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Your search keyword '"Zhan, Fang"' showing total 99 results
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99 results on '"Zhan, Fang"'

2. BGO quenching effect on spectral measurements of cosmic-ray nuclei in DAMPE experiment

Author

Chen, Zhan-Fang, Yue, Chuan, Jiang, Wei, Cui, Ming-Yang, Yuan, Qiang, Wang, Ying, Zhao, Cong, and Wei, Yi-Feng

Subjects
High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, Physics - Instrumentation and Detectors
Abstract

The Dark Matter Particle Explorer (DAMPE) is a satellite-borne detector designed to measure high energy cosmic-rays and $\gamma$-rays. As a key sub-detector of DAMPE, the Bismuth Germanium Oxide (BGO) imaging calorimeter is utilized to measure the particle energy with a high resolution. The nonlinear fluorescence response of BGO for large ionization energy deposition, known as the quenching effect, results in an under-estimate of the energy measurement for cosmic-ray nuclei. In this paper, various models are employed to characterize the BGO quenching factors obtained from the experimental data of DAMPE. Applying the proper quenching model in the detector simulation process, we investigate the tuned energy responses for various nuclei and compare the results based on two different simulation softwares, i.e. GEANT4 and FLUKA. The BGO quenching effect results in a decrease of the measured energy by approximately $2.5\%$ ($5.7 \%$) for carbon (iron) at $\sim$10 GeV/n and $<1\%$ above 1 TeV/n, respectively. Accordingly, the correction of the BGO quenching effect leads to an increase of the low-energy flux measurement of cosmic-ray nuclei., Comment: 13 pages, 4 figures, to be published in Nuclear Inst. and Methods in Physics Research, A

Published
2023
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3. SKA sensitivity for possible radio emission from dark matter in Omega Centauri

Author

Wang, Guan-Sen, Chen, Zhan-Fang, Zu, Lei, Gong, Hao, Feng, Lei, and Fan, Yi-Zhong

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

Omega Centauri, the largest known globular cluster in the Milky Way, is believed to be the remains of a dwarf galaxy's core. Giving its potential abundance of dark matter (DM), it is an attractive target for investigating the nature of this elusive substance in our local environment. Our study demonstrates that by observing Omega Centauri with the SKA for 1000 hours, we can detect synchrotron radio or Inverse Compton (IC) emissions from the DM annihilation products. It enables us to constrain the cross-section of DM annihilation down to $\sim {\rm 10^{-30}~cm^3~s^{-1}}$ for DM mass from several $\rm{GeV}$ to $\rm{100~GeV}$, which is much stronger compared with other observations. Additionally, we explore the axion, another well-motivated DM candidate, and provide stimulated decay calculations. It turns out that the sensitivity can reach $g_{\rm{a\gamma\gamma}} \sim 10^{-10} ~\rm{GeV^{-1}}$ for $2\times 10^{-7} ~\rm{eV} < m_a < 2\times 10^{-4} ~\rm{eV}$., Comment: 20 pages, 8 figures

Published
2023
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4. Altered immune pathways in patients of temporal lobe epilepsy with and without hippocampal sclerosis

Author

Xiang-Qian Che, Shi-Kun Zhan, Jiao-Jiao Song, Yu-Lei Deng, Wei-Liu, Peng-Huang, Jing-Zhang, Zhan-Fang Sun, Zai-Qian Che, and Jun Liu

Subjects
Immune pathway, RNA, Temporal lobe epilepsy, Hippocampal sclerosis, Medicine, Science
Abstract

Abstract Over the past decades, the immune responses have been suspected of participating in the mechanisms for epilepsy. To assess the immune related pathway in temporal lobe epilepsy (TLE), we explored the altered immune pathways in TLE patients with and without hippocampal sclerosis (HS). We analyzed RNA-seq data from 3 TLE-HS and 3 TLE-nonHS patients, including identification of differentially expressed RNA, function pathway enrichment, the protein–protein interaction network and construction of ceRNA regulatory network. We illustrated the immune related landscape of molecules and pathways on human TLE-HS. Also, we identified several differential immune related genes like HSP90AA1 and SOD1 in TLE-HS patients. Further ceRNA regulatory network analysis found SOX2-OT connected to miR-671-5p and upregulated the target gene SPP1 in TLE-HS patients. Also, we identified both SOX2-OT and SPP1 were significantly upregulated in five different databases including TLE-HS patients and animal models. Our findings established the first immune related genes and possible regulatory pathways in TLE-HS patients and animal models, which provided a novel insight into disease pathogenesis in both patients and animal models. The immune related SOX2-OT/miR-671-5p/SPP1 axis may be the potential therapeutic target for TLE-HS.

Published
2024
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7. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer

Author

Alemanno, Francesca, An, Qi, Azzarello, Philipp, Barbato, Felicia Carla Tiziana, Bernardini, Paolo, Bi, Xiao-Jun, Cai, Ming-Sheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, Deng-Yi, Chen, Jun-Ling, Chen, Zhan-Fang, Cui, Ming-Yang, Cui, Tian-Shu, Cui, Yu-Xing, Dai, Hao-Ting, De Benedittis, Antonio, De Mitri, Ivan, de Palma, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, Tie-Kuang, Dong, Zhen-Xing, Donvito, Giacinto, Droz, David, Duan, Jing-Lai, Duan, Kai-Kai, D'Urso, Domenico, Fan, Rui-Rui, Fan, Yi-Zhong, Fang, Fang, Fang, Kun, Feng, Chang-Qing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, Yi-Zhong, Guo, Dong-Ya, Guo, Jian-Hua, Han, Shuang-Xue, Hu, Yi-Ming, Huang, Guang-Shun, Huang, Xiao-Yuan, Huang, Yong-Yi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrios, Lei, Shi-Jun, Li, Shang, Li, Wen-Hao, Li, Wei-Liang, Li, Xiang, Li, Xian-Qiang, Liang, Yao-Ming, Liu, Cheng-Ming, Liu, Hao, Liu, Jie, Liu, Shu-Bin, Liu, Yang, Loparco, Francesco, Luo, Chuan-Ning, Ma, Miao, Ma, Peng-Xiong, Ma, Tao, Ma, Xiao-Yong, Marsella, Giovanni, Mazziotta, Mario Nicola, Mo, Dan, Mu, Maria, Niu, Xiao-Yang, Pan, Xu, Parenti, Andrea, Peng, Wen-Xi, Peng, Xiao-Yan, Perrina, Chiara, Qiao, Rui, Rao, Jia-Ning, Ruina, Arshia, Shangguan, Zhi, Shen, Wei-Hua, Shen, Zhao-Qiang, Shen, Zhong-Tao, Silveri, Leandro, Song, Jing-Xing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, Hao-Ran, Sun, Zhi-Yu, Surdo, Antonio, Teng, Xue-Jian, Tykhonov, Andrii, Wang, Jin-Zhou, Wang, Lian-Guo, Wang, Shen, Wang, Shu-Xin, Wang, Xiao-Lian, Wang, Ying, Wang, Yan-Fang, Wang, Yuan-Zhu, Wei, Da-Ming, Wei, Jia-Ju, Wei, Yi-Feng, Wu, Di, Wu, Jian, Wu, Li-Bo, Wu, Sha-Sha, Wu, Xin, Xia, Zi-Qing, Xu, En-Heng, Xu, Hai-Tao, Xu, Zhi-Hui, Xu, Zun-Lei, Xu, Zi-Zong, Xue, Guo-Feng, Yang, Hai-Bo, Yang, Peng, Yang, Ya-Qing, Yao, Hui-Jun, Yu, Yu-Hong, Yuan, Guan-Wen, Yuan, Qiang, Yue, Chuan, Zang, Jing-Jing, Zhang, Sheng-Xia, Zhang, Wen-Zhang, Zhang, Yan, Zhang, Yi, Zhang, Yong-Jie, Zhang, Yun-Long, Zhang, Ya-Peng, Zhang, Yong-Qiang, Zhang, Zhe, Zhang, Zhi-Yong, Zhao, Cong, Zhao, Hong-Yun, Zhao, Xun-Feng, Zhou, Chang-Yi, Zhu, Yan, and Liang, Yun-Feng

