7 results on '"adaptation and evolution"'
Search Results
2. Significant impact of redox regulation of estrogen‐metabolizing proteins on cellular stress responses.
- Author
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Maiti, Smarajit, Nazmeen, Aarifa, and Banerjee, Amrita
- Subjects
- *
HEAT shock proteins , *SULFOTRANSFERASES , *SULFATASES , *OXIDATION-reduction reaction , *CATALYTIC domains - Abstract
The ultimate driving force, stress, promotes adaptability/evolution in proliferating organisms, transforming tumorigenic growth. Estradiol (E2) regulates both phenomena. In this study, bioinformatics‐tools, site‐directed‐mutagenesis (human estrogen‐sulfotransferase/hSULT1E1), HepG2 cells tested with N‐acetyl‐cysteine (NAC/thiol‐inducer) or buthionine‐sulfoxamine (BSO/thiol‐depletory) were evaluated for hSULT1E1 (estradiol‐sulphating/inactivating) functions. Reciprocal redox regulation of steroid sulfatase (STS, E2‐desulfating/activating) results in the Cys‐formylglycine transition by the formylglycine‐forming enzyme (FGE). The enzyme sequences and structures were examined across the phylogeny. Motif/domain and the catalytic conserve sequences and protein‐surface‐topography (CASTp) were investigated. The E2 binding to SULT1E1 suggests that the conserved‐catalytic‐domain in this enzyme has critical Cysteine 83 at position. This is strongly supported by site‐directed mutagenesis/HepG2‐cell research. Molecular‐docking and superimposition studies of E2 with the SULT1E1 of representative species and to STS reinforce this hypothesis. SULT1E1‐STS are reciprocally activated in response to the cellular‐redox‐environment by the critical Cys of these two enzymes. The importance of E2 in organism/species proliferation and tissue tumorigenesis is highlighted. Significance statement: 1.Stress, the ultimate driving‐force promotes adaptability and evolution in proliferating‐organisms, transforming tumorigenic growth via Estradiol (E2) signaling.2.In this study, bioinformatics‐tools, site‐directed‐mutagenesis (of human estrogen sulfotransferase; hSULT1E1), HepG2 cells (treated with N‐acetyl‐cysteine; NAC, a thiol‐inducer) or buthionine‐sulfoxamine, BSO, a thiol‐depletor) were evaluated for hSULT1E1 (estradiol‐sulphating/inactivating) functions.3.Reciprocal redox‐regulation of steroid sulfatase (STs, E2‐desulfating, and activating) results Cys‐ formylglycine transition by formylglycine‐forming enzyme (FGE).4.Critical Cys83 (in SULT1E1) and the Cys‐formylglycine (in STS) transitions reciprocally activate SULT1E1‐STS in response to the cellular‐redox environment.5.The importance of E2 in organism/species proliferation and tissue tumorigenesis is highlighted. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria.
- Author
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Mendoza, Remilyn M., Kim, Sang Hoon, Vasquez, Robie, Hwang, In-Chan, Park, Young-Seo, Paik, Hyun-Dong, Moon, Gi-Seong, and Kang, Dae-Kyung
- Abstract
Due to their numerous well-established applications in the food industry, there have been many studies regarding the adaptation and evolution of lactic acid bacteria (LAB) in a wide variety of hosts and environments. Progress in sequencing technology and continual decreases in its costs have led to the availability of LAB genome sequence data. Bioinformatics has been central to the extraction of valuable information from these raw genome sequence data. This paper presents the roles of bioinformatics tools and databases in understanding the adaptation and evolution of LAB, as well as the bioinformatics methods used in the initial screening of LAB for probiotic potential. Moreover, the advantages, challenges, and limitations of employing bioinformatics for these purposes are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Editorial: Deep-sea chemosynthetic ecosystems: Living in extreme environments
- Author
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Hao Chen, Chaolun Li, Jian-Wen Qiu, Raul Bettencourt, Dong Feng, Yong Wang, Hongmei Jing, and Jin Sun
- Subjects
deep-sea ecosystem ,adaptation and evolution ,chemosynthetic symbiosis ,biodiversity and biogeochemistry ,methane oxidation ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Published
- 2023
- Full Text
- View/download PDF
5. The Competitions, Negotiations, and Collaborations of Regional Integration: A Perspective on Sustainable Management of Water Resources in Pingtung Plain, Taiwan
- Author
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Shuchen Tsai, Suhsin Lee, Zhe Zou, and Tajen Chu
- Subjects
Renewable Energy, Sustainability and the Environment ,Geography, Planning and Development ,sustainability ,regional integration ,heterogeneity ,adaptation and evolution ,Management, Monitoring, Policy and Law - Abstract
