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Your search keyword '"Xie, Suhong"' showing total 22 results
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22 results on '"Xie, Suhong"'

16. sj-docx-1-jbm-10.1177_03936155221078602 - Supplemental material for Prevalence of elevated Anti-p53 in Chinese patients with upper gastrointestinal or colorectal cancer

Author

Wang, Min, Xie, Suhong, Gao, Xiang, Feng, Jingjing, Deng, Minjie, Sun, Jiajun, He, Ying, Donner, Horst, Lu, Renqun, and Guo, Lin

Subjects
FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-jbm-10.1177_03936155221078602 for Prevalence of elevated Anti-p53 in Chinese patients with upper gastrointestinal or colorectal cancer by Min Wang, Suhong Xie, Xiang Gao, Jingjing Feng, Minjie Deng, Jiajun Sun, Ying He, Horst Donner and Renqun Lu, Lin Guo in The International Journal of Biological Markers

Published
2022
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19. Liquid Biopsy and Tissue Biopsy Comparison with Digital PCR and IHC/FISH for HER2 Amplification Detection in Breast Cancer Patients

Author

Xie, Suhong, primary, Wang, Yan, additional, Gong, Zhiyun, additional, Li, Yuan, additional, Yang, Wentao, additional, Liu, Guangyu, additional, Li, Jianwei, additional, Hu, Xin, additional, Wang, Yanchun, additional, Tong, Yin, additional, Yuan, Peng, additional, Si, Yiran, additional, Kang, Yikun, additional, Mao, Yong, additional, Qi, Xiaowei, additional, Liu, Yankui, additional, Ou, Jiajia, additional, Li, Zhaoliang, additional, Pan, Xin, additional, Lv, Zhaoqing, additional, Kaji, Kavanaugh, additional, Guo, Lin, additional, and Lu, Renquan, additional

Published
2022
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21. HBxintegration in diffuse large B-cell lymphoma inhibits Caspase-3-PARP related apoptosis

Author

Wang, Yanchun, Guan, Xiaolin, Lv, Fangfang, Rong, Yi, Meng, Xin, Tong, Ying, Ma, Xiaolu, Zheng, Hui, Chen, Cuncun, Xie, Suhong, Zhang, Heng, Dong, Feng, Guo, Lin, and Lu, Renquan

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common pathological type of non-Hodgkin lymphoma, and is closely associated with hepatitis B virus (HBV) infection status and hepatitis B X(HBx) gene integration. This project investigated the cellular biological effects and molecular mechanisms responsible for lymphomagenesis and the progression of HBxintegration in DLBCL. The data showed that clinical DLBCL cells demonstrated HBxintegration, and the sequencing analysis of integrated sites validated HBxintegration in the constructed HBx-transfected cells. Compared with control cells, HBx-transfected cells had a significantly reduced proportion of mitochondrial membrane potential, signals of chromosomal DNA breaks, and proportion of apoptotic cells. Further studies found that this decreased apoptosis level was associated with a significant reduction of cleaved Caspase-3 and downstream poly ADP-ribose polymerase (PARP) proteins, revealing the molecular mechanisms of HBx-associated apoptosis in DLBCL. Animal experiments also demonstrated that the protein expression of cleaved Caspase-3 and PARP was prominently reduced in HBx-transfected cells from subcutaneous tumors in mice. Furthermore, the HBx-integrated cells in clinical tissues had significantly lower cleaved PARP levels than the HBx-negative samples. Therefore, HBxintegration inhibits cell apoptosis through the Caspase-3-PARP pathway in DLBCL indicating a potential biomarker and therapeutic target in HBV related DLBCL.

Published
2024
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22. SCCA and CYFRA 21-1 Reference Intervals for Apparently Healthy Chinese Adults: a Multicenter Cross-Sectional Study.

Author

Jiang M, Gong Z, Shen J, Wu W, Zhang T, Xiang B, Chen F, Lin Y, Shen J, Xie S, Lu R, and Guo L

Subjects
Humans, Female, Male, Cross-Sectional Studies, Middle Aged, Adult, Reference Values, China epidemiology, Prospective Studies, Aged, Young Adult, East Asian People, Antigens, Neoplasm blood, Keratin-19 blood, Serpins blood, Biomarkers, Tumor blood
Abstract

Background: This study aimed to establish reference intervals for two biomarkers actively utilized in routine annual medical check-ups in China: squamous cell carcinoma antigen (SCCA) and cytokeratin 19 fragment (CYRFA 21-1), and to understand the influence of age, gender, and benign nodule(s) on their levels., Methods: This prospective multicenter cross-sectional study continuously enrolled apparently healthy adults attending annual medical check-ups at three sites in 2019. Serum SCCA and CYFRA 21-1 levels were measured using electrochemiluminescence immunoassays. Age- and gender-specific reference intervals for the two biomarkers were established by using the 0 - 95th percentiles with 90% confidence intervals (CIs). The 97.5th percentiles were also provided., Results: A total of 1,017 subjects were enrolled in this study. Both biomarkers were significantly lower in females, and age was negatively associated with SCCA while positively associated with CYFRA 21-1 (all p < 0.0001). No statistically significant differences were determined between subgroups without/with benign nodule(s) despite nodule(s) status (all p > 0.05). The overall reference interval for SCCA is 0 - 2.64 ng/mL and 0 - 4.39 ng/mL for CYFRA 21-1. The age-specific reference intervals for SCCA are 0 - 2.76 ng/mL (18 - 49 years) and 0 - 2.22 ng/mL (≥ 50 years), and for CYFRA 21-1, they are 0 - 3.86 ng/mL (18 - 49 years) and 0 - 4.89 ng/mL (≥ 50 years). The gender-specific reference intervals for SCCA are 0 - 2.83 ng/mL (male) and 0 - 2.49 ng/mL (female), and for CYFRA 21-1, they are 0 - 4.34 ng/mL (male) and 0 - 4.45 ng/mL (female)., Conclusions: The reference intervals for SCCA and CYFRA 21-1 established in this study could be utilized in annual medical check-ups and contribute to the screening of lung cancer in China.

Published
2024
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