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints on the velocity-averaged cross section for $\chi\chi \to \gamma\gamma$ and the decay lifetime for $\chi \to \gamma\nu$, both at 95% confidence level, have been calculated and the systematic uncertainties have been taken into account. Comparing to the previous Fermi-LAT results, though DAMPE has an acceptance smaller by a factor of $\sim 10$, similar constraints on the DM parameters are achieved and below 100 GeV the lower limits on the decay lifetime are even stronger by a factor of a few. Our results demonstrate the potential of high-energy-resolution observations on dark matter detection., Comment: 14 pages, 8 figures. Update the content to keep up with the published version

Published
2021
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8. Update on the genetic diversity and population structure of Echinococcus granulosus in Gansu Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region, Western China, inferred from mitochondrial cox1, nad1, and nad5 sequences

Author

Shumuye, Nigus Abebe, Li, Li, Ohiolei, John Asekhaen, Qurishi, Sayed Ajmal, Li, Wen-Hui, Zhang, Nian-Zhang, Wu, Yan-Tao, Wu, Yao-Dong, Gao, Sheng-Zhi, Zhang, Fu-Heng, Tian, Xue-Qi, Tian, Wen-Jun, Fu, Yong, Wang, Xie-Zhong, Pan, Yong-Hong, Zhan, Fang, Zhang, Lin-Sheng, Guo, Ming-Kuan, Li, Wen-Dong, Fu, Bao-Quan, Yan, Hong-Bin, and Jia, Wan-Zhong

Published
2023
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12. Constraints on dark matter annihilation from the Event Horizon Telescope observations of M87

Author

Guan-Wen Yuan, Zhan-Fang Chen, Zhao-Qiang Shen, Wen-Qing Guo, Ran Ding, Xiaoyuan Huang, and Qiang Yuan

Subjects
Phenomenological Models, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The fast developments of radio astronomy open a new window to explore the properties of Dark Matter (DM). The recent direct imaging of the supermassive black hole (SMBH) at the center of M87 radio galaxy by the Event Horizon Telescope (EHT) collaboration is expected to be very useful to search for possible new physics. In this work, we illustrate that such results can be used to detect the possible synchrotron radiation signature produced by DM annihilation from the innermost region of the SMBH. Assuming the existence of a spike DM density profile, we obtain the flux density due to DM annihilation induced electrons and positrons, and derive new limits on the DM annihilation cross section via the comparison with the EHT integral flux density at 230 GHz. Our results show that the parameter space can be probed by the EHT observations is largely complementary to other experiments. For DM with typical mass regions of being weakly interacting massive particles, the annihilation cross section several orders of magnitude below the thermal production level can be excluded by the EHT observations under the density spike assumption. Future EHT observations may further improve the sensitivity on the DM searches, and may also provide a unique opportunity to test the interplay between DM and the SMBH.

Published
2022
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15. Altered immune pathways in patients of temporal lobe epilepsy with and without hippocampal sclerosis.

Author

Che, Xiang-Qian, Zhan, Shi-Kun, Song, Jiao-Jiao, Deng, Yu-Lei, Wei-Liu, Peng-Huang, Jing-Zhang, Sun, Zhan-Fang, Che, Zai-Qian, and Liu, Jun

Abstract

Over the past decades, the immune responses have been suspected of participating in the mechanisms for epilepsy. To assess the immune related pathway in temporal lobe epilepsy (TLE), we explored the altered immune pathways in TLE patients with and without hippocampal sclerosis (HS). We analyzed RNA-seq data from 3 TLE-HS and 3 TLE-nonHS patients, including identification of differentially expressed RNA, function pathway enrichment, the protein–protein interaction network and construction of ceRNA regulatory network. We illustrated the immune related landscape of molecules and pathways on human TLE-HS. Also, we identified several differential immune related genes like HSP90AA1 and SOD1 in TLE-HS patients. Further ceRNA regulatory network analysis found SOX2-OT connected to miR-671-5p and upregulated the target gene SPP1 in TLE-HS patients. Also, we identified both SOX2-OT and SPP1 were significantly upregulated in five different databases including TLE-HS patients and animal models. Our findings established the first immune related genes and possible regulatory pathways in TLE-HS patients and animal models, which provided a novel insight into disease pathogenesis in both patients and animal models. The immune related SOX2-OT/miR-671-5p/SPP1 axis may be the potential therapeutic target for TLE-HS. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer

