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Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and progression. As promising anticancer targets, HDACs have gained a great deal of research interests and two decades of effort has led to the approval of five HDAC inhibitors (HDACis). However, currently traditional HDACis, although effective in approved indications, exhibit severe off-target toxicities and low sensitivities against solid tumors, which have urged the development of next-generation of HDACi. This review investigates the biological functions of HDACs, the roles of HDACs in oncogenesis, the structural features of different HDAC isoforms, isoform-selective inhibitors, combination therapies, multitarget agents and HDAC PROTACs. We hope these data could inspire readers with new ideas to develop novel HDACi with good isoform selectivity, efficient anticancer effect, attenuated adverse effect and reduced drug resistance.

In response to asynchronous and delayed sensors within multi-sensor integrated navigation systems, the computational complexity of joint optimization navigation solutions persistently rises. This paper introduces an adaptive fast integrated navigation algorithm for INS/GPS/VO based on factor graph. The factor graph model for INS/GPS/VO is developed subsequent to individual modeling of the Inertial Navigation System (INS), Global Positioning System (GPS), and Visual Odometer (VO) using the factor graph model approach. Additionally, an Adaptive Fast Incremental Smoothing (AFIS) factor graph optimization algorithm is proposed. The simulation results demonstrate that the factor-graph-based integrated navigation algorithm consistently yields high-precision navigation outcomes even amidst dynamic changes in sensor validity and the presence of asynchronous and delayed sensor measurements. Notably, the AFIS factor graph optimization algorithm significantly enhances real-time performance compared to traditional Incremental Smoothing (IF) algorithms, while maintaining comparable real-time accuracy.

In this paper, we present an innovative inertial navigation system (INS)/celestial navigation system (CNS)/scene-matching navigation (SMN) adaptive integrated navigation algorithm designed to achieve prolonged and highly precise navigation in sea areas. The algorithm establishes the structure of the INS/CNS/SMN integrated navigation system. To ensure the availability of CNS in the Nanhai Sea (South China Sea) area, a cloud and fog model is meticulously constructed. Three distinct types of sea area landmarks are defined, and an automated classification model for sea area landmarks, employing support vector machines (SVM), is developed. Corresponding matching methods and strategies for these landmarks are also delineated. Concurrently, the observable probability of each landmark is computed to generate a probability cloud, representing the usability of sea area landmarks. The proposed INS/CNS/SMN adaptive integrated navigation algorithm is simulated and validated across varied altitudes and trajectories in the sea area. The results show that CNS and SMN can dynamically assist INS in achieving prolonged and highly precise navigation.

Differences in acquisition time, light conditions, and viewing angle create significant differences among the airborne remote sensing images from Unmanned Aerial Vehicles (UAVs). Real-time scene matching navigation applications based on fixed reference maps are error-prone and have poor robustness. This paper presents a novel shadow-based matching method for the localization of low-altitude flight UAVs. A reference shadow map is generated from an accurate (0.5 m spatial resolution) Digital Surface Model (DSM) with the known date and time information; a robust shadow detection algorithm is employed to detect shadows in aerial images; the shadows can then be used as a stable feature for scene matching navigation. Combining the conventional intensity-based matching method, a fusion scene navigation scheme that is more robust to illumination variations is proposed. Experiments were performed with Google satellite maps, DSM data, and real aerial images of the Zurich region. The radial localization error of the Shadow-based Matching (SbM) is less than 7.3 m at flight height below 1200 m. The fusion navigation approach also achieves an optimal combination of shadow-based matching and intensity-based matching. This study shows the solution to the inconsistencies caused by changes in light, viewing angle, and acquisition time for accurate and effective scene matching navigation.