A consultative and cooperative perspective on water management is vital in regional sustainability. However, previous approaches often failed to consider the complex trade-offs involved in water resource allocation. This study explores theoretical perspectives on regional integration as a policy goal through the process of water allocation. The main purpose is to explain new areas created by allocation and regional integration with local-scale cases. The connections between post-structuralism, fragmentation, and heterogeneity are explored with five case studies of groundwater zoning: a Xinyuan buried pipe compensation, a Ligang well closure and power shutdown, a Dachaozhou artificial lake, a Wandan hold back well, and a Meinong anti-deep-water wells. Along with the case studies, secondary literature, interviews, and a field investigation were used. The time span of water conflicts was from 1973 to 2019, and the spatial scope is the groundwater distribution area. The study found that regional integration and dynamic balance are each other’s subject and object, which was empirically verified through the water conflicts in agriculture and the semiconductor industry. Regional integration comes through scaled and flexible methods of operation, and is produced through special market agents and post-structural spaces. In the process, the imbalance caused by conflict must also be adjusted and evolved through cooperation, competition, and negotiation to maintain the dynamic balance. This involves internal treatment of the local government, external integration of the central government, and technological evolution within the organization. Accordingly, several suggestions are proposed that may be helpful for sustainable water resource governance. In summary, this study makes up for the shortcomings of water management patterns constructed by simple spatial overlaying of regional integration. Our findings could effectively enhance negotiations and collaboration in water management for regional sustainability.
- Published
- 2022
- Full Text
- View/download PDF
6. Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria.
- Author
-
Mendoza RM, Kim SH, Vasquez R, Hwang IC, Park YS, Paik HD, Moon GS, and Kang DK
- Abstract
Due to their numerous well-established applications in the food industry, there have been many studies regarding the adaptation and evolution of lactic acid bacteria (LAB) in a wide variety of hosts and environments. Progress in sequencing technology and continual decreases in its costs have led to the availability of LAB genome sequence data. Bioinformatics has been central to the extraction of valuable information from these raw genome sequence data. This paper presents the roles of bioinformatics tools and databases in understanding the adaptation and evolution of LAB, as well as the bioinformatics methods used in the initial screening of LAB for probiotic potential. Moreover, the advantages, challenges, and limitations of employing bioinformatics for these purposes are discussed., Competing Interests: Conflict of interestThe authors declare no conflict of interest., (© The Korean Society of Food Science and Technology 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
- Published
- 2022
- Full Text
- View/download PDF
7. The Competitions, Negotiations, and Collaborations of Regional Integration: A Perspective on Sustainable Management of Water Resources in Pingtung Plain, Taiwan.
- Author
-
Tsai, Shuchen, Lee, Suhsin, Zou, Zhe, and Chu, Tajen
- Abstract
A consultative and cooperative perspective on water management is vital in regional sustainability. However, previous approaches often failed to consider the complex trade-offs involved in water resource allocation. This study explores theoretical perspectives on regional integration as a policy goal through the process of water allocation. The main purpose is to explain new areas created by allocation and regional integration with local-scale cases. The connections between post-structuralism, fragmentation, and heterogeneity are explored with five case studies of groundwater zoning: a Xinyuan buried pipe compensation, a Ligang well closure and power shutdown, a Dachaozhou artificial lake, a Wandan hold back well, and a Meinong anti-deep-water wells. Along with the case studies, secondary literature, interviews, and a field investigation were used. The time span of water conflicts was from 1973 to 2019, and the spatial scope is the groundwater distribution area. The study found that regional integration and dynamic balance are each other's subject and object, which was empirically verified through the water conflicts in agriculture and the semiconductor industry. Regional integration comes through scaled and flexible methods of operation, and is produced through special market agents and post-structural spaces. In the process, the imbalance caused by conflict must also be adjusted and evolved through cooperation, competition, and negotiation to maintain the dynamic balance. This involves internal treatment of the local government, external integration of the central government, and technological evolution within the organization. Accordingly, several suggestions are proposed that may be helpful for sustainable water resource governance. In summary, this study makes up for the shortcomings of water management patterns constructed by simple spatial overlaying of regional integration. Our findings could effectively enhance negotiations and collaboration in water management for regional sustainability. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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