Author

Yun-Feng Liang, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato, Paolo Bernardini, Xiao-Jun Bi, Ming-Sheng Cai, Elisabetta Casilli, Enrico Catanzani, Jin Chang, Deng-Yi Chen, Jun-Ling Chen, Zhan-Fang Chen, Ming-Yang Cui, Tian-Shu Cui, Yu-Xing Cui, Hao-Ting Dai, Antonio De Benedittis, Ivan De Mitri, Francesco de Palma, Maksym Deliyergiyev, Margherita Di Santo, Qi Ding, Tie-Kuang Dong, Zhen-Xing Dong, Giacinto Donvito, David Droz, Jing-Lai Duan, Kai-Kai Duan, Domenico D’Urso, Rui-Rui Fan, Yi-Zhong Fan, Fang Fang, Kun Fang, Chang-Qing Feng, Lei Feng, Piergiorgio Fusco, Min Gao, Fabio Gargano, Ke Gong, Yi-Zhong Gong, Dong-Ya Guo, Jian-Hua Guo, Shuang-Xue Han, Yi-Ming Hu, Guang-Shun Huang, Xiao-Yuan Huang, Yong-Yi Huang, Maria Ionica, Wei Jiang, Jie Kong, Andrii Kotenko, Dimitrios Kyratzis, Shi-Jun Lei, Shang Li, Wen-Hao Li, Wei-Liang Li, Xiang Li, Xian-Qiang Li, Yao-Ming Liang, Cheng-Ming Liu, Hao Liu, Jie Liu, Shu-Bin Liu, Yang Liu, Francesco Loparco, Chuan-Ning Luo, Miao Ma, Peng-Xiong Ma, Tao Ma, Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta, Dan Mo, Maria Muñoz Salinas, Xiao-Yang Niu, Xu Pan, Andrea Parenti, Wen-Xi Peng, Xiao-Yan Peng, Chiara Perrina, Rui Qiao, Jia-Ning Rao, Arshia Ruina, Zhi Shangguan, Wei-Hua Shen, Zhao-Qiang Shen, Zhong-Tao Shen, Leandro Silveri, Jing-Xing Song, Mikhail Stolpovskiy, Hong Su, Meng Su, Hao-Ran Sun, Zhi-Yu Sun, Antonio Surdo, Xue-Jian Teng, Andrii Tykhonov, Jin-Zhou Wang, Lian-Guo Wang, Shen Wang, Shu-Xin Wang, Xiao-Lian Wang, Ying Wang, Yan-Fang Wang, Yuan-Zhu Wang, Da-Ming Wei, Jia-Ju Wei, Yi-Feng Wei, Di Wu, Jian Wu, Li-Bo Wu, Sha-Sha Wu, Xin Wu, Zi-Qing Xia, En-Heng Xu, Hai-Tao Xu, Zhi-Hui Xu, Zun-Lei Xu, Zi-Zong Xu, Guo-Feng Xue, Hai-Bo Yang, Peng Yang, Ya-Qing Yang, Hui-Jun Yao, Yu-Hong Yu, Guan-Wen Yuan, Qiang Yuan, Chuan Yue, Jing-Jing Zang, Sheng-Xia Zhang, Wen-Zhang Zhang, Yan Zhang, Yi Zhang, Yong-Jie Zhang, Yun-Long Zhang, Ya-Peng Zhang, Yong-Qiang Zhang, Zhe Zhang, Zhi-Yong Zhang, Cong Zhao, Hong-Yun Zhao, Xun-Feng Zhao, Chang-Yi Zhou, Yan Zhu, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato , Paolo Bernardini , Xiao-Jun Bi , Ming-Sheng Cai , Elisabetta Casilli , Enrico Catanzani , Jin Chang , Deng-Yi Chenj , Jun-Ling Chen , Zhan-Fang Chen , Ming-Yang Cui , Tian- Shu Cuin , Yu-Xin Cui , Hao-Ting Dai , Antonio De Benedittis , Ivan De Mitri , Francesco de Palma , Maksym Deliyergiyev Margherita Di Santo , Qi Ding , Tie-Kuan Dong , Zhen-Xing Dong , Giacinto Donvito , David Droz, Jing-Lai Duan , Kai-Kai Duan , Domenico D’Urso , Rui-Rui Fan , Yi-Zhong Fan , Fan Fang , Kun Fang, Chang-Qin Feng , Lei Feng , Piergiorgio Fusco, Min Gao , Fabio Gargano , Ke Gong , Yi-Zhong Gong , Dong- Ya Guo , Jian-Hua Guo , Shuang-Xue Han, Yi-Ming Hu , Guang- Shun Huang , Xiao-Yuan Huang , Yong-Yi Huang , Maria Ionica , Wei Jiang , Jie Kong , Andrii Kotenko , Dimitrios Kyratzis , Shi- Jun Lei, Shang Li , Wen-Hao Li , Wei-Liang Li , Xiang Li , Xian Qiang Li , Yao-Ming Lian , Cheng-Ming Liu , Hao Liu , Jie Liu , Shu-Bin Liu , Yang Liu , Francesco Loparco , Chuan-Ning Luo , Miao Ma , Peng-Xiong Ma , Tao Ma , Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta , Dan Mo , Maria Muñoz Salinas , Xiao-Yang Niu , Xu Pan , Andrea Parenti , Wen-Xi Peng , Xiao- Yan Peng , Chiara Perrina , Rui Qiao , Jia-Ning Rao , Arshia Ruina , Zhi Shangguan , Wei-Hua Shen , Zhao-Qiang Shen , Zhong-Tao Shen , Leandro Silveri, Jing-Xing Song , Mikhail Stolpovskiy Hong Su , Meng Su , Hao-Ra Sun , Zhi-Yu Sun , Antonio Surdo , Xue-Jian Teng , Andrii Tykhonov , Jin-Zhou Wang , Lian-Guo Wang , Shen Wang , Shu-Xin Wang , Xiao-Lian Wang , Ying Wang , Yan-Fang Wang , Yuan-Zhu Wang , Da-Ming Wei , Jia-Ju Wei , Yi-Feng Wei , Di Wu , Jian Wu , Li-Bo Wu , Sha-Sha Wun , Xin Wu , Zi-Qing Xi , En-Heng Xu , Hai-Tao Xu , Zhi-Hui Xu , Zun-Lei Xu , Zi-Zong Xu , Guo-Feng Xuen , Hai-Bo Yang , Peng Yang , Ya-Qing Yang , Hui-Jun Yao , Yu-Hong Yu , Guan-Wen Yuan , Qiang Yuan , Chuan Yue , JingJing Zang Sheng-Xi Zhang , Wen-Zhang Zhang , Yan Zhang, Yi Zhangj, Yong-Jie Zhang , Yun-Long Zhang , Ya-Peng Zhang , Yong-Qiang Zhang , Zhe Zhang , Zhi-Yong Zhang , Cong Zhao , Hong-Yun Zhao , Xun-Feng Zhao , Chang-Yi Zhou , and Yan Zhu, Alemanno, Francesca, An, Qi, Azzarello, Philipp, Carla Tiziana Barbato, Felicia, Bernardini, Paolo, Bi, Xiao-Jun, Cai, Ming-Sheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, Deng-Yi, Chen, Jun-Ling, Chen, Zhan-Fang, Cui, Ming-Yang, Cui, Tian-Shu, Cui, Yu-Xin, Dai, Hao-Ting, De Benedittis, Antonio, De Mitri, Ivan, DE PALMA, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, Tie-Kuang, Dong, Zhen-Xing, Donvito, Giacinto, Droz, David, Duan, Jing-Lai, Duan, Kai-Kai, D’Urso, Domenico, Fan, Rui-Rui, Fan, Yi-Zhong, Fang, Fang, Fang, Kun, Feng, Chang-Qing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, Yi-Zhong, Guo, Dong-Ya, Guo, Jian-Hua, Han, Shuang-Xue, Hu, Yi-Ming, Huang, Guang-Shun, Huang, Xiao-Yuan, Huang, Yong-Yi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrio, Lei, Shi-Jun, Li, Shang, Li, Wen-Hao, Li, Wei-Liang, Li, Xiang, Li, Xian-Qiang, Lian, Yao-Ming, Liu, Cheng-Min, Liu, Hao, Liu, Jie, Liu, Shu-Bin, Liu, Yang, Loparco, Francesco, Luo, Chuan-Ning, Ma, Miao, Ma, Peng-Xiong, Ma, Tao, Ma, Xiao-Yong, Marsella, Giovanni, Nicola Mazziotta, Mario, Mo, Dan, Muñoz Salinas, Maria, Niu, Xiao-Yang, Pan, Xu, Parenti, Andrea, Peng, Wen-Xi, Peng, Xiao-Yan, Perrina, Chiara, Qiao, Rui, Ra, Jia-Ning, Ruina, Arshia, Shangguan, Zhi, Shen, Wei-Hua, Shen, Zhao-Qiang, Shen, Zhong-Tao, Silveri, Leandro, Song, Jing-Xing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, Hao-Ran, Sun, Zhi-Yu, Surdo, Antonio, Teng, Xue-Jian, Tykhonov, Andrii, Wang, Jin-Zhou, Wang, Lian-Guo, Wang, Shen, Wang, Shu-Xin, Wang, Xiao-Lian, Wang, Ying, Wang, Yan-Fang, Wang, Yuan-Zhu, Wei, Da-Ming, Wei, Jia-Ju, Wei, Yi-Feng, Wu, Di, Wu, Jian, Wu, Li-Bo, Wu, Sha-Sha, Wu, Xin, Xia, Zi-Qing, Xu, En-Heng, Xu, Hai-Tao, Xu, Zhi-Hui, Xu, Zun-Lei, Xu, Zi-Zong, Xue, Guo-Feng, Yang, Hai-Bo, Yang, Peng, Yang, Ya-Qing, Yao, Hui-Jun, Yu, Yu-Hong, Yuan, Guan-Wen, Yuan, Qiang, Yue, Chuan, Zann, Jing-Jing, Zhan, Sheng-Xia, Zhan, Wen-Zhang, Zhan, Yan, Zhan, Yi, Zhang, Yong-Jie, Zhang, Yun-Long, Zhang, Ya-Peng, Zhang, Yong-Qiang, Zhang, Zhe, Zhang, Zhi-Yong, Zhao, Cong, Zhao, Hong-Yun, Zhao, Xun-Feng, Zhou, Chang-Yi, and Yan Zhu, And

