25 results on '"Hu, Zhibin"'
Search Results
2. Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma
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Liu, Tongyan, Han, Chencheng, Fang, Panqi, Ma, Zhifei, Wang, Xiaoxiao, Chen, Hao, Wang, Siwei, Meng, Fanchen, Wang, Cheng, Zhang, Erbao, Dong, Guozhang, Zhu, Hongyu, Yin, Wenda, Wang, Jie, Zuo, Xianglin, Qiu, Mantang, Wang, Jinke, Qian, Xu, Shen, Hongbing, Xu, Lin, Hu, Zhibin, and Yin, Rong
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- 2022
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3. Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study
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You, Dongfang, Wang, Danhua, Wu, Yaqian, Chen, Xin, Shao, Fang, Wei, Yongyue, Zhang, Ruyang, Lange, Theis, Ma, Hongxia, Xu, Hongyang, Hu, Zhibin, Christiani, David C., Shen, Hongbing, Chen, Feng, and Zhao, Yang
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- 2022
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4. Stress, anxiety, and depression in infertile couples are not associated with a first IVF or ICSI treatment outcome
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Peng, Meijuan, Wen, Mingyang, Jiang, Tao, Jiang, Yangqian, Lv, Hong, Chen, Ting, Ling, Xiufeng, Li, Hong, Meng, Qingxia, Huang, Boxian, Tao, Shiyao, Huang, Lei, Liu, Cong, Xu, Xin, Lu, Qun, Liu, Xiaoyu, Xu, Bo, Han, Xiumei, Zhou, Kun, Chen, Jiaping, Lin, Yuan, Ma, Hongxia, Xia, Yankai, Shen, Hongbing, Hu, Zhibin, Chen, Feng, Du, Jiangbo, and Jin, Guangfu
- Published
- 2021
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5. The rates and medical necessity of cesarean delivery in China, 2012–2019: an inspiration from Jiangsu
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Song, Ci, Xu, Yan, Ding, Yuqing, Zhang, Yanfang, Liu, Na, Li, Lin, Li, Zhun, Du, Jiangbo, You, Hua, Ma, Hongxia, Jin, Guangfu, Wang, Xudong, Shen, Hongbing, Lin, Yuan, Jiang, Xiaoqing, and Hu, Zhibin
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- 2021
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6. Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus
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Wang, Yue, Chen, Xuejuan, Jiang, Tao, Gu, Yayun, Zhang, Xiaohan, Yuan, Wenwen, Zhao, Andi, Li, Rui, Wang, Zijin, Hu, Zhibin, and Liu, Hu
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- 2021
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7. Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types
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Shen, Sipeng, Zhang, Ruyang, Jiang, Yue, Li, Yi, Lin, Lijuan, Liu, Zhonghua, Zhao, Yang, Shen, Hongbing, Hu, Zhibin, Wei, Yongyue, and Chen, Feng
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- 2021
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8. Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women
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Hang, Dong, He, Xiaosheng, Kværner, Ane Sørlie, Chan, Andrew T., Wu, Kana, Ogino, Shuji, Hu, Zhibin, Shen, Hongbing, Giovannucci, Edward L., and Song, Mingyang
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- 2021
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9. Maternal mortality ratio in Jiangsu Province, China: recent trends and associated factors
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Li, Donghua, Yu, Chengxiao, Song, Ci, Ning, Weiqing, Xu, Yan, Ge, Huan, Lin, Song, Zhou, Wenjie, Lu, Yajun, Wang, Xudong, Hu, Zhibin, Lin, Yuan, and Wu, Jie
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- 2021
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10. Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study
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Lv, Hong, Li, Xiuzhu, Du, Jiangbo, Ling, Xiufeng, Diao, Feiyang, Lu, Qun, Tao, Shiyao, Huang, Lei, Chen, Shiyao, Han, Xiumei, Zhou, Kun, Xu, Bo, Liu, Xiaoyu, Ma, Hongxia, Xia, Yankai, Shen, Hongbing, Hu, Zhibin, Jin, Guangfu, Guan, Yichun, and Wang, Xinru
