102 results on '"Zarzour M"'
Search Results
2. Traumatic life events and its impact on fibromyalgia symptoms through serotonin activity on pain perception and personality traits
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Zarzour, M. and Bou Khalil, R.
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- 2022
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Catalog
3. Anxiety and sleep quality in a sample of Lebanese healthcare workers during the COVID-19 outbreak
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Zarzour, M., Hachem, C., Kerbage, H., Richa, S., Choueifaty, D. El, Saliba, G., Haddad, E., Melki, E., Sleilaty, G., Saliby, R., Sabbagh, C., and Choucair, J.
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- 2022
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4. Abstract No. 25 Safety and Efficacy of Percutaneous Thermal Ablation for Soft Tissue Sarcoma Metastases to the Liver
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Awad, A., primary, Pal, K., additional, Huang, S., additional, Yevich, S., additional, Kuban, J., additional, Tam, A., additional, Odisio, B., additional, Gupta, S., additional, Habibollahi, P., additional, Bishop, A., additional, Conley, A., additional, Somaiah, N., additional, Araujo, D., additional, Zarzour, M., additional, Ravin, R., additional, Roland, C., additional, Keung, E., additional, and Sheth, R., additional more...
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- 2024
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5. Syrian refugee young adults as community mental health workers implementing problem management plus: Protocol for a pilot randomized controlled trial to measure the mechanisms of effect on their own wellbeing, stress and coping.
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Nakkash R, Ghandour L, Brown G, Panter-Brick C, Bomar H, Tleis M, Al Masri H, Fares M, Al Halabi F, Najjar Y, Louis B, Hodroj M, Chamoun Y, Zarzour M, and Afifi RA
- Abstract
This pilot randomized controlled trial protocol aims to (1) assess the impact on the wellbeing of Syrian refugee young adults (18-24 years) of being a community mental health worker (CMHW) implementing WHO's evidence-based psychosocial intervention - Problem Management Plus (PM+) - with adults in their community, and (2) identify the mechanisms associated with the outcomes of enhanced wellbeing and coping, and reduced stress among these CMHWs. Over 108 million people have been forcibly displaced as of the end of 2022. Mental health consequences of these displacements are significant, yet human resources for health are not sufficient to meet the needs. A large proportion of refugee populations are youth and young adults (YA). Evidence indicates their engagement in supporting their communities leads to their own enhanced wellbeing and that of their community. This trial trains Syrian refugees to serve their communities as CMHW (n=19) or tutors (n=19) and compare wellbeing, stress and coping outcomes between these two groups and a control group (n = 40). We will also assess 7 mechanisms as potential pathways for the interventions to influence outcomes. Surveys will assess outcomes and mechanisms, hair samples will measure stress cortisol. The primary analysis will use a Bayesian Hierarchical Model approach to model the trajectories of the mechanisms and primary study endpoints over time for individuals in each of the arms. Our results will elucidate critical mechanisms in which engagement of young adults to support their community enhances their own wellbeing., Trial Registration: National Institutes of Mental Health, NCT05265611, Registered prospectively in 2021., Lebanon Clinical Trials Registry #: LBCTR2023015206, Registered in 2023., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.) more...
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- 2024
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6. Abstract No. 359 Cryoablation for the Management of Soft Tissue Sarcoma Metastases: A Single-Center Retrospective Study
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Pal, K., Awad, A., Yevich, S., Kuban, J., Tam, A., Huang, S., Odisio, B., Gupta, S., Habibollahi, P., Bishop, A., Conley, A., Somaiah, N., Zarzour, M., Araujo, D., Ravin, R., Roland, C., Keung, E., and Sheth, R. more...
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- 2024
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7. Sleep Quality Among Patients and Healthcare Providers in the Primary Healthcare Setting.
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Krasnik, Rastislava, Kolundžić, Mirjana, Mikov, Aleksandra, Zvekić-Svorcan, Jelena, Vukliš, Dragana, Kovačević, Milena, Mikić, Andrijana, Mikov, Igor, Dedić Novaković, Dajana, and Stanić, Milica
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SLEEP quality ,SLEEP interruptions ,MEDICAL personnel ,HYPNOTICS ,WORK environment - Abstract
Background/Objectives: As adults spend about 30% of each day asleep, having a sleep disorder can negatively affect their functioning. The study objective was to determine the factors that influence sleep quality among patients and healthcare providers in the primary healthcare setting. Methods: This study included respondents of both sexes aged 18–90 years, comprising outpatients and the healthcare providers working in the General Medicine Service at the "Liman" Department of the "Novi Sad" Health Center in Novi Sad, Republic of Serbia. Demographic data along with factors related to lifestyle and sleep habits were collected using a demographic questionnaire specifically designed for this research. The standardized Pittsburgh Sleep Quality Questionnaire, Serbian version (PSQI), was used to assess sleep quality. Results: The study sample comprised 92 respondents (42 healthcare providers and 50 patients), 73.9% of whom were female, with an average age of 50.0 years. Although 50% of healthcare providers reported sleeping only 3–6 h the previous night, according to the PSQI results, patients had lower overall sleep quality (54.0% vs. 33.3%; p = 0.046) and achieved lower scores in the DISTB (sleep disturbances, p = 0.001), SLPQUAL (subjective sleep quality, p = 0.013) and MEDS (use of sleeping medication, p = 0.003) PSQI domains. Conclusions: Sleep quality is impaired in more than half of patients and more than a third of healthcare providers. By detecting and acting on the factors in the home and work environment that affect quality of sleep, and by changing lifestyle habits, sleep quality in adults can be improved. [ABSTRACT FROM AUTHOR] more...
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- 2025
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8. Building Performance Based on Seismic Conceptual Design in Temporary Housing Semeru Eruption 2021.
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Bahar, M A
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- 2025
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9. Health Anxiety, Sleep Quality in Healthcare Workers Under Critical Conditions of Emerging Diseases.
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Montazeri, Akram, Sadaghloo, Adeleh, Fahimi, Kowsar, Gashmard, Roqayeh, and Zare, Azam
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COMMUNICABLE diseases ,CROSS-sectional method ,STATISTICAL correlation ,MEDICAL personnel ,ACADEMIC medical centers ,STATISTICAL sampling ,QUESTIONNAIRES ,ANXIETY ,DESCRIPTIVE statistics ,RESEARCH ,RESEARCH methodology ,SLEEP quality ,SOCIODEMOGRAPHIC factors ,PSYCHOLOGICAL tests ,DATA analysis software ,PSYCHOSOCIAL factors - Abstract
Background: One of the crises recently affecting human society is an emerging pandemic that has had a significant psychological impact on healthcare workers. Studies have shown that staff experience psychological disorders such as anxiety, depression, and insomnia when exposed to crises. Objectives: This study aimed to determine the association between health anxiety and the sleep quality of healthcare workers during crisis conditions. Methods: This cross-sectional, correlational descriptive-analytical study was conducted from late February 2019 to late March 2020. Using convenient sampling, 382 healthcare workers from medical universities in Golestan province participated in the survey. Data were collected via an internet link shared with participants through WhatsApp working groups. The instruments used in this research included demographic information, sleep quality, and health anxiety inventories. The data were analyzed using SPSS-21 with descriptive and analytical statistics. Results: Of the participants, 77.2% were women, 65.4% were single, 60.7% were nurses, and 64.4% had a bachelor's degree. The results revealed that 72.7% of the staff experienced moderate to high levels of anxiety. Regarding sleep quality, 28.3% (n = 108) of healthcare workers reported good sleep quality, while 71.7% (n = 274) reported poor sleep quality. Additionally, the results indicated a significant correlation between health anxiety scores and sleep quality scores (r = 0.129, P = 0.01). Conclusions: The results of this study showed that the critical conditions caused by emerging diseases have led to health anxiety among healthcare workers, negatively affecting their sleep quality. Therefore, medical center officials must address such psychological issues and implement preventive measures to maintain the mental health of healthcare workers. [ABSTRACT FROM AUTHOR] more...
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- 2024
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10. Searching for the 'X' factor: investigating the genetics of primary ovarian insufficiency.
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Knight, Anya, Sugin, Sara, and Jurisicova, Andrea
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X chromosome ,GENETIC testing ,EARLY intervention (Education) ,GENETIC models ,GENETIC variation - Abstract
Primary ovarian insufficiency (POI) is the cessation of ovarian function before the age of 40. The causes of POI are heterogeneous, but substantial evidence exists to support a genetic basis of POI, particularly in the critical involvement of genes on the X chromosome. Recent studies have revealed novel candidate genes through the identification of copy number variations associated with POI. This review summarizes the genes located on the X chromosome with variants shown to be associated with POI in humans and/or in mice. Additionally, we present evidence to support the potential involvement of these candidate genes in the etiology of POI. We conducted a literature search in PubMed to identify case studies and screenings for the genetic causes of POI. We then performed systematic searches for the proposed candidate genes to investigate their potential reproductive roles. Of the X-linked candidate genes investigated, 10 were found to have variants associated with cases of POI in humans. An additional 10 genes were found to play a supportive role in POI. Other genes were not implicated in any cases of POI but were associated with various roles in reproduction. In the majority of cases where variants were identified through whole-exome sequencing, rather than targeted screening of candidate genes, more than one genetic variant was identified. Overall, this review supports past findings that the X chromosome plays a critical role in ovarian function, as demonstrated by a link between POI and various disruptions to genes on the X chromosome. Current genetic screening for POI, which includes only FMR1, is inadequate to capture the majority of cases with a genetic origin. An expanded genetic testing may improve health outcomes for individuals with POI as it could lead to better early interventions and education about these health risks. [ABSTRACT FROM AUTHOR] more...