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Line-like structure, High Energy Physics - Experiment (hep-ex), Multidisciplinary, Astrophysics::High Energy Astrophysical Phenomena, DAMPE, Dark matter, Gamma-ray, Line-like structure, Settore FIS/01 - Fisica Sperimentale, DAMPE, Dark matter, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray, High Energy Physics - Experiment
Abstract

The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints on the velocity-averaged cross section for $\chi\chi \to \gamma\gamma$ and the decay lifetime for $\chi \to \gamma\nu$, both at 95% confidence level, have been calculated and the systematic uncertainties have been taken into account. Comparing to the previous Fermi-LAT results, though DAMPE has an acceptance smaller by a factor of $\sim 10$, similar constraints on the DM parameters are achieved and below 100 GeV the lower limits on the decay lifetime are even stronger by a factor of a few. Our results demonstrate the potential of high-energy-resolution observations on dark matter detection., Comment: 14 pages, 8 figures. Update the content to keep up with the published version

Published
2022

18. DArk Matter Particle Explorer: 7 years in Space

Author

Tykhonov, Andrii, primary, Alemanno, Francesca, additional, Altomare, Corrado, additional, An, Qi, additional, Azzarello, Philipp, additional, Barbato, Felicia Carla Tiziana, additional, Bernardini, Paolo, additional, Bi, Xiao Jun, additional, Cagnoli, Irene, additional, Cai, Ming Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng Yi, additional, Chen, Jun Ling, additional, Chen, Zhan Fang, additional, Chen, Zi Xuan, additional, Coppin, Paul, additional, Cui, Ming Yang, additional, Cui, Tian Shu, additional, Cui, Yu Xin, additional, De Mitri, Ivan, additional, de Palma, Francesco, additional, Di Giovanni, Adriano, additional, Di Santo, Margherita, additional, Ding, Qi, additional, Dong, Tie Kuang, additional, Dong, Zhen Xing, additional, DONVITO, Giacinto, additional, Droz, David, additional, Duan, Jing Lai, additional, Duan, Kai Kai, additional, Fan, Rui Rui, additional, Fan, Yi Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang Qing, additional, Feng, Lei, additional, Fernandez Alonso, Mateo, additional, Frieden, Jennifer Maria, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Ghose, Essna, additional, Gong, Ke, additional, Gong, Yi Zhong, additional, Guo, Dong Ya, additional, Guo, Jian Hua, additional, Han, Shuang Xue, additional, Hu, Yi Ming, additional, Huang, Guang Shun, additional, Huang, Xiao Yuan, additional, Huang, Yong Yi, additional, Ionica, Maria, additional, Jiang, Lu Yao, additional, Jiang, Wei, additional, Jiang, Yao Zu, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi Jun, additional, Li, Wei Liang, additional, Li, Wen Hao, additional, Li, Xiang, additional, Li, Xian Qiang, additional, Liang, Yao Ming, additional, Liu, Cheng Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan Ning, additional, Ma, Miao, additional, Ma, Peng Xiong, additional, Ma, Tao, additional, Ma, Xiao Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Niu, Xiao Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen Xi, additional, Peng, Xiao Yan, additional, Perrina, Chiara, additional, Putti-Garcia, Enzo, additional, Qiao, Rui, additional, Rao, Jia Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei Hua, additional, Shen, Zhao Qiang, additional, Shen, Zhong Tao, additional, Silveri, Leandro, additional, Song, Jing Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao Ran, additional, Sun, Zhi Yu, additional, Surdo, Antonio, additional, Teng, Xue Jian, additional, Wang, Jin Zhou, additional, Wang, Lian Guo, additional, Wang, Shen, additional, Wang, Xiao Lian, additional, Wang, Yan Fang, additional, Wang, Ying, additional, Wang, Yuan Zhu, additional, Wei, Da Ming, additional, Wei, Jia Ju, additional, Wei, Yi Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li Bo, additional, Wu, Sha Sha, additional, Wu, Xin, additional, Xia, Zi Qing, additional, Xu, En Heng, additional, Xu, Hai Tao, additional, Xu, Jing, additional, Xu, Zhi Hui, additional, Xu, Zi Zong, additional, Xu, Zun Lei, additional, Xue, Guo Feng, additional, Yang, Hai Bo, additional, Yang, Peng, additional, Yang, Ya Qing, additional, Yao, Hui Jun, additional, Yu, Yu Hong, additional, Yuan, Guan Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing Jing, additional, Zhang, Sheng Xia, additional, Zhang, Wen Zhang, additional, Zhang, Yan, additional, Zhang, Ya Peng, additional, Zhang, Yi, additional, Zhang, Yong Jie, additional, Zhang, Yong Qiang, additional, Zhang, Yun Long, additional, Zhang, Zhe, additional, Zhang, Zhi Yong, additional, Zhao, Cong, additional, Zhao, Hong Yun, additional, Zhao, Xun Feng, additional, Zhou, Chang Yi, additional, and Zhu, Yan, additional

Published
2023
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20. A PCA-based Method for Electron-Proton Discrimination of the DAMPE Experiment

Author

Cui, Ming-Yang, primary, Alemanno, Francesca, additional, Altomare, Corrado, additional, An, Qi, additional, Azzarello, Philipp, additional, Barbato, Felicia Carla Tiziana, additional, Bernardini, Paolo, additional, Bi, Xiao Jun, additional, Cagnoli, Irene, additional, Cai, Ming Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng Yi, additional, Chen, Jun Ling, additional, Chen, Zhan Fang, additional, Chen, Zi Xuan, additional, Coppin, Paul, additional, Cui, Ming Yang, additional, Cui, Tian Shu, additional, Cui, Yu Xin, additional, De Mitri, Ivan, additional, de Palma, Francesco, additional, Di Giovanni, Adriano, additional, Di Santo, Margherita, additional, Ding, Qi, additional, Dong, Tie Kuang, additional, Dong, Zhen Xing, additional, DONVITO, Giacinto, additional, Droz, David, additional, Duan, Jing Lai, additional, Duan, Kai Kai, additional, Fan, Rui Rui, additional, Fan, Yi Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang Qing, additional, Feng, Lei, additional, Fernandez Alonso, Mateo, additional, Frieden, Jennifer Maria, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Ghose, Essna, additional, Gong, Ke, additional, Gong, Yi Zhong, additional, Guo, Dong Ya, additional, Guo, Jian Hua, additional, Han, Shuang Xue, additional, Hu, Yi Ming, additional, Huang, Guang Shun, additional, Huang, Xiao Yuan, additional, Huang, Yong Yi, additional, Ionica, Maria, additional, Jiang, Lu Yao, additional, Jiang, Wei, additional, Jiang, Yao Zu, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi Jun, additional, Li, Wei Liang, additional, Li, Wen Hao, additional, Li, Xiang, additional, Li, Xian Qiang, additional, Liang, Yao Ming, additional, Liu, Cheng Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan Ning, additional, Ma, Miao, additional, Ma, Peng Xiong, additional, Ma, Tao, additional, Ma, Xiao Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Niu, Xiao Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen Xi, additional, Peng, Xiao Yan, additional, Perrina, Chiara, additional, Putti-Garcia, Enzo, additional, Qiao, Rui, additional, Rao, Jia Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei Hua, additional, Shen, Zhao Qiang, additional, Shen, Zhong Tao, additional, Silveri, Leandro, additional, Song, Jing Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao Ran, additional, Sun, Zhi Yu, additional, Surdo, Antonio, additional, Teng, Xue Jian, additional, Tykhonov, Andrii, additional, Wang, Jin Zhou, additional, Wang, Lian Guo, additional, Wang, Shen, additional, Wang, Xiao Lian, additional, Wang, Yan Fang, additional, Wang, Ying, additional, Wang, Yuan Zhu, additional, Wei, Da Ming, additional, Wei, Jia Ju, additional, Wei, Yi Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li Bo, additional, Wu, Sha Sha, additional, Wu, Xin, additional, Xia, Zi Qing, additional, Xu, En Heng, additional, Xu, Hai Tao, additional, Xu, Jing, additional, Xu, Zhi Hui, additional, Xu, Zi Zong, additional, Xu, Zun Lei, additional, Xue, Guo Feng, additional, Yang, Hai Bo, additional, Yang, Peng, additional, Yang, Ya Qing, additional, Yao, Hui Jun, additional, Yu, Yu Hong, additional, Yuan, Guan Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing Jing, additional, Zhang, Sheng Xia, additional, Zhang, Wen Zhang, additional, Zhang, Yan, additional, Zhang, Ya Peng, additional, Zhang, Yi, additional, Zhang, Yong Jie, additional, Zhang, Yong Qiang, additional, Zhang, Yun Long, additional, Zhang, Zhe, additional, Zhang, Zhi Yong, additional, Zhao, Cong, additional, Zhao, Hong Yun, additional, Zhao, Xun Feng, additional, Zhou, Chang Yi, additional, and Zhu, Yan, additional

