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1. Optimizing Management of Stable Angina: A Patient-Centered Approach Integrating Revascularization, Medical Therapy, and Lifestyle Interventions

Author

Montone, Rocco A., Rinaldi, Riccardo, Niccoli, Giampaolo, Andò, Giuseppe, Gragnano, Felice, Piccolo, Raffaele, Pelliccia, Francesco, Moscarella, Elisabetta, Zimarino, Marco, Fabris, Enrico, de Rosa, Salvatore, Calabrò, Paolo, Porto, Italo, Burzotta, Francesco, Grigioni, Francesco, Barbato, Emanuele, Chieffo, Alaide, Capodanno, Davide, Al-Lamee, Rasha, Ford, Tom J., Brugaletta, Salvatore, Indolfi, Ciro, Sinagra, Gianfranco, Perrone Filardi, Pasquale, and Crea, Filippo

Published
2024
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2. Red blood cell transfusion and mortality after transcatheter aortic valve implantation via transapical approach: A propensity-matched comparison from the TRITAVI registry

Author

Radico, Francesco, Biancari, Fausto, D’Ascenzo, Fabrizio, Saia, Francesco, Luzi, Giampaolo, Bedogni, Francesco, Amat-Santos, Ignacio J., De Marzo, Vincenzo, Dimagli, Arnaldo, Mäkikallio, Timo, Stabile, Eugenio, Blasco-Turrión, Sara, Testa, Luca, Barbanti, Marco, Tamburino, Corrado, Porto, Italo, Fabiocchi, Franco, Conrotto, Federico, Pelliccia, Francesco, Costa, Giuliano, Stefanini, Giulio G., Macchione, Andrea, La Torre, Michele, Bendandi, Francesco, Juvonen, Tatu, Pasceri, Vincenzo, Wańha, Wojciech, Benedetto, Umberto, Miraldi, Fabio, Dobrev, Dobromir, and Zimarino, Marco

Published
2024
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3. Management of high and intermediate-high risk pulmonary embolism: A position paper of the Interventional Cardiology Working Group of the Italian Society of Cardiology

Author

Andò, Giuseppe, Pelliccia, Francesco, Saia, Francesco, Tarantini, Giuseppe, Fraccaro, Chiara, D'Ascenzo, Fabrizio, Zimarino, Marco, Di Marino, Mario, Niccoli, Giampaolo, Porto, Italo, Calabrò, Paolo, Gragnano, Felice, De Rosa, Salvatore, Piccolo, Raffaele, Moscarella, Elisabetta, Fabris, Enrico, Montone, Rocco Antonio, Spaccarotella, Carmen, Indolfi, Ciro, Sinagra, Gianfranco, and Perrone Filardi, Pasquale

Published
2024
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5. Reproducibility of an artificial intelligence optical coherence tomography software for tissue characterization: Implications for the design of longitudinal studies

Author

Garg, Mohil, Garcia-Garcia, Hector M., Calderón, Andrea Teira, Gupta, Jaytin, Sortur, Shrayus, Levine, Molly B., Singla, Puneet, Picchi, Andrea, Sardella, Gennaro, Adamo, Marianna, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro, Paolo, Andò, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Sánchez, Jorge Sanz, and Valgimigli, Marco

Published
2024
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7. Autologous hGMSC-Derived iPS: A New Proposal for Tissue Regeneration.

Author

Della Rocca, Ylenia, Diomede, Francesca, Konstantinidou, Fanì, Gatta, Valentina, Stuppia, Liborio, Benedetto, Umberto, Zimarino, Marco, Lanuti, Paola, Trubiani, Oriana, and Pizzicannella, Jacopo

Subjects
INDUCED pluripotent stem cells, MESENCHYMAL stem cells, EPIBLAST, REGENERATIVE medicine, EXTRACELLULAR vesicles
Abstract

