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[Display omitted] • A 3D soft-rigid PVDF@SnO 2 nanofiber layer is electrospun on copper current collector. • The soft nanofiber layers realize uniform Li+ flux and dendrite-free Li deposition. • Rigid SnO 2 offers abundant Li+ nucleation sites and promotes highly stable SEI layer. • Nanofiber flexible skeleton can accommodate and mitigate electrode volume expansion. • Such soft-rigid nanofiber layers account for prolonged cycle life of Li metal cells. Lithium (Li) metal is regarded as the most desirable anode candidates for high-energy–density batteries by virtue of its lowest redox potential and ultrahigh theoretical specific capacity. However, uncontrollable Li dendritic growth, infinite volume variation and unstable solid electrolyte interface (SEI) ineluctably plague its commercialization process. Herein, the three-dimensional (3D) nanofiber functional layers with synergistic soft-rigid feature, consisting of tin oxide (SnO 2)-anchored polyvinylidene fluoride (PVDF) nanofibers, are directly electrospun on copper current collector. This strategy can effectively regulate uniform Li deposition and strengthen SEI stability through the dual effect of physical accommodation and chemical ionic intervention. On the one hand, the nanofiber interlayers with excellent electrolyte affinity and well-distributed Li+ transport pathways can promote uniform Li+ flux distribution and large-size Li deposition. On the other hand, the rigid SnO 2 contributes to reducing Li nucleation overpotential and stabilizing SEI layer assisted by its spontaneous reaction with Li. As a result, the smooth and dense Li deposition is achieved by such soft-rigid nanofiber interlayers, thereby extending the cycling life and improving the safety application of Li metal batteries. This work offers a new route for efficient protection of Li metal anodes and brings a new inspiration for developing high-energy–density Li metal batteries. [ABSTRACT FROM AUTHOR]

The expeditious advancement and elevation of the manufacturing industry's transformation and upgrading represent pivotal strides for China in its ascent toward the upper echelons of the global manufacturing value chain. Currently, China's manufacturing-industry transformation faces the dual-lag quandary of digitalization and servitization. The notion of digital servitization elucidates the interdependent relationship between digitalization and servitization, unveiling the mechanisms underlying the formation of digital servitization. This holds significant implications for advancing the comprehension of digitalization and servitization and, crucially, facilitates the acceleration of China's manufacturing sector transitioning from production-centric to service-centric paradigms. Harnessing the technology-organization-environment (TOE) theoretical framework, we constructed a model elucidating the driving factors underpinning manufacturing digital servitization. By employing the fuzzy-set qualitative comparative analysis (fsQCA), we explored strategic decisions and path dependencies in the transformation of manufacturing digital servitization, offering valuable insights to foster China's manufacturing sector in its digital-servitization journey. The following findings were obtained. (1) A singular condition was insufficient as a prerequisite for manufacturing digital servitization and necessitated the coordinated alignment of multiple variables. (2) Three pathways existed for achieving manufacturing digital servitization: TOE, organization-environment collaborative-oriented, and technology-organization collaborative-oriented. (3) The progression of manufacturing digital servitization resulted from the collective impact of numerous factors, exhibiting a characteristic of different paths leading to the same destination. Various manufacturing enterprises pursued distinct trajectories to achieve digital servitization, contingent upon their unique circumstances. These findings have the potential to provide valuable insights for effectively fostering manufacturing digital servitization. [ABSTRACT FROM AUTHOR]

Van der Waals (vdW) heterostructures based on inorganic layered materials have been demonstrated as potential candidates for a variety of electronic applications due to their flexibility in energy band engineering. However, the presence of unstable charge-trapping states in atomically thin two-dimensional (2D) materials may limit the performance of devices. Here, we aim to conduct a systematic investigation on hybrid heterostructured memory devices that consist of 2D layered organic and inorganic materials. The objective is to explore the potential of these devices in offering efficient charge-trapping states. Molybdenum disulfide (MoS2) is employed as a channel, while N, N′-Dimethyl-3,4,9,10-perylenedicarboximide (Me-PTCDI) serves as the charge-trapping layer to store charges from MoS2. The hysteresis window of these heterostructured devices can be effectively modified within a range of 13–70 V by manipulating both the thickness of the organic layer and the gate voltages. The largest hysteresis window is found in a combination of a few-layer Me-PTCDI (12.6 nm) and MoS2 (6 nm), showing a high on/off current ratio (>104) and a long retention time (104 s). Furthermore, the endurance test, which lasts for over 1000 cycles, demonstrates an exceptional level of stability and reliability. In addition, multilevel memory effects can be observed when gate pulses with different widths and amplitudes are applied. These 2D hybrid heterostructured devices have the capability to broaden the scope of material systems and present substantial potential for functional neuromorphic applications. [ABSTRACT FROM AUTHOR]

The atomic‐scale structure of cuprous selenide room temperature phase (α‐Cu2Se), which plays an important role in understanding the mechanism of its high thermoelectric performance, is still not fully determined. Here, direct observation with atomic‐scale resolution is realized to reveal the fine structure of α‐Cu2Se via spherical‐aberration‐corrected scanning transmission electron microscopy. It is observed to be an interesting self‐independent binary‐sublattice construction for Cu and Se in α‐Cu2Se, respectively, which shows a variety of ordered copper fluctuation structures are embedded in a rigid pseudo‐cubic Se sublattice. Ordering of Cu uses a variety of configurations with little energy difference, forming considerable amounts of "boundaries," which may lead to ultrastrong phonon scattering. Furthermore, density functional theory calculations indicate that the electronic structures are mainly determined by the rigid Se face‐centered cubic sublattice and not sensitive to the various copper fluctuations, which may guarantee the electron transfers with large carrier mobility. The self‐independent binary‐sublattice construction is speculated to enhance phonon scattering while still maintaining good electrical transport property. This study provides new critical information for further understanding the possible correlation between the specific structure and thermoelectric performance of α‐Cu2Se, as well as designing new thermoelectric materials. [ABSTRACT FROM AUTHOR]

