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Your search keyword '"Young, Neal S."' showing total 244 results
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244 results on '"Young, Neal S."'

1. A unified metric of human immune health

Author

Sparks, Rachel, Rachmaninoff, Nicholas, Lau, William W., Hirsch, Dylan C., Bansal, Neha, Martins, Andrew J., Chen, Jinguo, Liu, Candace C., Cheung, Foo, Failla, Laura E., Biancotto, Angelique, Fantoni, Giovanna, Sellers, Brian A., Chawla, Daniel G., Howe, Katherine N., Mostaghimi, Darius, Farmer, Rohit, Kotliarov, Yuri, Calvo, Katherine R., Palmer, Cindy, Daub, Janine, Foruraghi, Ladan, Kreuzburg, Samantha, Treat, Jennifer D., Urban, Amanda K., Jones, Anne, Romeo, Tina, Deuitch, Natalie T., Moura, Natalia Sampaio, Weinstein, Barbara, Moir, Susan, Ferrucci, Luigi, Barron, Karyl S., Aksentijevich, Ivona, Kleinstein, Steven H., Townsley, Danielle M., Young, Neal S., Frischmeyer-Guerrerio, Pamela A., Uzel, Gulbu, Pinto-Patarroyo, Gineth Paola, Cudrici, Cornelia D., Hoffmann, Patrycja, Stone, Deborah L., Ombrello, Amanda K., Freeman, Alexandra F., Zerbe, Christa S., Kastner, Daniel L., Holland, Steven M., and Tsang, John S.

Published
2024
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2. Venous and arterial thrombosis in patients with VEXAS syndrome

Author

Kusne, Yael, Ghorbanzadeh, Atefeh, Dulau-Florea, Alina, Shalhoub, Ruba, Alcedo, Pedro E., Nghiem, Khanh, Ferrada, Marcela A., Hines, Alexander, Quinn, Kaitlin A., Panicker, Sumith R., Ombrello, Amanda K., Reichard, Kaaren, Darden, Ivana, Goodspeed, Wendy, Durrani, Jibran, Wilson, Lorena, Olteanu, Horatiu, Lasho, Terra, Kastner, Daniel L., Warrington, Kenneth J., Mangaonkar, Abhishek, Go, Ronald S., Braylan, Raul C., Beck, David B., Patnaik, Mrinal M., Young, Neal S., Calvo, Katherine R., Casanegra, Ana I., Grayson, Peter C., Koster, Matthew J., Wu, Colin O., Kanthi, Yogendra, Patel, Bhavisha A., Houghton, Damon E., and Groarke, Emma M.

Published
2024
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5. Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS

Author

Wu, Zhijie, Gao, Shouguo, Gao, Qingyan, Patel, Bhavisha A., Groarke, Emma M., Feng, Xingmin, Manley, Ash Lee, Li, Haoran, Ospina Cardona, Daniela, Kajigaya, Sachiko, Alemu, Lemlem, Quinones Raffo, Diego, Ombrello, Amanda K., Ferrada, Marcela A., Grayson, Peter C., Calvo, Katherine R., Kastner, Daniel L., Beck, David B., and Young, Neal S.

Published
2023
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6. Spectrum of clonal hematopoiesis in VEXAS syndrome

Author

Gutierrez-Rodrigues, Fernanda, Kusne, Yael, Fernandez, Jenna, Lasho, Terra, Shalhoub, Ruba, Ma, Xiaoyang, Alessi, Hugh, Finke, Christy, Koster, Matthew J., Mangaonkar, Abhishek, Warrington, Kenneth J., Begna, Kebede, Xie, Zhuoer, Ombrello, Amanda K., Viswanatha, David, Ferrada, Marcela, Wilson, Lorena, Go, Ronald, Kourelis, Taxiarchis, Reichard, Kaaren, Olteanu, Horatiu, Darden, Ivana, Hironaka, Dalton, Alemu, Lemlem, Kajigaya, Sachiko, Rosenzweig, Sofia, Calado, Rodrigo T., Groarke, Emma M., Kastner, Daniel L., Calvo, Katherine R., Wu, Colin O., Grayson, Peter C., Young, Neal S., Beck, David B., Patel, Bhavisha A., and Patnaik, Mrinal M.