Published
2023
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21. Point-like Source Catalog Observed by DAMPE

Author

Duan, Kai-Kai, primary, Alemanno, Francesca, additional, Altomare, Corrado, additional, An, Qi, additional, Azzarello, Philipp, additional, Barbato, Felicia Carla Tiziana, additional, Bernardini, Paolo, additional, Bi, Xiao Jun, additional, Cagnoli, Irene, additional, Cai, Ming Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng Yi, additional, Chen, Jun Ling, additional, Chen, Zhan Fang, additional, Chen, Zi Xuan, additional, Coppin, Paul, additional, Cui, Ming Yang, additional, Cui, Tian Shu, additional, Cui, Yu Xin, additional, De Mitri, Ivan, additional, de Palma, Francesco, additional, Di Giovanni, Adriano, additional, Di Santo, Margherita, additional, Ding, Qi, additional, Dong, Tie Kuang, additional, Dong, Zhen Xing, additional, DONVITO, Giacinto, additional, Droz, David, additional, Duan, Jing Lai, additional, Duan, Kai Kai, additional, Fan, Rui Rui, additional, Fan, Yi Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang Qing, additional, Feng, Lei, additional, Fernandez Alonso, Mateo, additional, Frieden, Jennifer Maria, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Ghose, Essna, additional, Gong, Ke, additional, Gong, Yi Zhong, additional, Guo, Dong Ya, additional, Guo, Jian Hua, additional, Han, Shuang Xue, additional, Hu, Yi Ming, additional, Huang, Guang Shun, additional, Huang, Xiao Yuan, additional, Huang, Yong Yi, additional, Ionica, Maria, additional, Jiang, Lu Yao, additional, Jiang, Yao Zu, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi Jun, additional, Li, Wei Liang, additional, Li, Wen Hao, additional, Li, Xian Qiang, additional, Liang, Yao Ming, additional, Liu, Cheng Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan Ning, additional, Ma, Miao, additional, Ma, Peng Xiong, additional, Ma, Tao, additional, Ma, Xiao Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Niu, Xiao Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen Xi, additional, Peng, Xiao Yan, additional, Perrina, Chiara, additional, Putti-Garcia, Enzo, additional, Qiao, Rui, additional, Rao, Jia Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei Hua, additional, Shen, Zhao Qiang, additional, Shen, Zhong Tao, additional, Silveri, Leandro, additional, Song, Jing Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao Ran, additional, Sun, Zhi Yu, additional, Surdo, Antonio, additional, Teng, Xue Jian, additional, Tykhonov, Andrii, additional, Wang, Jin Zhou, additional, Wang, Lian Guo, additional, Wang, Shen, additional, Wang, Xiao Lian, additional, Wang, Yan Fang, additional, Wang, Ying, additional, Wang, Yuan Zhu, additional, Wei, Da Ming, additional, Wei, Jia Ju, additional, Wei, Yi Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li Bo, additional, Wu, Sha Sha, additional, Wu, Xin, additional, Xia, Zi Qing, additional, Xu, En Heng, additional, Xu, Hai Tao, additional, Xu, Jing, additional, Xu, Zhi Hui, additional, Xu, Zi Zong, additional, Xu, Zun Lei, additional, Xue, Guo Feng, additional, Yang, Hai Bo, additional, Yang, Peng, additional, Yang, Ya Qing, additional, Yao, Hui Jun, additional, Yu, Yu Hong, additional, Yuan, Guan Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing Jing, additional, Zhang, Sheng Xia, additional, Zhang, Wen Zhang, additional, Zhang, Yan, additional, Zhang, Ya Peng, additional, Zhang, Yi, additional, Zhang, Yong Jie, additional, Zhang, Yong Qiang, additional, Zhang, Yun Long, additional, Zhang, Zhe, additional, Zhang, Zhi Yong, additional, Zhao, Cong, additional, Zhao, Hong Yun, additional, Zhao, Xun Feng, additional, Zhou, Chang Yi, additional, and Zhu, Yan, additional

Published
2023
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23. Nickel vacancy tuning to tame polysulfide for Li–S batteries

Author

Xuanyang Li, Jian Tan, Zhan Fang, Mingxing Ye, and Jianfeng Shen

Subjects
Materials Chemistry, General Chemistry, Catalysis
Abstract

Ni vacancies causes redistribution of electrons and increases the surface polarity, which simultaneously enhances chemisorption and catalytic conversion of LiPSs.

Published
2023

27. Circ_0002295 facilitated myocardial fibrosis progression through the miR‐1287/CXCR2 axis.

Author

Ma, Guo‐Bin, Chen, Wen‐Xu, Zhan, Fang‐Jie, Xie, Wen‐Jing, Chen, Rong‐Wei, Chen, Hong, Ye, Wei‐Lin, Jiang, Yu, and Xu, Jian‐Ping

Subjects
CIRCULAR RNA, FIBROSIS, MYOCARDIAL infarction, HEART failure, MYOFIBROBLASTS
Abstract

Myocardial fibrosis (MF) is involved in hypertension, myocardial infarction and heart failure. It has been reported that circular RNA (circRNA) is a key regulatory factor of MF progression. In this study, we revealed that circ_0002295 and CXCR2 were elevated, and miR‐1287 was reduced in MF patients. Knockdown of circ_0002295 effectively suppressed the proliferation, migration and MF progression. Circ_0002295 was the molecular sponge of miR‐12878, and miR‐1287 inhibitor reversed the biological functions of circ_0002295 on the myocardial fibrosis. CXCR2 was a target gene of miR‐1287, and CXCR2 silencing relieved the impacts of miR‐1287 inhibitor on cardiac myofibroblasts. Circ_0002295 promoted MF progression by regulating the miR‐1287/CXCR2 axis, providing a possible circRNA‐targeted therapy for MF. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho