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- 2020
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11. The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression
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Shao, Lipei, Zuo, Xianglin, Yang, Yin, Zhang, Yu, Yang, Nan, Shen, Bin, Wang, Jianying, Wang, Xuchun, Li, Ruilei, Jin, Guangfu, Yu, Dawei, Chen, Yuan, Sun, Luan, Li, Zhen, Fu, Qiaofen, Hu, Zhibin, Han, Xiao, Song, Xin, Shen, Hongbin, and Sun, Yujie
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- 2019
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12. Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review
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Mao, Yingying, Yang, Wenjun, Qi, Qi, Yu, Fei, Wang, Tianpei, Zhang, Hongfei, Dai, Juncheng, Ma, Hongxia, Hu, Zhibin, Shen, Hongbing, Li, Gang, and Jin, Guangfu
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- 2019
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13. Influencing factors of pregnancy loss and survival probability of clinical pregnancies conceived through assisted reproductive technology
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Hu, Lingmin, Du, Jiangbo, Lv, Hong, Zhao, Jing, Chen, Mengxi, Wang, Yifeng, Wu, Fang, Liu, Feng, Chen, Xiaojiao, Zhang, Junqiang, Ma, Hongxia, Jin, Guangfu, Shen, Hongbing, Chen, Li, Ling, Xiufeng, and Hu, Zhibin
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- 2018
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14. Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.
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Zhai, Xiangjun, Gao, Jun, Hu, Zhibin, Tang, Jinhai, Qin, Jianwei, Wang, Shui, Wang, Xuechen, Jin, Guangfu, Liu, Jiyong, Chen, Wenshen, Chen, Feng, Wang, Xinru, Wei, Qingyi, and Shen, Hongbing
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BREAST cancer ,GENETIC polymorphisms ,TUMORS ,ONCOLOGY ,CANCER - Abstract
Background: Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibility to cancer. Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis. Two potentially functional polymorphisms [a 28-bp tandem repeat in the TYMS 5'-untranslated enhanced region (TSER) and a 6-bp deletion/insertion in the TYMS 3'-untranslated region (TS 3'-UTR)] were suggested to be correlated with alteration of thymidylate synthase expression and associated with cancer risk. Methods: To test the hypothesis that polymorphisms of the TYMS gene are associated with risk of breast cancer, we genotyped these two polymorphisms in a case-control study of 432 incident cases with invasive breast cancer and 473 cancer-free controls in a Chinese population. Results: We found that the distribution of TS3'-UTR (1494del6) genotype frequencies were significantly different between the cases and controls (P = 0.026). Compared with the TS3'-UTR del6/del6 wild-type genotype, a significantly reduced risk was associated with the ins6/ins6 homozygous variant genotype (adjusted OR = 0.58, 95% CI = 0.35-0.97) but not the del6/ins6 genotype (OR = 1.09, 95% CI = 0.82-1.46). Furthermore, breast cancer risks associated with the TS3'-UTR del6/del6 genotype were more evident in older women, postmenopausal subjects, individuals with a younger age at first-live birth and individuals with an older age at menarche. However, there was no evidence for an association between the TSER polymorphism and breast cancer risks. Conclusion: These findings suggest that the TS3'-UTR del6 polymorphism may play a role in the etiology of breast cancer. Further larger population-based studies as well as functional evaluation of the variants are warranted to confirm our findings. [ABSTRACT FROM AUTHOR]
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- 2006
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15. Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population.
