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Your search keyword '"Yao, Lanlin"' showing total 9 results
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9 results on '"Yao, Lanlin"'

2. Supplementary Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Author

Wen, Xuejun, primary, Shi, Changrong, primary, Zeng, Xinying, primary, Zhao, Liang, primary, Yao, Lanlin, primary, Liu, Zhida, primary, Feng, Lixia, primary, Zhang, Deliang, primary, Huang, Jinxiong, primary, Li, Yesen, primary, Lin, Qin, primary, Chen, Haojun, primary, Zhuang, Rongqiang, primary, Chen, Xiaoyuan, primary, Zhang, Xianzhong, primary, and Guo, Zhide, primary

Published
2023
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5. A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Author

Wen, Xuejun, primary, Shi, Changrong, additional, Zeng, Xinying, additional, Zhao, Liang, additional, Yao, Lanlin, additional, Liu, Zhida, additional, Feng, Lixia, additional, Zhang, Deliang, additional, Huang, Jinxiong, additional, Li, Yesen, additional, Lin, Qin, additional, Chen, Haojun, additional, Zhuang, Rongqiang, additional, Chen, Xiaoyuan, additional, Zhang, Xianzhong, additional, and Guo, Zhide, additional

Published
2022
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8. Dual Targeting of Integrin αvβ3and Neuropilin-1 Receptors Improves Micropositron Emission Tomography Imaging of Breast Cancer

Author

Yao, Lanlin, Li, Yesen, Chen, Haojun, Wen, Xuejun, Pang, Yizhen, Chen, Zijun, Guo, Zhide, Zhang, Xianzhong, Wu, Hua, and Guo, Wei

Abstract

The receptors neuropilin-1 (NRP-1) and integrin αvβ3are overexpressed in breast cancer and associated with neovascularization. We synthesized a heterodimeric tracer, 68Ga-DOTA-RGD-ATWLPPR, which simultaneously targets integrin αvβ3and NRP-1 in breast cancer. In this study, we evaluated the diagnostic efficacy of 68Ga-DOTA-RGD-ATWLPPR during micropositron emission tomography (microPET)/X-ray computed tomography (CT) imaging and gamma counting. We evaluated the receptor-binding characteristics and tumor-targeting efficacy of the tracer in vitroand in vivo. Static microPET/CT imaging and gamma counting studies showed that 68Ga-DOTA-RGD-ATWLPPR uptake in MCF-7 tumors is higher than that of monomeric tracers. 68Ga-DOTA-RGD-ATWLPPR uptake could be blocked with excess unlabeled RGD or ATWLPPR, demonstrating the sensitivity and specificity of the tracer. We did not observe bone tracer uptake in vivo, but the data indicated that 68Ga-DOTA-RGD-ATWLPPR is metabolized in the kidneys and the liver uptake is low. In conclusion, 68Ga-DOTA-RGD-ATWLPPR has improved binding affinity, targeting efficiency, and tumor retention time when compared to monomeric tracers, suggesting that it has potential as an imaging probe for breast cancer detection.

Published
2022
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9. Dual Targeting of Integrin α v β 3 and Neuropilin-1 Receptors Improves Micropositron Emission Tomography Imaging of Breast Cancer.

Author

Yao L, Li Y, Chen H, Wen X, Pang Y, Chen Z, Guo Z, Zhang X, Wu H, and Guo W

Subjects
Cell Line, Tumor, Female, Gallium Radioisotopes, Humans, Neuropilin-1 metabolism, Oligopeptides metabolism, Positron-Emission Tomography methods, Tissue Distribution, Breast Neoplasms pathology, Integrin alphaVbeta3 metabolism
Abstract

The receptors neuropilin-1 (NRP-1) and integrin α v β 3 are overexpressed in breast cancer and associated with neovascularization. We synthesized a heterodimeric tracer, 68 Ga-DOTA-RGD-ATWLPPR, which simultaneously targets integrin α v β 3 and NRP-1 in breast cancer. In this study, we evaluated the diagnostic efficacy of 68 Ga-DOTA-RGD-ATWLPPR during micropositron emission tomography (microPET)/X-ray computed tomography (CT) imaging and gamma counting. We evaluated the receptor-binding characteristics and tumor-targeting efficacy of the tracer in vitro and in vivo . Static microPET/CT imaging and gamma counting studies showed that 68 Ga-DOTA-RGD-ATWLPPR uptake in MCF-7 tumors is higher than that of monomeric tracers. 68 Ga-DOTA-RGD-ATWLPPR uptake could be blocked with excess unlabeled RGD or ATWLPPR, demonstrating the sensitivity and specificity of the tracer. We did not observe bone tracer uptake in vivo , but the data indicated that 68 Ga-DOTA-RGD-ATWLPPR is metabolized in the kidneys and the liver uptake is low. In conclusion, 68 Ga-DOTA-RGD-ATWLPPR has improved binding affinity, targeting efficiency, and tumor retention time when compared to monomeric tracers, suggesting that it has potential as an imaging probe for breast cancer detection.

Published
2022
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