With the aim to reduce the influence of flammability and brittleness of epoxy resin (EP) on its applications, a phosphorus‐containing oligomer (BID) containing phosphophenanthrene group and flexible chain segment is designed and applied to methyltetrahydrophthalic anhydride (MeTHPA) curing EP systems. Compared with EP/MeTHPA, the glass transition temperature (Tg) declines after introducing BID. But the addition of BID endows EP/MeTHPA with good flame retardancy. When the dosage is only 19.2 wt.%, the limiting oxygen index (LOI) of EP/BID/MeTHPA increases by 77% to 36% (P content: 1.5 wt.%) compared with EP and reaches the vertical combustion (UL‐94) V‐0 rating. Cone calorimetry (CC) results reveal that PHRR and THR drop by 40% and 31%. The pyrolytic process and char residue data analysis show that BID plays flame‐retardant role in gas phase and condensed phase. In addition, impact and flexural and tensile strength improve by 84%, 19% and 54% individually, proving that BID holds a potential on enhancing mechanical performance of EP/MeTHPA. [ABSTRACT FROM AUTHOR]

Mutations in the γ‐secretase complex have been well‐described in familial hidradenitis suppurativa (HS). No gene mutations have been identified in sporadic HS, which comprises 60%–70% of all HS cases. Obesity and smoking are risk factors for HS and are closely related to DNA methylation, an essential epigenetic phenomenon. Hence, we hypothesized that epigenetic modifications might be involved in sporadic HS. To investigate genes with aberrant methylation in sporadic HS cases and assess their expression in skin lesions and blood from patients with HS. Skin lesion samples and corresponding normal skin were obtained from three patients with HS and subjected to whole‐genome DNA methylation sequencing. Blood samples were collected from 20 patients with HS and 20 healthy controls (HCs). The HS mouse model was established by applying tamoxifen to NcstnΔKC mice. Target gene expression was analysed by immunohistochemistry, immunofluorescence, western blotting, enzyme‐linked immunosorbent assay (ELISA) and semiquantitative real‐time polymerase chain reaction (RT‐qPCR). Among 10 807 differentially methylated genes, we filtered 2101 genes with hypermethylated promoter regions, and following bioinformatics analyses, we focused on CXC chemokine ligand 16 (CXCL16). Subsequent functional experiments confirmed the downregulation of CXCL16 and its receptor, CXC chemokine receptor (CXCR) 6, in skin tissue from HS patients and NcstnΔKC mice. Serum CXCL16 concentrations were also significantly decreased in patients with HS. Our data revealed the downregulation of CXCL16 and CXCR6 in HS. [ABSTRACT FROM AUTHOR]

Background: Cashew (Anacardium occidentale L.) is a commercially important plant. Cashew nuts are a popular food source that belong to the tree nut family. Tree nuts are one of the eight major food allergens identified by the Food and Drug Administration in the USA. Allergies to cashew nuts cause severe and systemic immune reactions. Tree nut allergies are frequently fatal and are becoming more common. Aim: We aimed to identify the key allergenic epitopes of cashew nut proteins by correlating the phage display epitope prediction results with bioinformatics analysis. Design: We predicted and experimentally confirmed cashew nut allergen antigenic peptides, which we named Ana o 2 (cupin superfamily) and Ana o 3 (prolamin superfamily). The Ana o 2 and Ana o 3 epitopes were predicted using DNAstar and PyMoL (incorporated in the Swiss-model package). The predicted weak and strong epitopes were synthesized as peptides. The related phage library was built. The peptides were also tested using phage display technology. The expressed antigens were tested and confirmed using microtiter plates coated with pooled human sera from patients with cashew nut allergies or healthy controls. Results: The Ana o 2 epitopes were represented by four linear peptides, with the epitopes corresponding to amino acids 108–111, 113–119, 181–186, and 218–224. Furthermore, the identified Ana o 3 epitopes corresponding to amino acids 10–24, 13–27, 39–49, 66–70, 101–106, 107–114, and 115–122 were also screened out and chosen as the key allergenic epitopes. Discussion: The Ana o 3 epitopes accounted for more than 40% of the total amino acid sequence of the protein; thus, Ana o 3 is potentially more allergenic than Ana o 2. Conclusions: The bioinformatic epitope prediction produced subpar results in this study. Furthermore, the phage display method was extremely effective in identifying the allergenic epitopes of cashew nut proteins. The key allergenic epitopes were chosen, providing important information for the study of cashew nut allergens. [ABSTRACT FROM AUTHOR]

Chiral carbon dots (CDs) are a novel luminescent zero‐dimensional carbon‐based nanomaterial with chirality. They not only have the advantages of good biocompatibility, multi‐color‐emission, easy functionalization, but also exhibits highly symmetrical chiral optical characteristics, which broadens their applicability to enantioselectivity of some chiral amino acids like cysteine and lysine, asymmetric catalysis as well as biomedicine in gene expression and antibiosis. In addition, the exploration of the excited state chirality of CDs has developed its excellent circularly polarized luminescence (CPL) properties, opening up a new application scenario like recognition of chiral light sources and anti‐counterfeit printing with information encryption. This review mainly focuses on the mature synthesis approaches of chiral CDs, including chiral ligand method and supramolecular self‐assembly method, then we consider emerging applications of chiral CDs in CPL, biosensing and biological effect. Finally, we concluded with a perspective on the potential challenges and future opportunities of such fascinating chiral CDs. [ABSTRACT FROM AUTHOR]

• A dual-network structured nanofiber separator with fast ionic conductor is prepared. • This separator has well-distributed nanopore, high porosity and good heat-resistance. • LLZTO can well anchor free anions and offer fast Li+ channels to boost Li+ migration. • This separator achieves high t Li +, homogenized Li+ flux and uniform Li deposition. • Batteries with this separator show good cycle stability and high C-rate capability. Separator plays an important role in improving the long-term cycle stability and safety performance of high-energy–density lithium-metal batteries (LMBs). Herein, a robust thermotolerant separator is prepared by one-step electrospinning technique, combing fluorinated poly (m-phenylene isophthalamide) nanofibers with Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 (LLZTO), a fast ionic conductor. The synergistically incorporated poly (vinylidene fluoride-co-hexafluoropropylene) and LLZTO trigger off the formation of a fancy dual-network structure with high porosity and well-distributed nanopores, in which ultrafine secondary nanonets are tightly bound with three-dimensional nanofiber scaffold. LLZTO can not only provide sufficient Li+ migration channels, but also immobilize free anions to strengthen ionic transmission. Moreover, this nanofiber separator possesses high mechanical strength, excellent thermal stability and desirable electrolyte affinity. It can gel liquid electrolyte well, leading to high t Li +, homogenized Li+ flux and uniform Li deposition. Consequently, LMBs with this dual-network structured nanofiber separator deliver satisfactory cycle stability and high C-rate capability. This contribution provides new insights into the design and development of high-quality nanofiber separators for dendrite-free and high-safety LMBs. [ABSTRACT FROM AUTHOR]

