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Your search keyword '"Yuan, Yi-Wu"' showing total 8 results
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8 results on '"Yuan, Yi-Wu"'

5. Methionine restriction attenuates the migration and invasion of gastric cancer cells by inhibiting nuclear p65 translocation through TRIM47.

Author

Xin, Lin, Yuan, Yi-Wu, Liu, Chen-Xi, Sheng, Jie, Zhou, Qi, Liu, Zhi-Yang, Yue, Zhen-Qi, and Zeng, Fei

Subjects
*STOMACH cancer, *CANCER cells, *METHIONINE, *CELL migration, *PROTEIN expression, *PROTEIN stability
Abstract

The prevention and treatment of gastric cancer has been the focus and difficulty of medical research. We aimed to explore the mechanism of inhibiting migration and invasion of gastric cancer cells by methionine restriction (MR). The human gastric cancer cell lines AGS and MKN45 cultured with complete medium (CM) or medium without methionine were used for in vitro experiments. MKN45 cells were injected tail vein into BALB/c nude mice and then fed with normal diet or methionine diet for in vivo experiments. MR treatment decreased cell migration and invasion, increased E-cadherin expression, decreased N-cadherin and p-p65 expressions, and inhibited nuclear p65 translocation of AGS and MKN45 cells when compared with CM group. MR treatment increased IκBα protein expression and protein stability, and decreased IκBα protein ubiquitination level and TRIM47 expression. TRIM47 interacted with IκBα protein, and overexpression of TRIM47 reversed the regulatory effects of MR. TRIM47 promoted lung metastasis formation and partially attenuated the effect of MR on metastasis formation in vivo compared to normal diet group mice. MR reduces TRIM47 expression, leads to the degradation of IκBα, and then inhibits the translocation of nuclear p65 and the migration and invasion of gastric cancer cells. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Smart Nano‐switch with Flexible Modulation of Ion Transport Using Multiple Environmental Stimuli

Author

Li‐Dong Chen, Yuan‐Yi Wu, Di Zhang, Shuo‐Hui Cao, Lin‐Tao Xu, and Yao‐Qun Li

Subjects
Ions, Ion Transport, Polymers, Organic Chemistry, General Chemistry, Biochemistry
Abstract

In this work, we demonstrate a unique nano-switch with triple environmental stimuli based on the action of functional copolymer brushes in a single conical nanochannel. This nanodevice flexibly and efficiently modulates ion transport properties under the influence of three environmental stimuli: light, pH and temperature. The triple factors can not only play a regulatory role independently, but their synergistic cooperation could fully activate the ionic gate and reversibly control the gating direction. In addition, the nano-switch can switch transport properties on demand in the face of complex combinations of different factors. This work promotes the development of intelligent bionic ion channels, which holds promise for biosensing, energy conversion and biomedical research.

Published
2022

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