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- 2024
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11. Factors Associated with Health-related Quality of Life in Moroccan Adults with Asthma.
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El Abed, Hanane, Ait-Taleb Lahsen, Hanaâ, El Malki, Hicham, Erraji, Alaa Eddine, Benjelloun, Mohamed Chakib, Ragala, Mohammed El Amine, and Halim, Karima
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CROSS-sectional method ,PEARSON correlation (Statistics) ,HEALTH literacy ,HEALTH status indicators ,ACADEMIC medical centers ,T-test (Statistics) ,QUESTIONNAIRES ,MULTIPLE regression analysis ,HEALTH insurance ,MULTIVARIATE analysis ,POPULATION geography ,LONGITUDINAL method ,QUALITY of life ,STATISTICS ,DATA analysis software ,ASTHMA ,EDUCATIONAL attainment - Abstract
Introduction: The assessment of asthmatics' health-related quality of life (HRQOL) has become an important outcome measure of the disease's effects from the patient's perspective. This study aims to assess the asthmatics' QOL and determine the factors affecting it. Methods: A cross-sectional study was conducted among 220 adult people with asthma attending the Pneumology Department of Hassan II University Hospital in Fez from March to May 2022. Patients were questioned by a face-to-face questionnaire, an asthma control test, an observance questionnaire, a knowledge questionnaire, and a specific asthma QOL questionnaire. The influence of the variables was evaluated by bivariate analysis and multiple linear regression. Results: The mean age was 48.4 ± 15.4. 71.8% were women, half were not attending school, and 77.7% lived in urban areas. 67.7% were nonsmokers, and 72.73% were passive workers. Only 42.27% complied well with treatment, and 41.82% have well-controlled asthma. The majority of people had insufficient knowledge. The QOL was considered good for 20% of the participants, poor for 11.8%, and average for 68.2% of the patients. The mean of the global QOL score was 5.1 ± 0.9. The most significant factors associated with a higher QOL were good asthma control (ß = 0.70; P ≤ 0.001), good knowledge score (ß = 0.125; P = 0.013), insurance coverage (ß = 0.144; P = 0.005), and work activity (ß = 0.133; P = 0.007). Conclusion: Our study found multiple factors affecting asthma patients' QOL, including asthma control, knowledge, and socioeconomic status. We can take some measures to improve the situation through patient education. [ABSTRACT FROM AUTHOR] more...
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- 2024
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12. RELIABILITY AND VALIDITY OF THE KAZAKH-LANGUAGE ACT QUESTIONNAIRE AS AN ASTHMA CONTROL TOOL.
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Ispayeva, Zhanat, Bekmagambetova, Raikhan, Mustafina, Mereke, Kovzel, Elena, Tusupbekova, Galiya, Morenko, Marina, Saliev, Timur, Tanabayeva, Shynar, and Fakhradiyev, Ildar
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- 2024
13. Impact of Randomized Soil Properties and Rock Motion Intensities on Ground Motion.
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Chala, Ayele and Ray, Richard
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GROUND motion ,ROCK properties ,EARTHQUAKE intensity ,SEISMIC response ,MONTE Carlo method - Abstract
Seismic site response is inevitably influenced by natural variability of soil properties and anticipated earthquake intensity. This study presents the influence of variability in shear wave velocity (V
s ) and amplitude of input rock motion on seismic site response analysis. Monte Carlo simulations were employed to randomize the Vs profile for different scenarios. A series of 1-D equivalent linear (EQL) seismic site response analyses were conducted by combining the randomized Vs profile with different levels of rock motion intensities. The results of the analyses are presented in terms of surface spectral acceleration, amplification factors (AFs), and peak ground acceleration (PGA). The mean and standard deviation of these parameters are thoroughly discussed for a wide range of randomized Vs profile, number of Vs randomizations, and intensities of input rock motions. The results demonstrate that both the median PGA and its standard deviations across different number of Vs profile realization exhibit a slight variation. As few as twenty Vs profile realizations are sufficient to compute reliable response parameters. Both rock motion intensity and standard deviation of Vs variability cause significant variation in computed surface parameters. However, the variability in the number of records used to conduct site response has no significant impact on ground response if the records closely match the target spectrum. Incorporating the multiple sources of variabilities can reduce uncertainty when conducting ground response simulations. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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14. Impact of Anxiety and Depression on the Level of Asthma Control Among Jordanian Adults with Asthma.
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Karsaneh, Ola Abu Al, Anber, Arwa Al, Shboul, Sofian Al, Alrjoub, Moath, Almashaqbeh, Omran Ibrahim, Alqaisi, Mohammad, Abuatieh, Rahaf, Ananzeh, Suhaib Mohammad, Hamad, Anas Mousa, Almomani, Raneem, and Tommalieh, Mohammad Mahmoud more...
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ASTHMA ,ANXIETY ,ASTHMATICS ,MENTAL depression ,ADULTS - Abstract
Purpose: Recent studies imply that psychological factors may actively contribute to the development of asthma. It is generally known that people with asthma frequently suffer from psychological illnesses. This association can make it challenging to reach asthma control. This study aimed to assess the prevalence of depression and anxiety among Jordanian adults with asthma, in addition to the link between asthma control levels and these psychological disorders. Patients and Methods: This cross-sectional study included 175 adults with asthma who visited the tertiary asthma clinic in three Jordanian Governmental hospitals. Sociodemographic data was collected directly from the patients who were assessed for their level of depression and anxiety using a self-administered questionnaire, the Hospital Anxiety and Depression Scale (HADS). Also, asthma control was assessed using the Asthma Control Test (ACT). The relation between the different sociodemographic variables and clinical data, particularly depression and anxiety and asthma control level, was assessed. Results: Among 175 asthmatic patients, 60.57% had poor disease control, 8% had anxiety alone, 11.43% had depression alone, and 53.14% had anxiety plus depression. Poor asthma control was significantly associated with anxiety and depression (p= 0.044) and low levels of education (p=0.001). Further, a lower level of education was also related to higher levels of anxiety and depression. Conclusion: Most of the assessed Jordanian patients with asthma had their disease poorly controlled. Anxiety and depression are common among the studied sample of adults with asthma, and they appear to affect the level of disease control, suggesting the possibility that addressing these psychological conditions could enhance asthma control levels. [ABSTRACT FROM AUTHOR] more...
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- 2024
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15. The use and misuse of the SCOFF screening measure over two decades: a systematic literature review.
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Coop, Amy, Clark, Amelia, Morgan, John, Reid, Fiona, and Lacey, J. Hubert
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EATING disorders ,ANOREXIA nervosa ,SCIENCE journalism ,BULIMIA - Abstract
Purpose: The SCOFF questionnaire was designed as a simple, memorable screening tool to raise suspicion that a person might have an eating disorder. It is over 20 years since the creation of the SCOFF, during which time it has been widely used. Considering this, we wish to review the use of the SCOFF in peer-reviewed scientific journals, and to assess whether it is being used appropriately in the manner in which it was originally devised and tested. Methods: The Preferred Reporting Items for a Systematic Review and Meta-analysis (PRISMA) guidelines were followed, and all search strategies and methods were determined before the onset of the study. PubMed and Wiley Online Library were searched using the terms SCOFF and eating. Two reviewers were involved in the reviewing process. Criteria for appropriate use of the SCOFF were formalised with the tool's original authors. Results: 180 articles were included in the final review. 48 articles had used the SCOFF appropriately, 117 articles inappropriately and 15 articles had been mixed in the appropriateness of their use. Conclusion: This systematic review highlights the inappropriate use of the SCOFF in diverse languages and settings. When used correctly the SCOFF has made a significant contribution to the understanding of eating disorders and its simplicity has been applauded and led to widespread use. However in over two-thirds of studies, the use of the SCOFF was inappropriate and the paper highlights how and in what way it was misused, Guidelines for the appropriate use of the SCOFF are stated. Future validation and avenues of research are suggested. Level of evidence: Level I. [ABSTRACT FROM AUTHOR] more...
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- 2024
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16. Asthma medication adherence, control, and psychological symptoms: a cross-sectional study.
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Alqarni, Abdullah A., Aldhahir, Abdulelah M., Siraj, Rayan A., Alqahtani, Jaber S., Alghamdi, Dana A., Alghamdi, Sarah K., Alamoudi, Abeer A., Mohtaseb, Majduleen A., Majrshi, Mansour, AlGarni, Abdulkareem A., Badr, Omaima I., and Alwafi, Hassan more...