In this paper, the filtering problem of nonlinear networked systems with event-triggered data transmission tasks is studied. To reduce the transmission of excessive measurement data in the bandwidth-limited network, a data transmission mechanism with event trigger is introduced to analyze the error behavior of the extended Kalman filter. We prove that the real estimation error and error covariance matrices can be determined by restricting the initial conditions appropriately. Finally, the effectiveness of the filtering algorithm is verified by simulation. [ABSTRACT FROM AUTHOR]

[Display omitted] Fabricating a high-performance adsorbent as a desirable candidate for removing Pb2+ from aqueous water remains a challenge. Aramid nanofibers (ANFs) are promising building blocks that have realized multifunctional applications due to their intrinsic mechanical and chemical stability. Herein, an in situ loading strategy for preparing nanofiber composite aerogel was proposed by assembling ANFs into a 3D aerogel and applying it as host media for the in situ polymerization of pyrrole followed by facile redox reaction between the polypyrrole (PPy) and MnO 4 –1 to load manganese dioxide (MnO 2). The idea was to fully exploit the structural advantages of ultra-low bulk density, large specific surface area, and high porosity of ANFs, and the possible chemical adsorption characteristics of MnO 2 on the basis of ion exchange reaction. The adsorption capacity of 3D ANF/MnO 2 composite aerogel was as large as 554.36 mg/g for Pb2+. The adsorption mechanism based on an exchange reaction between Pb2+ and protons on the surface of MnO 2 was also investigated. The desorption results showed that the adsorption performance could remain up to 90% after five times of usage. In conclusion, this research provides promising insights into the preparation of high-performance lead adsorbent for water treatment. [ABSTRACT FROM AUTHOR]

Objective Methods Results Conclusion In this study, we investigated the safety and practicability of ultra‐fast track anesthesia (UFTA) for endoscopic thoracic sympathectomy (ETS).A total of 72 patients with palmar hyperhidrosis undergoing ETS were randomly divided into three groups: the UFTA group (group I), the group undergoing single‐lumen tracheal intubation with local infiltration anesthesia technique (group II), and the group undergoing single‐lumen tracheal intubation with routine anesthesia (group III). Mean arterial pressure (MAP) and heart rate (HR) were recorded for all three groups at the following six time points: Before anesthetics administration (T0), the time of intubating or inserting laryngeal mask airway (T1), the time of incising skin (T2), the time of disconnecting of the right sympathetic nerve (T3), the time of disconnecting of the left sympathetic nerve (T4), the time of withdrawing the tracheal tube or laryngeal mask airway (T5), and the time of transferring the patient to a post‐anesthesia care unit (PACU) (T6). The three groups were compared from the following perspectives: surgery duration; anesthesia recovery duration, that is, the duration from discontinuation of anesthesia to extubating the tracheal tube; the dose of propofol and remifentanil per kilogram body mass per unit time interval (the time at the end of the procedure, which lasted from anesthesia induction to incision suturing); and the visual analog scale (VAS) in the resting state in the PACU.Based on pairwise comparisons, the average HR and average MAP values of the three groups differed significantly from T2 to T6 (p < 0.05). As demonstrated by the correlation analysis between remifentanil and propofol with HR and MAP, the doses of the total amount of remifentanil and propofol were lower, and group I used less remifentanil and propofol than group II. No patient in group I experienced throat discomfort following surgery. Patients in groups II and III experienced a range of postoperative discomfort. The VAS scores of groups I and II were significantly lower than those of group III, with group I lower than group II.When utilized in ETS, UFTA can provide effective anesthesia for minor traumas. It is safe, effective, and consistent with the enhanced recovery philosophy of fast‐track surgery departments. [ABSTRACT FROM AUTHOR]

Here, we constructed a split-type and photocurrent polarity switching photoelectrochemical (PEC) biosensor for ultrasensitive detection of Uracil-DNA glycosylase (UDG, abnormal UDG activity is correlated with human immunodeficiency, cancers, bloom syndrome, neurodegenerative diseases and so on) based on SQ-COFs/BiOBr heterostructure, as the photoactive materials, methylene blue (MB) as the signal sensitizer, and catalytic hairpin assembly (CHA) for signal amplification. Specifically, the photocurrent intensity generated by SQ-COFs/BiOBr was about 2 and 6.4 times of that of BiOBr and SQ-COFs alone, which could be responsible for the detection sensitivity for the proposed biosensor. In addition, it is not common to construct heterojunctions between covalent organic skeletons and inorganic nanomaterials. In UDG recognition tube, the plenty of COP probes loaded methylene blue (MB) were obtained by magnetic separation with the help of the simple chain displacement reaction of CHA. MB, as a responsive substance, can efficiently switched the photocurrent polarity of the SQ-COFs/BiOBr electrode from cathode to anode, which reduce the background signal, further improve the sensitivity of the biosensor. Based on the above, the linear detection range of our designed biosensor is 0.001–3 U mL−1, and the detection limit (LODs) is as low as 4.07 × 10−6 U mL−1. Furthermore, the biosensor can still maintain good analytical performance for UDG in real sample, which means that it has broad application prospects in the field of biomedicine. [Display omitted] • A polarity-switching-mode and split-type photoelectrochemical bioanalysis is developed for Uracil-DNA glycosylase detection. • The biosensor is based on SQ-COFs/BiOBr heterostructure and catalytic hairpin assembly. • The COP probes can induce the polarity transition of photocurrent and avoid the generation of false positive signals. • The sensor is a homogeneous biosensor, which avoids complicated assembly on the electrodes, improving the sensitivity. [ABSTRACT FROM AUTHOR]

[Display omitted] • ZIF-67 was in situ assembled onto ANF aerogel to get 3D monolith adsorbent. • ANF/ZIF-67 aerogel showed stable and competitive structural features. • ANF/ZIF-67 aerogel demonstrated high adsorption capacity for Cu2+ and Cr6+. • ANF/ZIF-67 aerogel displayed excellent adsorption capacity for CV and MO. • The adsorption capacity maintained up to 80% after five times of usage. The fabrication of a high-efficiency adsorbent, as a promising candidate for removing metal ions and organic dyes from aqueous solution, is a research hotspot but remains challenging. Aramid nanofibers (ANFs) are emerging building blocks that have realized multifunctional applications in various fields because of their intrinsic mechanical and chemical stability. In this research, three-dimensional (3D) ANF aerogel was assembled and applied in for in situ assembly of zeolitic imidazole framework-67 (ZIF-67). The aim, was to fully exploit the structural advantages of this composite's ultra-low bulk density, large specific surface area, and high porosity, as well as provide more available adsorption sites by ZIF-67 polyhedrons, to facilitate pollutant adsorption from waste water. The prepared 3D ANF/ZIF-67 composite aerogel possessed favorable adsorption performance for heavy metal ions (250.95 and 183.29 mg/g for Cu2+ and Cr6+, respectively) and organic dyes (199.36 and 65.98 mg/g for CV and MO, respectively), greatly exceeding that of the corresponding 3D ANF aerogel. Desorption experiments further demonstrated that up to 80% adsorption performance for heavy metal ions and organic dyes could be maintained after five times of usage. Hence, this research can provide new insights into the preparation of highly efficient adsorbents for water treatment. [ABSTRACT FROM AUTHOR]

