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Your search keyword '"Zhou, Yan-Feng"' showing total 152 results
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152 results on '"Zhou, Yan-Feng"'

6. Gate-Tunable Transport in Quasi-One-Dimensional α‑Bi4I4 Field Effect Transistors

Author

Liu, Yulu, Chen, Ruoyu, Zhang, Zheneng, Bockrath, Marc, Lau, Chun Ning, Zhou, Yan-Feng, Yoon, Chiho, Li, Sheng, Liu, Xiaoyuan, Dhale, Nikhil, Lv, Bing, Zhang, Fan, Watanabe, Kenji, Taniguchi, Takashi, Huang, Jianwei, Yi, Ming, Oh, Ji Seop, and Birgeneau, Robert J

Subjects
Physical Sciences, Condensed Matter Physics, quasi-1D topological insulator, Bi4X4, Josephson transistor, topological superconductivity, Nanoscience & Nanotechnology
Abstract

Bi4I4 belongs to a novel family of quasi-one-dimensional (1D) topological insulators (TIs). While its β phase was demonstrated to be a prototypical weak TI, the α phase, long thought to be a trivial insulator, was recently predicted to be a rare higher order TI. Here, we report the first gate tunable transport together with evidence for unconventional band topology in exfoliated α-Bi4I4 field effect transistors. We observe a Dirac-like longitudinal resistance peak and a sign change in the Hall resistance; their temperature dependences suggest competing transport mechanisms: a hole-doped insulating bulk and one or more gate-tunable ambipolar boundary channels. Our combined transport, photoemission, and theoretical results indicate that the gate-tunable channels likely arise from novel gapped side surface states, two-dimensional (2D) TI in the bottommost layer, and/or helical hinge states of the upper layers. Markedly, a gate-tunable supercurrent is observed in an α-Bi4I4 Josephson junction, underscoring the potential of these boundary channels to mediate topological superconductivity.

Published
2022

9. Associations of combined healthy lifestyles with cancer morbidity and mortality among individuals with diabetes: results from five cohort studies in the USA, the UK and China

Author

Zhang, Yan-Bo, Pan, Xiong-Fei, Lu, Qi, Wang, Yan-Xiu, Geng, Ting-Ting, Zhou, Yan-Feng, Liao, Linda M., Tu, Zhou-Zheng, Chen, Jun-Xiang, Xia, Peng-Fei, Wang, Yi, Wan, Zhen-Zhen, Guo, Kun-Quan, Yang, Kun, Yang, Han-Dong, Chen, Shuo-Hua, Wang, Guo-Dong, Han, Xu, Wang, Yi-Xin, Yu, Danxia, He, Mei-An, Zhang, Xiao-Min, Liu, Lie-Gang, Wu, Tangchun, Wu, Shou-Ling, Liu, Gang, and Pan, An

Published
2022
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11. Association of Combined Healthy Lifestyles With Cardiovascular Disease and Mortality of Patients With Diabetes: An International Multicohort Study

Author

Zhang, Yan-Bo, Pan, Xiong-Fei, Lu, Qi, Wang, Yan-Xiu, Geng, Ting-Ting, Zhou, Yan-Feng, Liao, Linda M., Tu, Zhou-Zheng, Chen, Jun-Xiang, Xia, Peng-Fei, Wang, Yi, Wan, Zhen-Zhen, Guo, Kun-Quan, Yang, Kun, Yang, Han-Dong, Chen, Shuo-Hua, Wang, Guo-Dong, Han, Xu, Wang, Yi-Xin, Yu, Danxia, He, Mei-An, Zhang, Xiao-Min, Liu, Lie-Gang, Wu, Tangchun, Wu, Shou-Ling, Liu, Gang, and Pan, An

Published
2023
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21. Correction to: Associations of combined healthy lifestyles with cancer morbidity and mortality among individuals with diabetes: results from five cohort studies in the USA, the UK and China

Author

Zhang, Yan-Bo, Pan, Xiong-Fei, Lu, Qi, Wang, Yan-Xiu, Geng, Ting-Ting, Zhou, Yan-Feng, Liao, Linda M., Tu, Zhou-Zheng, Chen, Jun-Xiang, Xia, Peng-Fei, Wang, Yi, Wan, Zhen-Zhen, Guo, Kun-Quan, Yang, Kun, Yang, Han-Dong, Chen, Shuo-Hua, Wang, Guo-Dong, Han, Xu, Wang, Yi-Xin, Yu, Danxia, He, Mei-An, Zhang, Xiao-Min, Liu, Lie-Gang, Wu, Tangchun, Wu, Shou-Ling, Liu, Gang, and Pan, An

Published
2022
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27. Associations of Clinical Risk Factors and Novel Biomarkers With Age at Onset of Type 2 Diabetes.