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PATIENT compliance ,ASTHMA ,PSYCHOTHERAPY ,MENTAL depression ,CROSS-sectional method - Abstract
Background: Nonadherence to therapies and psychological disorders are associated with poor asthma control. This study aims to assess the prevalence of anxiety and depressive symptoms, asthma control, and adherence to inhalers and to investigate whether there is an association of anxiety and depressive symptoms with adherence to inhalers and asthma control. Methods: We measured anxiety and depressive symptoms using the Hospital Anxiety and Depression Scale in patients with asthma. Asthma Control Test and the 10-Item Test of Adherence to Inhalers Scale were used to assess levels of asthma control adherence to inhalers, respectively. Univariate and multivariate regression models assessed the associations of anxiety and depressive symptoms with adherence to inhalers and asthma control. Results: A total of 287 patients completed the study, of whom 72% were female. The mean ± SD age and body mass index of our study population were 44 ± 13 years and 29 ± 7.2 kg/m
2 , respectively. Poor adherence to inhaler use was highly prevalent (49.8%; 95% CI: 43.8 to 55.7). The prevalence of anxiety, depression and poor asthma control was 27.2% (95% CI: 22.1 to 32.7), 20.9% (95% CI: 16.3 to 26.1), and 22.7% (95% CI: 17.9 to 27.9), respectively. We found a negative relationship between asthma control and anxiety, and depressive symptoms (adjusted β: -0.25; 95% CI: -0.36 to -0.14; p < 0.001 and adjusted β: -0.29; 95% CI: -0.40 to -0.18; p < 0.001, respectively). A negative relationship was also observed between adherence to inhalers and anxiety and depressive symptoms (adjusted β: -0.34; 95% CI: -0.46 to -0.22; p < 0.001 and adjusted β: -0.36; 95% CI: − 0.48 to − 0.24; p < 0.001, respectively). Conclusions: The high prevalence of uncontrolled asthma symptoms and poor adherence to inhalers and their impact on anxiety and depression levels among patients with asthma point to the need for early screening for psychological symptoms and recognition of nonadherence as part of asthma assessment and management plan in primary care in Saudi Arabia to avoid further worsening of asthma symptoms. Further studies are needed to explore the effectiveness of specific psychoeducational interventions and investigate the long-term impact of early psychological symptom detection on asthma outcomes. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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17. Automated characterization and detection of fibromyalgia using slow wave sleep EEG signals with glucose pattern and D'hondt pooling technique.
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Karabey Aksalli, Isil, Baygin, Nursena, Hagiwara, Yuki, Paul, Jose Kunnel, Iype, Thomas, Barua, Prabal Datta, Koh, Joel E. W., Baygin, Mehmet, Dogan, Sengul, Tuncer, Turker, and Acharya, U. Rajendra
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Fibromyalgia is a soft tissue rheumatism with significant qualitative and quantitative impact on sleep macro and micro architecture. The primary objective of this study is to analyze and identify automatically healthy individuals and those with fibromyalgia using sleep electroencephalography (EEG) signals. The study focused on the automatic detection and interpretation of EEG signals obtained from fibromyalgia patients. In this work, the sleep EEG signals are divided into 15-s and a total of 5358 (3411 healthy control and 1947 fibromyalgia) EEG segments are obtained from 16 fibromyalgia and 16 normal subjects. Our developed model has advanced multilevel feature extraction architecture and hence, we used a new feature extractor called GluPat, inspired by the glucose chemical, with a new pooling approach inspired by the D'hondt selection system. Furthermore, our proposed method incorporated feature selection techniques using iterative neighborhood component analysis and iterative Chi2 methods. These selection mechanisms enabled the identification of discriminative features for accurate classification. In the classification phase, we employed a support vector machine and k-nearest neighbor algorithms to classify the EEG signals with leave-one-record-out (LORO) and tenfold cross-validation (CV) techniques. All results are calculated channel-wise and iterative majority voting is used to obtain generalized results. The best results were determined using the greedy algorithm. The developed model achieved a detection accuracy of 100% and 91.83% with a tenfold and LORO CV strategies, respectively using sleep stage (2 + 3) EEG signals. Our generated model is simple and has linear time complexity. [ABSTRACT FROM AUTHOR] more...
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- 2024
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18. Reclassification of a spindle cell sarcoma after identification of a TFG‐ROS1 fusion: A case demonstrating the clinical benefit of next‐generation sequencing in sarcoma.
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Lim, John J., Chen, Eleanor Y., Schaub, Stephanie K., and Wagner, Michael J.
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NUCLEOTIDE sequencing ,SARCOMA ,FLUORESCENCE in situ hybridization ,GENE rearrangement ,CELL morphology - Abstract
Background: Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal soft tissue sarcomas that often present diagnostic challenges due to their wide and varied morphology. A subset of IMTs have fusions involving ALK or ROS1. The role of next‐generation sequencing (NGS) for classification of unselected sarcomas remains controversial. Methods and Results: We report a case of a metastatic sarcoma in a 34‐year‐old female originally diagnosed as an unclassified spindle cell sarcoma with myofibroblastic differentiation and later reclassified as IMT after NGS revealed a TFG‐ROS1 rearrangement. Histologically, the neoplasm had spindle cell morphology with a lobulated to focally infiltrative growth pattern with scant inflammatory cell infiltrate. Immunohistochemistry demonstrated focal desmin and variable smooth muscle actin staining but was negative for SOX10, S100, and CD34. Fluorescence in situ hybridization was negative for USP6 or ALK gene rearrangements. NGS revealed a TFG‐ROS1 rearrangement and the patient was treated with crizotinib with clinical benefit. Conclusions: We discuss the role of NGS as well as its potential benefit in patients with unresectable, ALK‐negative metastatic disease. Considering this case and previous literature, we support the use of NGS for patients requiring systemic treatment. [ABSTRACT FROM AUTHOR] more...
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- 2024
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19. Video-based Teach-to-goal Intervention on Inhaler Technique on Jordanian Adults With Asthma and COPD
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Oriana Awwad, Professor
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- 2022
20. Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects.
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Antunes C, Arbo MD, and Konrath EL
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- Brazil, Medicine, Traditional, Plant Extracts pharmacology, Phytotherapy, Plants, Medicinal
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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans)., (© 2022 Wiley-VHCA AG, Zurich, Switzerland.) more...
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- 2022
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21. Cyber security's influence on smart cities: Challenges and solutions.
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Khan, Rizwan Ahmed and Khan, Mohd Waris
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SMART cities ,INTERNET security ,TECHNOLOGICAL innovations ,INTERNET of things ,URBAN growth ,SECURITY systems - Abstract
The world's urban population is growing, and smart city development projects are using the Internet of Things (IoT) to provide smarter, more efficient, and more sustainable solutions. Many of these challenges are addressed in this work, which contains a useful synthesis of key research as well as the creation of a smart city interaction model. The research is organized around several key themes in smart city research, such as privacy and security of mobile devices services; smart city infrastructure, power systems, healthcare; frameworks, algorithms, and protocols to improve security and privacy; operational threats for smart cities, citizen use and adoption of smart services; blockchain use; and social media use. There is a clear link between technological advancement and cybersecurity dangers, as cybersecurity threats are a major impediment to achieving these benefits. This article highlights the advantages and problems of smart cities, as well as the dangers to smart city cybersecurity and viable solutions. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
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22. Anxiety disorders among children and adolescents during COVID-19 lockdowns and school closures: a cross-sectional study in Kuwait.
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Alamiri, Bibi, Alkhamis, Moh A., Naguy, Ahmed, Alenezi, Hend F., and Shekaili, Muna Al
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COVID-19 pandemic ,STAY-at-home orders ,SCHOOL closings ,CLEFT palate children ,ANXIETY disorders ,SOCIAL anxiety ,MENTAL illness ,CROSS-sectional method - Abstract
Introduction: Investigating the epidemiology of mental health disorders resulting from COVID-19 intervention measures, primary school closures, and social isolation in children and adolescents needs to be prioritized over adults at the post-pandemic stage. Most preliminary psychosocial studies conducted during the pandemic have demonstrated that younger age groups are the most vulnerable to such implications. Thus, this study aims to estimate the probable prevalence of specific anxiety disorders in children and quantify their relationships with relevant demographic risk factors. Methods: We used a cross-sectional study comprising 430 children aged between 8- and 18 years old living in Kuwait during the period of school closures as well as full and partial lockdowns. The survey included questions about participants' characteristics, children's anxiety using the Screen for Child Anxiety Related Emotional Disorders Questionnaire (SCARED) scale, and children's emotions and behaviours using the Strengths and Difficulties Questionnaire (SDQ). Univariate and multivariate logistic regression analyses were used to summarize the demographic and characteristics of the participants and their association with general, social, and generalized anxieties, as well as behavioural and emotional difficulties. Results: We inferred that 24.83% of our participants had at least one anxiety disorder, while 20.19% were classified as abnormal on the SDQ scale. Our multivariate analysis revealed that lockdown duration and sex of the child were consistently significant predictors (p-values < 0.05) of the broad spectrum of selected mental disorders. Additionally, we inferred notable increases in the likelihood of mental disorders associated with the increased duration of lockdowns. Conclusions: Our findings revealed preliminary insights into the vulnerability of young populations to the indirect negative impacts of strict public health measures during pandemic emergencies. Thus, authorities should consider such implications when planning and implementing similar interventions in future pandemics. [ABSTRACT FROM AUTHOR] more...
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- 2024
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23. Mental health during the COVID-19 pandemic and first lockdown in Lebanon: Risk factors and daily life difficulties in a multiple-crises setting.