Author

Cun Liu, Wei-Wei Chen, Fu-Qiang Liu, Ai-Mei Ou-Yang, Jian Wang, En-Guo Wang, Xi-Ming Wang, and Zhan-Fang Zhu

Subjects
Premature aging, medicine.medical_specialty, business.industry, premature aging, International Journal of General Medicine, General Medicine, medicine.disease, urologic and male genital diseases, Gastroenterology, Pathophysiology, Coronary heart disease, female genital diseases and pregnancy complications, Klotho, medicine.anatomical_structure, Internal medicine, medicine, earlobe crease, In patient, Endothelial dysfunction, atherosclerosis, business, Earlobe, Hormone, Original Research
Abstract

Jian Wang,1,&ast; Zhan-Fang Zhu,2,&ast; Fu-Qiang Liu,3 Cun Liu,4 Ai-Mei Ou-Yang,1 Wei-Wei Chen,1 En-Guo Wang,1 Xi-Ming Wang5,6 1Department of Radiology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, 250013, People’s Republic of China; 2Department of Internal Medicine, The Hospital of Xi’an Jiaotong University, Xi’an, 710049, People’s Republic of China; 3Department of Cardiovascular, Shaanxi Provincial People’s Hospital, Xi’an, 710068, People’s Republic of China; 4Department of Ultrasound, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, 250013, People’s Republic of China; 5Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, People’s Republic of China; 6Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xi-Ming Wang Tel/Fax +86 531-68776846Email wangximing_dr@outlook.comObjective: Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that ELC patients with lower serum levels of the age-suppressing hormone Klotho, which is not only associated with premature aging but also with endothelial dysfunction, may be associated with atherosclerosis.Methods: A total of 135 patients aged 40– 68 years underwent coronary angiography. According to the presence or absence of coronary heart disease (CAD) and ELC, they were divided into three groups: CAD group and ELC group (ELC group, n = 45); no ELC group (non-ELC group, n = 45). There was no ELC or CAD in the control group (control group, n = 45). Serum Klotho concentration was obtained by enzyme-linked immunosorbent assay (ELISA).Results: The Klotho level in the ELC group was 365.6 ± 38.1 pg/mL, while the Klotho level in the non-ELC group was 568.8 ± 44.9 pg/mL. It is worth noting that the Klotho level of the ELC group was significantly lower than that of the non-ELC group (P < 0.001). The serum Klotho level of the control group was higher than that of the non-ELC group (593.3± 45.3 vs 568.8± 44.9 pg/mL, P = 0.702), but the difference was not statistically significant. Multiple logistic regression analysis showed that the Klotho level is a parameter that affects the appearance of ELC.Conclusion: Serum Klotho levels were considerably lower in patients with ELC. We concluded that the perturbations of Klotho in patients might be associated with ELC and with CAD.Keywords: earlobe crease, Klotho, atherosclerosis, premature aging

Published
2021

32. Thymoquinone induces apoptosis in temozolomide-resistant glioblastoma cells via the p38 mitogen-activated protein kinase signaling pathway

Author

Ai Mai, Shu‐Wen Ye, Jia‐Yu Tu, Jun Gao, Zhan‐Fang Kang, Qian‐Ming Yao, and Wei‐Jen Ting

Subjects
Guanine, Brain Neoplasms, Health, Toxicology and Mutagenesis, Mice, Nude, Apoptosis, General Medicine, Management, Monitoring, Policy and Law, Toxicology, p38 Mitogen-Activated Protein Kinases, Dacarbazine, Mice, Drug Resistance, Neoplasm, Purines, Cell Line, Tumor, Temozolomide, Animals, Glioblastoma, Antineoplastic Agents, Alkylating, Signal Transduction
Abstract

Temozolomide (TMZ) can cross the blood-brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes methyl groups from purine bases, counteracts methylation by TMZ. We evaluated the anticancer potential of thymoquinone (TQ), a hydrophobic flavonoid that inhibits resistance and induces apoptosis in various cancer cells, both in vitro and in vivo. In vitro experiments showed that compared with the Hs683 and M059J cell lines, U251 cells were more sensitive to TMZ. Compared to U251 cells, U251R cells, a TMZ drug-resistant strain established in this study, are characterized by increased expression of phosphorylated extracellular signal-regulated kinase (p-ERK) and MGMT. TQ treatments induced apoptosis in all cell lines. The p38 mitogen-activated protein kinase signal pathway was mainly activated in U251 and U251R cells; however, p-ERK and MGMT upregulation could not suppress TQ effects. Furthermore, si-p38 pretreatment of U251R cells in TQ treatments inhibited cell apoptosis. We speculate that TQ contributed to the phosphorylation and activation of p38, but not of ERK-induced apoptosis (irrespective of TMZ resistance). In vivo, U251R-derived tumors subcutaneously inoculated in nude mice exhibited significant tumor volume reduction after TQ or TQ + TMZ cotreatments. High-performance liquid chromatography assay confirmed the presence of TQ in murine brain tissues. Our findings demonstrate that TQ can effectively cross the BBB and function alone or in combination with TMZ to treat glioblastoma.

Published
2022

36. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer

Author

Liang, Yun-Feng, primary, Alemanno, Francesca, additional, An, Qi, additional, Azzarello, Philipp, additional, Tiziana Barbato, Felicia Carla, additional, Bernardini, Paolo, additional, Bi, Xiao-Jun, additional, Cai, Ming-Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng-Yi, additional, Chen, Jun-Ling, additional, Chen, Zhan-Fang, additional, Cui, Ming-Yang, additional, Cui, Tian-Shu, additional, Cui, Yu-Xing, additional, Dai, Hao-Ting, additional, Benedittis, Antonio De, additional, Mitri, Ivan De, additional, de Palma, Francesco, additional, Deliyergiyev, Maksym, additional, Santo, Margherita Di, additional, Ding, Qi, additional, Dong, Tie-Kuang, additional, Dong, Zhen-Xing, additional, Donvito, Giacinto, additional, Droz, David, additional, Duan, Jing-Lai, additional, Duan, Kai-Kai, additional, D’Urso, Domenico, additional, Fan, Rui-Rui, additional, Fan, Yi-Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang-Qing, additional, Feng, Lei, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Gong, Ke, additional, Gong, Yi-Zhong, additional, Guo, Dong-Ya, additional, Guo, Jian-Hua, additional, Han, Shuang-Xue, additional, Hu, Yi-Ming, additional, Huang, Guang-Shun, additional, Huang, Xiao-Yuan, additional, Huang, Yong-Yi, additional, Ionica, Maria, additional, Jiang, Wei, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi-Jun, additional, Li, Shang, additional, Li, Wen-Hao, additional, Li, Wei-Liang, additional, Li, Xiang, additional, Li, Xian-Qiang, additional, Liang, Yao-Ming, additional, Liu, Cheng-Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu-Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan-Ning, additional, Ma, Miao, additional, Ma, Peng-Xiong, additional, Ma, Tao, additional, Ma, Xiao-Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Salinas, Maria Muñoz, additional, Niu, Xiao-Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen-Xi, additional, Peng, Xiao-Yan, additional, Perrina, Chiara, additional, Qiao, Rui, additional, Rao, Jia-Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei-Hua, additional, Shen, Zhao-Qiang, additional, Shen, Zhong-Tao, additional, Silveri, Leandro, additional, Song, Jing-Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao-Ran, additional, Sun, Zhi-Yu, additional, Surdo, Antonio, additional, Teng, Xue-Jian, additional, Tykhonov, Andrii, additional, Wang, Jin-Zhou, additional, Wang, Lian-Guo, additional, Wang, Shen, additional, Wang, Shu-Xin, additional, Wang, Xiao-Lian, additional, Wang, Ying, additional, Wang, Yan-Fang, additional, Wang, Yuan-Zhu, additional, Wei, Da-Ming, additional, Wei, Jia-Ju, additional, Wei, Yi-Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li-Bo, additional, Wu, Sha-Sha, additional, Wu, Xin, additional, Xia, Zi-Qing, additional, Xu, En-Heng, additional, Xu, Hai-Tao, additional, Xu, Zhi-Hui, additional, Xu, Zun-Lei, additional, Xu, Zi-Zong, additional, Xue, Guo-Feng, additional, Yang, Hai-Bo, additional, Yang, Peng, additional, Yang, Ya-Qing, additional, Yao, Hui-Jun, additional, Yu, Yu-Hong, additional, Yuan, Guan-Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing-Jing, additional, Zhang, Sheng-Xia, additional, Zhang, Wen-Zhang, additional, Zhang, Yan, additional, Zhang, Yi, additional, Zhang, Yong-Jie, additional, Zhang, Yun-Long, additional, Zhang, Ya-Peng, additional, Zhang, Yong-Qiang, additional, Zhang, Zhe, additional, Zhang, Zhi-Yong, additional, Zhao, Cong, additional, Zhao, Hong-Yun, additional, Zhao, Xun-Feng, additional, Zhou, Chang-Yi, additional, and Zhu, Yan, additional

