylactic Colchicine After Catheter Ablation for Atrial Fibrillation: A Systematic Review.
- Author
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Khenhrani, Raja Ram, Maqbool, Khawaja Usama, Aslam, Muhammad Nouman, Veer, Maha, Umer, Muhammad Rizwan, Iqbal, Arham, Malik, Jahanzeb, and Mehmoodi, Amin
- Subjects
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COLCHICINE , *CATHETER ablation , *ATRIAL fibrillation , *ARRHYTHMIA , *INFLAMMATION - Abstract
Catheter ablation, a widely used treatment option for patients with AF who are symptomatic despite medical therapy, carries inherent risks and may lead to adverse events. This systematic review aims to evaluate the current evidence on the use of prophylactic colchicine after catheter ablation for AF in reducing the risk of AF recurrence and inflammatory biomarkers. Digital databases were searched systematically to identify studies reporting the outcomes of prophylactic use of colchicine after AF ablation. A total of four studies, recruiting 503 patients, were included in the final analysis. Overall, AF recurrence was higher in the placebo group compared to the colchicine group. However, side effects of colchicine were more frequently observed after colchicine treatment. Colchicine dosing ranged from 0.5 mg to 1.2 mg daily, and the duration of treatment ranged from 14 to 90 days. Gastrointestinal side effects were predominantly reported in the studies investigating initiation of colchicine. In conclusion, the use of prophylactic colchicine after catheter ablation for atrial fibrillation may be a promising strategy for reducing the risk of AF recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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