• A label-free and dual-amplified electrochemical bioanalysis is developed for sensitive detection of mucin 1. • The biosensor is based on a dual-amplification, originated from an inorganic-organic polymer hybrid mimic peroxidase (AuNPs@Cu 7 S 4 @Cu/Mn-AzoPPOP) and catalytic hairpin assembly. • The AuNPs@Cu 7 S 4 @Cu/Mn-AzoPPOP can not only serve as an label-free electrochemical probe, but also possesses significantly enhanced peroxidase-like catalytic activity. • AuNPs@Cu 7 S 4 @Cu/Mn-AzoPPOP generates a significantly enhanced CA and DPV signals towards the reduction of H 2 O 2. We constructed a label-free and dual-amplified electrochemical bioanalysis for ultrasensitive detection of mucin 1 (MUC1, a tumor biomarker for lung cancer, breast cancer, and ovarian cancer) based on an inorganic-organic polymer hybrid mimic peroxidase (AuNPs@Cu 7 S 4 @Cu/Mn-AzoPPOP) and catalytic hairpin assembly (CHA). The organic porous polymer (Cu/Mn-AzoPPOP) has a high surface area, which can load large amounts of Cu 7 S 4 and Au nanopartibcles (AuNPs). The formed inorganic-organic nanocomposite (AuNPs@Cu 7 S 4 @Cu/Mn-AzoPPOP) can not only serve as an electrochemical probe but also possesses significantly enhanced peroxidase-like performance, compared with that of only Cu 7 S 4 and only Cu/Mn-AzoPPOP. AuNPs@Cu 7 S 4 @Cu/Mn-AzoPPOP had high sensitivity towards the reduction of H 2 O 2 by means of differential pulse voltammetry (DPV) and chronoamperometry (CA). Based on the specific recognition between MUC1 and aptamers and its following cyclic reuse by simple strand displacement of CHA, further electrochemical signal amplification was achieved. The fabricated biosensor displayed ultra-sensitivity and highly selectivity for MUC1 determination, ranging from 1 fg/mL to 10 pg/mL, with low detection limits of 0.72 fg/mL (DPV) and 0.82 fg/mL (CA), respectively. Additionally, the proposed biosensor could also retain good performance in spiked serum samples, which implied its great promise for application in biomedical fields. [ABSTRACT FROM AUTHOR]

For molecular materials, the packing motif plays a pivotal role in determining the optoelectronic characteristics, and it can be tailored via altering not only the molecular structure but also the crystal polymorph. However, it remains a long-standing difficulty for one molecular material to achieve both herringbone packing and 1D slipped stacking, shielding the relationship between the two classic motifs and the functional properties. Herein, we demonstrate that pyridyl substitution at the 2,6-positions of anthracene opens up the possibility of crystal polymorphism from herringbone packing to 1D slipped stacking. The two crystal polymorphs show distinct crystal morphologies, emission spectra, optical anisotropy, and waveguiding properties, shedding light on the relationship between the packing arrangement and optical characteristics based on the same molecular structure. [ABSTRACT FROM AUTHOR]

The growing demand for mobile devices has generated interest in lightweight human pose estimation. Currently, lightweight estimation generally uses heatmap-based methods, which has demonstrated exceptional performance. However, their use of non-differentiable post-processing imposes considerable inference latencies. Conversely, integral-based approaches expedite the inference process by employing a soft-argmax operation but compromise in accuracy. Integrating explicit heatmap knowledge learned using the heatmap-based method into the implicit heatmap generated by the integral-based method, thereby combining the best of both worlds, offers a promising avenue. However, owing to the disparities in supervision and inference processes, the explicit and implicit heatmaps are heterogeneous. Consequently, direct transfer of knowledge presents difficulties in ensuring consistencies in heat value and location. In this paper, we propose a novel Heterogeneous Heatmap Distillation (HHD) framework that effectively tackles these challenges. The framework seamlessly integrates explicit heatmap knowledge that contains high-precision localization information into implicit heatmaps. The framework revolves around an unbiased heatmap alignment scheme encompassing two steps: heterogeneous heatmap normalization and unbiased cropping. Heterogeneous heatmap normalization separately normalizes the output feature maps of both the teacher and student models, alleviating potential heat value bias during the knowledge transfer. Unbiased cropping applies closed-form computation on the normalized teacher and student heatmap to eliminate location bias. Additionally, mirror expansion is implemented to handle potential cases wherein the cropped region extends beyond the image boundary. Extensive experiments demonstrate the efficiency and effectiveness of our methods on the MSCOCO and MPII datasets compared to other integral-based lightweight networks. Our source codes and pre-trained models are available at https://github.com/ducongju/HHD. • We propose a heterogeneousheatmap distillation(HHD) forhuman pose estimation. • The HHDtransfers knowledge from explicit heatmaps to implicit heatmaps. • Heterogeneous heatmap normalization mitigatesthe heat value bias between heatmaps. • Unbiasedcropping and mirror expansion mitigatethe location bias between heatmaps. [ABSTRACT FROM AUTHOR]

