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810 results on '"Zhang, Rongrong"'

1. Optimal Frequency in Second Messenger Signaling Quantifying cAMP Information Transmission in Bacteria

Author

Xiong, Jiarui, Wang, Liang, Lin, Jialun, Ni, Lei, Zhang, Rongrong, Yang, Shuai, Huang, Yajia, Chu, Jun, and Jin, Fan

Subjects
Physics - Biological Physics, Quantitative Biology - Molecular Networks, J.2.4
Abstract

Bacterial second messengers are crucial for transmitting environmental information to cellular responses. However, quantifying their information transmission capacity remains challenging. Here, we engineer an isolated cAMP signaling channel in Pseudomonas aeruginosa using targeted gene knockouts, optogenetics, and a fluorescent cAMP probe. This design allows precise optical control and real-time monitoring of cAMP dynamics. By integrating experimental data with information theory, we reveal an optimal frequency for light-mediated cAMP signaling that maximizes information transmission, reaching about 40 bits/h. This rate correlates strongly with cAMP degradation kinetics and employs a two-state encoding scheme. Our findings suggest a mechanism for fine-tuned regulation of multiple genes through temporal encoding of second messenger signals, providing new insights into bacterial adaptation strategies. This approach offers a framework for quantifying information processing in cellular signaling systems., Comment: 33 pages, 4 figures

Published
2024

7. On Existence Theorems for Conditional Inferential Models

Author

Zhang, Rongrong, Zhu, Michael Y., and Liu, Chuanhai

Subjects
Mathematics - Statistics Theory, Statistics - Methodology
Abstract

The framework of Inferential Models (IMs) has recently been developed in search of what is referred to as the holy grail of statistical theory, that is, prior-free probabilistic inference. Its method of Conditional IMs (CIMs) is a critical component in that it serves as a desirable extension of the Bayes theorem for combining information when no prior distribution is available. The general form of CIMs is defined by a system of first-order homogeneous linear partial differential equations (PDEs). When admitting simple solutions, they are referred to as regular, whereas when no regular CIMs exist, they are used as the so-called local CIMs. This paper provides conditions for regular CIMs, which are shown to be equivalent to the existence of a group-theoretical representation of the underlying statistical model. It also establishes existence theorems for CIMs, which state that under mild conditions, local CIMs always exist. Finally, the paper concludes with a simple example and a few remarks on future developments of CIMs for applications to popular but inferentially nontrivial statistical models.

Published
2023

8. HyBuffer: A Distributed Hybrid Shared Buffer for Multi-master Databases

Author

Zhang, Rongrong, Ye, Zhiwei, Cai, Peng, Zhou, Xuan, Zhou, Aoying, Cai, Dunbo, Qian, Ling, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Onizuka, Makoto, editor, Lee, Jae-Gil, editor, Tong, Yongxin, editor, Xiao, Chuan, editor, Ishikawa, Yoshiharu, editor, Amer-Yahia, Sihem, editor, Jagadish, H. V., editor, and Lu, Kejing, editor

Published
2024
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