The high mortality in the global population due to chronic diseases highlights the urgency to identify effective alternative therapies. Regenerative medicine provides promising new approaches for this purpose, particularly in the use of induced pluripotent stem cells (iPSCs). The aim of the work is to establish a new pluripotency cell line obtained for the first time by reprogramming human gingival mesenchymal stem cells (hGMSCs) by a non-integrating method. The hGMSC-derived iPS line characterization is performed through morphological analysis with optical and electron scanning microscopy and through the pluripotency markers expression evaluation in cytofluorimetry, immunofluorescence, and RT-PCR. To confirm the pluripotency of new hGMSC-derived iPS, the formation of embryoid bodies (EBs), as an alternative to the teratoma formation test, is studied in morphological analysis and through three germ layers' markers' expression in immunofluorescence and RT-PCR. At the end, a comparative study between parental hGMSCs and derived iPS cells is performed also for the extracellular vesicles (EVs) and their miRNA content. The new hGMSC-derived iPS line demonstrated to be pluripotent in all aspects, thus representing an innovative dynamic platform for personalized tissue regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Management of Myocardial Revascularization in Patients With Stable Coronary Artery Disease Undergoing Transcatheter Aortic Valve Implantation

Author

Costa, Giuliano, Pilgrim, Thomas, Amat Santos, Ignacio J., De Backer, Ole, Kim, Won-Keun, Barbosa Ribeiro, Henrique, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Ribichini, Flavio Luciano, Mylotte, Dzxcfewarren, Burzotta, Francesco, Watanabe, Yusuke, De Marco, Federico, Tesorio, Tullio, Rheude, Tobias, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro Santo, Mach, Markus, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Joner, Michael, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Kargoli, Faraj, Tamburino, Corrado, and Barbanti, Marco

Published
2022
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13. Red Blood Cell Transfusion Strategies in Cardiovascular Interventions.

Author

Foglietta, Melissa, Bacigalupi, Elena, Radico, Francesco, Pizzicannella, Jacopo, Appignani, Marianna, De Donno, Federica, Di Gregorio, Patrizia, Pelliccia, Francesco, and Zimarino, Marco

Abstract

Acute coronary syndrome, cardiac surgery, and cardiac structural interventions are among the most common situations leading to allogeneic red blood cell consumption due to the prevalence of bleeding and anemia. The wide variability in the use of transfusions derives from the current lack of data, and the absence of strong evidence and clear guideline recommendations. The current approach is to avoid unnecessary blood transfusions and limit their use to life-saving conditions; this conservative strategy derives from often controversial and inconclusive results of observational and randomized studies where liberal and restricted red blood transfusion strategies seemed to have similar outcomes. The pivotal question for future research lies in elucidating whether blood transfusions function as an active participant or merely a catalyst in amplifying adverse events. The present review aims to summarize the current literature data and critically analyze the available evidence for red blood transfusions in cardiac interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Revisiting Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Current Practice and Novel Perspectives

Author

Ottaviani, Andrea, primary, Mansour, Davide, additional, Molinari, Lorenzo V., additional, Galanti, Kristian, additional, Mantini, Cesare, additional, Khanji, Mohammed Y., additional, Chahal, Anwar A., additional, Zimarino, Marco, additional, Renda, Giulia, additional, Sciarra, Luigi, additional, Pelliccia, Francesco, additional, Gallina, Sabina, additional, and Ricci, Fabrizio, additional

Published
2023
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19. Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Author

Rheude, Tobias, primary, Costa, Giuliano, additional, Ribichini, Flavio Luciano, additional, Pilgrim, Thomas, additional, Amat Santos, Ignacio J., additional, De Backer, Ole, additional, Kim, Won‐Keun, additional, Ribeiro, Henrique Barbosa, additional, Saia, Francesco, additional, Bunc, Matjaz, additional, Tchétché, Didier, additional, Garot, Philippe, additional, Mylotte, Darren, additional, Burzotta, Francesco, additional, Watanabe, Yusuke, additional, Bedogni, Francesco, additional, Tesorio, Tullio, additional, Tocci, Marco, additional, Franzone, Anna, additional, Valvo, Roberto, additional, Savontaus, Mikko, additional, Wienemann, Hendrik, additional, Porto, Italo, additional, Gandolfo, Caterina, additional, Iadanza, Alessandro, additional, Bortone, Alessandro S., additional, Mach, Markus, additional, Latib, Azeem, additional, Biasco, Luigi, additional, Taramasso, Maurizio, additional, Zimarino, Marco, additional, Tomii, Daijiro, additional, Nuyens, Philippe, additional, Sondergaard, Lars, additional, Camara, Sergio F., additional, Palmerini, Tullio, additional, Orzalkiewicz, Mateusz, additional, Steblovnik, Klemen, additional, Degrelle, Bastien, additional, Gautier, Alexandre, additional, Del Sole, Paolo Alberto, additional, Mainardi, Andrea, additional, Pighi, Michele, additional, Lunardi, Mattia, additional, Kawashima, Hideyuki, additional, Criscione, Enrico, additional, Cesario, Vincenzo, additional, Biancari, Fausto, additional, Zanin, Federico, additional, Esposito, Giovanni, additional, Adam, Matti, additional, Grube, Eberhard, additional, Baldus, Stephan, additional, De Marzo, Vincenzo, additional, Piredda, Elisa, additional, Cannata, Stefano, additional, Iacovelli, Fortunato, additional, Andreas, Martin, additional, Frittitta, Valentina, additional, Dipietro, Elena, additional, Reddavid, Claudia, additional, Strazzieri, Orazio, additional, Motta, Silvia, additional, Angellotti, Domenico, additional, Sgroi, Carmelo, additional, Xhepa, Erion, additional, Kargoli, Faraj, additional, Tamburino, Corrado, additional, Joner, Michael, additional, and Barbanti, Marco, additional