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Elbejjani, Martine, Mansour, Sara, Hammoud, Rawan A., Ziade, Catrina, Assi, Batoul, Assi, Ahmad, El Sayed, Samya, El Hachem, Rita, and Kerbage, Hala
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COVID-19 pandemic ,MENTAL health ,MENTAL illness ,HEALTH facilities ,STAY-at-home orders ,GENERALIZED anxiety disorder - Abstract
Introduction: Research from around the world shows important differences in the impact of the COVID-19 pandemic and lockdowns on mental health. This study examined the extent of mental health challenges (depressive and anxiety symptoms and daily life difficulties) and their associations with pandemic- and response-related factors during the first lockdown in Lebanon, which happened amid a severe economic crisis and socio-political turmoil. Methods: Data come from a cross-sectional internet-based survey (May-June 2020). Association of depressive (Patient Health Questionnaire (PHQ-9)) and anxiety symptoms (Generalized Anxiety Disorder (GAD-7)) with outbreak-related worries and knowledge, information sources, and confidence and satisfaction in response measures were estimated using logistic regression adjusted for sociodemographic and socioeconomic indicators. Results: Among 510 participants (mean age 36.1±11.3; 69.4% women), 32.3% had elevated depressive and 27.3% had elevated anxiety symptoms; younger age, unemployment, loss of employment, and lower income were related to more mental health symptoms. Most prevalent daily life challenges were feelings of uncertainty (74.5%) and financial (52.2%) and emotional (42.2%) difficulties; these and all other daily life difficulties (work-related, caregiving, and online learning) were significantly higher among participants with higher depressive and anxiety symptoms. Higher outbreak-related worries were associated with higher depressive (OR = 1.36, 95% CI = 1.20,1.53) and anxiety symptoms (OR = 1.47, 95% CI = 1.30,1.67). Higher pandemic-related knowledge, reliance on and trust in local health agencies and professionals' information, and satisfaction and confidence regarding governmental and health institutions' response were all related to lower mental health symptoms. Conclusion: Results show that mental health burden in Lebanon during the first lockdown (when the COVID-19 outbreak was still minimal) is among the highest reported worldwide and highlight elevated emotional and financial tolls and widespread impact on daily life. In this high-burden and multiple-challenges context, results suggest an important role for the healthcare body, knowledge, and trust in the institutions managing the response. [ABSTRACT FROM AUTHOR] more...
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- 2024
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24. Complicated grief and posttraumatic stress after loss and separation under terror conditions.
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Jann, Philipp, Neldner, Sina, Neuner, Frank, and Mohammed, Rezhna
- Subjects
COMPLICATED grief ,POST-traumatic stress ,POST-traumatic stress disorder ,VIOLENT deaths ,INTERNALLY displaced persons - Abstract
The lives of people in conflict areas are often characterized by the experience of traumatic events frequently accompanied by loss and separation. These can equally trigger symptoms of posttraumatic stress disorder (PTSD) and complicated grief (CG). The aim of the present study was to investigate whether affected individuals could be assigned to distinct classes at symptom‐cluster levels of these two disorders. Moreover, we aimed to identify event‐related and sociodemographic predictors associated with membership in these pathological classes. Participants were Iraqi internally displaced persons (IDPs; N = 199) who fled their hometowns due to the ISIS conflict and reported having lost an important person within the past 5 years. Based on the PTSD Checklist for DSM‐5 (PCL‐5) and Inventory of Complicated Grief (ICG), a latent class analysis (LCA) was applied to examine different classes of symptom clusters. Multinomial logistic regression was used to determine which variables predicted assignment to these symptom classes. The impact of loss and separation among IDPs in Iraq manifested in CG symptoms in more than half of the affected population and was often accompanied by PTSD. LCA identified a low‐symptoms class (17.6%), CG class (33.7%), PTSD class (12.1%), and comorbid PTSD+CG class (36.7%). The sudden or violent death of a loved one was identified as a distinguishing factor for PTSD. Furthermore, separation was associated with comorbidity. Aid agencies should take these specific factors into account to improve effective and economic aid delivery to IDPs continuously affected by terror. [ABSTRACT FROM AUTHOR] more...
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- 2024
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25. The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis.
- Author
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Na Ren, Wen-Feng Wang, Liang Zou, Yan-Long Zhao, Hua Miao, and Ying-Yong Zhao
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NF-kappa B ,RENAL fibrosis ,CELLULAR signal transduction ,DIABETIC nephropathies ,ACUTE kidney failure - Abstract
Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress and inflammation play central roles in progressive renal fibrosis. Oxidative stress and inflammation are closely linked and form a vicious cycle in which oxidative stress induces inflammation through various molecular mechanisms. Ample evidence has indicated that a hyperactive nuclear factor kappa B (NF-κB) signaling pathway plays a pivotal role in renal fibrosis. Hyperactive NF-κB causes the activation and recruitment of immune cells. Inflammation, in turn, triggers oxidative stress through the production of reactive oxygen species and nitrogen species by activating leukocytes and resident cells. These events mediate organ injury through apoptosis, necrosis, and fibrosis. Therefore, developing a strategy to target the NF-κB signaling pathway is important for the effective treatment of renal fibrosis. This Review summarizes the effect of the NF-κB signaling pathway on renal fibrosis in the context of AKI and CKD (immunoglobulin A nephropathy, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy, and kidney transplantation). Therapies targeting the NF-κB signaling pathway, including natural products, are also discussed. In addition, NF-κB-dependent noncoding RNAs are involved in renal inflammation and fibrosis and are crucial targets in the development of effective treatments for kidney disease. This Review provides a clear pathophysiological rationale and specific concept-driven therapeutic strategy for the treatment of renal fibrosis by targeting the NF-κB signaling pathway. [ABSTRACT FROM AUTHOR] more...
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- 2024
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26. Mental health status and related factors influencing healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis.
- Author
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Huang, Jia, Huang, Zhu-Tang, Sun, Xin-Ce, Chen, Ting-Ting, and Wu, Xiao-Tian
- Subjects
MEDICAL personnel ,COVID-19 pandemic ,CINAHL database ,ACUTE stress disorder ,MENTAL health personnel - Abstract
Background: The mental health of healthcare workers during the coronavirus-2019 pandemic was seriously affected, and the risk of mental health problems was high. The present study sought to systematically evaluate the mental health problems of healthcare workers worldwide during the pandemic and to determine the latest global frequency of COVID-19 associated mental health problems. Methods: Data in the Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, Elsevier, MEDLINE, PubMed, PsycINFO and the Web of Science before November 11, 2022, were systematically searched. Cohort, case-control and cross-sectional studies were included. The meta-analysis used a random effects model to synthesize the comprehensive prevalence rate of mental health problems. Subgroup analyses were performed based on time of data collection; whether the country was or was not developed; continent; doctors and nurses; doctors/nurses vs. other healthcare workers; and psychological evaluation scale. Results: A total of 161 studies were included, including 341,014 healthcare workers worldwide, with women accounting for 82.8%. Occupationally, 16.2% of the healthcare workers were doctors, 63.6% were nurses and 13.3% were other medical staff. During the pandemic, 47% (95% confidence interval [CI], 35–60%) of healthcare workers reported job burnout, 38% (95% CI, 35–41%) experienced anxiety, 34% (95% CI 30–38%) reported depression, 30% (95% CI, 29–31%) had acute stress disorder, and 26% (95% CI, 21–31%) had post-traumatic stress disorder. Conclusions: The study found that there were common mental health problems among health care workers during the COVID-19 pandemic. The most common was job burnout, followed by anxiety, depression, acute stress and post-traumatic stress disorder. Although the global pandemic has been brought under control, its long-term impact on the mental health of healthcare workers cannot be ignored. Additional research is required to develop measures to prevent, monitor and treat psychological disorders among healthcare workers. [ABSTRACT FROM AUTHOR] more...
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- 2024
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27. Seismic site effect models for the Turkiye-Izmir-Bayrakli Basin.
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Cetin, Kemal Onder, Cakir, Elife, and Zarzour, Moutasem
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GROUND motion ,EARTHQUAKE intensity ,SEISMIC response ,SOIL profiles ,EARTH stations ,SPECTRAL sensitivity ,FAULT zones - Abstract
Due to the unique soil, morphological, and subsurface topographical conditions, amplified and prolonged seismic demand traces were observed in historical strong ground motion records from Bayrakli-Izmir-Turkiye. A vivid example of this response was recorded during the M
w 7.0 Samos event on October 30, 2020. After the event, structural damage and loss of life were unexpectedly concentrated in Bayrakli-Izmir, even though the fault rupture was located 70 km away. The presence of strong ground motion stations (SGMS) located on rock (#3514) and soil (#3513) sites enabled a quantitative assessment of the amplified and prolonged seismic demand traces. The seismic response of SGMS #3513 site was assessed by using 1-D equivalent linear and analytical methods. The idealized 1-D soil profile and input parameters were calibrated and fine-tuned by using the 2020 Samos earthquake accelerograms. Then, the calibrated equivalent linear site response model was further validated by the recordings from historical events. Alternatively, an analytical wave propagation-based model was proposed, the input parameters of which were probabilistically estimated based on, again, historical recordings. Finally, the seismic responses of the site during future earthquakes were predicted based on the calibrated and validated site response models. The predicted intensity-dependent amplification spectral responses were compared with the provisions of the TEC (2018). Even though limited in number in all five future seismic scenario events, amplification ratios suggested by TEC were exceeded by a factor of 2–4 at periods falling in the range of 0.5 to 1.2 s. This clearly suggested the need to further quantify the Bayrakli seismic basin responses with basin-specific models, rather than code-based, intensity-dependent generalized amplification factors. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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28. The Saudi initiative for asthma – 2024 update: Guidelines for the diagnosis and management of asthma in adults and children.
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Al-Moamary, Mohamed, Alhaider, Sami, Allehebi, Riyad, Idrees, Majdy, Zeitouni, Mohammed, Al Ghobain, Mohammed, Alanazi, Abdullah, Al-Harbi, Adel, Yousef, Abdullah, Alorainy, Hassan, and Al-Hajjaj, Mohamed more...
