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An extensive body of literature shows how people deal with conflicts, verbally and nonverbally, in interpersonal interactions. However, the role of technologically-mediated communication (TMC) in romantic relational conflict has received less attention. Through the lenses of Relational Turbulence and Expectancy Violations Theories, this study explored how a chronemic expectancy violation from a romantic partner impacts emotional well-being in a TMC-involved conflict discussion. Two online questionnaires were distributed. First, a pilot study was conducted to understand the basic online communication dynamics between emerging adult romantic partners (e.g., usual response latency) and possible emotions when they experience a chronemic expectancy violation from their partner on TMC. Results show that people are likely to experience negative affect and other specific emotions (e.g., disillusion, loneliness, frustration, hurt, anger) if their partner takes longer than expected to respond. The main study then further explored how individuals' expectations differ in a hypothetical TMC-involved conflict scenario where they use text-based TMC to discuss a recent romantic conflict with their partners. Participants were instructed to imagine a chronemic expectancy violation whereby their partner does not respond within their expected time period (i.e., conflict expected latency) and report their feelings about it. Results show that people expect their partners to respond more rapidly in the conflict scenario than usual and report negative feelings after the expectancy violations. Conflict-specific (e.g., seriousness), personal (e.g., attachment anxiety and avoidance), and relational (e.g., commitment) variables also influence the intensity of their emotional experiences. This research enhances comprehension of nonverbal cues in text-based TMC and potential emotional repercussions in romantic conflict management. [ABSTRACT FROM AUTHOR]

Romantic relationship dissolution and its aftermath have rarely been investigated through the lens of face threat. This research delves into the communication of relationship dissolution, and argues that rejectees' perceived face threat of dissolution language, when interacting with their self-concept clarity (attachment style and pre-dissolution commitment) can have an impact on their recovery length. I recruited 246 undergraduate participants who have experienced relationship dissolution as a rejectee and have recovered from the dissolution. Participants filled out a survey to assess their perceived face threat from rejectors' dissolution language, attachment styles, and pre-dissolution commitment. Model fit of perceived face threat measure was tested, and path analysis model was run. Results show that rejectees' perceived face threat of dissolution language and pre-dissolution commitment significantly lengthen their recovery period. Rejectees' attachment style does not have a direct impact on their recovery, but mediates through perceived face threat. Theoretical and practical implications were discussed. [ABSTRACT FROM AUTHOR]

The article presents the discussion on research on Chinese ritual impoliteness and rap battle competitions. Topics include opponents' facing by accusing the other of disobeying the Confucianist morality and teaching the opponent appropriate mannerism; and opponent engaged with the central theme of peace and love in rap battles connecting the novice's hypocrisy for taking the fake identity as a rasta singer.

Recently, nanomaterials have been well-studied in cancer therapy, but some of them often experience difficulties with degradation in vivo, which could cause severe damage to the human body. Among numerous biodegradable nanomaterials, antimonene nanosheets (AMNSs) are versatile, and possess photothermal and photodynamic properties and photoacoustic imaging (PAI) and drug loading ability. Herein, we employed a clearable multifunctional system. The small molecule photosensitizer IR820 and the gold nanoparticles (AuNPs) at small sizes of approximately 5 nm were loaded onto AMNSs coated with biodegradable chitosan (CS). This nanoplatform showed excellent photothermal and photodynamic properties, satisfactory degradability and photoacoustic imaging ability, good biocompatibility and effective NIR light triggered intracellular synergistic treatment. It also displayed good fluorescence imaging ability in the experiment of cell uptake. These suggested that this versatile nanoplatform was able to significantly enhance the therapeutic efficiency based on synergistic phototherapy, and could also be applied in fluorescence and photoacoustic dual imaging for integrating diagnosis and treatment. [ABSTRACT FROM AUTHOR]

The multiple diagnosis and treatment mechanisms of chemotherapy combined with photothermal/photodynamic therapy have very large application prospects in the field of cancer treatment. Therefore, in order to achieve effective and safe antitumour treatment, it is necessary to design an intelligent responsive polymer nanoplatform as a drug delivery system. Herein, the thermosensitive poly-N-isopropylacrylamide (PNIPAM) nanogel particles were prepared by soap-free emulsion polymerization and loaded with a large amount of photosensitizer indocyanine green (ICG) and anticarcinogen 5-fluorouracil (5-Fu), which effectively to realize the cooperative chemotherapy and photothermal/photodynamic therapy for tumours. The 5-Fu@ICG-PNIPAM nanogels significantly improved the bioavailability of the drug and achieved controlled release. In addition, under near-infrared laser (NIR) irradiation at 808 nm, 5-Fu@ICG-PNIPAM nanogels generated lots of heat and reactive oxygen, which significantly enhanced cellular uptake and in vitro antitumour treatment effects. The results showed that 5-Fu@ICG-PNIPAM nanogels were effectively endocytosed by HeLa cells, which also enhanced the drug's entrance into the nucleus. Moreover, compared with alone chemotherapy or photothermal/photodynamic therapy, 5-Fu@ICG-PNIPAM nanogels significantly increased cytotoxicity under NIR irradiation, suggesting that chemotherapy and photothermal/photodynamic synergistic therapy had excellent antitumour properties. Therefore, this temperature-responsive nanogel platform probably has great application prospects in clinical antitumour treatment. [ABSTRACT FROM AUTHOR]

Using a netnography approach, this study examines Martial, a Chinese fansub group, as an online community of practice. It finds four identities to be exhibited by members of the group: language-, education-, mediation-, and business-related identities. In its work flow and division of labour, Martial pools the collective intelligence of its members to localize Western culture through various "domestication" translation strategies. As a result, this research extends our understanding of intercultural communication by offering an example of how contemporary online fansub groups speak for Western culture on the Chinese Internet. [ABSTRACT FROM AUTHOR]

Multidrug resistance is highly associated with poor prognosis of chronic myeloid leukemia. This work aims to explore whether the laser tweezers Raman spectroscopy (LTRS) could be practical in separating adriamycin-resistant chronic myeloid leukemia cells K562/adriamycin from its parental cells K562, and to explore the potential mechanisms. Detection of LTRS initially reflected the spectral differences caused by chemoresistance including bands assigned to carbohydrates, amino acid, protein, lipids, and nucleic acid. In addition, principal components analysis as well as the classification and regression trees algorithms showed that the specificity and sensitivity were above 90%. Moreover, the band data-based classification and regression tree model and receiver operating characteristic curve further determined some important bands and band intensity ratios to be reliable indexes in discriminating K562 chemoresistance status. Finally, we highlighted three metabolism pathways correlated with chemoresistance. This work demonstrates that the label-free LTRS analysis combined with multivariate statistical analyses have great potential to be a novel analytical strategy at the single-cell level for rapid evaluation of the chemoresistance status of K562 cells. Graphical Abstract [ABSTRACT FROM AUTHOR]