SUMMARY: Camellia plants include more than 200 species of great diversity and immense economic, ornamental, and cultural values. We sequenced the transcriptomes of 116 Camellia plants from almost all sections of the genus Camellia. We constructed a pan‐transcriptome of Camellia plants with 89 394 gene families and then resolved the phylogeny of genus Camellia based on 405 high‐quality low‐copy core genes. Most of the inferred relationships are well supported by multiple nuclear gene trees and morphological traits. We provide strong evidence that Camellia plants shared a recent whole genome duplication event, followed by large expansions of transcription factor families associated with stress resistance and secondary metabolism. Secondary metabolites, particularly those associated with tea quality such as catechins and caffeine, were preferentially heavily accumulated in the Camellia plants from section Thea. We thoroughly examined the expression patterns of hundreds of genes associated with tea quality, and found that some of them exhibited significantly high expression and correlations with secondary metabolite accumulations in Thea species. We also released a web‐accessible database for efficient retrieval of Camellia transcriptomes. The reported transcriptome sequences and obtained novel findings will facilitate the efficient conservation and utilization of Camellia germplasm towards a breeding program for cultivated tea, camellia, and oil‐tea plants. Significance Statement: High‐quality transcriptomes of 116 Camellia plants from almost all sections of genus Camellia unveils their deep phylogeny and the transcriptional mechanism underlying the dynamic evolution of quality traits related secondary metabolites, which will facilitate the efficient conservation and utilization of Camellia germplasm towards a breeding program for cultivated tea, camellia, and oil‐tea plants. [ABSTRACT FROM AUTHOR]

Fiber reinforced thermoplastic composites are limited due to poor interfacial bonding between the nonpolar/nonreactive polymer matrix and fiber surface. Recently, a concept of controlled mechanical interlocking between fiber and matrix surface was proposed to improve the interfacial bonding in fiber reinforced thermoplastic composites. Study results show promising performance of the approach under static loading conditions. In this work, we study the effect of strain rate on the interfacial bonding behavior under dynamic loading conditions. A parametric study of the strain rate effect is performed for which different surface microarchitectures of a glass/polypropylene composite system are considered. A three network model is implemented for modeling mechanical behavior of polymer, which is calibrated using a set of stress–strain curves experimentally obtained at various strain rates. The strength calculations address both polymer fracture and detachment of the polymer matrix from the anchoring sites. The results show that under the strain rates ranging from 2 × 10−4/s to 2 × 10−1/s, even without any interfacial friction or adhesion, the interfacial shear strength could achieve close to 70% of the theoretical strength of perfect matrix‐fiber bonding. It is observed that, while strain rate has appreciable effects on the fiber/matrix interfacial strength and can cause change of failure mode in some cases; its influence also depends on the geometry of the anchoring sites. Moreover, there is an optimal geometric configuration at which maximum failure strength is achieved. Graphic charts showing the dependency of interfacial strength on the strain rate and geometric configuration parameters are obtained. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the rate of adverse events (AEs) caused by intravenous administration of sulfur hexafluoride microbubbles in abdominal and superficial applications retrospectively and to explore practical measures for prevention and treatment of them. Materials and methods: This study enrolled 83,778 contrast-enhanced ultrasound (CEUS) examinations using sulfur hexafluoride microbubbles intravenously performed during 11 years. Age, gender, and target organs of all CEUS patients were recorded. For cases of AEs, their medical history and laboratory results were also collected. The process of AEs was assessed and categorized. Besides, the management of AEs were recorded. Results: Twenty patients had sulfur hexafluoride microbubbles-related AEs. The AE rate was 0.024%. No significant difference was observed between patients with AEs and the whole group for age and sex distribution. All AEs happened in liver examinations. Among them, 7 (35%) were mild, 8 (40%) were moderate, and 5 (25%) were severe. They were categorized into 15 allergic-like reactions and 5 physiologic reactions. The manifestations of mild and moderate AEs mainly include urticaria, chills, and mild hypoxia, which could be eased by simple management. Severe cases had anaphylactic shock, generalized convulsions, and diffuse erythema with hypotension respectively. They need close monitoring and oxygen inhalation with anti-shock and anti-anaphylactic treatment. Most cases started within 30 min and recovered within 1 day. Conclusions: Intravenous administration of sulfur hexafluoride microbubbles in abdominal and superficial applications was safe with rare AEs. AEs were more likely to happen in abdominal applications than superficial ones. A well-designed emergency plan should be available for clinical use of sulfur hexafluoride microbubbles to reduce AEs and to deal with AEs properly. Critical relevance statement: Intravenous administration of sulfur hexafluoride microbubbles in abdominal and superficial applications reported few AEs and could be considered safe but severe AEs are life-threatening. We analyzed the influence factors of AEs and propose some methods for prevention and treatment of them, which can further improve the safety of sulfur hexafluoride microbubbles in clinical practice. Key points: • The AE rate of sulfur hexafluoride microbubbles in abdominal and superficial applications was 0.024%. • Patients were more likely to have AEs in abdominal applications than superficial ones. • Severe AEs are life-threatening and need prompt identification and treatment. • We summarized some detailed suggestions for clinical prevention and treatment of AEs. [ABSTRACT FROM AUTHOR]

Recently, there have been some attempts to introduce the method of deep learning-based optical flow(DL-based OF) into PIV measurements. These attempts have made it possible to estimate the flow field with higher accuracy and higher spatial resolution. The current mainstream deep-learning optical flow estimation method often requires a training set whose data distribution is closer to the real sample when completing the target task. However, there is a certain difference between the rigid body motion dataset commonly used in the field of computer vision and the fluid motion dataset in PIV measurements. Whether networks trained with rigid-body data can be directly applied to fluids has not been fully discussed. However, in existing attempts to introduce the DL-based OF method into the field of PIV measurement, the influence of the characteristics of the PIV particle image on the calculation results of the deep learning optical flow estimation (DL-based OF) has not been fully discussed. Therefore, the boundary conditions of the learning method for PIV calculation cannot be fully demonstrated. In this study, we selected the Flownet2 network, which is a classical baseline model on rigid body datasets, as a representative deep learning optical flow estimation method for experiments. Based on the characteristics of various particle images, this study generates a dataset with a wide range of parameters, such as particle density, particle diameter, sheet thickness, and maximum displacement, which are key to the generation of PIV simulation images and discusses the sensitivity of DL-based OF methods under extreme parameter conditions. This study compares (1) the model parameters trained using rigid body datasets such as Sintel, (2) the model parameters trained using synthetic PIV images, (3) the PIV-WIDIM method, and (4) the Optical Flow-Farneback method. The results reveal that the DL-based OF methods in (1) and (2) have a higher spatial resolution and estimation accuracy than the traditional methods in (3)] and (4). Training with the synthetic fluid dataset results in a smoother flow field in method (2)] compared with training with the rigid body dataset in method (1). In the case of limited training set parameters, Flownet2 can still be suitable for extreme conditions, such as small particle concentration, small particle diameter, insufficient particle brightness, or small particle displacement. • Introduce the deep learning optical flow estimation network Flownet2 into the PIV estimation task. • The result trained on Synthetic Fluid Dataset has better performance in flow field continuity. • Applicable to a wide range of boundary conditions with limited parameters in the training dataset. • Compared with traditional methods, it is more suitable for complex flow fields such as small-scale eddies. [ABSTRACT FROM AUTHOR]

