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Your search keyword '"Dubey, Sheri A."' showing total 11 results
Start Over Author "Dubey, Sheri A." Publication Year Range Last 50 years Publisher american society for microbiology
11 results on '"Dubey, Sheri A."'

2. A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV Challenge

Author

Wang, Dai, primary, Phan, Shannon, additional, DiStefano, Daniel J., additional, Citron, Michael P., additional, Callahan, Cheryl L., additional, Indrawati, Lani, additional, Dubey, Sheri A., additional, Heidecker, Gwendolyn J., additional, Govindarajan, Dhanasekaran, additional, Liang, Xiaoping, additional, He, Biao, additional, and Espeseth, Amy S., additional

Published
2017
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4. Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge

Author

Casimiro, Danilo R., primary, Cox, Kara, additional, Tang, Aimin, additional, Sykes, Kara J., additional, Feng, Meizhen, additional, Wang, Fubao, additional, Bett, Andrew, additional, Schleif, William A., additional, Liang, Xiaoping, additional, Flynn, Jessica, additional, Tobery, Timothy W., additional, Wilson, Keith, additional, Finnefrock, Adam, additional, Huang, Lingyi, additional, Vitelli, Salvatore, additional, Lin, Jing, additional, Patel, Deepa, additional, Davies, Mary-Ellen, additional, Heidecker, Gwendolyn J., additional, Freed, Daniel C., additional, Dubey, Sheri, additional, O'Connor, David H., additional, Watkins, David I., additional, Zhang, Zhi-Qiang, additional, and Shiver, John W., additional

Published
2010
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7. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual

Author

Geels, Mark J., primary, Cornelissen, Marion, additional, Schuitemaker, Hanneke, additional, Anderson, Kiersten, additional, Kwa, David, additional, Maas, Jolanda, additional, Dekker, John T., additional, Baan, Elly, additional, Zorgdrager, Fokla, additional, van den Burg, Remco, additional, van Beelen, Martijn, additional, Lukashov, Vladimir V., additional, Fu, Tong-Ming, additional, Paxton, William A., additional, van der Hoek, Lia, additional, Dubey, Sheri A., additional, Shiver, John W., additional, and Goudsmit, Jaap, additional

Published
2003
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8. Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene

Author

Casimiro, Danilo R., primary, Chen, Ling, additional, Fu, Tong-Ming, additional, Evans, Robert K., additional, Caulfield, Michael J., additional, Davies, Mary-Ellen, additional, Tang, Aimin, additional, Chen, Minchun, additional, Huang, Lingyi, additional, Harris, Virginia, additional, Freed, Daniel C., additional, Wilson, Keith A., additional, Dubey, Sheri, additional, Zhu, De-Min, additional, Nawrocki, Denise, additional, Mach, Henryk, additional, Troutman, Robert, additional, Isopi, Lynne, additional, Williams, Donna, additional, Hurni, William, additional, Xu, Zheng, additional, Smith, Jeffrey G., additional, Wang, Su, additional, Liu, Xu, additional, Guan, Liming, additional, Long, Romnie, additional, Trigona, Wendy, additional, Heidecker, Gwendolyn J., additional, Perry, Helen C., additional, Persaud, Natasha, additional, Toner, Timothy J., additional, Su, Qin, additional, Liang, Xiaoping, additional, Youil, Rima, additional, Chastain, Michael, additional, Bett, Andrew J., additional, Volkin, David B., additional, Emini, Emilio A., additional, and Shiver, John W., additional

Published
2003
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9. Vaccine-Induced Immune Responses in Rodents and Nonhuman Primates by Use of a Humanized Human Immunodeficiency Virus Type 1 pol Gene

Author

Casimiro, Danilo R., primary, Tang, Aimin, additional, Perry, Helen C., additional, Long, Romnie S., additional, Chen, Minchun, additional, Heidecker, Gwendolyn J., additional, Davies, Mary-Ellen, additional, Freed, Daniel C., additional, Persaud, Natasha V., additional, Dubey, Sheri, additional, Smith, Jeffrey G., additional, Havlir, Diane, additional, Richman, Douglas, additional, Chastain, Michael A., additional, Simon, Adam J., additional, Fu, Tong-Ming, additional, Emini, Emilio A., additional, and Shiver, John W., additional

Published
2002
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10. Evaluation of Cytotoxic T-Lymphocyte Responses in Human and Nonhuman Primate Subjects Infected with Human Immunodeficiency Virus Type 1 or Simian/Human Immunodeficiency Virus

Author

Fu, Tong-Ming, primary, Freed, Daniel C., additional, Trigona, Wendy L., additional, Guan, Liming, additional, Zhu, Lan, additional, Long, Romnie, additional, Persaud, Natasha V., additional, Manson, Kelledy, additional, Dubey, Sheri, additional, and Shiver, John W., additional

Published
2001
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11. A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV Challenge.

Author

Dai Wang, Phan, Shannon, DiStefano, Daniel J., Citron, Michael P., Callahan, Cheryl L., Indrawati, Lani, Dubey, Sheri A., Heidecker, Gwendolyn J., Govindarajan, Dhanasekaran, Xiaoping Liang, Biao He, and Espeseth, Amy S.

Subjects
*G proteins, *CERCOPITHECUS aethiops, *GENE expression, *RESPIRATORY syncytial virus, *PARAINFLUENZA viruses
Abstract

Human respiratory syncytial virus (RSV) is a common cause of severe respiratory disease among infants, immunocompromised individuals, and the elderly. No licensed vaccine is currently available. In this study, we evaluated two parainfluenza virus 5 (PIV5)-vectored vaccines expressing RSV F (PIV5/F) or G (PIV5/G) protein in the cotton rat and African green monkey models for their replication, immunogenicity, and efficacy of protection against RSV challenge. Following a single intranasal inoculation, both animal species shed the vaccine viruses for a limited time but without noticeable clinical symptoms. In cotton rats, the vaccines elicited RSV F- or G-specific serum antibodies and conferred complete lung protection against RSV challenge at doses as low as 103 PFU. Neither vaccine produced the enhanced lung pathology observed in animals immunized with formalin-inactivated RSV. In African green monkeys, vaccine-induced serum and mucosal antibody responses were readily detected, as well. PIV5/F provided nearly complete protection against RSV infection in the upper and lower respiratory tract at a dose of 106 PFU of vaccine. At the same dose levels, PIV5/G was less efficacious. Both PIV5/F and PIV5/G were also able to boost neutralization titers in RSV-preexposed African green monkeys. Overall, our data indicated that PIV5/F is a promising RSV vaccine candidate. IMPORTANCE A safe and efficacious respiratory syncytial virus (RSV) vaccine remains elusive. We tested the recombinant parainfluenza virus 5 (PIV5) vectors expressing RSV glycoproteins for their immunogenicity and protective efficacy in cotton rats and African green monkeys, which are among the best available animal models to study RSV infection. In both species, a single dose of intranasal immunization with PIV5-vectored vaccines was able to produce systemic and local immunity and to protect animals from RSV challenge. The vaccines could also boost RSV neutralization antibody titers in African green monkeys that had been infected previously. Our data suggest that PIV5-vectored vaccines could potentially protect both the pediatric and elderly populations and support continued development of the vector platform. [ABSTRACT FROM AUTHOR]

Published
2017
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