Published
2022
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37. Disrupting circ-GNB4 mitigates high glucose-induced human mesangial cells injury by regulating the proliferation, ECM accumulation, inflammation and oxidative stress through circ-GNB4/miR-23c/EGR1 pathway [RETRACTED]

Author

Jing Chang, Zhan Fang, Dan Wang, Haiyan He, Fang Sun, Jian Teng, and Lina Yang

Subjects
Pharmacology, Cardiology and Cardiovascular Medicine
Abstract

Diabetic nephropathy (DN) is the most common complication of diabetes mellitus. Although G protein subunit beta 4 (GNB4)-derived circular RNA (circ-GNB4; hsa_circ_0068087) is a promising candidate biomarker in diabetes mellitus, whether circ-GNB4 participates in DN occurrence and development remains unknown. Herein, we focused on DN-associated human renal mesangial cells (HRMCs) injury, and HRMCs were exposed in high glucose (HG) condition. Using quantitative polymerase chain reaction and western blotting, we found that circ-GNB4 and early growth response factor 1 (EGR1) were upregulated, whereas microRNA (miR)-23c was downregulated in DN patients' sera and HG-stimulated HRMCs. HG-induced injuries were measured by MTS method, western blotting, enzyme-linked immunosorbent assay and other special assay kits. Consequently, HG could inhibit superoxide dismutase activity, but induce cell proliferation and levels of malondialdehyde, Fibronectin, Collagen I, Collagen IV, interleukin-6, interleukin-1β, and tumor necrosis factor-α. However, HG-induced these injuries were overall suppressed by silencing circ-GNB4 or overexpressing miR-23c. Moreover, miR-23c knockdown could counteract the effect of circ-GNB4 deficiency, and EGR1 restoration abrogated miR-23c overexpression role in HG-stimulated HRMCs. Notably, circ-GNB4 could target miR-23c and EGR1 was targeted by miR-23c, as confirmed by dual-luciferase reporter assay and RNA immunoprecipitation. Moreover, EGR1 expression was positively modulated by circ-GNB4 via miR-23c. Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress. This study suggested circ-GNB4 as a potential target to interfere the development of DN.

Published
2022

38. Multimode Gesture Recognition Algorithm Based on Convolutional Long Short-Term Memory Network

Author

Ming-Xing Lu, Guo-Zhen Du, and Zhan-Fang Li

Subjects
Memory, Long-Term, Memory, Short-Term, General Computer Science, Gestures, Article Subject, General Mathematics, General Neuroscience, General Medicine, Neural Networks, Computer, Algorithms
Abstract

Gesture recognition utilizes deep learning network model to automatically extract deep features of data; however, traditional machine learning algorithms rely on manual feature extraction and poor model generalization ability. In this paper, a multimodal gesture recognition algorithm based on convolutional long-term memory network is proposed. First, a convolutional neural network (CNN) is employed to automatically extract the deeply hidden features of multimodal gesture data. Then, a time series model is constructed using a long short-term memory (LSTM) network to learn the long-term dependence of multimodal gesture features on the time series. On this basis, the classification of multimodal gestures is realized by the SoftMax classifier. Finally, the method is experimented and evaluated on two dynamic gesture datasets, VIVA and NVGesture. Experimental results indicate that the accuracy rates of the proposed method on the VIVA and NVGesture datasets are 92.55% and 87.38%, respectively, and its recognition accuracy and convergence performance are better than those of other comparison algorithms.

Published
2022
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39. Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway.

Author

Mai, Ai, Ye, Shu‐Wen, Tu, Jia‐Yu, Gao, Jun, Kang, Zhan‐Fang, Yao, Qian‐Ming, and Ting, Wei‐Jen

Subjects
MITOGEN-activated protein kinases, CELLULAR signal transduction, GUANINE, GLIOBLASTOMA multiforme, METHYLGUANINE, HIGH performance liquid chromatography, APOPTOSIS, METHYLTRANSFERASES
Abstract

Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes methyl groups from purine bases, counteracts methylation by TMZ. We evaluated the anticancer potential of thymoquinone (TQ), a hydrophobic flavonoid that inhibits resistance and induces apoptosis in various cancer cells, both in vitro and in vivo. In vitro experiments showed that compared with the Hs683 and M059J cell lines, U251 cells were more sensitive to TMZ. Compared to U251 cells, U251R cells, a TMZ drug‐resistant strain established in this study, are characterized by increased expression of phosphorylated extracellular signal‐regulated kinase (p‐ERK) and MGMT. TQ treatments induced apoptosis in all cell lines. The p38 mitogen‐activated protein kinase signal pathway was mainly activated in U251 and U251R cells; however, p‐ERK and MGMT upregulation could not suppress TQ effects. Furthermore, si‐p38 pretreatment of U251R cells in TQ treatments inhibited cell apoptosis. We speculate that TQ contributed to the phosphorylation and activation of p38, but not of ERK‐induced apoptosis (irrespective of TMZ resistance). In vivo, U251R‐derived tumors subcutaneously inoculated in nude mice exhibited significant tumor volume reduction after TQ or TQ + TMZ cotreatments. High‐performance liquid chromatography assay confirmed the presence of TQ in murine brain tissues. Our findings demonstrate that TQ can effectively cross the BBB and function alone or in combination with TMZ to treat glioblastoma. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Immobilization of molybdenum-based complexes on dendrimer-functionalized graphene oxide and their catalytic activity for the epoxidation of alkenes

Author

Yongqing Liu, Zhan-Fang Fan, Yang Liu, Maosheng Cheng, and Bin Lin

Subjects
Molybdenum, Materials science, Dendrimer, Graphene, Process Chemistry and Technology, Oxide, chemistry.chemical_element, Epoxidation, General Chemistry, Alkenes, Catalysis, law.invention, chemistry.chemical_compound, Chemistry, chemistry, X-ray photoelectron spectroscopy, Covalent bond, law, Polymer chemistry, Selectivity, QD1-999, Graphene oxide
Abstract

Two novel molybdenum-based heterogeneous catalysts immobilized on dendrimer-functionalized graphene oxide via electrostatic interactions (Mo-1) or covalent bonding (Mo-2) are reported. The catalysts show excellent catalysis in epoxidation of alkenes with high conversion, better selectivity and good recyclability. The characteristics were identified by SEM, TEM (EDS-mapping), FT-IR, XRD, and XPS. The cause of the difference between the two catalysts is supported by DFT calculations.

