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The modalities of management by reirradiation for recurrence or a second localization of head and neck squamous cell carcinoma (HNSCC) in previously irradiated terrain is challenging due to the great heterogeneity of data in the literature, mainly retrospective data reporting non-negligible risks of serious late toxicity events. With the recent development of more precise and conformal radiotherapy techniques such as intensity modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), stereotactic radiotherapy (SBRT), the benefit-to-risk ratio of reirradiation has evolved in recent years with encouraging results, but patient selection is crucial. The aim of this review is to discuss the role of HNSCC reirradiation in terms of patient selection and external photon radiotherapy techniques for definitive tumor reirradiation and postoperative reirradiation. [ABSTRACT FROM AUTHOR]

Liver transplant recipients have an increased risk of anal squamous cell carcinoma. High-risk patient groups have been identified, especially women who have received liver transplant for more than 10 years. New screening guidelines were published in January 2024. The aim is to screen high-grade dysplastic lesions, whose treatment has been shown to reduce the occurrence of squamous cell carcinoma. A HPV16 test is suggested, followed by clinical examination and anal cytology. If cytological lesions are found, high-resolution anoscopy should be performed. Liver transplant and colo-proctology teams need to organize systematic screening. [ABSTRACT FROM AUTHOR]

XP is generally considered to be a very serious disease in the tropics due to its pronounced sensitivity to sunlight. A disabling condition, first described by Kaposi in 1870, remains very rare in black people. We report a case of squamous cell carcinoma arising from XP, which is rare in dermatological consultations in Guinea. An 11-year-old Guinean student presented with an ulcerative-crust nodule of the scalp that had been evolving for 2 months. He was from a 1st degree consanguineous marriage and had undergone unsuccessful medical and traditional consultations and treatments. Examination showed an ulcerative-crusty nodule on the left parietal area, hypo-hyperpigmented macules on the exposed areas, cheilitis and photophobia. The rest of the examination was normal. Skin histopathology confirmed squamous cell carcinoma, and the CT scan showed no metastatic lesions. Multidisciplinary management was proposed. The patient remains under medical supervision. Skin cancers occurring in XP patients can be prevented by applying photoprotection measures, and genetic counselling before consanguineous unions could also help prevention. [ABSTRACT FROM AUTHOR]

Synchronous multiple primary lung tumors are a relatively rare entity with an increasing incidence in recent years due to the development of thoracic imaging and immunohistochemical techniques. The second lesion is considered in most cases as a secondary location, which partly explains the decrease in the incidence of this entity. We report the observation of a 74-year-old patient with two synchronous primary lung tumors, an adenocarcinoma and an epidermoid carcinoma. Through this clinical observation, we highlight the difficulty of diagnosing synchronous tumors and the major interest of new imaging modalities and immunohistochemical techniques for the optimal management of these tumors. [ABSTRACT FROM AUTHOR]

Squamous cell carcinoma of the male perineum is exceptional. We report the case of a 42-year-old patient with no previous medical history, presenting with pelvic discomfort lasting for 4 months. The patient was treated for perineal abscess in a health centre in Bamako. The anatomo-pathological examination confirmed the diagnosis. Treatment depends on the stage of the lesion and its location but it is associated with a poor prognosis. Given the results achieved in patients with epidermoid cancers of the esophagus and anus, treatment was based on therapeutic protocols combining chemotherapy and radiotherapy. The purpose of this work was to report the first case in our hospital unit. [ABSTRACT FROM AUTHOR]

Clear cell squamous cell carcinoma is a poorly known, very rare, and poorly described variant of squamous cell carcinoma, with only 10 cases reported in the literature. It usually occurs in the oral cavity, with predominance of the female sex. We report the case of a 47-year-old man presenting with a rapidly growing budding mass in the base of the tongue. The diagnosis of clear cell squamous cell carcinoma was retained based on histological and immunohistochemical results. [ABSTRACT FROM AUTHOR]

