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[Display omitted] Triple-negative breast cancer (TNBC) is insensitive to conventional therapy due to its highly invasive nature resulting in poor therapeutic outcomes. Recent studies have shown multiple genes associated with ferroptosis in TNBC, suggesting an opportunity for ferroptosis-based treatment of TNBC. However, the efficiency of present ferroptosis agents for cancer is greatly restricted due to lack of specificity and low intracellular levels of H 2 O 2 in cancer cells. Herein, we report a nano-theranostic platform consisting of gold (Au)-iron oxide (Fe 3 O 4) Janus nanoparticles (GION@RGD) that effectively enhances the tumor-specific Fenton reaction through utilization of near-infrared (NIR) lasers, resulting in the generation of substantial quantities of toxic hydroxyl radicals (•OH). Specifically, Au nanoparticles (NPs) converted NIR light energy into thermal energy, inducing generation of abundant intracellular H 2 O 2 , thereby enhancing the iron-induced Fenton reaction. The generated •OH not only lead to apoptosis of malignant tumor cells but also induce the accumulation of lipid peroxides, causing ferroptosis of tumor cells. After functionalizing with the activity-targeting ligand RGD (Arg-Gly-Asp), precise synergistic treatment of TNBC was achieved in vivo under the guidance of Fe 3 O 4 enhanced T 2 -weighted magnetic resonance imaging (MRI). This synergistic treatment strategy of NIR-enhanced ferroptosis holds promise for the treatment of TNBC. [ABSTRACT FROM AUTHOR]

The development of cobalt-based supported catalysts with high PMS catalytic activity and stability by adjusting the composition of the support is highly desirable yet remains scarce. In the work, a series of catalysts (Co 2 AlO 4 /Al 2 O 3 -xSiO 2) were prepared by impregnation and high-temperature calcination using Al 2 O 3 -xSiO 2 with a low Si–Al ratio as the support. Measurement techniques such as XRD, XPS, UV-DRS, FTIR, BET, SEM and HRTEM were used to characterize textural and chemical properties (ratio of Co3+/Co2+, specific surface area, pore size, pore volume, etc.). The ratio of Co3+/Co2+ and pore volume of Co 2 AlO 4 /Al 2 O 3 -xSiO 2 can be turned by controlling the ratio of Si to Al, which are closely related to the catalytic performance and reusability of the catalysts. The optimized catalyst (Co 2 AlO 4 /Al 2 O 3 -0.25SiO 2) can completely degrade 10 mg/L p-nitrophenol (PNP) in 40 min in the pH range of 3–9 with excellent reusability. The effects of several reaction parameters (i.e., PMS dosage, Co 2 AlO 4 /Al 2 O 3 -0.25SiO 2 dosage, reaction temperature, initial pH value, and inorganic ions) on PNP removal were comprehensively investigated. Sulfate radical (SO 4 •−) and singlet oxygen (1O 2) are making a major contribution to the degradation of PNP. Moreover, a millimeter-scale catalyst (CoSiAl-0.25/Al 2 O 3 pellet) was prepared by sol adsorption and high-temperature calcination method, which maintained high oxidation activity after treatment of 18 L wastewater (PNP of 10 mg/L) in a continuous flow process. The method is simple and easy to operate on a large scale, providing a new perspective on the design and preparation of cobalt-aluminum spinel catalysts for activated PMS. [Display omitted] • Co 2 AlO 4 /Al 2 O 3 -xSiO 2 were prepared by impregnation and calcination. • The ratio of Si–Al plays a key role in catalytic performance and reusability. • Sulfate radical (SO 4 •−) and singlet oxygen (1O 2) is the crucial reactive species. • The Co3+/Co2+ were the intrinsic active centers for PMS activation. • CoSiAl-0.25/Al 2 O 3 pellet exhibited better long-term PNP removal ability. [ABSTRACT FROM AUTHOR]