Published
2023
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21. Reproducibility of an Artificial Intelligence Optical Coherence Tomography Software for Tissue Characterization: Implications for the Design of Longitudinal Studies

Author

Garg, Mohil, primary, Garcia-Garcia, Hector M., additional, Calderón, Andrea Teira, additional, Gupta, Jaytin, additional, Sortur, Shrayus, additional, Levine, Molly B., additional, Picchi, Andrea, additional, Sardella, Gennaro, additional, Adamo, Marianna, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabro, Paolo, additional, Andò, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Sánchez, Jorge Sanz, additional, and Valgimigli, Marco, additional

Published
2023
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22. Diagnostic and Prognostic Value of Stress Cardiovascular Magnetic Resonance Imaging in Patients With Known or Suspected Coronary Artery Disease

Author

Ricci, Fabrizio, primary, Khanji, Mohammed Y., additional, Bisaccia, Giandomenico, additional, Cipriani, Alberto, additional, Di Cesare, Annamaria, additional, Ceriello, Laura, additional, Mantini, Cesare, additional, Zimarino, Marco, additional, Fedorowski, Artur, additional, Gallina, Sabina, additional, Petersen, Steffen E., additional, and Bucciarelli-Ducci, Chiara, additional

Published
2023
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23. Pathophysiology and Treatment of the No-Reflow Phenomenon in ST-Segment Elevation Myocardial Infarction: Focus on Low-Dose Fibrinolysis during Primary Percutaneous Intervention.

Author

Pelliccia, Francesco, Niccoli, Giampaolo, Zimarino, Marco, Andò, Giuseppe, Porto, Italo, Calabrò, Paolo, De Rosa, Salvatore, Gragnano, Felice, Piccolo, Raffaele, Moscarella, Elisabetta, Fabris, Enrico, Montone, Rocco Antonio, Spaccarotella, Carmen, Indolfi, Ciro, Sinagra, Gianfranco, and Perrone Filardi, Pasquale

Abstract

Primary percutaneous coronary intervention (PCI) is the current class I therapeutic approach to treat acute ST-elevation myocardial infarction (STEMI). While primary PCI can restore adequate flow in the infarcted artery in the majority of cases, some patients experience the 'no-reflow' phenomenon, i.e., an abnormal myocardial reperfusion occurring even after the occluded coronary artery has been opened. No-reflow occurs when microvascular obstruction arises from embolization of thrombus or components of the atheromatous plaques. These embolic materials travel downstream within the infarct-related artery at time of primary PCI, leading to compromised blood flow. Currently, no expert consensus documents exist to outline an optimal strategy to prevent or treat no-reflow. Interventional cardiologists frequently employ intracoronary adenosine, calcium channel blockers, nicorandil, nitroprusside or glycoprotein IIb/IIIa inhibitors. However, evidence suggests that these interventions consistently enhance myocardial blood flow in only a specific subset of patients experiencing no-reflow. A recent and innovative therapeutic approach gaining attention is low-dose fibrinolysis during primary PCI, which offers the potential to augment coronary flow post-myocardial revascularization. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Lipid-lowering therapy in patients with coronary artery disease undergoing percutaneous coronary interventions in Italy: an expert opinion paper of Interventional Cardiology Working Group of Italian Society of Cardiology