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Wang, Yanru, He, Yisha, Qin, Zhenzhen, Jiang, Yue, Jin, Guangfu, Ma, Hongxia, Dai, Juncheng, Chen, Jiaping, Hu, Zhibin, Guan, Xiaoxiang, and Shen, Hongbing
- Abstract
Introduction: Single-nucleotide polymorphisms (SNPs) at 6q25.1 that are associated with breast cancer susceptibility have been identified in several genome-wide association studies (GWASs). However, the exact causal variants in this region have not been clarified.Methods: In the present study, we genotyped six potentially functional single-nucleotide polymorphisms (SNPs) within the CCDC170 and ESR1 gene regions at 6q25.1 and accessed their associations with risk of breast cancer in a study of 1,064 cases and 1,073 cancer-free controls in Chinese women. The biological function of the risk variant was further evaluated by performing laboratory experiments.Results: Breast cancer risk was significantly associated with three SNPs located at 6q25.1-rs9383935 in CCDC170 and rs2228480 and rs3798758 in ESR1-with variant allele attributed odds ratios (ORs) of 1.38 (95% confidence interval (CI): 1.20 to 1.57, P=2.21×10(-6)), 0.84 (95% CI: 0.72 to 0.98, P=0.025) and 1.19 (95% CI: 1.04 to 1.37, P=0.013), respectively. The functional variant rs9383935 is in high linkage disequilibrium (LD) with GWAS-reported top-hit SNP (rs2046210), but only rs9383935 showed a strong independent effect in conditional regression analysis. The rs9383935 risk allele A showed decreased activity of reporter gene in both the MCF-7 and BT-474 breast cancer cell lines, which might be due to an altered binding capacity of miR-27a to the 3' untranslated region (3' UTR) sequence of CCDC170. Real-time quantitative reverse transcription PCR confirmed the correlation between rs9383935 genotypes and CCDC170 expression levels.Conclusions: The results of this study suggest that the functional variant rs9383935, located at the 3' UTR of CCDC170, may be one candidate of the causal variants at 6q25.1 that modulate the risk of breast cancer. [ABSTRACT FROM AUTHOR]- Published
- 2014
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16. Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women.
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Dai, Juncheng, Hu, Zhibin, Jiang, Yue, Shen, Hao, Dong, Jing, Ma, Hongxia, and Shen, Hongbing
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BREAST cancer risk factors ,CASE-control method ,CANCER in women ,SINGLE nucleotide polymorphisms ,GENOMICS ,DEMOGRAPHIC characteristics - Abstract
Introduction: Recently, several genome-wide association studies (GWAS) have identified novel single nucleotide polymorphisms (SNPs) associated with breast cancer risk. However, most of the studies were conducted among Caucasians and only one from Chinese.Methods: In the current study, we first tested whether 15 SNPs identified by previous GWAS were also breast cancer marker SNPs in this Chinese population. Then, we grouped the marker SNPs, and modeled them with clinical risk factors, to see the usage of these factors in breast cancer risk assessment. Two methods (risk factors counting and odds ratio (OR) weighted risk scoring) were used to evaluate the cumulative effects of the five significant SNPs and two clinical risk factors (age at menarche and age at first live birth).Results: Five SNPs located at 2q35, 3p24, 6q22, 6q25 and 10q26 were consistently associated with breast cancer risk in both testing set (878 cases and 900 controls) and validation set (914 cases and 967 controls) samples. Overall, all of the five SNPs contributed to breast cancer susceptibility in a dominant genetic model (2q35, rs13387042: adjusted OR = 1.26, P = 0.006; 3q24.1, rs2307032: adjusted OR = 1.24, P = 0.005; 6q22.33, rs2180341: adjusted OR = 1.22, P = 0.006; 6q25.1, rs2046210: adjusted OR = 1.51, P = 2.40 × 10-8; 10q26.13, rs2981582: adjusted OR = 1.31, P = 1.96 × 10-4). Risk score analyses (area under the curve (AUC): 0.649, 95% confidence interval (CI): 0.631 to 0.667; sensitivity = 62.60%, specificity = 57.05%) presented better discrimination than that by risk factors counting (AUC: 0.637, 95% CI: 0.619 to 0.655; sensitivity = 62.16%, specificity = 60.03%) (P < 0.0001). Absolute risk was then calculated by the modified Gail model and an AUC of 0.658 (95% CI = 0.640 to 0.676) (sensitivity = 61.98%, specificity = 60.26%) was obtained for the combination of five marker SNPs, age at menarche and age at first live birth.Conclusions: This study shows that five GWAS identified variants were also consistently validated in this Chinese population and combining these genetic variants with other risk factors can improve the risk predictive ability of breast cancer. However, more breast cancer associated risk variants should be incorporated to optimize the risk assessment. [ABSTRACT FROM AUTHOR]- Published
- 2012
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17. Human papillomavirus in semen and the risk for male infertility: a systematic review and meta-analysis.