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BIOTHERAPY ,ASTHMA diagnosis ,ASTHMA risk factors ,DRUG therapy for asthma ,MEDICAL protocols ,RISK assessment ,SELF-management (Psychology) ,DISEASE management ,IMMUNOTHERAPY ,PHYSICIAN-patient relations ,ASTHMA ,SYMPTOMS ,CHILDREN ,ADULTS - Abstract
The Saudi Initiative for Asthma 2024 (SINA-2024) is the sixth version of asthma guidelines for the diagnosis and management of asthma for adults and children that was developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up-to-date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA Panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is aligned for age groups: adults, adolescents, children aged 5–12 years, and children aged <5 years. SINA guidelines have focused more on personalized approaches reflecting a better understanding of disease heterogeneity with the integration of recommendations related to biologic agents, evidence-based updates on treatment, and the role of immunotherapy in management. The medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and the current situation at national and regional levels. There is also an emphasis on patient–doctor partnership in the management that also includes a self-management plan. [ABSTRACT FROM AUTHOR] more...
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- 2024
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29. Effect of interventional health educational program on clinical improvement in a sample of Egyptian school-age asthmatic children.
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El Nady, Hala G., El Refay, Amira S., Salah, Dina A., Atta, Hanan, Esmail, Doaa E., Saleh, Rehan M., and El Mosalami, Dalia M.
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- 2024
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30. Update on Familial Adenomatous Polyposis-Associated Desmoid Tumors.
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Yang, Wanjun and Ding, Pei-Rong
- Abstract
Desmoid tumors (DT) represent the second high risk of tumor in familial adenomatous polyposis (FAP) patients. Although FAP-associated DTs (FAP-DT) are caused by germline mutations in the adenomatous polyposis coli (APC) gene, extracolonic manifestations, sex, family history, genotype, and the ileal pouch anal anastomosis procedure are all linked to the development of DTs in FAP patients. Multidisciplinary management has replaced aggressive surgery as the preferred treatment of DTs. There is growing evidence to support the use of active surveillance strategy as first-line treatment for FAP-DT patients. Radiotherapy for intra-abdominal desmoids is now rarely used because of severe late toxicity. Pharmacotherapy, however, represents a promising future with the improvement of traditional cytotoxic drugs and the investigation of targeted drugs. Although nonsurgery treatment has been used widely nowadays, surgery remains the mainstay when symptomatic or life-threatening DTs are present. Further research will be needed for more optimal clinical practice. [ABSTRACT FROM AUTHOR] more...
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- 2023
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31. Application of diethylenetriaminepenta pentasodium salt as an eco-friendly depressant to effectively improve the flotation separation of scheelite and calcite.
- Author
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Hepeng Zhou, Handan Wu, Jiangfeng Guo, Xuekun Tang, Wen Huang, and Xianping Luo
- Subjects
SCHEELITE ,FLOTATION ,CALCITE ,SALT ,MINERALS ,CHELATES - Abstract
Diethylenetriaminepenta (methylene-phosphonic acid) pentasodium salt (DTPMPA), an ecofriendly reagent, was tried for the first time as a depressant for flotation separation of scheelite from calcite. Micro-flotation tests show that DTPMPA can selectively depress the floatability of calcite. In contrast, DTPMPA barely affects the flotation behavior of scheelite. Based on the selective depress effect, floatation separation of scheelite and calcite can be effectively achieved by using DTPMPA as depressant in artificially mixed minerals flotation tests. Based on a series of measurements, it found the surface of calcite was positively charged due to the existence of Ca ion site, which can be chelated with -PO3H-functional group on the surface of DTPMPA. In the flotation process, DTPMPA can be chemically absorbed on the surface of calcite to inhibit further collector adsorption. On contrast, little DTPMPA was adsorbed on the surface of scheelite due to the spatial site resistance and electrostatic repulsion induced by surface WO42+. All in all, these results exhibit DTPMPA has excellent selective depression ability on calcite, which can be potentially applied in the actual scheelite flotation process. [ABSTRACT FROM AUTHOR] more...
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- 2023
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32. A Novel Mutation in the MAP7D3 Gene in Two Siblings with Severe Intellectual Disability and Autistic Traits: Concurrent Assessment of BDNF Functional Polymorphism, X-Inactivation and Oxidative Stress to Explain Disease Severity.
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Kharrat, Marwa, Issa, Abir Ben, Tlili, Abdelaziz, Jallouli, Olfa, Alila-Fersi, Olfa, Maalej, Marwa, Chouchen, Jihen, Ghouylia, Yosra, Kamoun, Fatma, Triki, Chahnez, and Fakhfakh, Faiza
- Abstract
Intellectual disabilities (ID) and autism spectrum disorders (ASD) are characterized by extreme genetic and phenotypic heterogeneity. However, understanding this heterogeneity is difficult due to the intricate interplay among multiple interconnected genes, epigenetic factors, oxidative stress, and environmental factors. Employing next-generation sequencing (NGS), we revealed the genetic cause of ID and autistic traits in two patients from a consanguineous family followed by segregation analysis. Furthermore, in silico prediction methods and 3D modeling were conducted to predict the effect of the variants. To establish genotype–phenotype correlation, X-chromosome inactivation using Methylation-specific PCR and oxidative stress markers were also investigated. By analyzing the NGS data of the two patients, we identified a novel frameshift mutation c.2174_2177del (p.Thr725MetfsTer2) in the MAP7D3 gene inherited from their mother along with the functional BDNF Val66Met polymorphism inherited from their father. The 3D modeling demonstrated that the p.Thr725MetfsTer2 variant led to the loss of the C-terminal tail of the MAP7D3 protein. This change could destabilize its structure and impact kinesin-1's binding to microtubules via an allosteric effect. Moreover, the analysis of oxidative stress biomarkers revealed an elevated oxidative stress in the two patients compared to the controls. To the best of our knowledge, this is the first report describing severe ID and autistic traits in familial cases with novel frameshift mutation c.2174_2177del in the MAP7D3 gene co-occurring with the functional polymorphism Val66M in the BDNF gene. Besides, our study underlines the importance of investigating combined genetic variations, X-chromosome inactivation (XCI) patterns, and oxidative stress markers for a better understanding of ID and autism etiology. [ABSTRACT FROM AUTHOR] more...
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- 2023
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33. Estimating urban seismic damages and debris from building-level simulations: application to the city of Beirut, Lebanon.
- Author
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Iskandar, Rouba, Al Tfaily, Bilal, Cornou, Cécile, Bard, Pierre-Yves, Guillier, Bertrand, Harb, Jacques, Lacroix, Pascal, Adjizian-Gérard, Jocelyne, Beck, Elise, Dugdale, Julie, Salameh, Christelle, Saliba, Nada, and Zaarour, Rita more...
- Subjects
BUILDING failures ,REMOTE-sensing images ,EARTHQUAKES ,TALL buildings ,SEISMIC networks - Abstract
The estimation of seismic damages and debris at the urban scale—at a building-by-building level- is challenging for several reasons. First, commonly used methodologies for seismic damage estimation rarely take into account the local site effects, precisely at the building-level. Second, the available methods for debris estimation fail to estimate at the same time the quantity of debris generated per building according to its damage level and the distribution of the debris (extent and height) around buildings. Finally, the lack of comprehensive data on the building stock and the relevant building properties and their taxonomy further increases the complexity of assessing possible earthquake consequences at an urban scale. This paper addresses these challenges and proposes improvements to the assessment of seismic damages and debris from building-level simulations, along with the development of a 3D building model based on satellite images and heterogeneous data. These developments, applied to the city of Beirut, Lebanon, highlight the control of the site effects on the seismic damage's spatial distribution throughout the city and the large volume and extent of debris to be expected in the city for a strong earthquake. [ABSTRACT FROM AUTHOR] more...
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- 2023
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34. The Association of Asthma with Anxiety, Depression, and Mild Cognitive Impairment among Middle-Aged and Elderly Individuals in Saudi Arabia.
- Author
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Abuaish, Sameera, Eltayeb, Huda, Bepari, Asmatanzeem, Hussain, Syed Arif, Alqahtani, Raneem Saad, Alshahrani, Waad Saeed, Alqahtani, Amjad Hayf, Almegbil, Nada Saad, and Alzahrani, Wafa Nedal
- Subjects
OLDER people ,MONTREAL Cognitive Assessment ,MILD cognitive impairment ,COGNITION disorders ,ANXIETY ,ASTHMA - Abstract
Asthma is a common chronic inflammatory condition with increasing global prevalence. There is some evidence highlighting the effect of asthma on brain functioning. In Saudi Arabia, limited studies have examined the relationship between asthma and mental health, including cognition and mood disorders in older adults in particular. In this study, we examine the association between asthma and mental health outcomes in middle-aged and elderly individuals in Riyadh, Saudi Arabia. In a cross-sectional study, 243 subjects were recruited from outpatient clinics between 2020–2021 (non-asthmatic: n = 159, asthmatic: n = 84). The Montreal Cognitive Assessment test, the Hospital Anxiety and Depression Scale, and the Asthma Control Test were used to assess cognition, anxiety and depression, and asthma control, respectively. Logistic regression analysis while controlling for covariates revealed an association between asthma and symptoms of anxiety and depression (OR = 2.40 [95% CI: 1.07–5.35]) and mild cognitive impairment (MCI) (OR = 1.80 [95% CI: 1.00–3.24]). Poorly controlled asthma increased the odds of anxiety cases (OR = 4.88 [95% CI: 1.09–17.2]). Stratifying analysis by age intervals revealed that asthma was associated with symptoms of anxiety and depression (OR = 2.5 [95% CI: 1.00–6.08]) in middle-aged patients only, while elderly asthmatics had increased odds of having MCI (OR = 7.4 [95% CI: 2.34–23.31]). These findings highlight the possible effects of asthma and its control on mental health among middle-aged and elderly individuals in Saudi Arabia. [ABSTRACT FROM AUTHOR] more...