Author

Calabro', Paolo, Spaccarotella, Carmen, Cesaro, Arturo, Andò, Giuseppe, Piccolo, Raffaele, De Rosa, Salvatore, Zimarino, Marco, Mancone, Massimo, Gragnano, Felice, Moscarella, Elisabetta, Muscoli, Saverio, Romeo, Francesco, Barillà, Francesco, Filardi, Pasquale Perrone, Indolfi, Ciro, Niccoli, Giampaolo, Calabrò, Paolo, Spaccarotella, Carmen, Cesaro, Arturo, Andò, Giuseppe, Piccolo, Raffaele, De Rosa, Salvatore, Zimarino, Marco, Mancone, Massimo, Gragnano, Felice, Moscarella, Elisabetta, Muscoli, Saverio, Romeo, Francesco, Barillà, Francesco, Filardi, Pasquale Perrone, Indolfi, Ciro, Niccoli, Giampaolo, and Calabro', Paolo

Subjects
chronic coronary syndrome, low-density lipoprotein cholesterol, lipid-lowering therapy, dyslipidemia, percutaneous coronary intervention, General Medicine, Cardiology and Cardiovascular Medicine, acute coronary syndrome
Abstract

After percutaneous coronary interventions (PCIs), patients remain at high risk of developing recurrent cardiovascular events. Despite advances in interventional cardiology, the correct management of residual low-density lipoprotein cholesterol (LDL-C) risk continues to be crucial for improving long-term outcomes after PCI. However, several observational studies have demonstrated suboptimal LDL-C control, poor adherence to statin therapy, and underutilization of high-intensity statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors in real-world clinical practice despite a strong endorsement from international guidelines. Recent studies have shown that early intensive lipid-lowering therapy stabilizes atheromatous plaque and increases fibrous cap thickness in patients with acute coronary syndrome. This finding emphasizes the importance of achieving therapeutic targets by establishing an effective treatment as early as possible. The aim of this expert opinion paper of the Interventional Cardiology Working Group of the Italian Society of Cardiology is to discuss the management of lipid-lowering therapy in patients undergoing PCIs according to Italian reimbursement policies and regulations, with a particular focus on the discharge phase.

Published
2023

25. Lipid-lowering therapy in patients with coronary artery disease undergoing percutaneous coronary interventions in Italy: an expert opinion paper of Interventional Cardiology Working Group of Italian Society of Cardiology

Author

Calabrò, Paolo, primary, Spaccarotella, Carmen, additional, Cesaro, Arturo, additional, Andò, Giuseppe, additional, Piccolo, Raffaele, additional, De Rosa, Salvatore, additional, Zimarino, Marco, additional, Mancone, Massimo, additional, Gragnano, Felice, additional, Moscarella, Elisabetta, additional, Muscoli, Saverio, additional, Romeo, Francesco, additional, Barillà, Francesco, additional, Filardi, Pasquale Perrone, additional, Indolfi, Ciro, additional, and Niccoli, Giampaolo, additional

Published
2023
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26. Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Author

Rheude, Tobia, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thoma, Amat Santos, Ignacio J, De Backer, Ole, Kim, Won-Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S, Mach, Marku, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lar, Camara, Sergio F, Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, Barbanti, Marco, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Porto, Italo (ORCID:0000-0002-9854-5046), Rheude, Tobia, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thoma, Amat Santos, Ignacio J, De Backer, Ole, Kim, Won-Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S, Mach, Marku, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lar, Camara, Sergio F, Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, Barbanti, Marco, Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Porto, Italo (ORCID:0000-0002-9854-5046)

Abstract

Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

Published
2023

27. Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Author

Rheude, Tobias, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thomas, Amat-Santos, Ignacio J., De Backer, Ole, Kim, Won Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchétché, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S., Mach, Markus, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, Barbanti, Marco, Rheude, Tobias, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thomas, Amat-Santos, Ignacio J., De Backer, Ole, Kim, Won Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchétché, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S., Mach, Markus, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, and Barbanti, Marco

Abstract

Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI., Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