Sur le plan anatomique, esthétique, fonctionnel et psychosocial ; le visage représente une composante essentielle du corps humain. Il peut être ainsi le siège de plusieurs mutilations d'origine congénitale ou acquise. Ainsi, les épithèses faciales trouvent leurs indications pour restaurer ces pertes ou absences de substance faciales, et pallier aux diverses séquelles. Récemment, les technologies numériques ont démontré une avancée considérable dans l'avenir de la réhabilitation maxillo-faciale. La technique de conception et de fabrication assistées par ordinateur (CFAO) a permis aux praticiens d'acquérir des données numériques, et d'effectuer des reconstructions tridimensionnelles, puis de matérialiser et de fabriquer l'épithèse faciale grâce à divers procédés de fabrication, par addition ou soustraction. Cet article a pour objectif de décrire, à travers un cas clinique, les étapes de réalisation d'une épithèse nasale par la CFAO, chez une patiente qui a subi une exérèse chirurgicale de la pyramide nasale suite à un carcinome épidermoïde, ainsi, les aspects cliniques et techniques sont mis en exergue, à savoir la prise d'empreinte, les matériaux utilisés, la mise en place et le maquillage, ainsi que les logiciels et les concepts utiles pour la réalisation assistée par ordinateur d'une prothèse plastique faciale de type épithèse nasale. Notre thérapeutique va mettre le point également sur l'intérêt de l'approche pluridisciplinaire en Prosthodontie Maxillo-Faciale. The face is an important part of the human body from an anatomical, functional, aesthetic and psychosocial point of view. It can be the site of several mutilations resulting from trauma, treatment of neoplasms and congenital malformations. The plastic facial prosthesis is therefore indicated to restore these facial deformities and to compensate for the various consequences. Recently, digital technologies have shown an increasing impact on the future of maxillofacial rehabilitation. Computer-aided design and manufacturing technique enabled practitioners to acquire numerical data, perform three-dimensional reconstructions, and then materialize and manufacture the facial epithesis through various manufacturing processes, by addition or subtraction. The aim of this article is to describe, through a clinical case, the steps of realization of a nasal epithesis by CAD/CAM, in a patient who underwent a surgical exeresis of the nasal pyramid following a squamous cell carcinoma. Thus, the clinical and technical aspects are highlighted, as follows, the taking of the impression, the materials used, the set-up and the make-up, as well as the software and the useful concepts for the computer-assisted realization of a facial plastic prosthesis of the nasal epithesis type. Our therapy will also focus on the interest of the multidisciplinary approach in Maxillofacial Prosthodontics. [ABSTRACT FROM AUTHOR]

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Introduction: Chronic inflammatory bowel disease (IBD) is thought to increase the risk of high-grade histological intraepithelial lesions (HGIL) and cervical cancer. The risk factors for developing these lesions are poorly understood., Materials and Methods: This is a single-center retrospective case-control study including IBD patients followed at our University Hospital Center from 2011 to 2021 who presented with HGIL or cervical cancer. Four controls were case-matched according to IBD type, age, active smoking and multiparity., Results: Eighteen cases and 72 controls were included. We found no significant differences between the 2 groups with regard to mean age at IBD diagnosis, mean duration of IBD, IBD location, history of IBD-related surgery or even association with another chronic inflammatory disease. In our study, the use of immunosuppressants/biotherapies in these patients [50% (9/18) for cases vs. 56% (40/72) for controls; P=0.9] was not a risk factor for IGRA or cervical cancer. Similarly, neither the total duration of exposure to immunosuppressants/biotherapies (9.9±8years for cases vs. 6.6±5.3years for controls; P=0.1), nor combined therapies [11% (2/18) for cases vs. 6% (4/72) for controls; P=0.3], nor azathioprine or methotrexate use [22% (4/18) for cases vs. 11% (8/72) for controls; P=0.3] were found to be risk factors., Conclusion: In our study, we found no risk factors for patients with IBD to develop IGRA or cervical cancer., (Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)

Despite an increase in life expectancy and quality of life for patients suffering from severe forms of hereditary epidermolysis bullosa, the occurrence of one or more cutaneous squamous cell carcinomas remains a sometimes serious complication, sometimes life-threatening as early as adolescence. These carcinomas occur preferably on chronic wounds or dystrophic scars in areas not exposed to the sun, and are generally multifocal and recurrent. Their clinical and histological diagnosis is difficult. Regular medical and paramedical monitoring of the skin during dressing repairs enables early detection and rapid, curative surgical management. The pathophysiology of these cutaneous carcinomas is the subject of research aimed at proposing non-surgical alternatives to the patients concerned., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)