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- 2023
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35. 2-D and 3-D basin site effects in Izmir-Bayrakli during the October 30, 2020 Mw7.0 Samos earthquake.
- Author
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Cetin, Kemal Onder, Zarzour, Moutasem, Cakir, Elife, Tuna, S. Caglar, and Altun, Selim
- Subjects
EARTHQUAKES ,SEISMIC response ,STRUCTURAL design ,DWELLINGS - Abstract
During the October 30, 2020 M
w 7.0 Samos Earthquake, the Turkiye-Izmir-Bayrakli district was affected the most due to the geometry and the deep-soft alluvial nature of the basin, although the district is approximately 70 km away from the epicenter. In this study, the seismic response of the Bayrakli basin, and the role of the soil stratigraphy and basin geometry on the recorded amplifications and prolonging of seismic shakings are investigated by using 1-, 2- and 3-D non-linear finite element-based dynamic response analyses. The assessment results are presented in the form of spectral amplification ratios, A T . The highest A (T) values were estimated at spectral periods T = 0.85 and 1 s. They exceed five in both the east–west and the north–south directions, more pronounced in the latter one. A T was decomposed into the product of two independent amplification factors, namely rock to soil amplifications, A Soil (T) , and 1-D soil column to 3-D soil basin amplifications, A Basin (T) . A Basin (T) values for T = 0.85 and 1 s are estimated as high as 1.4 and 1.6, in the east–west and the north–south directions, respectively. These values suggest that the 3-D geometry of the Bayrakli basin amplifies the spectral accelerations by 40–60% at T = 0.85 and 1 s. The unique combination of a deep-soft alluvial site with 3-D basin geometry, and overlying 7–9 story residential buildings, consistently favors and amplifies the seismic energy in the spectral period range of 0.7–1.0 s. This multi-fold increased seismic demand, combined with poor structural design and construction details, lead to localized structural damage and over 117 life losses. [ABSTRACT FROM AUTHOR] more...- Published
- 2023
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36. Contribution to the Characterization of Vibration Isolators Based on Metal Mesh.
- Author
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Garcia, Pablo, De-Juan, Ana, Ríos, Daniel, Herráez, Marta, and Viadero, Fernando
- Subjects
METAL mesh ,DYNAMIC testing ,ENERGY dissipation ,HYSTERESIS loop ,HYSTERESIS - Abstract
The prediction of the behavior of vibration isolators is essential for effective and efficient design of these devices, as well as for accurately characterizing the isolator behavior. In this work, an experimental study was performed to characterize the behavior of metal-mesh isolators. Although these elements' performance is of great interest because of their usage in several applications, their characterization is complex due to their nonlinear nature, among other factors. This study's aim was to obtain the quasi-static behavior of these isolators, although dynamic tests are required for their complete characterization. These quasi-static tests allowed for the highlighting of some characteristics in a simpler and faster manner and also provided a starting point for designing future dynamic tests. The quasi-static tests performed resulted in the calculation of the hysteresis cycle under different operating conditions and manufacturing parameters. The study of different insulator characteristics, such as the energy dissipation coefficient and stiffness, led to interesting conclusions about the isolator performance. From the results, it was observed that the relative density affected most the nonlinear behavior of the insulator. Moreover, to correctly characterize their behavior, not only the Coulomb's damping but also the viscous damping had to be considered. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
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37. Variables associated with asthma control among adult patients.
- Author
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Al-Qerem, Walid, Jarab, Anan, Abu Heshmeh, Shrouq R., and Ling, Jonathan
- Subjects
ASTHMATICS ,ASTHMA ,RESPIRATORY infections ,WHEEZE ,ADULTS ,CASE-control method ,VOCAL cord dysfunction - Abstract
Objective: Asthma is one of the most prevalent chronic diseases with a substantial impact on the health status of affected patients. Further research is necessary to identify factors contributing to poor asthma control. The current study aimed to investigate the factors associated with poor asthma control among adult asthmatic patients. Methods: In this case-control study, the Asthma Control Test (ACT) was translated into Arabic and distributed to adults with asthma attending two hospitals in Jordan to evaluate the degree of asthma control. The following variables were collected for each patient: sociodemographic information, comorbidities, appropriate use of inhaler technique, spirometric measurements, and medications use. Binary regression was used to evaluate factors associated with asthma control. Results: A total of 314 participants with a mean age of 51.47 years (±16.37) completed the study. ACT score had a mean of 16.68 (±4.86). The majority of asthmatic patients had insufficiently controlled asthma (64.6%). Binary regression results showed that previous respiratory infection history (p = 0.014, OR = 0.473 (95%CI 0.261–0.857)), higher exposure to irritants (p = 0.010, OR = 0.747 (95%CI 0.598–0.933)) decreased the odds of being in the controlled asthma group. Patients receiving inhaled corticosteroids (ICS) had higher odds of being in the controlled asthma group (p = 0.039, OR = 2.372 (95%CI 1.043–5.392)). Conclusions: The majority of asthma patients had insufficiently managed disease. The main factors that contributed to poor asthma control were respiratory infection history, increased exposure to asthma symptoms triggers, and ICS nonuse. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
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38. Video-based teach-to-goal intervention on inhaler technique on adults with asthma and COPD: A randomized controlled trial.
- Author
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Al-Kharouf, Mohammad Samer, Abdeljalil, Mariam Hantash, Obeidat, Nathir M., Oweidat, Khaled Al, and Awwad, Oriana
- Subjects
INHALERS ,RANDOMIZED controlled trials ,PATIENT compliance ,ASTHMATICS ,CHRONIC obstructive pulmonary disease ,ASTHMA - Abstract
Background: Incorrect use of inhalers is a problem associated with poor patient outcomes. Despite improvement in the technique after verbal educations, this deteriorates over-time requiring re-enforcement through different educative strategies. This study aimed to assess the impact of a novel video-based teach-to-goal (TTG) educational intervention on: mastery of inhaler technique, disease control, medication adherence and disease-related quality of life (QoL) over-time among asthma and COPD patients. Methods: This prospective, open-label, randomized controlled trial was registered in ClinicalTrials.gov: Identifier NCT05664347. After baseline assessment participants received either a verbal (control group) or a video-based (intervention group) TTG strategy. After 3-month the intervention was assessed for impact on the intended outcomes. Inhaler technique was assessed using standardized checklists, disease control using the Asthma control test and COPD assessment test respectively for asthma and COPD patients while adherence using the Morisky Green Levine scale. For QoL, the mini asthma quality of life questionnaire and the St. George respiratory questionnaire were used for asthmatic and COPD patients, respectively. Differences in outcomes between intervention-control groups were analyzed using either Chi-Square (X
2 )/Fisher Exact or Mann Whitney test. The impact of intervention on outcomes over-time was examined using either McNemar or Wilcoxon test. Results: At baseline, intervention (n = 51) and control (n = 52) groups had comparable demographic/clinical characteristics. At follow-up, inhaler technique improved among intervention group compared to control group (93.4% vs 67%) and to baseline (93.4% to 49.5%), (P<0.05). Similarly, medication adherence ameliorated among the intervention group in comparison to control group (88.2% to 61.5%) and to baseline (88.2% to 66.7%), (P<0.05). In regards to disease control, results showed an amelioration among the intervention group compared to baseline (35.3% to 54.9%) (P<0.05). QoL scores improved significantly among asthma patients (intervention group) at follow-up vs baseline. Better scores were also observed for COPD patients compared to controls, (P<0.05). Conclusion: Video-based (TTG) was effective in enhancing inhaler technique over time as well as improving disease control, medication adherence, and QoL. Trial registration: ClinicalTrials.gov: NCT05664347. https://clinicaltrials.gov/ct2/show/NCT05664347. [ABSTRACT FROM AUTHOR] more...- Published
- 2023
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39. Knowledge, Attitudes, and Practices of Influenza Vaccination among Parents of Children with Asthma: A Cross-Sectional Study.