Published
2023

29. CRT-600.1 Reproducibility of an Artificial Intelligence Optical Coherence Tomography Software for Tissue Characterization: Implications for the Design of Longitudinal Studies

Author

Garg, Mohil, primary, Garcia-Garcia, Hector M., additional, Calderón, Andrea Teira, additional, Gupta, Jaytin, additional, Sortur, Shrayus, additional, Levine, Molly B., additional, Picchi, Andrea, additional, Sardella, Gennaro, additional, Adamo, Marianna, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabro, Paolo, additional, Andò, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Sánchez, Jorge Sanz, additional, and Valgimigli, Marco, additional

Published
2023
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30. 1062 DIAGNOSTIC AND PROGNOSTIC VALUE OF STRESS CMR IMAGING TO EVALUATE STABLE CHEST PAIN: A TWENTY-YEAR META-ANALYSIS

Author

Ricci, Fabrizio, primary, Khanji, Mohammed Yunus, additional, Bisaccia, Giandomenico, additional, Cipriani, Alberto, additional, Cesare, Annamaria Di, additional, Ceriello, Laura, additional, Mantini, Cesare, additional, Zimarino, Marco, additional, Fedorowski, Artur, additional, Gallina, Sabina, additional, Petersen, Steffen, additional, and Bucciarelli-ducci, Chiara, additional

Published
2022
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31. Reproducibility of an artificial intelligence optical coherence tomography software for tissue characterization: Implications for the design of longitudinal studies

Author

Garg, Mohil, Garcia-Garcia, Hector M, Calderón, Andrea Teira, Gupta, Jaytin, Sortur, Shrayus, Levine, Molly B, Singla, Puneet, Picchi, Andrea, Sardella, Gennaro, Adamo, Marianna, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro, Paolo, Andò, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Sánchez, Jorge Sanz, and Valgimigli, Marco

Subjects
610 Medicine & health
Abstract

BACKGROUND To assess the reproducibility of coronary tissue characterization by an Artificial Intelligence Optical Coherence Tomography software (OctPlus, Shanghai Pulse Medical Imaging Technology Inc.). METHODS 74 patients presenting with multivessel ST-segment elevation myocardial infarction (STEMI) underwent optical coherence tomography (OCT) of the infarct-related artery at the end of primary percutaneous coronary intervention (PPCI) and during staged PCI (SPCI) within 7 days thereafter in the MATRIX (Minimizing Adverse Hemorrhagic Events by Transradial Access Site and angioX) Treatment-Duration study (ClinicalTrials.gov, NCT01433627). OCT films were run through the OctPlus software. The same region of interest between either side of the stent and the first branch was identified on OCT films for each patient at PPCI and SPCI, thus generating 94 pairs of segments. 42 pairs of segments were re-analyzed for intra-software difference. Five plaque characteristics including cholesterol crystal, fibrous tissue, calcium, lipid, and macrophage content were analyzed for various parameters (span angle, thickness, and area). RESULTS There was no statistically significant inter-catheter (between PPCI and SPCI) or intra-software difference in the mean values of all the parameters. Inter-catheter correlation for area was best seen for calcification [intraclass correlation coefficient (ICC) 0.86], followed by fibrous tissue (ICC 0.87), lipid (ICC 0.62), and macrophage (ICC 0.43). Some of the inter-catheter relative differences for area measurements were large: calcification 9.75 %; cholesterol crystal 74.10 %; fibrous tissue 5.90 %; lipid 4.66 %; and macrophage 1.23 %. By the intra-software measurements, there was an excellent correlation (ICC > 0.9) for all tissue types. The relative differences for area measurements were: calcification 0.64 %; cholesterol crystal 5.34 %; fibrous tissue 0.19 %; lipid 1.07 %; and macrophage 0.60 %. Features of vulnerable plaque, minimum fibrous cap thickness and lipid area showed acceptable reproducibility. CONCLUSION The present study demonstrates an overall good reproducibility of tissue characterization by the Artificial Intelligence Optical Coherence Tomography software. In future longitudinal studies, investigators may use discretion in selecting the imaging endpoints and sample size, accounting for the observed relative differences in this study.