Published
2023
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7. Differential diagnosis of bone marrow failure syndromes guided by machine learning

Author

Gutierrez-Rodrigues, Fernanda, Munger, Eric, Ma, Xiaoyang, Groarke, Emma M., Tang, Youbao, Patel, Bhavisha A., Catto, Luiz Fernando B., Clé, Diego V., Niewisch, Marena R., Alves-Paiva, Raquel M., Donaires, Flávia S., Pinto, André Luiz, Borges, Gustavo, Santana, Barbara A., McReynolds, Lisa J., Giri, Neelam, Altintas, Burak, Fan, Xing, Shalhoub, Ruba, Siwy, Christopher M., Diamond, Carrie, Raffo, Diego Quinones, Craft, Kathleen, Kajigaya, Sachiko, Summers, Ronald M., Liu, Paul, Cunningham, Lea, Hickstein, Dennis D., Dunbar, Cynthia E., Pasquini, Ricardo, De Oliveira, Michel Michels, Velloso, Elvira D. R. P., Alter, Blanche P., Savage, Sharon A., Bonfim, Carmem, Wu, Colin O., Calado, Rodrigo T., and Young, Neal S.

Published
2023
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10. Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia

Author

Kelkka, Tiina, Tyster, Mikko, Lundgren, Sofie, Feng, Xingmin, Kerr, Cassandra, Hosokawa, Kohei, Huuhtanen, Jani, Keränen, Mikko, Patel, Bhavisha, Kawakami, Toru, Maeda, Yuka, Nieminen, Otso, Kasanen, Tiina, Aronen, Pasi, Yadav, Bhagwan, Rajala, Hanna, Nakazawa, Hideyuki, Jaatinen, Taina, Hellström-Lindberg, Eva, Ogawa, Seishi, Ishida, Fumihiro, Nishikawa, Hiroyoshi, Nakao, Shinji, Maciejewski, Jaroslaw, Young, Neal S., and Mustjoki, Satu

Published
2022
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11. Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome

Author

Ganesan, Saravanan, primary, Murray, Rebecca M., additional, Sotelo, Jesus, additional, Eton, Elliot O., additional, Takashima, Kouhei, additional, Botella, Theo, additional, Beattie, Kai, additional, Indart, Alyssa C., additional, Chraiki, Nada, additional, Croizier, Carolyne, additional, Izzo, Franco, additional, Potenski, Catherine, additional, Marro, Samuele, additional, Wu, Zhijie, additional, Gao, Shouguo, additional, Young, Neal S., additional, Blair, John D., additional, Satija, Rahul, additional, Terrier, Benjamin, additional, Heiblig, Mael, additional, Papapetrou, Eirini P, additional, Sujobert, Pierre, additional, Kosmider, Olivier, additional, Beck, David B., additional, and Landau, Dan A., additional

Published
2024
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12. Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis

Author

Ferrada, Marcela A., Savic, Sinisa, Cardona, Daniela Ospina, Collins, Jason C., Alessi, Hugh, Gutierrez-Rodrigues, Fernanda, Kumar, Dinesh Babu Uthaya, Wilson, Lorena, Goodspeed, Wendy, Topilow, James S., Paik, Julie J., Poulter, James A., Kermani, Tanaz A., Koster, Matthew J., Warrington, Kenneth J., Cargo, Catherine, Tattersall, Rachel S., Duncan, Christopher J.A., Cantor, Anna, Hoffmann, Patrycja, Payne, Elspeth M., Bonnekoh, Hanna, Krause, Karoline, Cowen, Edward W., Calvo, Katherine R., Patel, Bhavisha A., Ombrello, Amanda K., Kastner, Daniel L., Young, Neal S., Werner, Achim, Grayson, Peter C., and Beck, David B.