Liver cytosol antibody type 1 (anti‐LC1) is reported to be a marker of type 2 autoimmune hepatitis (AIH), a type of autoimmune liver disease (AILD). However, anti‐LC1 is not entirely disease‐specific, and its clinical value in other hepatic diseases has not been well elucidated. Our study aimed to explore the associations between the diagnoses and outcome of decompensated cirrhosis or liver failure (DC/LF) in patients positive for anti‐LC1. A total of 157 patients positive for anti‐LC1 were included in our final analysis. DC/LF was defined as the outcome of patients positive for anti‐LC1. The risk of DC/LF according to diagnosis was estimated using multivariable Cox proportional hazards models, while stratified Cox regression models were used in the subgroup analyses. The diagnoses of patients positive for anti‐LC1 were found to be comprised of various liver disorders. Versus other diagnoses, viral hepatitis was associated with a 2.25‐fold increased risk of DC/LF in these patients, independent of sex, age, disease course, treatment and drinking history. Additionally, the associations were more significant by subgroup analysis in male patients, younger patients, non‐newly diagnosed patients, patients without treatment and patients without drinking history. Anti‐LC1 is not a disease‐specific antibody, as it was found in multiple types of hepatic disease. Furthermore, viral hepatitis rather than AILD was associated with an increased risk of DC/LF in patients positive for anti‐LC1. These findings emphasize the important role of viral hepatitis in the progression of DC/LF in patients positive for anti‐LC1. [ABSTRACT FROM AUTHOR]

Caloric restriction (CR) can prolong life and ameliorate age‐related diseases; thus, its molecular basis might provide new insights for finding biomarker and intervention for aging and age‐related disease. Glycosylation is an important post‐translational modification, which can timely reflect the changes of intracellular state. Serum N‐glycosylation was found changed with aging in humans and mice. CR is widely accepted as an effective anti‐aging intervention in mice and could affect mouse serum fucosylated N‐glycans. However, the effect of CR on the level of global N‐glycans remains unknown. In order to explore whether CR affect the level of global N‐glycans, we performed a comprehensive serum glycome profiling in mice of 30% calorie restriction group and ad libitum group at 7 time points across 60 weeks by MALDI‐TOF‐MS. At each time point, the majority of glycans, including galactosylated and high mannose glycans, showed a consistent low level in CR group. Interestingly, O‐acetylated sialoglycans presented an upward change different from other derived traits, which is mainly reflected in two biantennary α2,6‐linked sialoglycans (H5N4Ge2Ac1, H5N4Ge2Ac2). Liver transcriptome analysis further revealed a decreased transcriptional level of genes involved in N‐glycan biosynthesis while increased level of acetyl‐CoA production. This finding is consistent with changes in serum N‐glycans and O‐acetylated sialic acids. Therefore, we provided one possible molecular basis for the beneficial effect of CR from N‐glycosylation perspective. [ABSTRACT FROM AUTHOR]

The demand for flame retardancy in epoxy thermosetting resins (EP) has become increasingly urgent, but the mechanical properties should not be damaged while ensuring flame-retardancy efficiency. To achieve this, a heterocyclic compound (BDP) containing reactive functional groups was successfully synthesized by 2,4-Diamino-6-phenyl-1,3,5-triazine (DPT), paraformaldehyde and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) in a one-pot process. From the analysis of the curing behavior, the addition of BDP facilitated the curing reaction of EP by reducing the apparent activation energy (E c). Dynamic mechanical analysis (DMA) and flexural tests indicated an increase in the glass transition temperature (T g) and flexural strength of the flame-retardant epoxy resin (FREP) increased by 5.2% and 8.9% respectively, caused by an enhancement of intermolecular forces. As well, a V-0 classification in vertical combustion with a limiting oxygen index (LOI) of 35.2% was attained at a phosphorus content of merely 0.48 wt%. Cone calorimetric (CC) test demonstrated that total smoke production (TSP) and the peak heat release rate (PHRR) of EP-7.5/BDP were reduced by approximately 19.2% and 29.4% respectively in comparison to EP. This positive smoke inhibition and flame retardancy were caused by the blocking and dilution effect presented by the FREP during combustion. [Display omitted] • A heterocyclic compound containing P/N was synthesized as a flame retardant (BDP) for EP using a simple strategy. • The introduction of BDP improved the heat resistance of the EP/DDM system without loss of flexural properties. • The sample showed good flame retardancy at low addition levels while exhibiting smoke suppression. [ABSTRACT FROM AUTHOR]

Although clinical outcomes of CLL have improved with the use of BCL-2 inhibitor, ABT-199, acquired resistance eventually occurs in many cases, which leads to CLL disease progression. Thus, understanding the mechanisms that mediate this relapse is important to design improved therapies. Herein, we report that cytokine IFN-γ, secreted by dysfunctional T cells, enhanced CLL cells resistance to ABT-199. IFN-γ stimulation significantly increased the expression of BCL-2, MCL-1 and BCL-xL. Blocking JAK1/2-STAT3 signaling pathway impaired the expression of these anti-apoptotic proteins after IFN-γ stimulation. The combination of ABT-199 with JAK1/2 inhibitor Ruxolitinib or STAT3 inhibitors Stattic and C188-9 increased malignant B cell death. In summary, we show that IFN-γ enhanced CLL cells resistance to ABT-199 at least in part by up-regulating BCL-2, MCL-1 and BCL-xL expression via JAK1/2-STAT3 pathway, and thus blocking this pathway with inhibitors increased ABT-199 efficiency to induce CLL cell apoptosis, suggesting a potential therapeutically relevant combination to overcome ABT-199 resistance. [ABSTRACT FROM AUTHOR]

