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2. Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites

Author

Li Wang, Yu Qie, Yu Yang, and Qiang Zhao

Subjects
Receptors, Estrogen, Environmental Chemistry, Estrogens, General Chemistry, DDT
Abstract

DDT and its metabolites (DDTs) can induce estrogenic effects. Previous mechanistic investigations mainly concentrated on activating the genomic transcription of estrogen receptor (ER) pathways. Here, we identified whether estrogen-related receptor γ (ERRγ), an orphan nuclear receptor, is a potential target of DDTs by receptor binding, transcriptional activity, and receptor-mediated pathway assays. Fluorescence polarization-based binding assays showed that all eight DDTs bound to ERRγ directly, with

Published
2022
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