Published
2022
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18. Opportunistic Infections, Mortality Risk, and Prevention Strategies in Patients With Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic (VEXAS) Syndrome.

Author

Czech, Mary, Cuellar-Rodriguez, Jennifer, Patel, Bhavisha A, Groarke, Emma M, Cowen, Edward W, Turturice, Benjamin, Beck, David B, Wilson, Lorena, Goodspeed, Wendy, Darden, Ivana, Young, Neal S, Hickstein, Dennis, Ombrello, Amanda, Hoffman, Patrycjia, Arikan, Evsen Apaydin, Sinaii, Ninet, Hathaway, Londa, Castelo-Soccio, Leslie, Fike, Alice, and Kastner, Daniel B

Subjects
PNEUMOCYSTIS pneumonia, HERPES simplex virus, OPPORTUNISTIC infections, VARICELLA-zoster virus, GENETIC disorders
Abstract

Background VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a genetic disorder characterized by bone marrow failure and systemic inflammation, putting patients at risk for infections. This study comprehensively examines the prevalence of opportunistic infections in patients with VEXAS, evaluating their impact on clinical outcomes and potential preventive measures. Methods Patients with confirmed VEXAS were included. Survival analysis and logistic regression were used to identify associations between opportunistic infections and mortality. Infection rates (IRs) for Pneumocystis jirovecii pneumonia (PJP) and alphaherpesviruses were calculated over a prospective 8-month observation period in relationship to prophylaxis. Results Of 94 patients with VEXAS, 6% developed PJP; 15% had alphaherpesvirus reactivation, with varicella zoster virus (VZV) being the most common herpesvirus; and 10% contracted a nontuberculous mycobacterial (NTM) infection. Risk of death was significantly increased per month following a diagnosis of PJP (hazard ratio [HR], 72.41 [95% confidence interval {CI}, 13.67–533.70]) or NTM (HR, 29.09 [95% CI, 9.51–88.79]). Increased odds for death were also observed in patients with a history of herpes simplex virus (HSV) reactivation (odds ratio [OR], 12.10 [95% CI, 1.29–114.80]) but not in patients with VZV (OR, 0.89 [95% CI,.30–2.59]). Prophylaxis for PJP (IR, 0.001 vs 0 per person-day, P <.01) and VZV (IR, 0.006 vs 0 per person-day, P =.04) markedly decreased infection rates with a number needed to treat of 4 and 7, respectively. Conclusions Opportunistic infections are common in patients with VEXAS. Patients who develop PJP, HSV, or NTM are at increased risk for death. Prophylaxis against PJP and VZV is highly effective. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Ahemolytic PNH (white cell PNH): Clinical features and implications of a distinct phenotype of paroxysmal nocturnal haemoglobinuria

Author

Tombul, Zehra, primary, Bahaj, Waled, additional, Ozturk, Merve, additional, Patel, Bhavisha, additional, Toprak, Ahmet, additional, Ibrahim, Ibrahim, additional, Chen, Weina, additional, Fuda, Franklin, additional, Ogbue, Olisaemeka D., additional, Gurnari, Carmelo, additional, Parker, Charles, additional, Young, Neal S., additional, Maciejewski, Jaroslaw P., additional, Duran, Munevver, additional, and Bat, Taha, additional

Published
2024
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24. Granulocyte transfusions in severe aplastic anemia