Author

Chen, Jun-Xiang, Geng, Tingting, Zhang, Yan-Bo, Wang, Yi, Li, Rui, Qiu, Zixin, Wang, Yuexuan, Yang, Kun, Zhang, Bing-Fei, Ruan, Hua-Ling, Zhou, Yan-Feng, Pan, An, Liu, Gang, and Liao, Yun-Fei

Subjects
TYPE 2 diabetes diagnosis, HYPERTENSION, FATTY acids
Abstract

Context Younger onset of type 2 diabetes (T2D) was associated with higher risks of vascular complications and mortality. Objective To prospectively assess risk profiles for incident T2D stratified by age at onset. Methods A total of 471 269 participants free of T2D at baseline were included from the UK Biobank. Approximately 70 clinical, lipid, lipoprotein, inflammatory, and metabolic markers, and genetic risk scores (GRSs) were analyzed. Stratified Cox proportional-hazards regression models were used to estimate hazard ratios (HRs) for T2D with age of diagnosis divided into 4 groups (≤50.0, 50.1-60.0, 60.1-70.0, and >70.0 years). Results During 11 years of follow-up, 15 805 incident T2D were identified. Among clinical risk factors, obesity had the highest HR at any age, ranging from 13.16 (95% CI, 9.67-17.91) for 50.0 years and younger to 4.13 (3.78-4.51) for older than 70.0 years. Other risks associated with T2D onset at age 50.0 years and younger included dyslipidemia (3.50, 2.91-4.20), hypertension (3.21, 2.71-3.80), cardiovascular disease (2.87, 2.13-3.87), parental history of diabetes (2.42, 2.04-2.86), education lower than college (1.89, 1.57-2.27), physical inactivity (1.73, 1.43-2.10), smoking (1.38, 1.13-1.68), several lipoprotein particles, inflammatory markers, liver enzymes, fatty acids, amino acids, as well as GRS. Associations of most risk factors and biomarkers were markedly attenuated with increasing age at onset (P interaction <.05), and some were not significant for onset at age older than 70.0 years, such as smoking, systolic blood pressure, and apolipoprotein B. Conclusion Most risk factors or biomarkers had stronger relative risks for T2D at younger ages, which emphasizes the necessity of promoting primary prevention among younger individuals. Moreover, obesity should be prioritized. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Associations of Clinical Risk Factors and Novel Biomarkers With Age at Onset of Type 2 Diabetes

Author

Chen, Jun-Xiang, primary, Geng, Tingting, additional, Zhang, Yan-Bo, additional, Wang, Yi, additional, Li, Rui, additional, Qiu, Zixin, additional, Wang, Yuexuan, additional, Yang, Kun, additional, Zhang, Bing-Fei, additional, Ruan, Hua-Ling, additional, Zhou, Yan-Feng, additional, Pan, An, additional, Liu, Gang, additional, and Liao, Yun-Fei, additional

Published
2023
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30. Safety and Efficacy of Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Single Center Experience