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Lyu Z, Feng X, Li N, Zhao W, Wei L, Chen Y, Yang W, Ma H, Yao B, Zhang K, Hu Z, Shen H, Hang D, and Dai M
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- DNA, Viral analysis, Databases, Factual, Humans, Male, Odds Ratio, Papillomaviridae isolation & purification, Papillomavirus Infections diagnosis, Prevalence, Risk, Infertility, Male etiology, Papillomaviridae genetics, Papillomavirus Infections epidemiology, Semen virology
- Abstract
Background: Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for male infertility remain inconclusive., Methods: Four electronic databases were searched for English language studies conducted between January 1990 and December 2016 that reported HPV DNA prevalence in semen. Based on the PRISMA guidelines, HPV prevalence was estimated among general population and fertility clinic attendees, respectively, and heterogeneity testing was performed using Cochran's Q and I
2 statistics. The association between HPV positivity and male infertility was evaluated by a meta-analysis of case-control studies., Results: A total of 31 eligible studies comprising 5194 males were included. The overall prevalence of HPV DNA in semen was 11.4% (95% CI = 7.8-15.0%) in general population (n = 2122) and 20.4% (95% CI = 16.2-24.6%) in fertility clinic attendees (n = 3072). High-risk type prevalence was 10.0% (95% CI = 5.9-14.0%) and 15.5% (95% CI = 11.4-19.7%), respectively. HPV16 was the most common type, with a prevalence of 4.8% (95% CI = 1.7-7.8%) in general population and 6.0% (95% CI = 3.8-8.2%) in fertility clinic attendees. A significantly increased risk of infertility was found for males with HPV positivity in semen (OR = 2.93, 95% CI = 2.03-4.24)., Conclusions: Seminal HPV infection is common worldwide, which may contribute to the risk of male infertility.- Published
- 2017
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18. Independent prognostic role of human papillomavirus genotype in cervical cancer.
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Hang D, Jia M, Ma H, Zhou J, Feng X, Lyu Z, Yin J, Cui H, Yin Y, Jin G, Hu Z, Shen H, Zhang K, Li N, and Dai M
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- Adult, Aged, Alphapapillomavirus pathogenicity, Disease-Free Survival, Female, Genotype, Human papillomavirus 16 genetics, Human papillomavirus 16 pathogenicity, Humans, Kaplan-Meier Estimate, Middle Aged, Papillomavirus Infections complications, Papillomavirus Infections mortality, Prognosis, Proportional Hazards Models, Uterine Cervical Neoplasms therapy, Alphapapillomavirus genetics, Papillomavirus Infections virology, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms virology
- Abstract
Background: Although the correlation of HPV genotype with cervical precursor lesions and invasive cancer has been confirmed, the role of HPV genotype in cervical cancer prognosis is less conclusive. This study aims to systematically investigate the independent prognostic role of HPV genotype in cervical cancer., Methods: A total of 306 eligible patients provided cervical cell specimens for HPV genotyping before therapy and had a median follow-up time of 54 months after diagnosis. Survival times were measured from the date of diagnosis to the date of cervical cancer-related death (overall survival, OS) and from the date of diagnosis to the date of recurrence or metastasis (disease free survival, DFS). Log-rank tests and Cox proportional hazard models were performed to evaluate the association between HPV genotype and survival times., Results: A total of 12 types of high-risk HPV were detected and the leading ten types belong to two species: alpha-9 and alpha-7. HPV16 and 18 were the two most common types, with the prevalence of 60.8% and 8.8%, respectively. In the univariate analysis, HPV16-positive cases were associated with better OS (P = 0.037) and HPV16-related species alpha-9 predicted better OS and DFS (both P < 0.01). After adjusting for age, FIGO stage, and therapy, HPV16 showed a hazard ratio (HR) of 0.36 (95% CI: 0.18, 0.74; P = 0.005) for OS, and alpha-9 resulted in a HR of 0.17 (95% CI: 0.08, 0.37; P < 0.001) for OS and 0.32 (95% CI: 0.17, 0.59; P < 0.001) for DFS., Conclusions: HPV genotype poses differential prognoses for cervical cancer patients. The presence of HPV16 and its related species alpha-9 indicates an improved survival.