Published
2021

46. Pollution and Health Risk Assessment of Heavy Metals in Farmlands and Vegetables Surrounding a Lead-Zinc Mine in Yunnan Province, China.

Author

Lai, Li, Li, Bo, Li, Zu-ran, He, Yong-mei, Hu, Wen-you, Zu, Yan-qun, and Zhan, Fang-dong

Abstract

To investigate the contaminant characteristics of heavy metals in soils and vegetables surrounding a lead-zinc mine in Huize County, Yunnan Province, thirty surface soil samples and vegetable samples were collected to measure the contents of heavy metals, including lead (Pb), zinc (Zn), copper (Cu), and cadmium (Cd). The potential risk was evaluated by using the single factor pollution index, Nemerow comprehensive pollution index, and target hazard index. The results showed that the contents of Pb, Zn, Cu, and Cd in the soil were 954.1, 2236.5, 151.1, and 4.83 mg·kg−1, respectively. Compared with the soil background values in Yunnan Province, the soil surrounding the lead-zinc mine was polluted by Pb, Zn and Cd. The Nemerow comprehensive pollution index evaluation indicated that the soil was heavily polluted. The contents of Pb, Zn, Cu, and Cd in vegetables were 117.5–778.6, 430.3–2212.4, 16.8–89, and 1.28–34.3 mg·kg−1, respectively. Among them, the contents of Pb and Cd in vegetables exceeded the pollutant limit in food products of China's National Standard for Food Safety (GB 2762–2017). The contents of Pb, Zn and Cd in the soil were extremely significantly or significantly correlated with the contents of Pb, Zn and Cd in the edible parts of vegetables. The results indicated that there was serious heavy metal pollution and significant health risk for the soil and vegetables surrounding the lead-zinc mine. The research results not only reveal the contaminant characteristics of heavy metals in soils and vegetables surrounding a lead-zinc mine in Huize County, Yunnan Province, but also could provide a scientific evidence for reasonable utilization and ecological remediation. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Constraints on dark matter annihilation from the Event Horizon Telescope observations of M87*.

Author

Yuan, Guan-Wen, Chen, Zhan-Fang, Shen, Zhao-Qiang, Guo, Wen-Qing, Ding, Ran, Huang, Xiaoyuan, and Yuan, Qiang

Subjects
*WEAKLY interacting massive particles, *ANNIHILATION reactions, *PROPERTIES of matter, *DARK matter, *SUPERMASSIVE black holes, *SYNCHROTRON radiation, *RADIO astronomy
Abstract

The fast developments of radio astronomy open a new window to explore the properties of Dark Matter (DM). The recent direct imaging of the supermassive black hole (SMBH) at the center of M87 radio galaxy by the Event Horizon Telescope (EHT) collaboration is expected to be very useful to search for possible new physics. In this work, we illustrate that such results can be used to detect the possible synchrotron radiation signature produced by DM annihilation from the innermost region of the SMBH. Assuming the existence of a spike DM density profile, we obtain the flux density due to DM annihilation induced electrons and positrons, and derive new limits on the DM annihilation cross section via the comparison with the EHT integral flux density at 230 GHz. Our results show that the parameter space can be probed by the EHT observations is largely complementary to other experiments. For DM with typical mass regions of being weakly interacting massive particles, the annihilation cross section several orders of magnitude below the thermal production level can be excluded by the EHT observations under the density spike assumption. Future EHT observations may further improve the sensitivity on the DM searches, and may also provide a unique opportunity to test the interplay between DM and the SMBH. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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48. Constraints on dark matter annihilation from the Event Horizon Telescope observations of M87*.

Author

Yuan, Guan-Wen, Chen, Zhan-Fang, Shen, Zhao-Qiang, Guo, Wen-Qing, Ding, Ran, Huang, Xiaoyuan, and Yuan, Qiang

Subjects
WEAKLY interacting massive particles, ANNIHILATION reactions, PROPERTIES of matter, DARK matter, SUPERMASSIVE black holes, SYNCHROTRON radiation, RADIO astronomy
Abstract

The fast developments of radio astronomy open a new window to explore the properties of Dark Matter (DM). The recent direct imaging of the supermassive black hole (SMBH) at the center of M87 radio galaxy by the Event Horizon Telescope (EHT) collaboration is expected to be very useful to search for possible new physics. In this work, we illustrate that such results can be used to detect the possible synchrotron radiation signature produced by DM annihilation from the innermost region of the SMBH. Assuming the existence of a spike DM density profile, we obtain the flux density due to DM annihilation induced electrons and positrons, and derive new limits on the DM annihilation cross section via the comparison with the EHT integral flux density at 230 GHz. Our results show that the parameter space can be probed by the EHT observations is largely complementary to other experiments. For DM with typical mass regions of being weakly interacting massive particles, the annihilation cross section several orders of magnitude below the thermal production level can be excluded by the EHT observations under the density spike assumption. Future EHT observations may further improve the sensitivity on the DM searches, and may also provide a unique opportunity to test the interplay between DM and the SMBH. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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49. Graphene oxide-Bicine composite as a novel adsorbent for removal of various contaminants from aqueous solutions

Author

Xinyu Jiang, Jingang Yu, Zhan-Fang Cao, Hao Ren, and Yong-Yuan Chen

Subjects
Materials science, Aqueous solution, Graphene, Process Chemistry and Technology, Bicine, Composite number, Oxide, Contamination, Pollution, law.invention, chemistry.chemical_compound, Adsorption, chemistry, Chemical engineering, law, Chemical Engineering (miscellaneous), Waste Management and Disposal
Published
2021

50. Reasonable application range of flocculation–solidification combined method in treatment of hydraulically dredged mud slurry.

Author

Zhang, Rong-Jun, Xu, Zhi-Hao, Zheng, Jun-Jie, Tu, Lin-Wei, and Huang, Zhan-fang

Subjects
MUD, SLURRY, SOLIDIFICATION, FLOCCULATION, CEMENT, THERAPEUTICS
Abstract

An improved method, i.e., flocculation–solidification combined method (FSCM), has been developed for building a working platform more efficiently at the surface of newly reclaimed ground filled with hydraulically dredged mud slurry at extra high water content (EHW-MS). Previous experimental results have demonstrated the significant superiority of FSCM over conventional pure cement solidification method (PCSM) under some application conditions. This study focuses on further clarifying the reasonable boundary for the application conditions, i.e., identifying the reasonable application range, of FSCM in EHW-MS treatment. A number of laboratory experiments are performed to characterize the deposition and strength gain behavior of FSCM or PCSM treated EHW-MS samples with various values of the equivalent initial water content (wei) and Atterberg limits. The deposition and strength characteristics resulting from FSCM and PCSM are then compared comprehensively to illustrate the influence of wei and Atterberg limits on the superiority of FSCM over PCSM. Results indicate well that FSCM shows more significant superiority over PCSM with the increase of either wei or Atterberg limits, and plastic limit > 14 (or liquid limit > 23) and wei > 232% can be considered as the reasonable application range of FSCM in EHW-MS treatment, within which the solidification efficiency of FSCM is at least 1.20 times higher than that of PCSM. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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