Author

Pan,Xian, Wu,Shao-Jie, Tang,Yi, Zhou,Yan-Feng, Luo,Jie-Wei, and Fang,Zhu-Ting

Subjects
Journal of Hepatocellular Carcinoma
Abstract

Xian Pan,1,2,&ast; Shao-Jie Wu,1,2,&ast; Yi Tang,1,2,&ast; Yan-Feng Zhou,1,2 Jie-Wei Luo,1,3 Zhu-Ting Fang1,2 1Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, People’s Republic of China; 3Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jie-Wei Luo; Zhu-Ting Fang, Tel +86 59188217540, Email docluo0421@aliyun.com; 470389481@qq.comPurpose: In China, many patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. Several studies have shown that triple therapy [transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs)] is beneficial for patient survival. In this study, we aimed to evaluate the efficacy of triple therapy (TACE + TKIs + ICIs) for unresectable HCC (uHCC) and the conversion rate of surgical resection (SR). The primary endpoints were objective response rate (ORR) and disease control rate (DCR) based on the modified Response Evaluation Criteria in Solid Tumors (mRECIST) and RECIST v1.1 and adverse events (AEs), while the secondary endpoint was the conversion rate of patients with uHCC treated with triple therapy followed by SR.Patients and Methods: Forty-nine patients with uHCC who received triple therapy at Fujian Provincial Hospital between January 2020 and June 2022 were retrospectively included. The treatment efficacy, SR conversion rate, and associated AEs were recorded.Results: Among the 49 patients enrolled, the ORRs assessed by mRECIST and RECIST v1.1 were 57.1% (24/42) and 14.3% (6/42), respectively, and the DCRs were 92.9% (39/42) and 88.1% (37/42), respectively. Seventeen (34.7%) patients met the criteria for resectable HCC and underwent resection. The median interval between the start of triple therapy and resection was 113.5 days (range 94.75 to 182 d), and the median number of TACE was 2 (range 1 to 2.5). The patients did not achieve median overall survival or median progression-free survival. Treatment-related AEs occurred in 48 (98%) patients, and 18 (36.7%) patients had grade ≥ 3 AEs.Conclusion: Triple combination therapy resulted in a relatively high ORR and conversion resection rate following uHCC treatment.Keywords: TACE, immune checkpoint inhibitors, tyrosine kinase inhibitor, surgical resection

Published
2023

31. Differences in HDL-related mortality risk between individuals with and without hypertension: a prospective cohort study in UK Biobank

Author

Chen, Jun-Xiang, primary, Li, Rui, additional, Geng, Tingting, additional, Wang, Yuexuan, additional, Lu, Qi, additional, Tu, Zhou-Zheng, additional, Li, Yue, additional, Liao, Yun-Fei, additional, Yang, Kun, additional, Zhou, Li-Rong, additional, Tong, Wen-Wei, additional, Zhou, Yan-Feng, additional, Liu, Gang, additional, and Pan, An, additional

Published
2023
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39. KLF9 inhibits the proliferation, invasion, and migration of renal cell carcinoma through the SDF‐1/CXCR4 axis.

Author

Yu, Peng, Cheng, Long, Xia, Wei‐Mu, Liu, Ding‐Yi, Yu, Jia‐Shun, Zhou, Yan‐Feng, and Zheng, Yong‐Jun

Subjects
RENAL cell carcinoma, CELL migration, STROMAL cell-derived factor 1, KRUPPEL-like factors, RECOMBINANT proteins
Abstract

Altered Krüppel‐like factor 9 (KLF9) expression can regulate the progression of several cancers, including renal cell carcinoma (RCC). This study was conducted to investigate the role of KLF9 in the proliferation, invasion, and migration of RCC cells via regulation of stromal cell‐derived factor‐1 (SDF‐1)/CXC chemokine receptor 4 (CXCR4). The expression patterns of KLF9, SDF‐1, and CXCR4 in the experimental cell lines were determined by real‐time quantitative polymerase chain reaction and Western blotting. After transfection of the KLF9 siRNA and KLF9 pcDNA, cell proliferation, invasion, and migration were evaluated by experiments including cell counting kit‐8, colony formation, and Transwell assays. The binding of KLF9 to the SDF‐1 promoter was analyzed by chromatin immunoprecipitation and dual‐luciferase assay. The rescue experiment was performed using the recombinant SDF‐1 protein and KLF9 pcDNA. KLF9 was downregulated in the RCC cells. KLF9 knockdown induced the proliferation, invasion, and migration of RCC cells, whereas KLF9 overexpression elicited the opposite roles. Mechanically, KLF9 bound to the SDF‐1 promoter, repressed SDF‐1 transcription, and reduced the SDF‐1/CXCR4 expression levels. Activation of the SDF‐1/CXCR4 axis attenuated the inhibitory role of KLF9 overexpression in RCC cell growth. Ordinarily, KLF9 suppressed the proliferation, invasion, and migration of RCC cells by repressing the SDF‐1/CXCR4 signaling. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Changes in Impaired Fasting Glucose and Borderline High Low-Density Lipoprotein-Cholesterol Status Alter the Risk of Cardiovascular Disease: A 9-Year Prospective Cohort Study

Author

Wang, Xianxuan, primary, Zhou, Yan-Feng, additional, Huang, Zegui, additional, Yu, Xinran, additional, Chen, Zekai, additional, Cai, Zefeng, additional, Lan, Yulong, additional, Li, Werijian, additional, Cai, Zhiwei, additional, Fang, Wei, additional, Chen, Guanzhi, additional, Wu, Weiqiang, additional, Wu, Shouling, additional, and Chen, Youren, additional