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- 2017
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19. Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population.
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Sun J, Qian Y, Jiang Y, Chen J, Dai J, Jin G, Wang J, Hu Z, Liu S, Shen C, and Shen H
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- Adult, Aged, Alleles, Cholesterol, HDL blood, Cholesterol, HDL genetics, Coronary Disease pathology, Dyslipidemias pathology, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Alkyl and Aryl Transferases genetics, Coronary Disease genetics, Dyslipidemias genetics, Phosphotransferases (Alcohol Group Acceptor) genetics, Potassium Channels, Voltage-Gated genetics
- Abstract
Background: Several genome-wide association studies have discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of which influence HDL-cholesterol concentrations. However, there are few reports on the associations between these polymorphisms and HDL-C concentrations in Chinese population. This study aimed to evaluate the associations between functional polymorphisms in three genes (MVK, MMAB and KCTD10) and HDL-C concentrations, as well as coronary heart disease (CHD) susceptibility in Chinese individuals., Methods: We systematically selected and genotyped 18 potentially functional polymorphisms in MVK, MMAB and KCTD10 by using the TaqMan OpenArray Genotyping System in a Chinese population including 399 dyslipidemia cases, 697 CHD cases and 465 controls. Multivariate logistic regression analyses were performed to estimate the relationship between the genotypes and dyslipidemia, CHD risk with adjustment of relevant confounders., Results: Among six polymorphisms showing significant associations with dyslipidemia, the minor alleles of rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB were significantly associated with a decreased risk of CHD (additive model: OR = 0.71, 95 % CI = 0.53-0.97, P = 0.029 for rs11066782; OR = 0.73, 95 % CI = 0.54-0.99, P = 0.044 for rs11613718 and OR = 0.57, 95 % CI = 0.40-0.80, P = 0.001 for rs11067233). Further combined analysis showed that individuals carrying "3-4" favorable alleles presented a 62 % (OR = 0.38, 95 % CI = 0.21-0.66) decreased risk of CHD compared with those carrying "0-2" favorable alleles., Conclusions: These findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of CHD by altering plasma HDL-C levels in Han Chinese.
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- 2016
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20. Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case-control study.
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Miao L, Wang L, Zhu L, Du J, Zhu X, Niu Y, Wang R, Hu Z, Chen N, Shen H, and Ma H
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- Carcinoma, Squamous Cell pathology, Case-Control Studies, Female, Follow-Up Studies, Head and Neck Neoplasms pathology, Humans, Male, Middle Aged, Neoplasm Staging, Polymerase Chain Reaction, Prognosis, Risk Factors, Biomarkers, Tumor genetics, Carcinoma, Squamous Cell genetics, Head and Neck Neoplasms genetics, MicroRNAs genetics, Polymorphism, Single Nucleotide genetics
- Abstract
Background: MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population., Methods: In this study, we genotyped five common single-nucleotide polymorphisms (SNPs) in several key miRNAs (miR-149 rs2292832, miR-146a rs2910164, miR-605 rs2043556, miR-608 rs4919510, and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population., Results: The results revealed that miR-605 rs2043556 [dominant model: adjusted odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58-0.88; additive model: adjusted OR 0.74, 95% CI 0.62-0.89] and miR-196a2 rs11614913 (dominant model: adjusted OR 1.36, 95% CI 1.08-1.72; additive model: adjusted OR 1.28, 95% CI 1.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma (OSCC). Furthermore, when these two loci were evaluated together based on the number of putative risk alleles (rs2043556 A and rs11614913 G), a significant locus-dosage effect was noted on the risk of OSCC (P trend < 0.001). However, no significant association was detected between the other three SNPs (miR-149 rs2292832, miR-146a rs2910164, and miR-608 rs4919510) and HNSCC risk., Conclusion: Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.