Author

Rajput, Roma V., primary, Shah, Vaani, additional, Shalhoub, Ruba N., additional, West-Mitchell, Kamille, additional, Cha, Nu Ri, additional, Conry-Cantilena, Cathy, additional, Leitman, Susan F., additional, Young, David J., additional, Wells, Brian, additional, Aue, Georg, additional, Dunbar, Cynthia E., additional, Patel, Bhavisha A., additional, Childs, Richard W., additional, Young, Neal S., additional, Wu, Colin O., additional, Groarke, Emma M., additional, and Kalsi, Shelley S., additional

Published
2023
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25. Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu’s arteritis, ANCA-associated vasculitis and giant cell arteritis

Author

Gutierrez-Rodrigues, Fernanda, primary, Wells, Kristina V, additional, Jones, Adrianna I, additional, Hironaka, Dalton, additional, Rankin, Cameron, additional, Gadina, Massimo, additional, Sikora, Keith A, additional, Alemu, Lemlem, additional, Calado, Rodrigo T, additional, Quinn, Kaitlin A, additional, Patel, Bhavisha, additional, Young, Neal S, additional, and Grayson, Peter C, additional

Published
2023
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27. Hematopoiesis under telomere attrition at the single-cell resolution

Author

Thongon, Natthakan, Ma, Feiyang, Santoni, Andrea, Marchesini, Matteo, Fiorini, Elena, Rose, Ashley, Adema, Vera, Ganan-Gomez, Irene, Groarke, Emma M., Gutierrez-Rodrigues, Fernanda, Chen, Shuaitong, Lockyer, Pamela, Schneider, Sarah, Bueso-Ramos, Carlos, Montalban-Bravo, Guillermo, Class, Caleb A., Soltysiak, Kelly A., Pellegrini, Matteo, Sahin, Ergun, Bertuch, Alison A., DiNardo, Courtney D., Garcia-Manero, Guillermo, Young, Neal S., Dwyer, Karen, and Colla, Simona

Published
2021
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29. S176: FUNCTIONAL AND ANTIGEN-SPECIFIC CHARACTERIZATION OF IMMUNE CELLS AT THE SINGLE-CELL LEVEL REVEALS CONVERGENCE OF ADAPTIVE AND INNATE IMMUNITY IN IMMUNE APLASTIC ANEMIA

Author

Huuhtanen, Jani, primary, Lundgren, Sofie, additional, Keränen, Mikko, additional, Feng, Xingim, additional, Dulau-Florea, Alina, additional, Patel, Bhavisha, additional, Zaimoku, Yoshitaka, additional, Kerr, Cassandra, additional, Jokinen, Emmi, additional, Heinonen, Markus, additional, Rajala, Hanna, additional, Siitonen, Sanna, additional, Ebeling, Freja, additional, Ryland, Georgina, additional, Fox, Lucy, additional, Blombery, Piers, additional, Hellström-Lindberg, Eva, additional, Maciejewski, Jaroslaw P., additional, Young, Neal S., additional, Lähdesmäki, Harri, additional, and Mustjoki, Satu, additional

Published
2023
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31. Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy

Author

Nakamura, Ryotaro, primary, Patel, Bhavisha A., additional, Kim, Soyoung, additional, Wong, F. Lennie, additional, Armenian, Saro H., additional, Groarke, Emma M., additional, Kessler, Daniel A., additional, Hebert, Kyle M., additional, Heim, Michael, additional, Eapen, Mary, additional, and Young, Neal S., additional

Published
2023
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32. What causes aplastic anaemia?

Author

Gale, Robert Peter, primary, Hinterberger, Wolfgang, additional, Young, Neal S., additional, Gennery, Andrew R., additional, Dvorak, Christopher C., additional, Hebert, Kyle M., additional, Heim, Michael, additional, Broglie, Larisa, additional, and Eapen, Mary, additional

Published
2023
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36. Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial

Author

Clé, Diego V., primary, Catto, Luiz Fernando B., additional, Gutierrez-Rodrigues, Fernanda, additional, Donaires, Flávia S., additional, Pinto, Andre L., additional, Santana, Barbara A., additional, Darrigo, Luiz Guilherme, additional, Valera, Elvis T., additional, Koenigkam-Santos, Marcel, additional, Baddini-Martinez, José, additional, Young, Neal S., additional, Martinez, Edson Z., additional, and Calado, Rodrigo T., additional