Published
2022
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46. Rare Cases of Bronchial Aneurysm and Comparison of Interventional Embolization in the Treatment of True Bronchial Aneurysm and Pseudobronchial Aneurysm

Author

Lin, Jia-Li, primary, Ji, Yuan-Yuan, additional, Zhang, Ming-Zhe, additional, Tang, Yi, additional, Wang, Ruo-Li, additional, Ruan, Dan-Dan, additional, Zhou, Yan-Feng, additional, Wu, Shao-Jie, additional, Cai, Sen-Lin, additional, Zhang, Jian-Hui, additional, Meng, Xiao-Rong, additional, Luo, Jie-Wei, additional, and Fang, Zhu-Ting, additional

Published
2022
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48. Three-Dimensional Heterogeneity of Cerebellar Interposed Nucleus-Recipient Zones in the Thalamic Nuclei

Author

Kuang-Yi Ma, Zhi-Ying Wu, Ying Shen, Zhou-Yan Feng, Xin-Yu Cai, Zhao-Xiang Wang, Wan-Meng Huang, and Xin-Tai Wang

Subjects
Cerebellum, Physiology, General Neuroscience, Thalamus, Stimulation, General Medicine, Human physiology, Biology, Deep cerebellar nuclei, Axons, Electrophysiology, medicine.anatomical_structure, Cerebellar Nuclei, Interposed nucleus, Ventrolateral nucleus, Thalamic Nuclei, medicine, Original Article, Neuroscience
Abstract

The cerebellum is conceptualized as a processor of complex movements and is also endowed with roles in cognitive and emotional behaviors. Although the axons of deep cerebellar nuclei are known to project to primary thalamic nuclei, macroscopic investigation of the characteristics of these projections, such as the spatial distribution of recipient zones, is lacking. Here, we studied the output of the cerebellar interposed nucleus (IpN) to the ventrolateral (VL) and centrolateral (CL) thalamic nuclei using electrophysiological recording in vivo and trans-synaptic viral tracing. We found that IpN stimulation induced mono-synaptic evoked potentials (EPs) in the VL but not the CL region. Furthermore, both the EPs induced by the IpN and the innervation of IpN projections displayed substantial heterogeneity across the VL region in three-dimensional space. These findings indicate that the recipient zones of IpN inputs vary between and within thalamic nuclei and may differentially control thalamo-cortical networks. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-021-00780-y.

Published
2021

50. KLF9inhibits the proliferation, invasion, and migration of renal cell carcinoma through the SDF‐1/CXCR4axis

Author

Yu, Peng, Cheng, Long, Xia, Wei‐Mu, Liu, Ding‐Yi, Yu, Jia‐Shun, Zhou, Yan‐Feng, and Zheng, Yong‐Jun

Abstract

Altered Krüppel‐like factor 9 (KLF9) expression can regulate the progression of several cancers, including renal cell carcinoma (RCC). This study was conducted to investigate the role of KLF9 in the proliferation, invasion, and migration of RCC cells via regulation of stromal cell‐derived factor‐1 (SDF‐1)/CXC chemokine receptor 4 (CXCR4). The expression patterns of KLF9, SDF‐1, and CXCR4 in the experimental cell lines were determined by real‐time quantitative polymerase chain reaction and Western blotting. After transfection of the KLF9 siRNA and KLF9 pcDNA, cell proliferation, invasion, and migration were evaluated by experiments including cell counting kit‐8, colony formation, and Transwell assays. The binding of KLF9 to the SDF‐1 promoter was analyzed by chromatin immunoprecipitation and dual‐luciferase assay. The rescue experiment was performed using the recombinant SDF‐1 protein and KLF9 pcDNA. KLF9 was downregulated in the RCC cells. KLF9 knockdown induced the proliferation, invasion, and migration of RCC cells, whereas KLF9 overexpression elicited the opposite roles. Mechanically, KLF9 bound to the SDF‐1 promoter, repressed SDF‐1 transcription, and reduced the SDF‐1/CXCR4 expression levels. Activation of the SDF‐1/CXCR4 axis attenuated the inhibitory role of KLF9 overexpression in RCC cell growth. Ordinarily, KLF9 suppressed the proliferation, invasion, and migration of RCC cells by repressing the SDF‐1/CXCR4 signaling.

Published
2023
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