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- 2016
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21. Stability SCAD: a powerful approach to detect interactions in large-scale genomic study.
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Gou J, Zhao Y, Wei Y, Wu C, Zhang R, Qiu Y, Zeng P, Tan W, Yu D, Wu T, Hu Z, Lin D, Shen H, and Chen F
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- Algorithms, Humans, Logistic Models, Lung Neoplasms genetics, Genome-Wide Association Study methods, Genomics, Polymorphism, Single Nucleotide genetics
- Abstract
Background: Evidence suggests that common complex diseases may be partially due to SNP-SNP interactions, but such detection is yet to be fully established in a high-dimensional small-sample (small-n-large-p) study. A number of penalized regression techniques are gaining popularity within the statistical community, and are now being applied to detect interactions. These techniques tend to be over-fitting, and are prone to false positives. The recently developed stability least absolute shrinkage and selection operator (SLASSO) has been used to control family-wise error rate, but often at the expense of power (and thus false negative results)., Results: Here, we propose an alternative stability selection procedure known as stability smoothly clipped absolute deviation (SSCAD). Briefly, this method applies a smoothly clipped absolute deviation (SCAD) algorithm to multiple sub-samples, and then identifies cluster ensemble of interactions across the sub-samples. The proposed method was compared with SLASSO and two kinds of traditional penalized methods by intensive simulation. The simulation revealed higher power and lower false discovery rate (FDR) with SSCAD. An analysis using the new method on the previously published GWAS of lung cancer confirmed all significant interactions identified with SLASSO, and identified two additional interactions not reported with SLASSO analysis., Conclusions: Based on the results obtained in this study, SSCAD presents to be a powerful procedure for the detection of SNP-SNP interactions in large-scale genomic data.
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- 2014
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22. Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese.
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Qian Y, Liu S, Lu F, Li H, Dong M, Lin Y, Du J, Lin Y, Gong J, Jin G, Dai J, Hu Z, and Shen H
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- Aged, Alleles, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Body Mass Index, Case-Control Studies, China, Diabetes Mellitus, Type 2 etiology, Female, Genetic Markers, Genome-Wide Association Study, Genotype, Humans, Logistic Models, Male, Middle Aged, Obesity complications, Odds Ratio, Polymorphism, Single Nucleotide, Asian People genetics, Diabetes Mellitus, Type 2 genetics, Genetic Variation, Obesity genetics, Proteins genetics
- Abstract
Background: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese., Results: Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19)., Conclusions: Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.
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- 2013
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23. Genome-wide analysis of human hotspot intersected genes highlights the roles of meiotic recombination in evolution and disease.
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Zhou T, Hu Z, Zhou Z, Guo X, and Sha J
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- Databases, Genetic, Humans, Open Reading Frames genetics, Recombination, Genetic, Biological Evolution, Genome, Human, Meiosis
- Abstract
Background: Meiotic recombination events are not randomly located, but rather cluster at hotspot regions. Recently, the fine-scale mapping of genome-wide human recombination hotspots was performed. Here, we systematically analyzed the evolutionary and disease-associated features of hotspots that overlapped with protein-coding genes., Results: In this study, we defined hotspot intersected genes as HI genes. We found that HI genes were prone to be located in the extracellular part and were functionally enriched in cell-to-cell communication. Tissue-specific genes and secreted protein encoding genes were overrepresented in HI genes, while housekeeping genes were underrepresented. Compared to slowly evolving housekeeping genes and random genes with lower recombination rates, HI genes evolved faster. The fact that brain and blood specific genes were overrepresented in HI genes indicates that they may be involved in the evolution of human intelligence and the immune system. We also found that genes related to disease were enriched in HI genes, especially genes with disease-associated chromosomal rearrangements. Hotspot sequence motifs were overrepresented in common sequences of HI genes and genes with disease-associated chromosomal rearrangements. We further listed repeat elements that were enriched both in hotspots and genes with disease-associated chromosomal rearrangements., Conclusion: HI genes are evolving and may be involved in the generation of key features of human during evolution. Disease-associated genes may be by-products of meiotic recombination. In addition, hotspot sequence motifs and repeat elements showed the connection between meiotic recombination and genes with disease-associated chromosomal rearrangements at the sequence level. Our study will enable us to better understand the evolutionary and biological significance of human meiotic recombination.