BACKGROUND: In this study, the optimal conditions for the extraction and purification of glycyrrhizic acid from Radix Glycyrrhizae (RG) and baicalein and wogonin from Radix Scutellariae (RS) by foam fractionation were studied on the basis of central composite design (CCD) and response surface methodology. RESULTS: The results showed that herbal proportion (RG:RS), gas flow and ethanol concentration were the main factors guiding the foam fractionation of RG and RS. The optimum technological parameters were obtained as follows: herbal proportion (RG:RS), 1.86:1.14; gas flow, 109 mL min−1; and ethanol concentration, 53%. Under the optimal operating conditions, the maximal extraction yields of baicalein, glycyrrhizic acid and wogonin were 56.67, 13.25 and 9.51 mg g−1, respectively, which were 2.32‐, 1.22‐ and 1.84‐fold higher than those of ultrasonic extraction and 17.28‐, 1.15‐ and 9.91‐fold higher than those of ultrasonic extraction without hydrolysis, respectively. Investigations on the antioxidant activity showed that the foam‐fractionated extract exhibited better free radical scavenging activity (IC50 13.80 μg mL−1) than that of the ultrasonic extract (IC50 223.00 μg mL−1). Antibacterial activity showed that the minimum inhibitory concentrations of the foam fractionated extract against Staphylococcus aureus, Candida albicans, Group A Streptococcus and Pseudomonas aeruginosa were 1.38, 1.38, 0.69 and 5.50 mg mL−1, respectively. CONCLUSION: The results indicate that the foam fractionated extract exhibited better extraction yields and free radical scavenging activity than did the ultrasonic extract. Therefore, this fast and eco‐friendly method was established and could be a basis for the extraction and separation of other active constituents from herbal medicines. © 2022 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Lithium (Li) metal is deemed as a promising anode for next-generation high-energy-density battery. However, the rebellious dendrites growth leads to the low Coulombic efficiency and safety hazards, which has been a key challenge in the application of Li metal anode. Herein, the ZnF 2 /ZnS heterostructures and N-doped carbon decorated porous carbon nanofibers (ZnF 2 /ZnS/NC/PCNFs) are fabricated through the electro-blow spinning (EBS), metal-organic framework (MOF)-assisted method, and carbonization process. And its application performances as coating functional interlayer of lithium metal batteries (LMBs) to suppress the Li dendrites growth are systematically researched. The conductive interconnected skeleton of NC/PCNFs provides convenient electrons/ions transmission channels and reduces local current density. The lithiophilic ZnF 2 and ZnS nanoparticles can trigger similar alloying reaction with Li-ions to guide the uniform Li deposition. In particular, the inbuilt electric field triggered at the interface of ZnF 2 /ZnS heterostructures improves charge transfer and surface reaction kinetics. Combining with these merits, the Li|LiFePO 4 (Li|LFP) cells with ZnF 2 /ZnS/NC/PCNFs deliver an optimal initial discharge capacity of 143.2 mAh g−1 and capacity retention rate of 93.6% after 600 cycles at 1 C. Moreover, the Li|Li symmetric cells show lower overpotential than that without the interlayer. Extraordinarily, the lithium-sulfur (Li|S) cells with ZnF 2 /ZnS/NC/PCNFs also display excellent cycle stability due to the strong captured or adsorbed ability to dissolved lithium polysulfides. All these results reveal that the utilization of the ZnF 2 /ZnS/NC/PCNFs interlayer provides new insight for protecting the Li metal anode and improving the electrochemical properties and safety of LMBs. [Display omitted] • The ZnF 2 /ZnS/NC/PCNFs interlayer was successfully prepared. • The interlayer provided convenient ions/electrons transmission channel. • ZnF 2 /ZnS heterostructures could enhance the charge transfer kinetics. • The interlayer could inhibit the Li dendrites growth for LMBs and absorb lithium polysulfides for Li.|S batteries. [ABSTRACT FROM AUTHOR]

Background: In October 2015, China's one-child policy was universally replaced by a so-called two-child policy. This study investigated the association between the enactment of the new policy and changes in the number of births, and health-related birth outcomes.Methods: We used difference-in-difference model to analyse the birth record data in Pudong New Area, Shanghai.The design is descriptive before-and-after comparative study.Results: The data covered three policy periods: the one-child policy period (January 2008 to November 2014); the partial two-child policy period (December 2014 to June 2016); the universal two-child policy period (July 2016 to December 2017). There was an estimate of 7656 additional births during the 18 months of the implementation of the universal two-child policy. The trend of monthly percentage of births to mothers aged ≥35 increased by 0.24 percentage points (95% confidence interval 0.19 to 0.28, p < 0.001) during the same period. Being a baby boy, preterm birth, low birth weight, parents with lower educational attainment, and assisted delivery were associated with a higher risk of birth defects.Conclusions: The universal two-child policy was associated with an increase in the number of births and maternal age. Preterm birth, low birth weight, and assisted delivery were associated with a higher risk of birth defects, which suggested that these infants needed additional attention in the future. [ABSTRACT FROM AUTHOR]

The retina, the most crucial unit of the human visual perception system, combines sensing with wavelength selectivity and signal preprocessing. Incorporating energy conversion into these superior neurobiological features to generate core visual signals directly from incoming light under various conditions is essential for artificial optoelectronic synapses to emulate biological processing in the real retina. Herein, self‐powered optoelectronic synapses that can selectively detect and preprocess the ultraviolet (UV) light are presented, which benefit from high‐quality organic asymmetric heterojunctions with ultrathin molecular semiconducting crystalline films, intrinsic heterogeneous interfaces, and typical photovoltaic properties. These devices exhibit diverse synaptic behaviors, such as excitatory postsynaptic current, paired‐pulse facilitation, and high‐pass filtering characteristics, which successfully reproduce the unique connectivity among sensory neurons. These zero‐power optical‐sensing synaptic operations further facilitate a demonstration of image sharpening. Additionally, the charge transfer at the heterojunction interface can be modulated by tuning the gate voltage to achieve multispectral sensing ranging from the UV to near‐infrared region. Therefore, this work sheds new light on more advanced retinomorphic visual systems in the post‐Moore era. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the prevalence and associated factors of fundus tessellation in highly myopic children and adolescents. Methods: A total of 513 high myopes (spherical equivalent [SE] ≤ −5.0 D, 4–19 years of age) without any advanced pathological myopic lesions were enrolled. Fundus photographs and choroidal thickness (ChT) data were collected by SS‐OCT. A novel grading approach was adopted to classify fundus tessellation into four categories on colour fundus photography, referring to the location of tessellation divided by an Early Treatment Diabetic Retinopathy Study grid centred on the fovea, through which closer to the fovea represents higher grades of fundus tessellation. Peripapillary atrophy (PPA) area and ovality index were also measured. Results: Among the participants, with a mean age of 13.47 ± 3.13 years and mean SE of − 8.34 ± 1.91 D, there were 29 (5.7%), 95 (18.5%), 233 (45.4%) and 156 (30.4%) participants with grade 0 to grade 3 fundus tessellation, respectively. The ChT in both the macular and peripapillary area was negatively correlated with the fundus tessellation grade (R = −0.763 and −0.537, respectively, all p < 0.001). Higher grades of fundus tessellation were independently associated with thinner macular ChT (OR = 1.734, 95% CI: 1.621–1.856, p < 0.001), longer axial length (OR = 1.368, 95% CI: 1.105–1.695, p = 0.004), larger PPA area (OR = 1.391, 95% CI: 1.073–1.802, p = 0.013) and the female sex (OR = 1.605, 95% CI: 1.092–2.359, p = 0.016). Conclusion: The fundus tessellation grade could reflect the ChT, representing the severity of myopic maculopathy among young high myopes who rarely had any advanced lesions of pathological myopia. Fundus tessellation grade might be a potential index for assessing early‐stage myopic maculopathy in children and adolescents. [ABSTRACT FROM AUTHOR]