Published
2022
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37. Differential diagnosis of bone marrow failure syndromes guided by machine learning

Author

Gutierrez-Rodrigues, Fernanda, primary, Munger, Eric, additional, Ma, Xiaoyang, additional, Groarke, Emma M., additional, Tang, Youbao, additional, Patel, Bhavisha A, additional, Catto, Luiz Fernando B., additional, Clé, Diego V, additional, Niewisch, Marena R., additional, Paiva, Raquel MA, additional, Donaires, Flavia, additional, Pinto, André Luiz, additional, Borges, Gustavo, additional, Santana, Barbara A., additional, McReynolds, Lisa J, additional, Giri, Neelam, additional, Altintas, Burak, additional, Fan, Xing, additional, Shalhoub, Ruba N, additional, Siwy, Christopher Mark, additional, Diamond, Carrie, additional, Quinones Raffo, Diego, additional, Craft, Kathleen Marie, additional, Kajigaya, Sachiko, additional, Summers, Ronald M, additional, Liu, Paul P., additional, Cunningham, Lea, additional, Hickstein, Dennis D, additional, Dunbar, Cynthia E., additional, Pasquini, Ricardo, additional, de Oliveira, Michel Michels, additional, Velloso, Elvira D R P, additional, Alter, Blanche P, additional, Savage, Sharon A, additional, Bonfim, Carmem M.S., additional, Wu, Colin O., additional, Calado, Rodrigo T., additional, and Young, Neal S, additional

Published
2022
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38. Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL

Author

Rejeski, Kai, primary, Wu, Zhijie, additional, Blumenberg, Viktoria, additional, Kunz, Wolfgang G., additional, Müller, Susanna, additional, Kajigaya, Sachiko, additional, Gao, Shouguo, additional, Bücklein, Veit L., additional, Frölich, Lisa, additional, Schmidt, Christian, additional, von Bergwelt-Baildon, Michael, additional, Feng, Xingmin, additional, Young, Neal S., additional, and Subklewe, Marion, additional

Published
2022
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39. Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Author

Rajput, Roma V., primary, Shah, Vaani, additional, Shalhoub, Ruba, additional, West-Mitchell, Kamille, additional, Conry-Cantilena, Cathy, additional, Young, David J., additional, Dunbar, Cynthia E., additional, Patel, Bhavisha A., additional, Childs, Richard W., additional, Young, Neal S., additional, Wu, Colin O., additional, Groarke, Emma M., additional, and Kalsi, Shelley S., additional

Published
2022
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40. Clonal Hematopoiesis in a Broad Age Spectrum of Systemic Vasculitis

Author

Gutierrez-Rodrigues, Fernanda, primary, Jones, Adrianna I., additional, Wells, Kristina, additional, Hironaka, Dalton, additional, Rankin, Cameron, additional, Sikora, Keith A, additional, Quinn, Kaitlin, additional, Ferrada, Marcela, additional, Patel, Bhavisha A., additional, Grayson, Peter C., additional, and Young, Neal S., additional

Published
2022
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41. Eosinophilia in Vexas Syndrome: Expanding Hematologic Phenotype

Author

Prabahran, Ashvind Anand, primary, Gutierrez-Rodrigues, Fernanda, additional, Ahmad, Serene, additional, Cowen, Edward W, additional, Darden, Ivana, additional, Groarke, Emma M., additional, Ferrada, Marcela, additional, Grayson, Peter C., additional, Klion, Amy D, additional, Calvo, Katherine R., additional, Maric, Irina, additional, Young, Neal S., additional, and Patel, Bhavisha A., additional