Published
2023
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34. Urine alkalinisation to prevent contrast-induced acute kidney injury: the prospective, randomised, controlled, open-label TEATE trial

Author

Lombardi, Marco, primary, Molisana, Michela, additional, Genovesi, Eugenio, additional, De Innocentiis, Carlo, additional, Limbruno, Ugo, additional, Misuraca, Leonardo, additional, Moretti †, Luciano, additional, Di Vito, Luca, additional, Renda, Giulia, additional, Zimarino, Marco, additional, Di Nicola, Marta, additional, and De Caterina, Raffaele, additional

Published
2022
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36. Are we ready to withdraw acetylsalicylic acid after complex percutaneous coronary intervention?

Author

Bufano, Gabriella and Zimarino, Marco

Subjects
clopidogrel, Aspirin, Dual Anti-Platelet Therapy, Hemorrhage, General Medicine, Clinical Cardiology, Editorial, Treatment Outcome, Percutaneous Coronary Intervention, high-risk, Purinergic P2Y Receptor Antagonists, Humans, Drug Therapy, Combination, Original Article, cardiovascular diseases, Cardiology and Cardiovascular Medicine, Platelet Aggregation Inhibitors
Abstract

Background It remains unclear whether P2Y12 monotherapy, especially clopidogrel, following short-duration dual antiplatelet therapy (DAPT) is associated with favorable outcomes in patients undergoing complex percutaneous coronary intervention (PCI). Therefore, this study analyzed the efficacy and safety of P2Y12 inhibitor monotherapy, mostly clopidogrel (78%), in complex PCI following short-term DAPT. Methods The post-hoc analysis of the SMART-CHOICE trial involving 2,993 patients included 498 cases of complex PCIs, defined by at least one of the following features: 3 vessels treated, ≥ 3 stents implanted, ≥ 3 lesions treated, bifurcation with ≥ 2 stents implanted, and a total stent length of ≥ 60 mm. The primary endpoint was major adverse cardiac and cerebrovascular event (MACCE), defined as the composite of all-cause death, myocardial infarction, and stroke. The primary safety endpoint included bleeding, defined as Bleeding Academic Research Consortium (BARC) types 2 to 5. Results Complex PCI group had a higher risk of MACCE (4.0% vs. 2.3%, hazard ratio [HR] = 1.74, 95% confidence interval [CI]: 1.05–2.89, p = 0.033) and a similar risk of BARC types 2–5 bleeding (2.6% vs. 2.6%, HR = 1.02, 95% CI: 0.56–1.86, p = 0.939) compared with those without complex PCIs. Patients undergoing complex PCIs, followed by P2Y12 inhibitor monotherapy and 12 months of DAPT exhibited similar rates of MACCE (3.8% vs. 4.2%, HR = 0.92, 95% CI: 0.38–2.21, p = 0.853). Conclusions P2Y12 inhibitor monotherapy, mostly clopidogrel, following 3 months of DAPT did not increase ischemic events in patients with complex PCIs.

Published
2021

37. High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction

Author

Ricci, Fabrizio, primary, Neumann, Johannes T., additional, Rübsamen, Nicole, additional, Sörensen, Nils A., additional, Ojeda, Francisco, additional, Cataldo, Ivana, additional, Zeller, Tanja, additional, Schäfer, Sarina, additional, Hartikainen, Tau S., additional, Golato, Maria, additional, Palermi, Stefano, additional, Zimarino, Marco, additional, Blankenberg, Stefan, additional, Westermann, Dirk, additional, and De Caterina, Raffaele, additional

Published
2022
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40. Impact of dual antiplatelet therapy duration on clinical outcome after coronary bifurcation stenting: results from the EuroBifurcation Club registry.

Author

CIRILLO, Plinio, DI SERAFINO, Luigi, GAMRA, Habib, ZIMARINO, Marco, BARBATO, Emanuele, BRIGUORI, Carlo, AMAT-SANTOS, Ignatio J., CHIEFFO, Alaide, ERGLIS, Andrejs, GIL, Robert J., KEDEV, Sasko A., PETROV, Ivo, RADICO, Francesco, NIGLIO, Tullio, NAKAMURA, Sunao, COSTA, Ricardo A., KANIC, Vojko, PERFETTI, Matteo, PELLICANO, Mariano, and MARIC, Kristina

Published
2023
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42. Impact of dual antiplatelet therapy duration on clinical outcome after coronary bifurcation