Introduction: The study aimed to describe clinical indications for eye enucleation and exenteration, the occurrence of complications and long-term outcome in cattle, and examine owners' attitude towards enucleation and exenteration and their satisfaction with the surgical outcome. Medical records from the two veterinary teaching hospitals in Switzerland were reviewed to identify cattle that underwent unilateral enucleation or exenteration between January 2013 and December 2020. Data extracted included medical history, ocular examination, clinical diagnosis, surgical procedure including anesthesia, suture material and pattern used, complications, and treatment thereof. Long-term follow-up was evaluated via national animal database inquiries to determine survival time and via owners' interviews with the use of a standardized questionnaire that included questions regarding the occurrence of complications and reason for culling, production performances and perceived quality of life after surgery, concerns, factors affecting the decision to proceed with surgery, and general satisfaction with the outcome. Descriptive statistics, Fisher's exact tests and unpaired t-test were used to summarize the data and assess association between variables. Association was considered significant if p < 0,05. Thirty-eight cases were identified, with a median age of 5 years. More than half of the cases (55,3 %) were diagnosed with non-neoplastic ocular lesions represented by severe trauma with loss of globe content, globe rupture with history of infectious keratoconjunctivitis or hypopyon, or congenital malformations. The remaining cases were diagnosed with neoplastic lesions, including ocular squamous cell carcinoma (OSCC), melanoma, or sarcoma. Complications following surgery were reported in 29 % of cases and included postoperative infection and recurrence of OSCC. There was no significant association between ocular diagnosis and the occurrence of postoperative complications or survival time. Surgery did not seem to influence the animals' postoperative production performance or the perceived quality of life. Most owners (92 %) were satisfied with the surgical outcome. The occurrence of postoperative complications leading to increased overall costs and culling was the main reason for lower owner satisfaction.

The face is an important part of the human body from an anatomical, functional, aesthetic and psychosocial point of view. It can be the site of several mutilations resulting from trauma, treatment of neoplasms and congenital malformations. The plastic facial prosthesis is therefore indicated to restore these facial deformities and to compensate for the various consequences. Recently, digital technologies have shown an increasing impact on the future of maxillofacial rehabilitation. Computer-aided design and manufacturing technique enabled practitioners to acquire numerical data, perform three-dimensional reconstructions, and then materialize and manufacture the facial epithesis through various manufacturing processes, by addition or subtraction. The aim of this article is to describe, through a clinical case, the steps of realization of a nasal epithesis by CAD/CAM, in a patient who underwent a surgical exeresis of the nasal pyramid following a squamous cell carcinoma. Thus, the clinical and technical aspects are highlighted, as follows, the taking of the impression, the materials used, the set-up and the make-up, as well as the software and the useful concepts for the computer-assisted realization of a facial plastic prosthesis of the nasal epithesis type. Our therapy will also focus on the interest of the multidisciplinary approach in Maxillofacial Prosthodontics., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)

Vulvar squamous cell carcinoma arises from precursor lesions: vulvar intraepithelial neoplasias (VIN). Most of them are caused by the human papillomavirus (HPV), and the precursor lesion for this group is VIN usual type/high grade squamous intraepithelial lesion (uVIN/HSIL) of variable clinical presentation and having a light invasive potential. Some VIN are HPV-independent and arise in older women against the background of chronic dermatoses, mostly lichen sclerosus. Their histological diagnosis is more subtle. They have a higher invasive potential. A third precursor, leading to well-differentiated, or even verrucous, carcinomas, is still ill-defined to this day. We detail these lesions' clinics, histology, and biomarkers (immunohistochemical and molecular)., (Copyright © 2021. Published by Elsevier Masson SAS.)

The penile carcinoma is rare, but many items playing a role are complex and it is important to know as well the anatomy, but also the carcinogenesis for a perfect patient's management., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

The management of a penile carcinoma is complex, a collaboration between radiologist, pathologist and urologist is necessary to obtain a correct staging. In this review we try to demonstrate step by step how to achieve a complete pathology report, how to manage the patient (imaging, biopsy, fresh frozen section and surgery)., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

The most frequent cancer of the penis is the squamous cell carcinoma. Several variants of squamous cell carcinoma exist. It is important to make a difference between squamous cell carcinomas with and without a HPV infection. Furthermore, it is extremely important to recognize the different variants as their prognosis differs. These tumors are rare therefore classifying them can be challenging. This review is supposed to give an overview on the existing entities since 2016, but also allows a glimpse into the future with some comments on the upcoming WHO classification 2021., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)