Published
2022
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42. DNMT3A/TET2 Mutant Clonal Hematopoiesis in Vexas Syndrome Results in DNA Hypomethylation and Transcriptional Activation of WT1 and MPL Oncogenic Pathways

Author

Fernandez, Jenna A., primary, Patel, Bhavisha A., additional, Gutierrez-Rodrigues, Fernanda, additional, Kusne, Yael, additional, Lasho, Terra, additional, Finke, Christy, additional, Koster, Matthew, additional, Mangaonkar, Abhishek A., additional, Gangat, Naseema, additional, Warrington, Kenneth, additional, Reichard, Kaaren K., additional, Olteanu, Horatiu, additional, Grayson, Peter C., additional, Young, Neal S., additional, Beck, David B., additional, and Patnaik, Mrinal M., additional

Published
2022
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43. The Role of Heterozygous Variants in SAMD9/9L and Recessive Bone Marrow Failure-Related Genes in Adults with Severe Aplastic Anemia

Author

Hironaka, Dalton, primary, Ma, Xiaoyang, additional, Patel, Bhavisha A., additional, Groarke, Emma M., additional, Lotter, Jennifer, additional, Rios, Olga, additional, Coelho-Silva, Juan L, additional, Wu, Colin O., additional, Cammenga, Jorg, additional, Gutierrez-Rodrigues, Fernanda, additional, and Young, Neal S., additional

Published
2022
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46. Clonal Hematopoiesis in Vexas Syndrome

Author

Patel, Bhavisha A., primary, Gutierrez-Rodrigues, Fernanda, additional, Kusne, Yael, additional, Fernandez, Jenna A., additional, Lasho, Terra, additional, Shalhoub, Ruba, additional, Ma, Xiaoyang, additional, Alessi, Hugh, additional, Finke, Christy, additional, Koster, Matthew, additional, Mangaonkar, Abhishek A., additional, Warrington, Kenneth, additional, Begna, Kebede H., additional, Xie, Zhuoer, additional, Ombrello, Amanda, additional, Viswanatha, David S., additional, Ferrada, Marcela, additional, Wilson, Lorena, additional, Go, Ronald, additional, Kourelis, Taxiarchis, additional, Reichard, Kaaren K., additional, Olteanu, Horatiu, additional, Groarke, Emma M., additional, Darden, Ivana, additional, Hironaka, Dalton, additional, Rosenzweig, Sofia, additional, Kastner, Daniel L., additional, Calvo, Katherine R., additional, Wu, Colin O., additional, Grayson, Peter C., additional, Beck, David B., additional, Patnaik, Mrinal M.M., additional, and Young, Neal S., additional

Published
2022
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47. Thrombotic Manifestations in Patients with Vexas Syndrome

Author

Alcedo Andrade, Pedro E., primary, Shalhoub, Ruba, additional, Dulau-Florea, Alina, additional, Nghiem, Khanh, additional, Ferrada, Marcela, additional, Wilson, Lorena, additional, Darden, Ivana, additional, Goodspeed, Wendy, additional, Calvo, Katherine R., additional, Beck, David B., additional, Kastner, Daniel L., additional, Grayson, Peter C., additional, Young, Neal S., additional, Wu, Colin O., additional, Kanthi, Yogendra, additional, Patel, Bhavisha A., additional, and Groarke, Emma M., additional

Published
2022
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50. Predictors, Risk Factors and Outcomes of Patients with SAA with Anti-HLA Class I Antibodies Treated with Immunosuppressive Therapy

Author

Durrani, Jibran, primary, Chen, Leonard, additional, Shalhoub, Ruba, additional, Cha, Nu Ri, additional, Ma, Xiaoyang, additional, Lotter, Jennifer, additional, Rios, Olga, additional, Wu, Colin O., additional, Flegel, Willy A., additional, Young, Neal S., additional, Patel, Bhavisha A., additional, and Groarke, Emma M., additional

Published
2022
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