1. CAR T cells in solid tumors and metastasis: paving the way forward.
- Author
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Sirini C, De Rossi L, Moresco MA, and Casucci M
- Subjects
- Humans, Animals, Neoplasm Metastasis, T-Lymphocytes immunology, Neoplasms immunology, Neoplasms pathology, Neoplasms therapy, Immunotherapy, Adoptive methods, Tumor Microenvironment immunology, Receptors, Chimeric Antigen immunology
- Abstract
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignancies, encounters significant hurdles when applied to solid tumors. While notable responses to CAR T cells remain sporadic in these patients, challenges persist due to issues such as on-target off-tumor toxicity, difficulties in their trafficking and infiltration into the tumor, and the presence of a hostile and immunosuppressive microenvironment. This review aims to explore recent endeavors aimed at overcoming these obstacles in CAR T cell therapy for solid tumors. Specifically, we will delve into promising strategies for enhancing tumor specificity through antigen targeting, addressing tumor heterogeneity, overcoming physical barriers, and counteracting the immune-suppressive microenvironment., Competing Interests: Declarations Conflict of interest M.C. has received research support from Kite/Gilead, is a consultant of Alia Therapeutics and is an inventor on different patents on cancer immunotherapy and genetic engineering., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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