- Author
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Al-Qerem, Walid, Jarab, Anan, Hammad, Alaa, Alasmari, Fawaz, Ling, Jonathan, Al-Zayadneh, Enas, Al-Iede, Montaha, Alazab, Badi'ah, and Hajeer, Leen
- Subjects
ASTHMA in children ,INFLUENZA vaccines ,MEDICAL personnel ,VACCINATION of children ,HEALTH attitudes - Abstract
Asthma is the most common chronic disease in childhood. Exacerbation is a significant problem for asthmatic patients, and viral infections remain the most frequent triggers of asthma exacerbations. This study explored knowledge, attitudes, and practices (KAP) of parents of asthmatic children towards providing influenza vaccine to their children. This cross-sectional study enrolled parents of asthmatic children who visited the outpatient respiratory clinics of two Jordanian hospitals. The present study enrolled 667 parents of asthmatic children (62.8% female). The median age of the participants' children was 7 years. The results showed that 60.4% of the children with asthma never received a flu vaccine. Most of those who had received the flu vaccine reported that the side effects were mild (62.7%). Asthma duration was positively and significantly associated with increased vaccine hesitancy/rejection (OR = 1.093, 95% CI = (1.004–1.190), p = 0.04; and OR = 1.092, 95% CI = (1.002–1.189), p = 0.044, respectively). As the attitude towards flu vaccine score increases, odds of vaccination hesitancy/rejection decreased (OR = 0.735, 95% CI = (0.676–0.800), p < 0.001; and OR = 0.571, 95% CI = (0.514–0.634), p < 0.001, respectively). The main reasons for vaccination hesitancy/refusal included "I don't think my child needs it" (22.3%) followed by "I forget it" (19.5%). The rate of vaccination among children was low and emphasized the necessity of encouraging parents with asthmatic children to vaccinate their children by conducting health awareness campaigns and also emphasized the role of doctors and other healthcare professionals. [ABSTRACT FROM AUTHOR] more...
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- 2023
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40. Generic drugs use during the COVID-19 pandemic among Lebanese patients using psychotropics: An opportunity for generic drug promotion.
- Author
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Hatem, Georges, Ankouni, Ali, Salhab, Sethrida, Kteich, Walaa, and Awada, Sanaa
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GENERIC drugs ,COVID-19 pandemic ,COVID-19 ,DRUG utilization ,PSYCHIATRIC drugs ,LEBANESE - Abstract
Introduction: The Coronavirus disease of 2019 (COVID-19) pandemic has imposed several challenges leading to the shortage of medications due to the disruption of their supply chains. Among others, patients using psychotropics encountered difficulties finding their medication despite the efforts of investing in local production. Encouraging patients to use generic drugs can be an effective strategy to ensure sustainable access to medication. Objectives: This study aimed to describe the consumption of psychotropic medications during the COVID-19 pandemic and the willingness together with the reasons for using generic drugs. It also assessed the association between generic drugs and the general characteristics of the patients. Design: A cross-sectional study was performed over a period of 4 months (July–October 2021) targeting 128 patients using psychotropic drugs. Results: The sample included more women than men with a mean age of 38 years. Antidepressants were the psychotropic medications mostly consumed followed by anti-anxiety medications. Almost 13% of the patients started using psychotropics either through self-prescription or a friend's advice and 73.4% used generic drugs. Fear of dependence, unavailability of the brand drug, and pharmacist's recommendation were the main reported reasons for using generic drugs. Conclusion: During the COVID-19 pandemic, the consumption of psychotropics increased due to new prescriptions and self-medication. No differences were noted between using generics and the characteristics of the patients in contrast to previous studies which support the implementation of generic prescription and substitution policies. [ABSTRACT FROM AUTHOR] more...
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- 2023
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41. Determination of bioactive anti-nonalcoholic fatty liver effect extracts from Phyllanthus niruri using tri-step infrared spectroscopy.
- Author
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Tan, Chu Shan, Ch'ng, Yung Sing, Tew, Wan Yin, and Yam, Mun Fei
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INFRARED spectroscopy ,FATTY liver ,NON-alcoholic fatty liver disease ,FOURIER transform infrared spectroscopy ,NEAR infrared spectroscopy ,STARCH ,PHYLLANTHUS - Abstract
Phyllanthus niruri, belongs to Family of Phyllanthaceae, is a phytomedicine for liver related diseases such as hepatitis B, and jaundice. The aim of this study is to distinguish the fingerprint of P. niruri extract which active in ameliorating non-alcoholic fatty liver disease by tri-steps infrared spectroscopy, namely fourier transform infrared spectroscopy (FTIR), second derivative infrared spectroscopy (SD-IR), and two-dimensional correlation infrared spectroscopy (2D-IR). The structural information of the samples indicated that the P. niruri raw herb contains large amount of starch and protein, while the main components of methanolic and water extracts of P. niruri are esters and hydroxyl acids, respectively. However, the active 50% methanolic extract of P. niruri may has higher content of flavonoids and phenolic compounds. As a result, tri-steps infrared spectroscopic analysis not only can provide useful information regarding to the main chemical constituents of P. niruri, and its various extracts but also can be used as an analytical tool to distinguish activity of P. niruri extracts in anti-nonalcoholic fatty liver effect. [ABSTRACT FROM AUTHOR] more...
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- 2023
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42. Free Vibration Characteristics Analysis of Metal-Rubber Cylindrical Shells Based on Viscoelastic Theory.
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Bai, Yan, Deng, Pengfei, Fu, Ke, and Li, He
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CYLINDRICAL shells ,FREE vibration ,RAYLEIGH-Ritz method ,ELASTIC foundations ,ORTHOGONAL polynomials - Abstract
The cylindrical shell made of metal rubber has a strong ability to reduce and absorb vibration, which widens its application in the industrial field. Therefore, it is of great significance to study the vibration characteristics of metal-rubber cylindrical shells (MRCSs). However, there is relatively little research on this aspect. Based on this, the dynamic properties of MRCS are investigated in this paper based on viscoelastic theory, the Rayleigh–Ritz method, and the Gram–Schmidt orthogonal polynomials. The correctness of the proposed model was verified by comparison with the literature and experimental verification. The results show that the preloading state and boundary conditions have significant effects on the natural frequency and modal loss factor of MRCS. The effect of the Pasternak elastic foundation on the natural frequency and modal loss factor of MRCS varies with the change of the axial half wave number m. The effect of the Pasternak elastic foundation on higher-order vibrations is similar to that of the artificial spring technique. [ABSTRACT FROM AUTHOR] more...
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- 2023
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43. Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review.
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YUKIKO OHSHIMA, JUN NISHIO, SHIZUHIDE NAKAYAMA, KAORI KOGA, MIKIKO AOKI, and TAKUAKI YAMAMOTO
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MAGNETIC resonance imaging ,BENIGN tumors ,MOLECULAR pathology - Abstract
Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of one disease process. The lesion typically presents as a relatively small (<5 cm), mobile, slow-growing, painless mass. Magnetic resonance imaging reveals the lesion to be a welldefined subcutaneous mass with a mixture of adipose and nonadipose components. Intense enhancement of the non-adipose component is seen after contrast administration. Histologically, SCL is composed of variable distributions of mature adipocytes, bland spindle cells and ropey collagen bundles and PL also contains pleomorphic and multinucleated floret-like giant cells. By immunohistochemistry, the spindle and pleomorphic/floretlike giant cells of SCL/PL are diffusely positive for CD34 and show loss of nuclear RB transcriptional corepressor 1 (RB1) expression. Recent cytogenetic and molecular genetic studies have shown heterozygous deletions of 13q14, including the RB1 gene. SCL/PL can be successfully treated with simple excision, with a very low recurrence rate. Knowledge of these peculiar tumors is important because it can mimic a variety of benign and malignant soft-tissue tumors. This review provides an updated overview of the clinical, radiological, histopathological, cytogenetic, and molecular genetic features of SCL/PL. [ABSTRACT FROM AUTHOR] more...
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- 2023
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44. The rationale of applying inspiratory/expiratory muscle training within the same respiratory cycle in children with bronchial asthma: a placebo-controlled randomized clinical investigation.
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Elnaggar, Ragab K., Osailan, Ahmad M., and Elbanna, Mohammed F.
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ASTHMA ,ASTHMA in children ,RESPIRATORY muscles ,MUSCLE strength ,POSITIVE pressure ventilation ,VITAL capacity (Respiration) - Abstract
Even though positive implications of inspiratory muscle training (In-MT) have been established in children and adolescents with bronchial asthma (C/AwBA), the role of combined inspiratory and expiratory muscle training (Ex-MT) within the same respiratory cycle (In/Ex-SC) is still unknown. This study was, therefore, set out to explore the effect of In/Ex-SC on respiratory muscle strength, pulmonary functions, and control of asthma symptoms in C/AwBA. This was a placebo-controlled randomized clinical investigation that included 51 C/AwBA (12-18 years). Participants were assigned randomly into three groups: Placebo, In-MT only, or combined In/Ex-SC training (n = 17, each group). The training was conducted for ∼35 min, thrice/week over 12 weeks. The maximal inspiratory (IP
max ) and expiratory (EPmax ) pressure (indicating the strength of the inspiratory and expiratory muscles, respectively), pulmonary functions [forced expiratory volume in one second (FEV1 ), forced vital capacity (FVC), and FEV1 /FVC index], and asthma control test (ACT) were assessed before and after the intervention. The In/Ex-SC yielded larger increases in IPmax and EPmax than either the Placebo training (P=.031 and P=.009 respectively) or the In-MT (P=.029 and P=.032 respectively). Further, In/Ex-SC produced favorable improvement in FEV1 , FVC, and FEV1 /FVC compared to the Placebo training (P=.001, P=.004, and P=.0005 respectively) or In-MT (P=.038, P=.037, and P=.025 respectively) training. Furthermore, In/Ex-SC led to better control of asthma symptoms than the Placebo (P<.001) or In-MT (P=.002) training. This study provides evidence that combined In/Ex-SC can considerably improve respiratory muscle strength, enhance pulmonary function, and promote control over asthma symptoms in C/AwBA. [ABSTRACT FROM AUTHOR] more...- Published
- 2023
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45. Sleep Quality between Nurses and the General Population during the COVID-19 Pandemic in Portugal: What Are the Differences?
