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1. The successful transfer of a modern CHO fed-batch process to different single-use bioreactors.

Author

Ruhl, Sebastian, Husemann, Ute, Jurkiewicz, Elke, Dreher, Thomas, and Greller, Gerhard

Subjects
*CHO cell, *CELL lines, *BIOREACTORS, *PHARMACEUTICAL industry, *MANUFACTURING processes
Abstract

The article discusses successful transfer of a modern CHO cell fed-batch process to different single-use bioreactors. Topics discussed include use of single-use bioreactors in pharmaceutical industry, use of secreting human IgG1 for fed-batch process, characterization of used bioreactors in terms of process engineering, performing daily sampling procedure before bolus feed, and analysing metabolites like glucose and lactate.

Published
2013
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