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- 2013
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24. Seroprevalence of avian influenza A (H5N1) virus among poultry workers in Jiangsu Province, China: an observational study.
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Huo X, Zu R, Qi X, Qin Y, Li L, Tang F, Hu Z, and Zhu F
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- Animal Husbandry, Animals, China epidemiology, Female, Humans, Influenza A Virus, H5N1 Subtype immunology, Interviews as Topic, Male, Middle Aged, Poultry, Seroepidemiologic Studies, Antibodies, Viral blood, Influenza A Virus, H5N1 Subtype isolation & purification, Influenza, Human epidemiology, Occupational Diseases epidemiology, Zoonoses epidemiology
- Abstract
Background: Since 2003 to 06 Jan 2012, the number of laboratory confirmed human cases of infection with avian influenza in China was 41 and 27 were fatal. However, the official estimate of the H5N1 case-fatality rate has been described by some as an over estimation since there may be numerous undetected asymptomatic/mild cases of H5N1 infection. This study was conducted to better understand the real infection rate and evaluate the potential risk factors for the zoonotic spread of H5N1 viruses to humans., Methods: A seroepidemiological survey was conducted in poultry workers, a group expected to have the highest level of exposure to H5N1-infected birds, from 3 counties with habitat lakes of wildfowl in Jiangsu province, China. Serum specimens were collected from 306 participants for H5N1 serological test. All participants were interviewed to collect information about poultry exposures., Results: The overall seropositive rate was 2.61% for H5N1 antibodies. The poultry number was found associated with a 2.39-fold significantly increased subclinical infection risk after adjusted with age and gender., Conclusions: Avian-to -human transmission of avian H5N1 virus remained low. Workers associated with raising larger poultry flocks have a higher risk on seroconversion.
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- 2012
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25. Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.
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Bai Y, Xu L, Yang X, Hu Z, Yuan J, Wang F, Shao M, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Liu Y, Jin L, Wei Q, Huang W, Shen H, Lu D, and Wu T
- Subjects
- Aged, Case-Control Studies, Humans, Lung Neoplasms epidemiology, Middle Aged, Risk Factors, Asian People genetics, DNA Repair genetics, DNA-Binding Proteins genetics, Endonucleases genetics, Genetic Variation genetics, Lung Neoplasms genetics, Nuclear Proteins genetics, Transcription Factors genetics
- Abstract
Background: The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk of cancer in XP patients, we hypothesized that inherited sequence variations in XPC may alter DNA repair and thus susceptibility to cancer., Methods: In this hospital-based case-control study, we investigated five XPC tagging, common single nucleotide polymorphisms (tagging SNPs) in 1,010 patients with newly diagnosed lung cancer and 1,011 matched cancer free controls in a Chinese population., Results: In individual tagging SNP analysis, we found that rs3731055AG+AA variant genotypes were associated with a significantly decreased risk of lung adenocarcinoma [adjusted odds ratio (OR), 0.71; 95% confidence interval (CI), 0.56-0.90] but an increased risk of small cell carcinomas [adjusted OR, 1.79; 95% CI, 1.05-3.07]. Furthermore, we found that haplotype ACCCA was associated with a decreased risk of lung adenocarcinoma [OR, 0.78; 95% CI, 0.62-0.97] but an increased risk of small cell carcinomas [OR, 1.68; 95% CI, 1.04-2.71], which reflected the presence of rs3731055A allele in this haplotype. Further stratified analysis revealed that the protective effect of rs3731055AG+AA on risk of lung adenocarcinoma was more evident among young subjects (age < or= 60) and never smokers., Conclusion: These results suggest that inherited sequence variations in XPC may modulate risk of lung cancer, especially lung adenocarcinoma, in Chinese populations. However, these findings need to be verified in larger confirmatory studies with more comprehensively selected tagging SNPs.
- Published
- 2007
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