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Sampaio, Francisco, Gaspar, Susana, Fonseca, César, Lopes, Manuel José, Paiva, Teresa, and Guedes de Pinho, Lara
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- 2023
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46. Assessing the Pharmacist's Role in Counseling Asthmatic Adults Using the Correct Inhaler Technique and Its Effect on Asthma Control, Adherence, and Quality of Life.
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AL-awaisheh, Rawa'a Ibrahim, Alsayed, Ahmad R, and Basheti, Iman A
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INHALERS ,PHARMACISTS ,ASTHMATICS ,QUALITY of life ,ADULTS - Abstract
Purpose: This study was designed to assess inhaler technique skills, asthma control level, adherence, and quality of life scores amongst asthmatic patients living in Amman, Jordan, investigating the role of pharmacist's educational intervention. Patients and Methods: This single-blinded randomized parallel-group active-controlled study was conducted at the Jordan University Hospital (JUH) clinic in 2019. Patients were assessed at baseline and follow-up (after three months) on their inhaler technique (based on validated published checklists), asthma control based on the asthma control test (ACT) questionnaire, adherence to treatment, and quality of life (QoL). Patients in the active group were counseled on correct inhaler technique and administration skills, orally and using inhaler adhesive labels delivered by the clinical pharmacist. Results: Asthma patients (n = 157; active, n = 79, and control, n = 78) were recruited into the study and grouped based on the controller inhaler they were using (Turbohaler (TH) and Accuhaler (ACC). There was no statistically significant difference between both groups at baseline for inhaler technique, adherence, ACT, and QoL. At follow-up, 93.7% of the active group patients used their inhalers correctly, while only 16.7% of the control group used them correctly (P-value < 0.001). Also, the ACT mean score was significantly higher for the active group (21.21± 5.27) versus the control group (15.92± 7.31; P-value < 0.001). The QoL mean score was significantly improved for the active group compared with the control group (active = 63.85± 24.78, Control = 38.746± 3.23, P-value < 0.001). Improvement in adherence for the active group was noticed compared with the control group but did not reach a significant level (P-value=0.691). Conclusion: Through a practical educational intervention, pharmacists were found to significantly improve patients' asthma inhaler technique, ACT scores, and QoL scores for patients with asthma. [ABSTRACT FROM AUTHOR] more...
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- 2023
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47. The mediating role of anxiety and depression between problematic social media use and bulimia nervosa among Lebanese university students.
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Sfeir, Michel, Rahme, Clara, Obeid, Sahar, and Hallit, Souheil
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BULIMIA ,ANXIETY ,SOCIAL media ,COMPULSIVE eating ,CONVENIENCE sampling (Statistics) ,EATING disorders ,BINGE-eating disorder - Abstract
Background: Bulimia nervosa (BN) is a disorder that is characterized by binge eating and inappropriate compensatory behavior to control weight. The aim of this study was to evaluate the mediating role of anxiety and depression between problematic social media use (PSMU) and BN among a sample of Lebanese university students. Methods: This cross-sectional study was carried out between July and September 2021; a total of 363 university students was recruited through convenience sampling. The PROCESS SPSS Macro version 3.4, model four was used to test the indirect effect and calculate three pathways. Pathway A determined the regression coefficient for the effect of PSMU on mental health issues (depression/anxiety); Pathway B examined the association between mental health issues on BN, and Pathway C' estimated the direct effect of PSMU on BN. Pathway AB was used to calculate the indirect effect of PSMU on BN via depression/anxiety. Results: Results showed that depression and anxiety partially mediated the association between PSMU and BN. Higher levels of PSMU were associated with more depression and anxiety; higher depression and anxiety were associated with more BN. PSMU was directly and significantly associated with more BN. When entering anxiety (M1) then depression (M2) as consecutive mediators in a first model, the results showed that only depression mediated the association between PSMU and bulimia. When taking depression (M1) then anxiety (M2) as consecutive mediators in a second model, the results showed that the mediation PSMU → Depression → Anxiety → Bulimia was significant. Higher PSMU was significantly associated with more depression, which was significantly associated with more anxiety, which was significantly associated with more bulimia. Finally, higher PSMU was directly and significantly associated with more bulimia Conclusion: The current paper highlights the relationship that social media use has on BN and other aspects of mental health such as anxiety and depression in Lebanon. Future studies should replicate the mediation analysis conducted in the current study while taking into account other eating disorders. Additional investigations of BN and its correlates must strive to improve the comprehension of these associations' pathways through designs that allow to draw temporal frameworks, in order to efficiently treat this eating disorder and prevent its negative outcomes. Plain English summary: Bulimia nervosa, an eating disorder, is characterized by an impulsive consumption of food in a short period of time, followed by behaviors that compensate the eating such as vomiting or excessive exercise in order to avoid weight gain. Individuals with problematic social media use were found to have higher levels of bulimia symptoms. Symptoms of bulimia can also be associated with both depression and anxiety. The aim of the current study was to examine the mediating role of anxiety and depression between problematic social media use and bulimia nervosa. The results of our study found that problematic social media use was directly associated with more bulimia nervosa and also associated with higher depression and anxiety, both of which were associated with bulimia nervosa. Tackling associated disorders may help reduce symptoms of bulimia nervosa. Clinicians should carefully examine these associations while assessing and implementing treatment plans. [ABSTRACT FROM AUTHOR] more...
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- 2023
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48. Asthma education and its impact on pediatric asthma severity: a prospective cohort study.
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Omara, Heba A., Mansour, Mervat G., and Badr, Raffay M.
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STANDARDIZED tests ,ADRENERGIC agonists ,ASTHMA ,ASTHMA in children ,COHORT analysis ,LONGITUDINAL method - Abstract
Asthma education has been shown to improve asthma control. Our goal was to evaluate the efficacy of asthma education on the frequency of utilization of health-care services, lung function results, degree of asthma severity, and quality of life (QOL) level in children with asthma. A single-arm prospective interventional trial was conducted in a tertiary facility. Thirty children with asthma and their parents were recruited for the research. Following an assessment of the participants' and caregivers' knowledge about asthma using an asthma knowledge questionnaire, degree of asthma control using asthma control test, inhaler technique using standardized inhaler technique checklists, and QOL using pediatric asthma QOL questionnaires, they participated in a three-month education program in the form of monthly live interactive sessions followed by weekly phone interviews. Measures taken before and after the intervention were compared. The educational intervention improved asthma control dramatically including daytime asthma symptoms, night awakenings, and frequency of use of short-acting beta2- adrenergic receptor agonists. Furthermore, the number of emergency department visits and hospitalizations fell considerably after the intervention (p < 0.001 for all). Asthma education was also linked to better inhalation technique and lung function (p < 0.001). Furthermore, all quality-of-life measures increased (p < 0.001 for all). Implementing an asthma education program that included both children with asthma and their parents improved asthma control levels, lung function measures, and overall quality of life. Furthermore, it increased asthma awareness, decreased the use of health-care resources, and reduced asthma severity, resulting in better asthma management. [ABSTRACT FROM AUTHOR] more...
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- 2023
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49. "INTEGRO INTEGRated Psychotherapeutic InterventiOn" on the Management of Chronic Pain in Patients with Fibromyalgia: The Role of the Therapeutic Relationship.
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Pasini, Ilenia, Perlini, Cinzia, Donisi, Valeria, Mason, Anna, Schweiger, Vittorio, Secchettin, Erica, Lugoboni, Fabio, Valenza, Gaetano, and Del Piccolo, Lidia
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- 2023
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50. New Staging System and Prognostic Model for Malignant Phyllodes Tumor Patients without Distant Metastasis: A Development and Validation Study.
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Ruan, Zhaohui, Quan, Qi, Wang, Qianyu, Jiang, Jiaxin, and Peng, Roujun
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PHYLLODES tumors ,PROGNOSTIC models ,DUCTAL carcinoma ,WEB-based user interfaces ,PROGNOSIS ,METASTASIS - Abstract
Simple Summary: Malignant phyllodes tumor of the breast (MPTB) is a rare fibroepithelial tumor. Because of its rarity, research based on large clinical datasets is currently lacking. Moreover, the prognostic factors of MPTB have yet to be determined. Prognostic models and staging systems for MPTB patients are needed, but are also lacking. Here, we conducted a comparison between MPTB cases and invasive ductal carcinoma cases. Our findings reveal substantial differences in the clinical features of invasive ductal carcinoma and MPTB. We applied the KAPS algorithm to explore and establish a new stage- and age-stratification system. The system exhibited a good prognostic stratification ability for both the internal cohort and the external cohort. Furthermore, we developed independent prognostic models for MPTB using Cox proportional hazards regression and random survival forests (RSF). Finally, we built a user-friendly web app to allow researchers and doctors to access our model. Purpose: To build a new staging system and new prognostic models for MPTB. Methods: We performed a comprehensive analysis of the data from the SEER database. Results: We discussed the characteristics of MPTB by comparing 1085 MPTB cases with 382,718 invasive ductal carcinoma cases. We established a new stage- and age-stratification system for MPTB patients. Furthermore, we built two prognostic models for MPTB patients. The validity of these models was confirmed through multifaceted and multidata verification. Conclusions: Our study provided a staging system and prognostic models for MPTB patients, which can not only help to predict patient outcomes, but also enhance the understanding of the prognostic factors associated with MPTB. [ABSTRACT FROM AUTHOR] more...
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- 2023
- Full Text
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