Author

CIRILLO, Plinio, DI SERAFINO, Luigi, GAMRA, Habib, ZIMARINO, Marco, BARBATO, Emanuele, BRIGUORI, Carlo, AMAT-SANTOS, Ignatio J., CHIEFFO, Alaide, ERGLIS, Andrejs, GIL, Robert J., KEDEV, Sasko A., PETROV, Ivo, RADICO, Francesco, NIGLIO, Tullio, NAKAMURA, Sunao, COSTA, Ricardo A., KANIC, Vojko, PERFETTI, Matteo, PELLICANO, Mariano, MARIC, Kristina, TESORIO, Tullio, VUKCEVIC, Vladan, ESPOSITO, Giovanni, STANKOVIC, Goran, and on behalf of The EuroBifurcation Club

Subjects
dual antiplatelet therapy, percutaneous coronary intervention
Abstract

Optimal duration of Dual Antiplatelet Therapy (DAPT) following percutaneous coronary intervention (PCI) of a bifurcation stenosis is still debated. We evaluated the impact of DAPT duration on clinical outcomes in all- comers patients undergoing bifurcation PCI included in the European Bifurcation Club (EBC) registry.

Published
2022

44. 651 Prevention of contrast induced nephropathy with urine alkalinization: the final results of the TEATE study

Author

Molisana, Michela, primary, Lombardi, Marco, additional, Genovesi, Eugenio, additional, Innocentiis, Carlo De, additional, Limbruno, Ugo, additional, Misuraca, Leonardo, additional, Moretti, Luciano, additional, Vito, Luca Di, additional, Renda, Giulia, additional, Zimarino, Marco, additional, Nicola, Marta Di, additional, and Caterina, Raffaele De, additional

Published
2021
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45. Ultra-Short Term Evaluation of Coronary Vessel Wall Changes in Reference Segments Adjacent to Culprit Lesions in ST-Segment Elevation Myocardial Infarction

Author

Dan, Kazuhiro, Garcia-Garcia, Hector M., Yacob, Omar, Kayode Kuku, Diaz-Torres, Miguel A., Picchi, Andrea, Sardella, Gennaro, Adamo, Marianna, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro, Paolo, Ando, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Karagiannis, Alexios, Dijkstra, Jouke, and Valgimigli, Marco

Subjects
ST-segment elevation myocardial infarction, optical coherence tomography, reference vessel segment, Percutaneous Coronary Intervention, dissection, vasoconstriction, Coronary Vessels, Humans, ST Elevation Myocardial Infarction
Abstract

Background. Culprit lesions of ST-segment elevation myocardial infarction (STEMI) patients are friable, soft, and prone to disruption during primary percutaneous coronary intervention (pPCI). The presence of dissections in reference vessel segments (RVSs), adjacent to stented culprit lesions, and dynamic luminal changes in proximal or distal RVSs have not yet been investigated. We therefore sought to assess the healing patterns of edge dissections and the changes of lumen area at RVSs within 1 week post stent implantation in patients with STEMI. Methods. In the MATRIX trial (ClinicalTrials.gov NCT01433627), optical coherence tomography (OCT) was performed at the end of pPCI and within 1 week during staged PCI. The RVS dissection was defined as: type 1 = flap; type 2 = cavity; type 3 = double barrel; and type 4 = fissure. We compared separately the fate of residual dissection and luminal area/dimension by OCT in the target vessel between pPCI and staged PCI, including 1-year clinical outcomes. Results. Out of 151 patients, 46 patients had dissections in 50 RVSs and did not experience worse clinical outcome. Dissections were 44% type 1, 28% type 2, 12% type 3, and 16% type 4. Overall, 18% of the dissections healed. The mean lumen area of the RVS enlarged in 82 patients (59%) from pPCI to staged PCI. Compared with the proximal RVS, there was a significant increase in the lumen diameter at the distal RVS (0.06 +/- 0.25 mm vs -0.01 +/- 0.21 mm; P=.01). Conclusion. Dissections occur frequently after pPCI. One-fifth of them heal within 1 week and do not seem to negatively impact clinical outcomes. Distal RVS lumen area increased compared with proximal RVS, likely reflecting a different vasoconstriction pattern over time.

Published
2021

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