Recycling precious metals from electronic waste not only benefits environmental protection, but is also favorable for alleviating resource shortages. Ionic porous organic polymers, as one type of burgeoning material, are regarded as excellent adsorbents due to their high ion density, but their application in precious metal recovery is still very limited. Here, V-PPOP-Br, a highly stable and easy-to-build cationic porous organic polymer, was successfully prepared for the first time. By linking porphyrins with viologens, V-PPOP-Br obtained the characteristics of a hierarchical porous structure, a high ion density skeleton, and a rich nitrogen content, which gave it an ultrahigh adsorption capacity (Q max = 792.22 mg g−1) and rapid adsorption rate for Au(III). V-PPOP-Br also had an effective Au(III) recovery capability from SIM cards. Mechanism investigation confirmed that this remarkable adsorption performance was attributed to the interplay of ion exchange, redox reactions and coordination. Moreover, V-PPOP-Br had excellent recyclability and could maintain an ultrahigh adsorption efficiency of 81% after eight consecutive adsorption-desorption experiments. These excellent performances as well as the roughly calculated gold recycling economics ($37.37/g V-PPOP-Br) confirmed that it possesses promising potential as an ionic porous material for gold recovery. [Display omitted] • A porphyrin and viologen-linked cationic POP was prepared via Zincke reaction. • The V-PPOP-Br exhibited ultrahigh adsorption capacity for Au(III). • The mechanism was ascribed to the ion exchange, redox reaction, and coordination. • The V-PPOP-Br could selectively recover gold from the SIM card. • The V-PPOP-Br possessed great recyclability and practical application potential. [ABSTRACT FROM AUTHOR]

Nanozymes have been widely used in biosensors instead of natural enzymes because of low cost, high stability and ease of storage. However, few works use oxidase-like nanozymes to fabricate electrochemical biosensors. Herein, we proposed a sensitive electrochemical biosensor to detect uracil-DNA glycosylase (UDG) based on the hollow Mn/Ni layered doubled hydroxides (h-Mn/Ni LDHs) as oxidase-like nanozyme. Briefly, the h-Mn/Ni LDHs, which was prepared by a facile hydrothermal method, exhibited excellent oxidase-like activity because the hollow structure provided rich active sites and high specific surface area. Then, the signal probes were constructed by assembling the hairpin DNA (hDNA), single DNA1 and DNA2 on the h-Mn/Ni LDHs, respectively. In the presence of UDG, the uracil bases in the stem of hDNA were specifically excised, generating apyrimidinic (AP) sites and inducing the unwinding of the hDNA. Afterwards, the h-Mn/Ni LDHs@Au-hDNA/DNA1 was connected on the electrode via hybridization between unwinded hDNA and capture DNA (cDNA). Subsequently, the self-linking process allowed the retention of numerous h-Mn/Ni LDHs through simple DNA hybridization to amplify the signal of o -phenylenediamine (o -PD). Unlike many peroxidase-like nanozyme-based electrochemical biosensors, there is no need to add H 2 O 2 during the experimental process, which effectively reduced the background signal as well as improved the stability of the biosensor. As expected, the biosensor exhibited excellent performance with a wide linear range and a low detection limit. This work highlights an appealing opportunity to develop a no H 2 O 2 platform based on h-Mn/Ni LDHs for future application in biological analysis and clinical diagnosis. • An electrochemical biosensor was developed for UDG detection with high sensitivity. • The h-Mn/Ni LDHs shows excellent oxidase-like activity due to the hollow structure. • The background signal effectively reduced by the absence of unstable H 2 O 2. • Self-linking process enhanced the signal, and improved the sensitivity. [ABSTRACT FROM AUTHOR]

In this work, the novel flexible ordered carbon nanofibers membrane including cellulose nanocrystal (CNC) and MnS nanoparticles (MnS@CNC/CNFs) were prepared through the microfluidic spinning technology (MST) and carbonization process. Then the application of the prepared MnS@CNC/CNFs as the interlayer between the separator and lithium (Li) anode for lithium-metal battery (LMBs) was systematically investigated. The ordered carbon nanofibers framework with a regular arrangement structure could induce more uniform deposition of Li ions. Moreover, the MnS@CNC/CNFs interlayer possessed remarkable electrical conductivity and large specific surface area, which not only provided a high transmission channel for ions and electrons but also enhanced the interfacial compatibility between the Li anode or separator and interlayer. The doped MnS in the interconnected CNFs skeleton could provide more active sites to trigger the analogous alloying reaction with Li, and the polar hydroxyl groups (-OH) in the CNC could also induce strong chemical interactions toward Li ions. These comprehensive effects brought out the more homogeneous distribution of Li ions flux and the dendrite-free electrode. The assembled Li|LiFePO 4 (LFP) batteries with the freestanding interlayer achieved an initial discharge capacity of 148.2 mAh g−1 and retention rate of 83.1% after 600 cycles at 1 C. The Li/Li symmetric batteries further indicated that the flexible ordered MnS@CNC/CNFs membrane could effectively inhibit the Li dendrite growth and enhance the cycling stability. The design of the MnS@CNC/CNFs based on MST offered a facile method for preparing CNFs and a potential solution for highly safe LMBs. [Display omitted] • The flexible and ordered MnS@CNC/CNFs was successfully prepared. • Microfluidic spinning technology was used to prepare the ordered nascent fibers. • The unique ordered structure can achieve more uniform deposition of Li ions. • The CNFs, MnS and CNC possessed a synergistic effect for inhibiting the Li dendrite growth. • Li|LFP battery and Li symmetric battery with the interlayer presented stable cycle performance. [ABSTRACT FROM AUTHOR]